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Kanazawa University research: Sensing a biomarker

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2 years ago

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KANAZAWA, Japan, June 7, 2024 /PRNewswire/ — Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Biosensors and Bioelectronics: X a novel approach for detecting a particular biomolecule associated with several diseases. The results show good sensitivity and selectivity, and may lead to the development of a low-cost, rapid detection device useful in cancer prognosis.

Human diseases are often the result of DNA transcriptions gone wrong. Transcription refers to the copying of parts of a DNA molecule — the ‘genetic code’ — into an RNA molecule, which in turn is required for converting the encoded information into proteins. The latter play crucial roles in various biochemical processes taking place in the human body. One transcriptional modification mechanism is adenosine-to-inosine editing, in which adenosine (one of four RNA building blocks) is chemically modified, resulting in an altered RNA molecule. This type of modification is facilitated by catalyst proteins called ADARs (adenosine deaminases acting on RNA). Three such ADARs have been identified in humans. One of them, ADAR1, has been found to be more abundant in the presence of several kinds of chronic diseases, including neurological disorders and cancer. ADAR1 is therefore considered a biomarker — a ‘signature molecule’ — for assessing a patient’s condition and chances of survival. Madhu Biyani from Kanazawa University and colleagues have now developed a new, electrochemical biosensor for detecting ADAR1, offering a low-cost, rapid tool for measuring ADAR1 concentrations in cells. The detector is expected to be useful for monitoring cancer progression.

The procedure presented by Biyani and colleagues is new in two ways. The first is that it uses newly identified aptamers as molecules that can recognize and capture ADAR1. Aptamers are molecules consisting of sequences of (synthetic) DNA, RNA or other biomolecules that bind to a particular target molecule, in this case ADAR1. The second novelty lies in the use of a field-deployable electrochemical sensor DEPSOR (BioSeeds Corp.), which has the advantages of, apart from being fast and non-expensive, requiring only small samples.

In order to find the optimal aptamer — that is, the one that chemically binds easiest to ADAR1 — the researchers screened a large set of DNA sequences and narrowed it down to 15 candidate aptamers. Each of these candidates was then tested in an electrochemical sensing platform: the amount of ADAR1 is ‘sensed’ through chemical reactions that result in an electrical current. The latter can be easily detected. The more ADAR1 in a sample, the higher the measured current.

The candidate aptamer resulting in the highest electrochemical current, called Apt38483, was then checked further. Its electrochemical response to ‘false’ proteins was very low, confirming it to be the optimal aptamer in terms of both sensitivity and selectivity. The scientists then tested an Apt38483-based prototype device on diluted cell samples. They found that even in a 625-fold diluted sample, ADAR1 could still be detected, highlighting the high sensitivity of the device.

The electrochemical biosensor developed by Biyani and colleagues for the detection of ADAR1 in cell samples is a promising platform for monitoring cancer progression in clinical samples. Quoting the scientists: “In the future, it will be promising to evaluate the system for the identification of low to high levels of ADAR1 expression in a cancer cell line sample for clinical prognosis.”

Figure

https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/Figure1-6.png

Caption

A novel electrochemical biosensor for the detection of ADAR1 in cells is expected to be useful in cancer prognosis. © 2024 Biyani, et al. Published by Elsevier B.V.

Background

Electrochemical biosensors

Electrochemical biosensors are devices that convert biological information, such as the presence of a particular molecule (called the analyte), into a measurable signal. Essentially, biosensors consist of a bioreceptor, an interface and a transducer element. The bioreceptor binds to the analyte at the interface, which results in a signal that is picked up and converted by the transducer into an electric signal. The electric signal is processed through a computer; for example, the signal can be converted into an analyte concentration reading. Electrochemical biosensors are normally robust, low-cost and easy to miniaturize.

Madhu Biyani from Kanazawa University and colleagues have now developed an electrochemical biosensor for the detection of ADAR1, an RNA-editing enzyme associated with cancer progression. They identified a particular biomolecule as the optimal bioreceptor, showing good sensitivity and selectivity for ADAR1. The developed device is expected to be useful for monitoring cancer progression.

Reference

Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, and Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples, Biosensors and Bioelectronics: 19, 100491 (2024).

