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Liver Cancer: A Promising Avenue for More Effective Immunotherapies

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3 years ago

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Research team identifies biomarker that may explain treatment failure in some people

LAVAL, QC, Feb. 14, 2024 /CNW/ – A research team of Canadian and French scientists, led by INRS professor Maya Saleh, has been investigating immunotherapy resistance in certain patients with hepatocellular carcinoma (HCC) associated with steatotic liver disease. The findings are published in the journal Cell Reports.

Hepatocellular carcinoma is associated with known risk factors such as chronic hepatitis B or C infection, alcohol abuse, and metabolic dysfunction. It is the most common type of liver cancer. Despite major advances in immunotherapy, this cancer is often fatal: around 75% of patients with advanced HCC fail to respond to this type of treatment, for reasons that had yet to be clarified.

This encouraged the research team to explore the link between metabolic dysfunction-associated liver disease, a chronic inflammatory disease of the liver, and therapeutic resistance to immunotherapy in HCC patients.

“We have identified an immune biomarker for HCC associated with stetatotic liver disease, which will allow us to develop new immunotherapies,” explains Professor Maya Saleh, an international specialist in immuno-oncology. “We could envisage immunotherapies that restore an effective immune response against HCC by attenuating the damaging liver inflammation.”

Discovery of a potential therapeutic target

HCC remains a major public health concern; in North America, its incidence has doubled in the past three decades. Prior to the approval of immunotherapy, the treatment options for advanced HCC were limited and ineffective. As an example, sorafenib improves mean overall survival by just 3 months and is associated with significant side effects.

Immunotherapies, when administered in combinations, increase the average survival of HCC patients by 17 months on average.

Thanks to the use of “omics” technologies, which allow large quantities of biological data to be analyzed in a short timeframe, the team developed an immune map of the tumour and adjacent non-tumoral liver in 10 patients. These initial immune maps led them to study databases of hundreds of patients in order to validate the immune profiles related to risk factors and associated with disease severity.

These initial results indicate that the chronic inflammation from steatotic liver disease makes the liver cancer environment unique, with an expansion of immunosuppressive cells that paralyse the immunological attack of the tumour.

The research team has demonstrated that the immunosuppressive cells express an inflammatory receptor, named TREM1, which makes them more dangerous. They therefore highlighted TREM1 as a potential therapeutic target in HCC associated with steatotic liver disease.

Interesting implications for immunotherapy research

By identifying this biomarker, which could explain treatment failure in people with HCC, the team has paved the way for a new approach to classifying patients. This would allow them to determine who would be more likely to respond to immunotherapy before treatment even begins.

Such a scientific breakthrough would ease the psychological burden for patients who don’t respond to immunotherapy. Important physical impacts, including side effects, could also be prevented.

“This is a promising avenue for the next few years. We will continue the analysis by characterizing the immune component of tumours in a larger cohort of patients, including comprehensive imaging of tumour cell composition and the use of artificial intelligence to link immune profiles to response to therapy. This could have a significant impact on the field,” concludes Professor Saleh.

About the study

This paper was co-authored by Julie Giraud, Domitille Chalopin, Eloïse Ramel, Thomas Boyer, Atika Zouine, Marie-Alix Derieppe, Nicolas Larmonier, Olivier Adotevi, Brigitte Le Bail, Jean-Frédéric Blanc, Christophe Laurent, Laurence Chiche, Marc Derive, Macha Nikolski, and Maya Saleh.

Entitled “THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1,” it was published in Cell Reports Vol 43, Issue 2. DOI: 10.1016/j.celrep.2024.11377.

This research was funded to Dr. Saleh by the Fondation ARC, IDEX Bordeaux, ITMO Cancer, the Nouvelle-Aquitaine region in France, and SIRIC BRIO.

About INRS 

INRS is an academic institution dedicated exclusively to graduate research and training. Since its creation in 1969, it has actively contributed to Quebec’s economic, social, and cultural development. INRS ranks first in Quebec and Canada in research intensity. It is made up of four interdisciplinary research and training centres located in Quebec City, Montreal, Laval, and Varennes, which focus their efforts on strategic sectors: water, earth, and environment (Eau Terre Environnement Research Centre); energy, materials, and telecommunications (Énergie Matériaux Télécommunications Research Centre); urbanization, culture, and society (Urbanisation Culture Société Research Centre); and health and biotechnology (Armand-Frappier Santé Biotechnologie Centre). The INRS community includes over 1,500 students, postdoctoral fellows, and faculty and staff members. 

