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Liver Cancer: A Promising Avenue for More Effective Immunotherapies

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Research team identifies biomarker that may explain treatment failure in some people

LAVAL, QC, Feb. 14, 2024 /CNW/ – A research team of Canadian and French scientists, led by INRS professor Maya Saleh, has been investigating immunotherapy resistance in certain patients with hepatocellular carcinoma (HCC) associated with steatotic liver disease. The findings are published in the journal Cell Reports.

Hepatocellular carcinoma is associated with known risk factors such as chronic hepatitis B or C infection, alcohol abuse, and metabolic dysfunction. It is the most common type of liver cancer. Despite major advances in immunotherapy, this cancer is often fatal: around 75% of patients with advanced HCC fail to respond to this type of treatment, for reasons that had yet to be clarified.

This encouraged the research team to explore the link between metabolic dysfunction-associated liver disease, a chronic inflammatory disease of the liver, and therapeutic resistance to immunotherapy in HCC patients.

“We have identified an immune biomarker for HCC associated with stetatotic liver disease, which will allow us to develop new immunotherapies,” explains Professor Maya Saleh, an international specialist in immuno-oncology. “We could envisage immunotherapies that restore an effective immune response against HCC by attenuating the damaging liver inflammation.”

Discovery of a potential therapeutic target

HCC remains a major public health concern; in North America, its incidence has doubled in the past three decades. Prior to the approval of immunotherapy, the treatment options for advanced HCC were limited and ineffective. As an example, sorafenib improves mean overall survival by just 3 months and is associated with significant side effects.

Immunotherapies, when administered in combinations, increase the average survival of HCC patients by 17 months on average.

Thanks to the use of “omics” technologies, which allow large quantities of biological data to be analyzed in a short timeframe, the team developed an immune map of the tumour and adjacent non-tumoral liver in 10 patients. These initial immune maps led them to study databases of hundreds of patients in order to validate the immune profiles related to risk factors and associated with disease severity.

These initial results indicate that the chronic inflammation from steatotic liver disease makes the liver cancer environment unique, with an expansion of immunosuppressive cells that paralyse the immunological attack of the tumour.

The research team has demonstrated that the immunosuppressive cells express an inflammatory receptor, named TREM1, which makes them more dangerous. They therefore highlighted TREM1 as a potential therapeutic target in HCC associated with steatotic liver disease.

Interesting implications for immunotherapy research

By identifying this biomarker, which could explain treatment failure in people with HCC, the team has paved the way for a new approach to classifying patients. This would allow them to determine who would be more likely to respond to immunotherapy before treatment even begins.

Such a scientific breakthrough would ease the psychological burden for patients who don’t respond to immunotherapy. Important physical impacts, including side effects, could also be prevented.

“This is a promising avenue for the next few years. We will continue the analysis by characterizing the immune component of tumours in a larger cohort of patients, including comprehensive imaging of tumour cell composition and the use of artificial intelligence to link immune profiles to response to therapy. This could have a significant impact on the field,” concludes Professor Saleh.

About the study

This paper was co-authored by Julie Giraud, Domitille Chalopin, Eloïse Ramel, Thomas Boyer, Atika Zouine, Marie-Alix Derieppe, Nicolas Larmonier, Olivier Adotevi, Brigitte Le Bail, Jean-Frédéric Blanc, Christophe Laurent, Laurence Chiche, Marc Derive, Macha Nikolski, and Maya Saleh.

Entitled “THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1,” it was published in Cell Reports Vol 43, Issue 2. DOI: 10.1016/j.celrep.2024.11377.

This research was funded to Dr. Saleh by the Fondation ARC, IDEX Bordeaux, ITMO Cancer, the Nouvelle-Aquitaine region in France, and SIRIC BRIO.

