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Expert Systems Celebrates Completion of Single Dose Studies and Start of Multiple Human Dosing for Lomonitinib, a Selective Pan-FLT3/IRAK4 Inhibitor, Achieved in Just 3 Years

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ROCKVILLE, Md., Feb. 23, 2024 /PRNewswire/ — Expert Systems, a leader in AI-enabled drug discovery, proudly announces a significant milestone in partnership with Eilean Therapeutics LLC: the successful completion of a single ascending dose Phase 1 clinical trial for lomonitinib, a selective pan-FLT3/IRAK4 inhibitor, alongside the launch of a multiple ascending dose Phase 1 study.

“Lomonitinib has demonstrated an exceptional safety profile, with no significant adverse events reported at doses achieving robust target engagement. This positions it as a leading best-in-class candidate for the treatment of FLT3-mutated AML,” commented Bill Farley, CBO at Expert Systems. “We are proud that our comprehensive hybrid AI-based platform has helped advance a new treatment like lomonitinib to clinical trials in just 3 years.”

Supported by Orbimed, Torrey Pines Investment, and Dr. John C. Byrd, Eilean Therapeutics is committed to leading the development of innovative therapies that significantly enhance treatment outcomes in both hematologic and solid malignancies. This effort is bolstered by leveraging Expert Systems’ cutting-edge AI platform to speed up the discovery and development process.

About Lomonitinib

Lomonitinib is a highly potent and selective inhibitor of FLT3 ITD (internal tandem duplications), tyrosine kinase domain (TKD), and other clinically significant FLT3 mutations, and an IRAK4 inhibitor. FLT3 mutations are the most frequently identified mutations in AML. There are two main mechanisms of resistance to FLT3 inhibitors: the FLT3-ITD-F691L mutation – deemed the “gatekeeper” mutation that confers resistance to all currently approved FLT3 inhibitors; and the activation of the IRAK4 escape pathway. Lomonitinib effectively inhibits both of these resistance pathways, promising a new treatment for patients with FLT3-mutated AML.

About Expert Systems, Inc.

Expert Systems, Inc., an advanced accelerator platform, is equipped with a comprehensive, hybrid AI-based system that covers the entire spectrum of preclinical drug discovery and early development phases. This includes target identification, virtual screening, non-clinical and clinical pharmacology, chemical liability assessment, and toxicology. Utilizing a unique combination of proprietary and public databases, Expert Systems employs specialized software tools to evaluate the intellectual property landscape and construct a competitive drug intelligence strategy to de-risk candidate selection for rapid transition from in silico to first-in-human trials. Expert Systems has been pivotal in establishing seed and Series A companies, organizing and managing over 30 research and development programs across various financial investors and strategic partners in North America, Europe, and Australia. To learn more, visit www.expertsystems.inc

About Eilean Therapeutics

Eilean Therapeutics LLC is a cutting-edge biopharmaceutical company, established through a collaboration between Orbimed, Torrey Pines Investment, and Dr. John C. Byrd, dedicated to the identification of both best-in-class and first-in-class small molecule inhibitors targeting escape mutations in both hematologic and solid cancers. The company harnesses the Expert Systems Inc. hybrid AI platform alongside its key partners’ exclusive data, chem-bio platforms, knowledge, and expertise. This enables Eilean Therapeutics to select molecular mechanisms of pathology with high clinical relevance, precisely designing and expediting the discovery and development processes for leading-edge therapies. Eilean Therapeutics is committed to leveraging its unique capabilities and platform to create novel, groundbreaking medicines for patients with hematologic and solid malignancies, marking a new era in targeted cancer therapy. For more information, visit www.eileanther.com

Media Contact:

Bill Farley

CBO

bfarley@expertsystems.inc

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SOURCE Expert Systems, Inc.

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PlanetiQ Selected for NOAA’s Space-Based Environmental Monitoring IDIQ

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Selection builds on PlanetiQ’s long-standing relationship with NOAA and adds thermospheric neutral density to its environmental data offerings

GOLDEN, Colo., Sept. 11, 2026 /PRNewswire/ — PlanetiQ, a leading provider of commercial satellite-based environmental data, today announced that it has been selected as an industry partner under NOAA’s new Space-Based Environmental Monitoring (SBEM) Indefinite Delivery, Indefinite Quantity (IDIQ) contract. Through the SBEM IDIQ, PlanetiQ will be eligible to compete for task orders to provide NOAA with two types of commercial environmental data: Global Navigation Satellite System-Radio Occultation (GNSS-RO) observations for atmospheric profiling and ionospheric monitoring, and thermospheric neutral density data for satellite orbit prediction.

“This selection builds on our long-standing partnership with NOAA and expands the ways our data can support the agency, from high-resolution atmospheric and ionospheric observations to thermospheric neutral density for satellite orbit prediction,” said Ira Scharf, CEO of PlanetiQ.  

