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Groundbreaking Study in Noninvasive Chromosomal Testing for Embryos Recognized as Seminal Contribution in the Field

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Olive Fertility Centre co-director, Dr. Gary Nakhuda, co-authored a groundbreaking study highlighting the advances and limitations in noninvasive preimplantation genetic testing for aneuploidy (niPGT-A).

VANCOUVER, BC, July 8, 2024 /PRNewswire-PRWeb/ — Dr. Gary Nakhuda, MD, co-director Olive Fertility Centre, and his team have made a significant leap in the field of reproductive medicine with their groundbreaking study highlighting the advances and limitations in noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) recently published in the prestigious journal Fertility & Sterility. “We are honoured that our paper about the NICEST (Noninvasive Chromosomal Embryo Screening Trial) study was published in Fertility & Sterility and recognized as a Seminal Contribution to the field,” says Dr. Nakhuda.

We are honoured that our paper about the NICEST (Noninvasive Chromosomal Embryo Screening Trial) study was published in Fertility & Sterility and recognized as a Seminal Contribution to the field.

The study involved 120 patients under the age of 35 undergoing in vitro fertilization (IVF) treatment and focused on analyzing the positive predictive value and false positive risk of detecting chromosomal abnormalities using niPGT-A. Currently, PGT-A is the standard method for detecting chromosomal abnormalities in embryos. However, it requires an invasive biopsy of the embryo, which is labor-intensive and demands the expertise of highly skilled embryologists.

In contrast, niPGT-A utilizes DNA secreted by the embryo into the culture media during its growth. Typically discarded after the embryos have matured, this “spent” culture media contains minuscule amounts of DNA that can be isolated and amplified. The noninvasive approach offers several advantages over conventional PGT-A. Besides eliminating the risk to the embryo, niPGT-A could potentially make PGT-A more accessible by reducing the reliance on highly skilled embryologists, thereby lowering costs. However, the technique’s current limitations, primarily related to obtaining reliable samples due to the small amount of DNA available, were acknowledged in the study.

Study Highlights: Promising Results and Key Challenges

Positive Predictive Value: The study reported a 94.4%-100% positive predictive value for detecting aneuploidy using niPGT-A, indicating a high level of accuracy in identifying nonviable embryos with whole chromosome abnormalities.Clinical Outcomes: Embryos categorized as having “uncertain reproductive potential” showed a sustained implantation rate of 77.8%, similar to those without detected abnormalities. This suggests that some embryos deemed abnormal by standard criteria may still have the potential for successful implantation.Technological Limitations: Despite its promise, niPGT-A faces significant challenges. A total of 22.5% of samples had undetermined or uncertain results, highlighting the need for further refinement of the technology.

The editorial accompanying the study praised Dr. Nakhuda and his team for their meticulous work. “Nakhuda et al.’s non-selection study is a major step forward in validating niPGT-A and providing clinical information regarding its technological limitations,” the editorial stated, emphasizing the importance of cautious optimism. “We commend the investigators for their hard work in working to validate niPGT-A and taking great care to look before we leap,” the editorial continued, highlighting the careful balance required in adopting new technologies in reproductive medicine to ensure both effectiveness and safety for patients.

Dr. Nakhuda’s study provides a foundation for future research and development in niPGT-A. By identifying current limitations and areas for improvement, the study paves the way for further validation and optimization of this noninvasive technique. Future studies with larger sample sizes and diverse patient populations will be essential in determining the broader applicability of niPGT-A. Dr. Nakhuda and his team are already planning a follow-up study to further validate niPGT-A, aiming to finalize its validation and pave the way for its future clinical application.

“Our research was significant since it was the first to document the predictive values of noninvasive PGT-A (niPGT-A) in a transparent and blinded fashion,” says Dr. Nakhuda. “We still have work to do but are confident that niPGT-A will change the paradigm of embryo screening in the near future.”

About Olive Fertility Centre:

Olive Fertility Centre olivefertility.com is one Canada’s leading fertility centres with clinics in Vancouver, Surrey, Victoria, and Kelowna. We offer an award-winning IVF lab, personal care teams, and innovative programs including specialized genetic testing, egg freezing, and prenatal NIPT testing.