About INRS 

INRS is an academic institution dedicated exclusively to graduate research and training. Since its creation in 1969, it has actively contributed to Quebec’s economic, social, and cultural development. INRS ranks first in Quebec and Canada in research intensity. It is made up of four interdisciplinary research and training centres located in Quebec City, Montreal, Laval, and Varennes, which focus their efforts on strategic sectors: water, earth, and environment (Eau Terre Environnement Research Centre); energy, materials, and telecommunications (Énergie Matériaux Télécommunications Research Centre); urbanization, culture, and society (Urbanisation Culture Société Research Centre); and health and biotechnology (Armand-Frappier Santé Biotechnologie Centre). The INRS community includes over 1,500 students, postdoctoral fellows, and faculty and staff members. 

SOURCE Institut National de la recherche scientifique (INRS)

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Intesa Communications Group Named ‘Customers First’ Winner in San Diego Regional Chamber of Commerce 2026 Small Business Awards

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The award-winning, women-owned San Diego public relations and government affairs firm was recognized for exceptional client service that has fueled 14 years of growth

SAN DIEGO, July 21, 2026 /PRNewswire/ — Intesa Communications Group, a leading San Diego public relations and government affairs firm, has been named the “Customers First” winner in the San Diego Regional Chamber of Commerce’s 2026 Small Business Awards. Announced July 9 at the Chamber’s annual Small Business Awards event, the recognition honors the small business whose commitment to customer service most clearly sets it apart from the competition.

Founded in 2012, the certified women-owned San Diego firm has grown from a boutique agency into one of the region’s leading public relations and government affairs firms. Intesa has doubled its team over the past two years, sustained three consecutive years of double-digit revenue growth and expanded its client portfolio by 26% last year. Intesa provides public relations, strategic communications, and government affairs services for a wide range of organizations, including San Diego State University, SeaWorld San Diego, Expedia Group, H.G. Fenton Company, San Diego Foundation, San Diego Workforce Partnership, and SBCS.

“This award belongs to every member of our team and to the clients who trust us with their most valuable asset: their reputation,” said Margie Newman Tsay, founding partner of Intesa Communications Group. “Our clients stay with us for years because we show up prepared, fully invested and ready for the moments that matter most. Being recognized for putting customers first is the highest compliment our business community can pay us.”

Intesa’s client-first approach has produced measurable results across public relations and government affairs efforts throughout the region. For example, in its first month working with the Jacobs & Cushman San Diego Food Bank, the firm helped reimagine the organization’s summer food drive messaging, generating more than 15 million impressions and helping deliver 489,026 pounds of food and $344,505 in donations — the equivalent of more than one million meals and a 175% increase from the previous year. Similarly, Logan Heights Community Development Corporation credits the firm with an 81:1 return on investment after Intesa parachuted in to help the nonprofit promote the California Mortgage Relief Program.

“Small businesses are the heart of our economy: fueling innovation, creating jobs and defining the character of communities across the San Diego region,” said Chris Cate, president and CEO of the Chamber. “We celebrate the resilience, ingenuity and community impact of our small business leaders. They are the very spirit behind our purpose to champion business and empower leaders.”

The Chamber award is as much a reflection of Intesa’s clients as it is the firm itself. The opportunity to partner with organizations doing meaningful work across the region is what makes recognition like this possible. True to form, the Intesa team plans to mark the win by thanking the clients behind the work.

“We call ourselves dot connectors, and this award is what that looks like in practice,” said Maddy Kilkenny, partner at Intesa Communications Group, who leads the firm’s government affairs practice. “Whether our team of 10 people is helping a client navigate a policy decision at City Hall or a story on the front page of the newspaper, we aim to leave them stronger and more confident than before. Hearing our clients say we deliver on that is the best win of all.”

According to the Chamber’s award requirements, businesses with 100 or fewer employees were eligible for nomination. They were voted on by a panel of chamber members, who reviewed the nominations and selected the winners of all four categories.

The recognition adds to more than 60 awards Intesa has earned for excellence in public relations, strategic communications, and public affairs, including honors from PR News, the Public Relations Society of America, PR Daily, the International Association of Business Communicators, the San Diego Business Journal (SDBJ), MARCOM, and the American Marketing Association, among others. It also comes on the heels of two Intesa team members, Emily Alvarenga and Margaret Lutz Chantung, recently receiving SDBJ’s “40 Under 40” and “Indispensable” awards, respectively.

For more information about Intesa Communications Group, visit www.intesacom.com.