DOI: 10.1016/j.biosx.2024.100491

https://doi.org/10.1016/j.biosx.2024.100491

Contact
Hiroe Yoneda
Senior Specialist in Project Planning and Outreach
NanoLSI Administration Office, Nano Life Science Institute (WPI-NanoLSI)
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan
Email: nanolsi-office@adm.kanazawa-u.ac.jp
Tel: +81 (76) 234-4555

About Nano Life Science Institute (WPI-NanoLSI), Kanazawa University

Understanding nanoscale mechanisms of life phenomena by exploring “uncharted nano-realms”.

Cells are the basic units of almost all life forms. We are developing nanoprobe technologies that allow direct imaging, analysis, and manipulation of the behavior and dynamics of important macromolecules in living organisms, such as proteins and nucleic acids, at the surface and interior of cells. We aim at acquiring a fundamental understanding of the various life phenomena at the nanoscale.

https://nanolsi.kanazawa-u.ac.jp/en/

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Lubbock Plastic Surgeon Dr. Thanapoom Boonipat Leads Suturing Workshop for Texas Tech Women in STEM Premed Students

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14 minutes ago

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October 25, 2026

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Suturing workshop

LUBBOCK, Texas, Oct. 25, 2026 /PRNewswire/ — Dr. Thanapoom “Mo” Boonipat, plastic surgeon and founder of FacePlus Plastic Surgery Institute in Lubbock, led a hands-on suturing workshop and career Q&A session for premed students at Texas Tech University. The event was organized by Women in STEM at Texas Tech University.

During the workshop, students practiced suturing fundamentals on suture pads using surgical instruments, with Dr. Boonipat demonstrating technique and coaching students individually. The session also included an open discussion about the path to a career in medicine, including medical school, residency training, and choosing a surgical specialty.

“Every surgeon remembers the first time they held a needle driver. Giving premed students that experience early — along with honest answers about the road ahead — can make the path into medicine feel real and reachable. I was glad to spend the afternoon with such motivated students.” — Dr. Thanapoom Boonipat

“Organizations like Women in STEM do important work connecting young women with mentors and hands-on experience in fields where they are still underrepresented, including surgery. FacePlus is proud to support that effort here in our own community in Lubbock.” — Dr. Thanapoom Boonipat

Women in STEM is a Texas Tech University student organization that supports women pursuing undergraduate and graduate studies in science, technology, engineering and mathematics. Events like this connect students with practicing professionals and give them early, practical exposure to clinical skills.

Dr. Boonipat is a plastic and craniofacial surgeon. His training includes an integrated plastic surgery residency at Mayo Clinic and a craniofacial, maxillofacial, and facial aesthetics fellowship at Chang Gung Memorial Hospital in Taiwan, following medical school at Dartmouth and undergraduate study in biomedical engineering at Johns Hopkins. He founded FacePlus Plastic Surgery Institute in Lubbock in 2024.

About FacePlus Plastic Surgery Institute:
FacePlus Plastic Surgery Institute is a plastic surgery practice in Lubbock, Texas, founded by Thanapoom Boonipat, MD. The practice provides cosmetic and reconstructive plastic surgery, including facial, breast, and body procedures, serving patients in Lubbock and across West Texas. For more information, visit facepluspsi.com.

Media Contact:
FacePlus Plastic Surgery Institute
moboonipatmd@facepluspsi.com
(806) 503-2090
Lubbock, Texas

Press Release Service provided by 24-7PressRelease.com

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SOURCE FacePlus Plastic Surgery Institute

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Vantrue Announces Early Black Friday Sale with Up to 44% Off Select Dash Cams

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3 hours ago

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October 25, 2026

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November 1–21, 2026 | Official Website: Vantrue.com

SHENZHEN, China, Oct. 25, 2026 /PRNewswire/ — Vantrue, a dash cam brand dedicated to helping drivers capture the road with confidence, is launching its three-week Black Friday campaign from November 1 to November 21, 2026. The event brings together discounts of up to 44% on selected dash cams, a 100% win-rate prize wheel for subscribers, and exclusive bidding events, giving drivers multiple ways to discover and save on Vantrue products.

