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Study Uncovers How Much of Biological Aging is Driven by Random Noise Versus Dynamic Biologic Change

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2 years ago

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LEXINGTON, Ky., May 23, 2024 /PRNewswire/ — A new groundbreaking study, recently published in *Nature Aging*, by researchers from the University of Chinese Academy of Sciences, TruDiagnostic, and Harvard, has unveiled significant insights into the mechanisms of epigenetic clocks, which are widely used to predict biological age. The study’s findings suggest that a large portion of the predictive accuracy of chronological clocks can be attributed to stochastic, or random, DNA methylation (DNAm) changes rather than deterministic biological aging processes.

Epigenetic clocks, such as those developed by Horvath and Zhang, have gained prominence for their ability to estimate an individual’s biological age with remarkable accuracy, based solely on patterns of DNA methylation. However, the precise mechanisms by which these changes in DNAm occur has remained largely unexplored until now.

The research team, led by Dr. Andrew Teschendorff, utilized sophisticated simulation models and extensive DNAm data from over 25 independent cohorts totaling 22,770 samples. Their analysis revealed that between 66% to 90% of the accuracy of various epigenetic clocks could be explained by stochastic processes. This finding was particularly pronounced in Zhang’s clock, which showed that up to 90% of its predictive capability could be attributed to these random changes.

Dr. Andrew E. Teschendorff, a senior author of the study, noted, “Our results further indicate that biological age-acceleration is unlikely to be the result of an increased rate of stochastic change, but instead being driven by non-stochastic processes. However, one exception to this seems to be mitotic age-acceleration in precancerous lesions.”

Furthermore, the study distinguished between different types of epigenetic clocks, finding that those more predictive of chronological age, like Zhang’s clock, were largely influenced by stochastic DNAm changes. In contrast, clocks like PhenoAge, which are more reflective of biological age, showed a lower degree of stochastic influence. This suggests that first generation clocks, trained to predict chronological age, have less utility in predicting outcomes of aging than clocks trained on other phenotypes of aging or biomarkers.

These insights are vital for the future development and refinement of epigenetic clocks, potentially guiding medical professionals towards more accurate assessments of biological aging and associated health risks.

“One trend we have seen in recent years is that clocks trained to predict chronological age have lower predictive power than newer clocks trained on biological information. Additionally, chronological clocks can sometimes increase with known lifespan extension interventions. This is counter intuitive. This study might explain why. Clocks trained to predict chronological age are driven by random variation over time while clocks which are predictive of lifespan seem to be much more dynamic and responsive to the ways we live our life” added Dr. Varun Dwaraka, a co-author of the study. 

The full study is available in the latest issue of *Nature Aging* and provides a comprehensive view of the stochastic components influencing epigenetic aging. This research not only advances our understanding of genetic aging mechanisms but also enhances the potential for personalized medical strategies based on more accurate DNA methylation profiling.

For further information, access the full paper here.

About TruDiagnostic

Home to the largest, private DNA methylation database in the world, TruDiagnostic is a leading health data company and CLIA-certified laboratory that specializes in epigenetic testing and research. In partnership with notable biotech developers, researchers, and academic institutions, we are transforming the healthcare potential of epigenetic data into actionable applications. We aim to improve people’s lives by arming patients and physicians with novel biological insights; enabling them to make the right lifestyle and medical decisions through information found in the fluid epigenome. With the ability to analyze more than 1,000,000 locations on one’s DNA, our TruAge biological aging tests provide the most in-depth results, and multi-omic correlations to accelerated aging.

Additional Contacts

Hannah Went, Director of Operations

General Inquiries  

(937) 570-0471  

(833) 963-1700

hannah@trudiagnostic.com

support@trudiagnostic.com

www.trudiagnostic.com

www.trudiagnostic.com

**Contact:**
Dr. Andrew E. Teschendorff
Email: andrew@sinh.ac.cn
University of Chinese Academy of Sciences, Shanghai, China

Emilie Arroyo, Media Relations
(786) 247-4579
emilie@trudiagnostic.com  
www.trudiagnostic.com

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SOURCE TruDiagnostic

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Lexar Launches the Professional SILVER GO microSDXC™ UHS-I Card

Published

14 minutes ago

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October 22, 2026

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V30 rating provides seamless 4K 60fps recording

SAN JOSE, Calif., Oct. 22, 2026 /PRNewswire-PRWeb/ — Lexar, a global leader in memory and storage, today announced the new Lexar® Professional SILVER GO microSDXC™ UHS-I Card, a versatile storage solution designed for videographers, gamers and creators who need reliable, high-performance storage across their favorite portable devices with microSD slots. Combining fast data transfers, support for high-quality video capture and durable construction, the new card helps users spend less time managing storage and more time creating and capturing their next adventure.

“Gamers and creators are pushing their hardware harder than ever, from massive game libraries to hours of 4K footage. We designed the Lexar SILVER GO so their storage is never the thing holding them back.”