SOURCE Institut National de la recherche scientifique (INRS)

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HR Path Strengthens its Australian Presence with Strategic Acquisition of Payroll Experts Australia

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October 21, 2026

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PARIS, Oct. 21, 2026 /PRNewswire/ — HR Path, a global leader in HR consulting and HRIS solutions, today announces its strategic acquisition of Payroll Experts Australia, a Brisbane-based company specialising in payroll compliance, remediation, workforce management and HR systems consulting.

Founded in 2009, Payroll Experts Australia has delivered more than 530 projects for over 260 organisations across Australia and New Zealand. Independent of any software vendor, the company supports employers across the full payroll, workforce management and HR systems lifecycle, with expertise spanning payroll compliance and audit, remediation, award and agreement interpretation, payroll processing, advisory and end-to-end systems implementation.

The acquisition strengthens HR Path’s ability to provide end-to-end HR transformation services across the ANZ market. Payroll Experts Australia’s specialist capabilities complement HR Path’s existing HRIS technology and SAP SuccessFactors expertise, enabling the combined organisation to support clients with a broader range of locally grounded services, from strategic advisory and systems implementation to payroll compliance and operational support. 

Payroll Experts Australia will continue to operate under the brand “Payroll Experts Australia, an HR Path Company”. Its leadership team and employees will remain in their current roles, ensuring continuity of service for clients while giving the business access to HR Path’s international capabilities and resources. 

The transaction builds on HR Path’s expansion in the region. HR Path has been active in Australia since 2019, following the acquisition of DDG. It opened an Australian office in 2024 and acquired RKM Consulting in 2025, strengthening its HRIS technology and SAP SuccessFactors capabilities across Australia and New Zealand.  

“The acquisition of Payroll Experts Australia, a company renowned for its expertise in payroll compliance, is a strategic move that supports our ambition to be the global reference in HR transformation,” said François Boulet, Co-founding Partner at HR Path. “Their deep knowledge and strong client relationships in Australia complement our global capabilities, enabling us to deliver even more value to our clients. This partnership is about synergy, innovation, and shared commitment to excellence.”

“We are very happy about this new chapter!” said Steve Keenaghan, Chief Executive Officer at Payroll Experts Australia. “This step opens up exciting opportunities for our team and our clients and ensures our continued growth and success. We will maintain our commitment to delivering exceptional, independent payroll expertise while exploring new possibilities within HR Path.”

Contact:

Fabienne LATOUR  Fabienne.latour@hr-path.com

 

 

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Sungrow Powers Up for All Energy Australia 2026 With New Residential Innovation and Full Ecosystem Showcase

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October 21, 2026

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MELBOURNE, Australia, Oct. 21, 2026 /PRNewswire/ — Sungrow, the global leader in PV inverter and energy storage solutions, is set to make a strong return to All Energy Australia 2026, the region’s largest and most influential renewable energy exhibition. It will introduce its next-generation all-in-one residential flagship PowerHarbour, alongside a comprehensive showcase of technologies for residential, C&I, and utility-scale applications.

As Australia accelerates toward a cleaner, more resilient energy future, Sungrow’s presence at All Energy will once again serve as a central meeting point for industry leaders, installers, innovators, and policymakers. The booth will offer visitors a rich blend of product demonstrations, technical insights, interactive experiences, and opportunities to connect with Sungrow’s local engineering and sales teams.

A New Addition to Residential Energy Storage

At the upcoming All-Energy 2026, Sungrow will officially unveil PowerHarbour in Australia for the first time. It is a residential all in one solution designed to simplify energy independence for homeowners. It combines sleek design, intelligent integration, advanced safety features and a modular design that can deliver up to 120kWh of capacity. The enhanced AFCI 3.0 protection makes it one of the most flexible and homeowner‑friendly systems on the market. The result is a clean, integrated solution that empowers households to take control of their energy with confidence and ease.

C&I Solutions for Diverse Applications

The exhibition will also showcase Sungrow’s C&I portfolio, including PowerKeeper, deployed across diverse Australian environments, and the ST255CS liquid-cooled BESS cabinet, designed for applications such as microgrid stability and FCAS. Together, these solutions demonstrate Sungrow’s capabilities in delivering flexible, reliable energy storage for a wide range of commercial and industrial needs.