About Intesa Communications Group
Intesa Communications Group is a certified women-owned San Diego public relations and government affairs firm that helps leaders communicate and advocate with confidence. Since 2012, Intesa has partnered with the region’s trusted leaders and organizations, providing strategic communications and public affairs counsel on high-stakes issues at the intersection of reputation, policy and public perception. The firm’s work has earned more than 60 industry awards across 53 recognized client campaigns, including the San Diego Regional Chamber of Commerce “Customers First” 2026 award. Learn more at www.intesacom.com.

View original content to download multimedia:https://www.prnewswire.com/news-releases/intesa-communications-group-named-customers-first-winner-in-san-diego-regional-chamber-of-commerce-2026-small-business-awards-302831350.html

SOURCE Intesa Communications Group

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The Inner Circle acknowledges Shankari Thiagarajan as Pinnacle Professional of The Year

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HOUSTON, July 21, 2026 /PRNewswire/ — Prominently featured in The Inner Circle, Shankari Thiagarajan is acknowledged as a Pinnacle Professional of The Year for her contributions to Information Technology and Agile Delivery.     

Shankari Thiagarajan has established a distinguished career in information technology project and program management, recognized for her expertise in agile delivery, digital transformation, and cross functional leadership across multiple industries. Currently serving as project manager and scrum master at Astellas Pharma Inc., she oversees agile delivery initiatives supporting global life science programs.

With more than 15 years of experience spanning technology and pharmaceutical sectors, Ms. Thiagarajan has developed a reputation for leading complex implementations and driving operational efficiency. Her expertise includes agile methodologies, project and delivery management, product ownership, healthcare IT, telecom and network optimization, financial services modernization, retail technology upgrades, and GIS and digital mapping solutions.

Ms. Thiagarajan earned a Master of Business Administration in Organizational Leadership from Campbellsville University, a Master of Science in Information Systems from Virginia Tech, and a Bachelor of Engineering in Information Technology from Jawaharlal Nehru Technological University College of Engineering Hyderabad.

Throughout her career, she has contributed to major organizations across a wide range of industries. Her accomplishments include leading agile transformations at Cigna, overseeing retail technology upgrades at Walmart, managing large scale telecom transformation initiatives at T Mobile and Verizon, and modernizing financial platforms at Security Finance. She also contributed to the early development of Google Maps during her tenure at Google India, advancing to team lead within a year.

In addition to her corporate achievements, Ms. Thiagarajan is the creator of the YouTube channel My Experiments with Life – #Positivity #Learning, launched in 2023. Through this platform, she shares motivational content and insights focused on personal growth, technology, spirituality, and lifelong learning.

Her professional accomplishments have been recognized through honors including Marquis Who’s Who 2026, a featured podcast interview with Jim Masters on Close Up TV hosted across Apple Radio, Spotify, and iHeart., recognition in The National Law Review & EIN Presswire, and a certificate of appreciation from Virginia Tech for academic excellence and community involvement.

Outside of her professional work, Ms. Thiagarajan enjoys creating motivational YouTube content, exploring technology and spirituality, listening to contemporary music, and pursuing philanthropic and educational interests. She credits her strong work ethic and determination to the example set by her parents.

Looking ahead, she plans to continue advancing her leadership capabilities and pursue executive level opportunities that allow her to make significant contributions within the information technology sector.

Guided by a philosophy rooted in courage, persistence, and continuous learning, Ms. Thiagarajan remains committed to professional growth while inspiring others to pursue excellence and self-improvement.

Contact: Katherine Green, 516-825-5634, editorialteam@continentalwhoswho.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/the-inner-circle-acknowledges-shankari-thiagarajan-as-pinnacle-professional-of-the-year-302831357.html

SOURCE The Inner Circle

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University of Phoenix Leaders Present at Building Blackboard Together 2026

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Presentations explored learning technology, accessibility and online pedagogy as higher education adapts to an AI-enabled future

PHOENIX, July 21, 2026 /PRNewswire/ — University of Phoenix leaders shared insights on artificial intelligence, accessibility, online learning and student support at Building Blackboard Together 2026, Blackboard’s flagship user conference, held July 13-15 in Dallas, Texas. The conference brought together educators, institutional leaders and industry experts to explore innovations, technologies and emerging practices shaping the future of teaching and learning.