“Gamers and creators are pushing their hardware harder than ever, from massive game libraries to hours of 4K footage. We designed the Lexar SILVER GO so their storage is never the thing holding them back,” said Lizette Lynch, Director of Brand Marketing at Lexar North America. “With a combination of fast transfers, reliable performance and rugged durability, the SILVER GO gives users the speed and storage they need to capture, create and play with confidence.”

The Lexar SILVER GO microSD Card offers top-notch performance of max read speeds of 250MB/s and max write speeds of 180MB/s1. Users can reach max transfer speeds when pairing the cards with the Lexar microSD/SD Reader. With a V30 Video Speed Class rating, the Lexar SILVER GO microSD Card delivers smooth, uninterrupted 4K 60fps Ultra HD recording and keeps pace with rapid-fire burst shooting. The Lexar SILVER GO microSD Card is optimized for action cameras, drones and handheld consoles including DJI, Insta360, GoPro, Nintendo Switch, and Steam Deck2, to name a few.

Available in capacities 64GB-512GB, the SILVER GO microSDXC is built for durability, with features such as IPX7 waterproof, wearproof, drop-proof, temperature-proof, X-ray-proof, shockproof, magnetic-proof, and vibration resistance. The free Lexar Recovery Tool gives users peace of mind, helping users attempt to recover accidentally deleted files. Separately, Lexar products are backed by a limited lifetime warranty, subject to applicable terms and conditions.

The Lexar SILVER GO microSDXC is available through Amazon, with the 512GB available at an MSRP of $144.99, 256GB available at an MSRP of $84.99, 128GB available at an MSRP of $54.99, and 64GB available at an MSRP of $34.99. For more information, visit americas.lexar.com.

Lexar Professional SILVER GO microSDXC™ UHS-I Card Availability:

LINK: https://americas.lexar.com/product/lexar-professional-silver-go-microsdxc-uhs-i-card/

1 Speeds based on internal testing. Actual performance may vary.

2 All product and company names, and brands mentioned are trademarks or registered trademarks of their respective owners. Their use is for identification purposes only and does not imply endorsement, sponsorship or affiliation with Lexar.

About Lexar

Founded in California in 1996, Lexar has dedicated 30 years advancing reliable, high-performance memory solutions and now operates more than 100,000 sales channels across six continents, serving over 100 million users in more than 70 countries. Its award-winning portfolio, from memory cards and SSDs to DRAM and mobile storage, continues to empower creators, professionals, and everyday users worldwide. For more information, please visit americas.lexar.com.

Media Contact

Media Team, Lexar, 1 6263720725, lexar@boltpr.com, https://americas.lexar.com/

View original content to download multimedia:https://www.prweb.com/releases/lexar-launches-the-professional-silver-go-microsdxc-uhs-i-card-302916816.html

SOURCE Lexar

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Lexar Launches the Professional SILVER GO microSDXC™ UHS-I Card

Published

14 minutes ago

on

October 22, 2026

By

V30 rating provides seamless 4K 60fps recording

SAN JOSE, Calif., Oct. 22, 2026 /PRNewswire-PRWeb/ — Lexar, a global leader in memory and storage, today announced the new Lexar® Professional SILVER GO microSDXC™ UHS-I Card, a versatile storage solution designed for videographers, gamers and creators who need reliable, high-performance storage across their favorite portable devices with microSD slots. Combining fast data transfers, support for high-quality video capture and durable construction, the new card helps users spend less time managing storage and more time creating and capturing their next adventure.

“Gamers and creators are pushing their hardware harder than ever, from massive game libraries to hours of 4K footage. We designed the Lexar SILVER GO so their storage is never the thing holding them back.”

“Gamers and creators are pushing their hardware harder than ever, from massive game libraries to hours of 4K footage. We designed the Lexar SILVER GO so their storage is never the thing holding them back,” said Lizette Lynch, Director of Brand Marketing at Lexar North America. “With a combination of fast transfers, reliable performance and rugged durability, the SILVER GO gives users the speed and storage they need to capture, create and play with confidence.”

The Lexar SILVER GO microSD Card offers top-notch performance of max read speeds of 250MB/s and max write speeds of 180MB/s1. Users can reach max transfer speeds when pairing the cards with the Lexar microSD/SD Reader. With a V30 Video Speed Class rating, the Lexar SILVER GO microSD Card delivers smooth, uninterrupted 4K 60fps Ultra HD recording and keeps pace with rapid-fire burst shooting. The Lexar SILVER GO microSD Card is optimized for action cameras, drones and handheld consoles including DJI, Insta360, GoPro, Nintendo Switch, and Steam Deck2, to name a few.

Available in capacities 64GB-512GB, the SILVER GO microSDXC is built for durability, with features such as IPX7 waterproof, wearproof, drop-proof, temperature-proof, X-ray-proof, shockproof, magnetic-proof, and vibration resistance. The free Lexar Recovery Tool gives users peace of mind, helping users attempt to recover accidentally deleted files. Separately, Lexar products are backed by a limited lifetime warranty, subject to applicable terms and conditions.

The Lexar SILVER GO microSDXC is available through Amazon, with the 512GB available at an MSRP of $144.99, 256GB available at an MSRP of $84.99, 128GB available at an MSRP of $54.99, and 64GB available at an MSRP of $34.99. For more information, visit americas.lexar.com.