Media Contact
Mairi Campbell, Olive Fertility Centre, 1 778-885-5300, mairi.campbell@telus.net, https://www.olivefertility.com/

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MESCIUS inc. Recognized in 2024 ComponentSource Awards

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PITTSBURGH, July 19, 2024 /PRNewswire/ — MESCIUS inc, a global provider of award-winning enterprise software development tools, is pleased to announce that it has been recognized as the 2024 number two publisher and top five publisher by ComponentSource, the world’s largest marketplace for software components and development tools. ComponentSource also recognized MESCIUS for its many top-selling products on its annual listing.

Discover what MESCIUS products received top awards in the 2024 ComponentSource Awards.

As the component and tools market continues to expand with more mature technologies, MESCIUS inc. is pleased to offer high-performing and robust components that allow developers to “write once, deploy anywhere” across mobile, web, desktop, server, and multiple OS platforms.

ActiveReports. NET Professional received a #5 Product Award and a Top 5 Product Award. Spread. NET and ComponentOne Studio Enterprise were each honored with Top 10 Product Awards. ActiveReports .NET Standard and ComponentOne Studio WinForms received a Top 25 Product Award, while SpreadJS and Wijmo earned Top 50 Product Awards. ComponentOne Studio ActiveX, ComponentOne Studio WPF, and ActiveReportsJS secured a Top 100 Product Award. In addition to the various product awards, MESCIUS inc received a #2 Publisher Award and a Top 5 Publisher Award.

Publisher and product rankings are calculated based on ComponentSource’s actual sales orders placed by customers globally during 2023.

View the 2024 Publisher Awards List.View the 2024 Product Awards List.

“As with previous years, these awards are derived from the orders we’ve received from our global customer base,” said Sam Patterson, ComponentSource CEO. “They offer an authentic snapshot of the global market for commercial software components and development tools in 2023. We believe our awards provide precise, real-world insights into how our customers are utilizing these components and development tools in their most recent projects.”

“The rebranding from GrapeCity Developer Solutions to MESCIUS Inc. in 2023 marked a significant milestone, introducing not only a new name but also a revitalized approach to our product suite,” stated Joseph Lininger, Director of Marketing at MESCIUS (formerly GrapeCity). “We are delighted to continue our longstanding partnership with ComponentSource, which has been instrumental in distributing our .NET and JavaScript grids, UI components, reporting tools, spreadsheet and document APIs, and mobile controls. This collaboration ensures that our global developer community remains well-equipped with superior products and services they have come to expect from us.”

About ComponentSource ComponentSource is the world’s largest marketplace for reusable software components for all platforms. The respected barometer for the component industry, ComponentSource pioneered the open market for reusable software components in 1995 and continues to drive the market through its award-winning e-business model and groundbreaking work to establish the first widely accepted reusable component standard. A global e-business with customers in over 180 countries, ComponentSource is headquartered in Atlanta, GA United States and has offices in Reading, England, Dublin, Ireland and Tokyo, Japan. For more information, please visit http://www.componentsource.com.

About MESCIUS MESCIUS inc. is one of the world’s largest providers of developer components. The company retains 400 employees and hundreds of thousands of customers worldwide. MESCIUS inc. is committed to providing enterprises around the world with state-of-the-art developer tools and components, software services, and solutions. For more information, visit https://developer.mescius.com.

All product and company names herein may be trademarks of their respective owners.

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tKash Celebrates 1st Anniversary with Major Milestones and Exciting Promotions

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Achieving 100,000 Registrations, International Reach, and Celebratory Promotions Highlight tKash’s Remarkable First Year

KUALA LUMPUR, Malaysia, July 19, 2024 /PRNewswire/ — tKash, a pioneering financial services app, is celebrating its first anniversary with notable achievements and exciting promotions. Launched with a vision to simplify financial transactions, tKash has reached impressive milestones, including 100,000 registrations and up to 10,000 daily active users.

Since its inception, tKash has been dedicated to providing seamless and secure financial services. The app has enabled users to transfer up to RM 1 million across borders, offering peace of mind with its reliable and efficient service. In addition to money transfers, tKash provides convenient currency exchange services for up to 10 countries’ currencies, including Bangladesh, Indonesia, India, the Philippines, Pakistan, Singapore, Vietnam, Thailand, and Myanmar.

One of the standout features of tKash is its Live FC (foreign currency) Rates, which allows users to track currency fluctuations in real time, ensuring they make informed decisions when exchanging currencies.