Every Eligible Spin Wins a Prize

The Black Friday excitement starts with Vantrue’s 100% win-rate spin wheel. Visitors can subscribe through the official website and spin for a chance to receive exciting rewards, including the latest Vantrue dash cams, special prize bundles, and other surprises. Each subscriber is eligible for one spin during the campaign.

Black Friday Deals in Two Waves

Vantrue’s Black Friday offers will roll out in two waves, featuring discounts on selected dash cams for everyday drivers, rideshare professionals, and those looking to upgrade their in-car recording setup.

Wave 1: November 1–10, 2026

Vantrue E1 Lite: 36% off — $69.99 (regular price: $109.99)
 Vantrue N2X: 36% off — $159.99 (regular price: $249.99)
 Vantrue N4S: 44% off — $199.99 (regular price: $359.99)
 

Wave 2: November 11–21, 2026

Vantrue E1 Pro S: 35% off — $129.99 (regular price: $199.99)
 Vantrue N5S: 36% off — $293.99 (regular price: $459.99)
 Vantrue N4 Pro S: 40% off — $279.99 (regular price: $469.99)
 

Exclusive Bidding Events Add More Excitement

In addition to the promotional pricing, Vantrue will host two special bidding events, offering participants another way to pursue selected dash cams at competitive prices.

BID #1: November 5–7, 2026 — Bid on featured products for a chance to secure them at a lower price.BID #2: November 12–14, 2026 — Return for another opportunity to bid on premium models.

With multiple ways to participate throughout the three-week event, Vantrue’s Black Friday campaign combines savings, interactive rewards, and special shopping opportunities in one destination.

Join Vantrue’s Black Friday Event

From November 1 through November 21, 2026, drivers can explore the latest offers, take part in the prize wheel, and join the bidding events through Vantrue’s official website.

Visit https://www.vantrue.com/ for campaign details and product offers.

About Vantrue

Founded in 2015, Vantrue is a leading global dash cam brand dedicated to providing intelligent, reliable, and user-centric driving solutions. With a focus on innovative technology, dependable performance, and user-friendly design, Vantrue develops dash cams for everyday drivers, families, and professionals on the road. Committed to helping drivers capture every journey with greater confidence and peace of mind, Vantrue continues to innovate to make every drive safer and every moment worth capturing.

Media Contact
Vantrue Media Relations
Email: support@vantrue.net
Website: https://www.vantrue.com

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SOURCE Vantrue

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LexisNexis Coplogic Solutions Introduces Field Clarity for LexisNexis® Desk Officer Reporting System (DORS) at IACP 2026

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6 hours ago

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October 25, 2026

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A new, modern DORS and Field Clarity, the First AI-Guided Smartphone Video Assistant, Enhances Community Experience and Helps Improve Evidence, Case Building

ORLANDO, Fla., Oct. 25, 2026 /PRNewswire/ — LexisNexis® Coplogic™ Solutions today announced its modernized LexisNexis® Desk Officer Reporting System (DORS) community online reporting solution and the addition of DORS with Field Clarity, an AI-guided video assistant designed to improve field documentation accuracy and enable faster resolution by law enforcement agencies (LEAs). Field Clarity is designed to help community members submit reports to their local LEAs using DORS via intuitive step-by-step instructions. A hands-on experience for DORS with Field Clarity will be available for demonstration during the 2026 International Association of Chiefs of Police (IACP) annual conference.

“Agencies generally look to strategic partners like us not just for technology, but also for relief, reinforcement, and credibility across three tightly connected challenges: public expectation, workforce strain and digital evidence overload,” said Jason LaRue, associate vice president, LexisNexis Coplogic Solutions. “Our modernized LexisNexis Desk Officer Reporting System (DORS) helps agencies improve officer safety along with community member experiences. Field Clarity strengthens video evidence quality and digital evidence management to reduce friction and alleviate strain on a challenged workforce.”