Lexar Professional SILVER GO microSDXC™ UHS-I Card Availability:

LINK: https://americas.lexar.com/product/lexar-professional-silver-go-microsdxc-uhs-i-card/

1 Speeds based on internal testing. Actual performance may vary.

2 All product and company names, and brands mentioned are trademarks or registered trademarks of their respective owners. Their use is for identification purposes only and does not imply endorsement, sponsorship or affiliation with Lexar.

About Lexar

Founded in California in 1996, Lexar has dedicated 30 years advancing reliable, high-performance memory solutions and now operates more than 100,000 sales channels across six continents, serving over 100 million users in more than 70 countries. Its award-winning portfolio, from memory cards and SSDs to DRAM and mobile storage, continues to empower creators, professionals, and everyday users worldwide. For more information, please visit americas.lexar.com.

Media Contact

Media Team, Lexar, 1 6263720725, lexar@boltpr.com, https://americas.lexar.com/

View original content to download multimedia:https://www.prweb.com/releases/lexar-launches-the-professional-silver-go-microsdxc-uhs-i-card-302916816.html

SOURCE Lexar

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Racquel Oden to Receive The ELC’s 2026 Achievement Award for Leadership in Financial Services and Expanding Opportunity

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14 minutes ago

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October 22, 2026

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HSBC executive recognized for a career building businesses, developing talent, and widening access to wealth and financial prosperity

WASHINGTON, Oct. 22, 2026 /PRNewswire/ — The Executive Leadership Council (ELC) will honor Racquel Oden, HSBC’s U.S. Head of International Wealth and Premier Banking and Private Banking, with the 2026 ELC Achievement Award at The ELC Recognition Gala on October 30, 2026, at the Gaylord National Resort & Convention Center in National Harbor, Maryland.

With more than 25 years of financial services experience, Oden has built a career at the intersection of business growth, client leadership, and talent development. At HSBC, she leads businesses serving affluent and globally connected clients in the United States, bringing a client-first approach to one of the world’s largest financial services organizations.

“Racquel brings a rare combination of commercial discipline and genuine investment in people,” said Michael C. Hyter, President and CEO of The Executive Leadership Council. “She understands that leadership is measured in business results, certainly, but also in the people you prepare for greater responsibility and the doors you make easier for others to open. Her career reflects the kind of enterprise leadership The ELC has championed for 40 years.”

Oden’s career spans some of the world’s most prominent financial institutions. Prior to HSBC, she served as a Managing Director at JPMorgan Chase, where she led Network Expansion and held leadership roles across national sales, Consumer Banking and Wealth Management. She previously spent eight years at Merrill Lynch in several Managing Director roles and more than a decade at UBS in senior leadership positions. She began her Wall Street career in equity trading at Morgan Stanley.

Throughout that journey, Oden has described her leadership philosophy as one rooted in service and in helping people become the strongest versions of themselves. That philosophy also informs her work to expand access to wealth, opportunity, and financial fluency.

Her leadership extends across corporate and civic institutions. Oden serves on the corporate board of National Life Group and chairs the Board of Directors of the Thurgood Marshall College Fund. She also serves on the boards of the Apollo Theater and the New York City Police Foundation.

Her honors include the National Urban League’s 2026 Women of Power award and recognition among Barron’s Most Influential Women in Finance, American Banker’s Most Powerful Women in Finance and Forbes’ 50 Over 50.

Oden holds a Bachelor of Arts from James Madison University and an MBA from Hampton University.

The ELC Achievement Award recognizes corporate executives whose careers reflect exceptional professional accomplishment, leadership and impact. Oden joins a distinguished group of past ELC honorees whose influence has reached across companies, industries and communities.

The ELC Marks 40 Years of Developing Leaders
Oden will receive the Achievement Award during a milestone year for The Executive Leadership Council. Founded in 1986, The ELC is celebrating its 40th anniversary in 2026, marking four decades of developing leaders who perform at the highest levels of business and strengthening the leadership pipeline that sustains that excellence.

The 2026 ELC Recognition Gala will take place Friday, October 30, at the Gaylord National Resort & Convention Center in National Harbor, Maryland. Hosted by Emmy Award-winning television journalist and Entertainment Tonight co-host Kevin Frazier, the black-tie celebration will feature a special musical performance by 10-time GRAMMY Award winner Chaka Khan.

The Gala is the signature fundraising event of The ELC’s 2026 Gala Week, October 28–31, which will bring together more than 3,000 members, students, senior executives and business leaders as The ELC celebrates its 40th anniversary.

Gala Week is designed to span the leadership journey. The Honors Symposium connects ELC Scholars with senior executives and hiring managers as they prepare to enter the workplace. The Mid-Level Managers’ Symposium develops high-performing professionals preparing for greater leadership responsibility. Corporate Board Navigator helps ELC members prepare for corporate board service.

ABOUT THE ELC

The Executive Leadership Council is an independent nonprofit founded in 1986 that opens channels of opportunity for the development of global executives to positively impact business and our communities. Learn more at elcinfo.com.

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SOURCE The Executive Leadership Council

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