Representing University of Phoenix were Marc Booker, Ph.D., vice provost of strategy; Kelly Hermann, vice president of Accessibility and Student Affairs; and Erin Amsden, group product manager. Through presentations and panel discussions, the leaders shared perspectives on responsible AI adoption, accessibility leadership, student engagement and the evolving role of learning technologies in supporting institutional goals and student success.

“Building Blackboard Together provides an opportunity to engage with peers across higher education who are navigating many of the same opportunities and challenges around technology, accessibility and learning mobility,” said Dr. Booker. “These conversations help advance practical approaches for supporting learners while thoughtfully integrating innovation into the educational experience.”

During the conference, University of Phoenix was also recognized with the 2026 Blackboard Catalyst Award for Ethical AI Leadership, which honors institutions advancing responsible, transparent and inclusive approaches to artificial intelligence that promote trust and equitable outcomes for learners and educators. The recognition follows the University’s ongoing efforts to support AI literacy, responsible use and AI-enabled learning experiences.

Exploring the Expanding Role of the Learning Management System

As part of the Strategic Leadership Summit, Booker served as a panelist for “The LMS as Mission-Critical: Connecting Learning, Experience & Evidence.” The session examined how learning management systems are evolving beyond course management to support learning, engagement and institutional insight across the student lifecycle.

Panelists discussed how institutions are leveraging learning technologies alongside student information systems to support teaching and learning, advising, co-curricular engagement and data-informed decision-making while addressing increasing expectations surrounding artificial intelligence, student success and accountability.

Sharing Lessons from AI-Powered Student Support

Booker also presented “Scaling AI-Powered Support Across the Student Experience at University of Phoenix,” a session focused on the University’s process for expanding its AI support assistant across the online classroom environment, moving from proof of concept to full-scale deployment over a six-month period.

In addition, Booker participated in “Online Pedagogy to Drive Institutional Growth: Best Practices and Success Stories,” a panel discussion exploring how institutions are designing engaging online learning experiences and leveraging Blackboard technologies to support quality course delivery and student engagement.

Advancing Accessibility Leadership

Hermann joined the session “Communicating Up: Turning Accessibility Work into Leadership-Ready Stories.” The presentation focused on strategies for translating accessibility initiatives into narratives, evidence and visualizations that resonate with institutional leaders.

The discussion explored ways to connect accessibility efforts to broader institutional priorities, demonstrate impact through data and support informed decision-making that advances accessibility and learner success.

Examining Emerging Challenges in Artificial Intelligence

Amsden served as a panelist for “Agentic AI in Pedagogy: Threats and Opportunities.” The session addressed the growing influence of agentic AI and its implications for academic integrity, assessment design and learner engagement.

Panelists explored how technology, pedagogy and security practices can work together to promote authentic student work while helping institutions balance innovation with responsible AI implementation.

Contributing to the Future of Teaching and Learning

Amsden, Booker and Hermann are key members of University of Phoenix’s dynamic leadership team, frequently invited to share their expertise at prestigious national conferences and events. In 2026, University leaders will participate in the ASU + GSV Summit, 1EdTech Learning Impact Conference, SXSW EDU Conference, and PESC Data Summit. These engagements underscore the University’s commitment to innovation and thought leadership in higher education, providing valuable insights and fostering collaborations that drive the future of learning.

About University of Phoenix

University of Phoenix is Built for Real Life. 50 Years Strong. The University innovates to help working adults enhance their careers and develop skills in a rapidly changing world through flexible online learning, relevant courses, academic AI pillars, and skills-mapped curriculum for associate, bachelor’s and master’s degree programs. Active students and alumni have access to Career Services for Life® resources including career guidance and tools. For more information, visit phoenix.edu.

View original content to download multimedia:https://www.prnewswire.com/news-releases/university-of-phoenix-leaders-present-at-building-blackboard-together-2026-302831360.html

SOURCE University of Phoenix

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