Key Highlights
Integrated into LexisNexis® Desk Officer Reporting System (DORS), Field Clarity is the first AI-Guided video assistant for community member online reporting that:

Transforms data capture from passive intake into intelligent, guided capture to help create more positive officer and civilian mobile-first experiencesDrives more accurate field documentation, evidence and case building to help with faster resolution and enhanced public safetyBenefits civilians submitting reports with intuitive, step-by-step instructions, almost like having a digital assistant with them in real timeBenefits officers by bringing video, photos and scanned data together for a clearer picture of an event without the need to track down additional details

How the DORS with Field Clarity Solution Works
DORS allows each law enforcement agency to collect information directly from civilians on more than 200 incident types based on the needs of their community. DORS and Field Clarity make the filing of an online report experience easier by guiding users intuitively through each step of the process on their smartphone device, similar to having a personal digital assistant. Instead of asking a driver, for example, to fill out forms and guess what’s needed, the Field Clarity conversational interface prompts them to scan their driver’s license, capture a VIN or record a short walkaround video explaining what happened during the incident, all while capturing the data necessary to complete the report.

For civilians, being able to easily film on-scene evidence means less confusion and need for reentries or follow-up by the sworn officer responsible for approving reports. For officers, the benefits include cleaner, more complete accident reports and less time spent requesting and gathering additional details. With reports fed directly into the agency’s Record Management System (RMS), law enforcement also benefits from more efficient workflows and stronger documented cases for their investigators. DORS is used by nearly 600 agencies in North America, saving agencies approximately 900,000 personnel hours and $90 million annually*

“Trust in law enforcement is built one interaction at a time. Every opportunity for a community member to engage with their police department matters, including something as routine as filing a report,” said Sarah E. Connolly, co-founder of Guardian Communications, FBI-LEEDA instructor and retired Baltimore Police lieutenant and PIO. “When technology makes that process easier, improves the quality of information collected and supports a more responsive agency, it has the potential to do more than improve efficiency. It can help strengthen the relationship between law enforcement and the communities they serve.”

LexisNexis Coplogic Solutions delivers solutions and capabilities that can create a clearer line of sight from the field to law enforcement leadership, strengthening the connection between daily operations, workforce support, data management and community trust. DORS with Field Clarity is available through LexisNexis® Command Center, a single access point to the LexisNexis Coplogic Solutions data and analytics solutions suite, including LexisNexis®  BuyCrash®, LexisNexis® eCrash and LexisNexis® eCitation solutions. Coplogic Solutions also offers Unified Performance Dashboards for crash and citation mapping and illustrated visualizations, which connect field data with contextual insight in a single, coherent view – so law enforcement leaders can better understand and more confidently explain to their communities not just what is happening in near-real time, but also why. 

To speak with Coplogic law enforcement experts about LexisNexis Desk Officer Reporting System (DORS) with Field Clarity and experience the solution firsthand, visit LexisNexis Coplogic Solutions at IACP Booth #941, October 24 – 27, 2026 in Orlando, Florida. To learn more, check out this video: LexisNexis® Desk Officer Reporting System (DORS).

About LexisNexis Risk Solutions
LexisNexis® Risk Solutions provides customers with information-based analytics and decision tools that combine public and industry-specific content with advanced technology and algorithms to assist them in evaluating and predicting risk and enhancing operational efficiency. Headquartered in metro Atlanta, Georgia, the company has offices throughout the world, serves customers in more than 190 countries and territories and is part of RELX. For more information, please visit LexisNexis Risk Solutions.

About LexisNexis Coplogic Solutions
LexisNexis® Coplogic™ Solutions is committed to meeting law enforcement agencies where they are on the road to saving more lives and helping take them where they want to be by delivering an innovative full suite of data sophistication solutions to create workflow efficiencies while delivering world-class crash and citation data and analytics visualizations through advanced technology. Our proven solutions, developed by and specifically for law enforcement, can help agencies operate more effectively, increase services to their communities and improve traffic and overall public safety through electronic, mobile-first authoring capabilities, web-based eCommerce solutions, analytics and more. For more information, please visit risk.lexisnexis.com/Coplogic.

Media Contacts: 
Chaz Abbott
LexisNexis Risk Solutions
chaz.abbott@lexisnexisrisk.com
+1 949.922.1167

*Based on a 2025 LexisNexis Coplogic Solutions internal study

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SOURCE LexisNexis Risk Solutions

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