The company’s growth and success have not gone unnoticed. tKash proudly featured its video on the iconic New York Times Square billboard and displayed billboards in Kuala Lumpur, enhancing its brand visibility on an international scale. Influencers from countries such as Thailand have shared positive reviews on social media, further boosting tKash’s presence on social media.

To celebrate its first anniversary, tKash is running a special promotion where users who refer their friends have the chance to share in a RM100,000 prize pool, making it even more rewarding to engage with the app. The company continues to innovate, with regular updates to its app, which are available for download on both the PlayStore and AppStore. In January 2024, tKash launched its official website, providing users another platform to access its services.

In just one year, tKash has proven to be a game-changer in the financial services industry, making everyday transactions smoother and more accessible. With its tech-savvy team and commitment to customer satisfaction, tKash is poised for continued growth and success.

tKash is a leading financial services app committed to making financial transactions easier and more accessible. With secure money transfers, real-time currency exchange rates, and a user-friendly interface, tKash transforms how people manage their finances. For more information, visit tKash.co.

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Saronic Raises $175 Million in Series B Funding, Valuing Company at $1 Billion

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Funding will accelerate Saronic’s growth and further scale production of its autonomous surface vessels for the U.S. Navy and its allies

AUSTIN, Texas, July 19, 2024 /PRNewswire/ — Saronic, a defense technology leader that designs and manufactures autonomous surface vessels (ASVs), today announced a $175 million Series B raise placing the company’s valuation at $1 billion. The funding round was led by Andreessen Horowitz (a16z), with participation from both new and existing investors, including 8VC, Caffeinated Capital, Elad Gil, and NightDragon, among others.

Saronic is redefining maritime superiority for the U.S. Navy and its allies by delivering the most effective and advanced ASVs at the speed and scale needed to meet the rapidly growing needs of the Joint Force. Saronic’s ASVs are designed to serve as a force multiplier for the existing Fleet, working alongside manned systems to allow naval forces to go farther and do more with less risk to life and mission. 

“We are creating an entirely new capability for the maritime domain, one that delivers naval power without the costs and delays of a shipyard,” said Saronic CEO Dino Mavrookas. “As the future of naval warfare will rely on manned and unmanned teaming, we must build solutions that easily integrate into the existing fleet and can be produced at scale to meet any emerging threat. We are grateful to our investment partners who believe so strongly in Saronic’s ability to meet that need.”

Saronic’s investor group is composed of firms committed to ensuring that the U.S. military maintains its decisive advantage in the face of an increasingly complex and competitive global threat landscape through the integration of advanced technology and innovative capabilities that truly meet the needs of the warfighter. 

“Our nation’s future depends on us continuing to build and deploy the best, most innovative technology” said Katherine Boyle, General Partner at a16z. “Saronic is developing the solutions we need to protect the warfighter and stay ahead of our adversaries, and we are proud to support their continued growth.”

This new investment will accelerate Saronic’s growth both domestically and internationally. At home, it will allow further expansion of Saronic’s in-house manufacturing capabilities and enable increased production of all its ASV models. Additionally, it will advance the research and development of new autonomous capabilities for naval and maritime forces, including increased technology and payload integration with government and commercial partners. Internationally, this investment will support Saronic’s expansion to more fully serve U.S. allies and partners in key markets.

“To deter China and other adversaries, the United States and our allies must bring intelligent, autonomous new capabilities to naval warfare,” said Alex Moore, Partner at 8VC. “Saronic delivers these capabilities on a relevant scale and timeline, and has enlisted the top engineers and operators in the industry.”

Saronic’s family of ASVs includes Spyglass (6′), Cutlass (14′) and Corsair, its largest model, which is currently in development and testing. Each vessel features integrated autonomous capabilities to meet a customer’s specific requirements and can carry diverse payloads in communication- and GPS-denied environments. Through the vertical integration of hardware and software as well as the use of a Modular Open Systems Architecture (MOSA), Saronic’s ASVs deliver greater interoperability at a price point that makes them attritable. Having a cost-effective capability that can be deployed without putting human operators in harm’s way increases the survivability of the fleet and enables commanders to engage in situations where the risk is too high to deploy a traditional manned system.

For more information about Saronic, please visit: https://www.saronic.com.  

Media Contact: Press@saronic.com 

 

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