Utility-Scale Innovation on Display

For utility developers and EPCs, Sungrow will present a full-size PowerTitan 3.0, giving visitors a rare opportunity to see the battery container up close. Together, PowerTitan 3.0 and 1+X modular inverter demonstrate advanced energy storage, grid-forming capabilities, and flexible deployment for complex project environment. Backed by dedicated local project management, comprehensive technical support, and a growing project pipeline across Australia and New Zealand.

Visit Sungrow at Booth KK123

Sungrow invites all attendees to visit Booth KK123 at All Energy Australia 2026 to experience its latest residential, commercial, and utility‑scale innovations firsthand. Attendees can expect a vibrant and engaging atmosphere throughout the day featuring lucky draws with exciting prizes, free premium coffee, photobooth and insightful presentations. The booth promises a full day of discovery, connection, and inspiration. Sungrow looks forward to welcoming partners, customers, and renewable energy enthusiasts as we continue powering Australia’s clean energy future together.

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SOURCE Sungrow

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AglaiaSense and Leopard Imaging to Demonstrate Privacy-First AI Traffic Sensing at Smart City Expo World Congress in Barcelona

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October 21, 2026

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FREMONT, Calif. and BARCELONA, Spain, Oct. 21, 2026 /PRNewswire/ — AglaiaSense and Leopard Imaging will exhibit together at Smart City Expo World Congress, November 3–5, 2026, at Fira Barcelona Gran Vía.

The two companies proposed AI-VIVA (Vision Intelligence for València and Arterials) and is selected as a finalist in the fifth urban challenge of Barcelona Innova Lab Mobility (BILM), on the application of artificial intelligence to traffic-light regulation. AI-VIVA combines AglaiaSense’s edge-AI traffic solutions with Leopard Imaging’s patented privacy architecture. At the show, the team will give a live demonstration of AglaiaSense’s signature MS500 and GS500 cameras, with the AglaiaSense AI Box, powered by NVIDIA, which adds local processing to coordinate groups of neighboring intersections.

The cameras analyze images inside the device, using the Sony IMX500 and IMX501 intelligent vision sensors. They count and classify vehicles, buses, cyclists and pedestrians in real time. Raw video is discarded on the device within 400–800 milliseconds, and only anonymous metadata is transmitted. Cities can feed that data into signal-control software to adapt traffic lights to real demand.

MS500: about 2 W average power, 1080p, powered from a standard NEMA or ZHAGA street-light socket.

GS500: about 6.5 W average, dual 4K cameras, with Ethernet, LTE Cat 4 and GPS; powered by PoE, 12–24 V DC or a NEMA adapter.

Both cameras: IP66-rated, −20 °C to +65 °C, mounted on existing poles, so no trenching or new masts are needed.

Bandwidth: more than 95% lower than CCTV-based monitoring.

“Cities want safer, smoother streets without turning every crossing into a surveillance point,” said Leon Luo, CEO of AglaiaSense. “Being named a finalist in Barcelona tells us the approach resonates.”

“Privacy has to be built into the camera, not added later,” said Bill Pu, CEO of Leopard Imaging.

AglaiaSense’s solutions are deployed across North America and Asia, and the company won first place in the Pedestrian Safety Challenge Hackathon, run by the Edge AI Foundation (formerly the tinyML Foundation) and the City of San José. In field tests, the systems achieved detection and counting accuracy above 95%. The City of Lakewood, Colorado, compared the GS500 with traditional IP cameras and LiDAR on real roads and found it more accurate, more energy-efficient, and less costly to deploy. At a high-risk crossing where pedestrians often crossed outside the crosswalk, the system alerted approaching drivers in real time.

Visit us at Pavilion 3, Level 0, Street D, Stand 71. To book a meeting, email sales@aglaiasense.com.

About AglaiaSense

AglaiaSense, is an edge-AI company specializing in privacy-first, vision-based sensing for smart cities. Its GS500 and MS500 cameras run AI on the image sensor to count and classify road users in real time and send only anonymous metadata.

About Leopard Imaging

Leopard Imaging is a global leader in high-definition embedded cameras and AI-based imaging solutions in industries including automotive, aerospace, drones, IoT, and robotics.

Media contact:

Cathy Zhao

+1 (408) 263-0988

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