The SBEM IDIQ, established by NOAA’s National Environmental Satellite, Data, and Information Service (NESDIS) through its Commercial Data Program. The contract has a five-year base period followed by a five-year option and is effective from September 1, 2026, through August 31, 2036.

Under SBEM, PlanetiQ will provide data from its existing satellite constellation as well as additional satellites planned for launch later this year. The company’s GNSS-RO observations provide high-resolution atmospheric profiles for numerical weather prediction and measurements of the ionosphere, including Total Electron Content (TEC) and scintillation. PlanetiQ will also introduce thermospheric neutral density data as a new commercial data product for NOAA NESDIS, supporting improved satellite orbit prediction and space-weather applications.

“PlanetiQ has built its business around delivering high-quality GNSS-RO data with the precision needed to improve weather forecasting,” said Ira Scharf, CEO of PlanetiQ. “This selection builds on our long-standing partnership with NOAA and expands the ways our data can support the agency, from high-resolution atmospheric and ionospheric observations to thermospheric neutral density for satellite orbit prediction. We look forward to continuing to work with NOAA to advance weather forecasting and space weather applications.”

Per NOAA’s own press release, NOAA is expanding its procurement and use of new commercial environmental satellite data streams that will enhance weather forecasting and space weather monitoring. The SBEM IDIQ contract is a key part in the agency’s ongoing effort to boost U.S. weather forecasting capabilities.

PlanetiQ currently provides GNSS-RO data to NOAA NESDIS under the agency’s previous commercial data contract vehicle. The company’s most recent task order, announced in August, provides GNSS-RO and ionospheric data and bridges the transition to the new SBEM contract.

About PlanetiQ

PlanetiQ provides the highest-quality GNSS radio occultation (RO) data available from a commercial constellation of satellites, offering unmatched temporal and spatial resolution. The data drive accurate, high-impact weather and climate forecast models, helping improve Numerical Weather Prediction and AI forecasts, safeguard lives and property from severe weather. In 2025, PlanetiQ was awarded NOAA’s largest-ever contract for satellite weather data, valued at $24.3 million. PlanetiQ is a space-tech company that serves the most mission-critical government, defense, and industry leaders, including international weather agencies, enabling more resilient operations across sectors. Founded in 2015 and privately owned, PlanetiQ designs, builds, and operates the preeminent commercial constellation of GNSS-RO satellites, setting the standard for precision and reliability in atmospheric monitoring. For more information, contact info@planetiq.com

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SOURCE PlanetiQ

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New Bloomberg Tax Projections Give Tax Professionals an Early Start on 2027 Planning

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ARLINGTON, Va., Sept. 11, 2026 /PRNewswire/ — Bloomberg Tax & Accounting released its 2027 Projected U.S. Tax Rates, which indicates a 3.2% increase in inflation from 2026 (compared to the 2.7% increase from 2025). The full report is available at https://aboutbtax.com/bmN8.

Bloomberg Tax’s annual Projected U.S. Tax Rates Report provides early, accurate notice of the potential tax savings that could be realized due to increases in deduction limitations, upward adjustments to tax brackets, and increases to numerous other key thresholds.

In an unprecedented event, the Bureau of Labor Statistics did not report the data from October of 2025. Thus, the C-CPI-U has been computed on an 11-month average.

The report accounts for several new adjustments made under the One Big Beautiful Bill Act (OBBBA) that affect tax planning for taxpayers in 2027 and beyond. For corporate taxpayers and passthroughs, they include an adjustment to the employer-provided child care credit, initially enhanced by the OBBBA. It also includes an adjustment to the threshold for information at source reporting requirements, which was initially increased by the OBBBA. For individuals, the report includes varied income tax rates with steeper adjustments for lower brackets.

“Tax professionals are being asked to make consequential planning decisions amid constant policy change and growing complexity,” said Evan Croen, head of Bloomberg Tax & Accounting. “By providing trusted projections before official figures are released and carrying those updates directly into the tools where professionals work, we can help them move from information to action sooner and spend more time applying their expertise to the decisions that matter most.”

The updated rates flow directly into Bloomberg Tax’s innovative software solutions including Bloomberg Tax Provision, Bloomberg Tax Fixed Assets, and Bloomberg Tax Workpapers. This is an example of the power and efficiency of Bloomberg Tax & Accounting’s integrated suite of solutions, which modernizes the corporate tax process, from data collection to tax calculations that power key deliverable.

Other key adjustments, with comparisons of the 2026 amounts and 2027 projections, include:

Individual Income Tax Rate Brackets 

Married Filing Jointly and Surviving Spouses

2026 Tax Rate Bracket Income Ranges

Projected 2027 Tax Rate Bracket Income Ranges

10% – $0 to $24,800

10% – $0 to $25,600

12% – Over $24,800 to $100,800

12% – Over $25,600 to $104,050

22% – Over $100,800 to $211,400

22% – Over $104,050 to $218,250

24% – Over $211,400 to $403,550

24% – Over $218,250 to $416,650

32% – Over $403,550 to $512,450

32% – Over $416,650 to $529,100

35% – Over $512,450 to $768,700

35% – Over $529,100 to $793,650

37% – Over $768,700

37% – Over $793,650

Unmarried Individuals (other than Surviving Spouses and Heads of Households)

2026 Tax Rate Bracket Income Ranges

Projected 2027 Tax Rate Bracket Income Ranges

10% – $0 to $12,400

10% – $0 to $12,800

12% – Over $12,400 to $50,400

12% – Over $12,800 to $52,025

22% – Over $50,400 to $105,700

22% – Over $52,025 to $109,125

24% – Over $105,7000 to $201,775

24% – Over $109,125 to $208,325

32% – Over $201,775 to $256,225

32% – Over $208,325 to $264,550

35% – Over $256,225 to $640,600

35% – Over $264,550 to $661,375

37% – Over $640,6000

37% – Over $661,375

Standard Deduction

Filing Status

2026

Standard Deduction

Projected 2027

Standard Deduction

Married Filing Jointly/Surviving Spouses

$31,500

$33,200

Heads of Household

$23,625

$24,925 ($24,950)

All Other Taxpayers

$15,7500

$16,600

Alternative Minimum Tax (AMT)

Filing Status

2026

AMT Exemption Amount

Projected 2027

AMT Exemption Amount

Married Filing Jointly/Surviving Spouses

$140,200

$144,700

Unmarried Individuals

(other than Surviving Spouses)

$90,100

$93,000

Married Filing Separately

$70,100

$72,350

Estates and Trusts

$31,400

$32,500

About Bloomberg Tax

Bloomberg Tax delivers a comprehensive suite of solutions designed to help tax and accounting professionals navigate a complex global landscape. By combining practitioner-driven insights with intelligent, AI-powered tools, we provide the expertise you need to ensure compliance, streamline workflows, and drive strategic decision-making. Our integrated solutions simplify intricate calculations and adapt to changing regulations in real time, empowering your organization to mitigate risk, optimize tax strategies, and achieve measurable results with confidence and precision.

Bloomberg Tax is part of Bloomberg Industry Group, an affiliate of Bloomberg L.P., a global leader in business and financial information, data, news, and insights.

For more information, visit bloombergtax.com.

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SOURCE Bloomberg Tax

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o15 Capital Partners Announces Realization of $31 Million Senior Secured Credit Facility to Simplify Compliance

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ATLANTA, Sept. 11, 2026 /PRNewswire/ — o15 Capital Partners (“o15”), through its Emerging America Credit Opportunities (“EACO”) fund and its affiliates, is pleased to announce the successful exit of a $31 million senior secured credit facility provided to Simplify Compliance Holdings, LLC (“Simplify” or the “Company”), a diversified provider of B2B training, events, and subscription information backed by Leeds Equity Partners (“Leeds Equity”). Repayment followed the sale of the Company’s datacenterHawk business unit to S&P Global.

The successful realization reinforces o15’s continued conviction in the lower middle market, where disciplined underwriting, sector expertise, and close sponsor partnerships can drive strong investment outcomes. The facility provided flexible capital to support the Company’s strategic objectives and Leeds Equity’s ongoing value creation initiatives.

“Leeds Equity was an excellent partner throughout this investment, and the outcome speaks to their track record building durable businesses,” said Kenneth Saffold, co-CEO and Managing Partner at o15. “We were glad to underwrite behind the strength of Simplify’s digital-first product suite across compliance, workforce training, and data and information assets.”

“o15 was a thoughtful and responsive partner throughout this investment. Their speed and ability to tailor a solution to the Company’s needs were meaningful factors in our financing relationship,” said Chris Mairs, Managing Director at Leeds Equity.

The exit underscores o15’s differentiated investment approach, combining thoughtful structuring, sector expertise, and a focus on measurable impact. Business services and information platforms remain a core area of focus for o15, given the critical role these businesses play across the lower middle market.

About o15 Capital Partners

Based in Atlanta, o15 Capital Partners is an alternatives investment firm that provides growth capital to undercapitalized lower middle market businesses and communities in the Healthcare, Education and Business Services industries.

To learn more about o15 Capital Partners or discuss a new investment opportunity, please visit and follow us on LinkedIn, or reach out to a member of our investment team.

Disclaimer: The information herein should not be construed as investment advice or a recommendation of any security, investment, or investment strategy. References to this investment are for illustrative purposes only, are not representative of all investments made by o15, and should not be construed as a recommendation of any particular investment or investment strategy. Other investments made by o15 have had, and future investments may have different characteristics and results.

media@o15.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/o15-capital-partners-announces-realization-of-31-million-senior-secured-credit-facility-to-simplify-compliance-302876584.html

SOURCE o15 Capital Partners

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