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Implantica announces excellent RefluxStop™ investigator initiated study results published in Scientific Reports, a Nature journal

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VADUZ, Liechtenstein, July 30, 2024 /PRNewswire/ — Implantica AG (publ.), a medtech company at the forefront of introducing advanced technology into the body, announces the independent study ‘Multicentric short term and safety study of ineffective esophageal motility (IEM) patients treated with RefluxStop device’ was recently published in Nature Scientific Reports.

This investigator-initiated independent multicenter study was conducted at the General Hospital of the Medical University of Vienna, Austria, and King Edward VII Hospital in London, UK, from 2021 through 2023. All 40 patients had Ineffective Esophageal Motility (IEM) preoperatively, a notoriously difficult-to-treat subgroup of GERD patients.

Three months after the RefluxStop™ procedure, symptoms completely resolved or improved in 90% of the patients, PPI consumption was reduced by 84% and Quality of Life GERD-HRQL score was reduced from 32.8 to 6.6, an improvement of 80%, with limited side effects.

Patients with ineffective esophageal motility (IEM) have a weaker transportation of food down the esophagus and, therefore, often have swallowing difficulties. These patients are usually not recommended for surgery with standard of care surgical methods because they encircle and put pressure on the food passageway causing swallowing problems to worsen. This patient group comprises about one-third of the acid reflux sufferers that have no well working treatment today.

Prof. Dr. Sebastian Schoppmann of the Medical University of Vienna says, “It’s exciting to conduct the first real-world multicenter study assessing the safety and efficacy of the RefluxStop procedure. We found patients treated with RefluxStop experienced substantial improvements in quality of life and reflux symptoms with minimal safety issues despite all having ineffective esophageal motility. IEM is a well-known group of patients without any effective treatment options.” He adds, “Given RefluxStop’s great promising early results showing significant improvement in patient outcomes in GERD, we are now planning additional studies to validate our findings further and hopefully establish this as an effective treatment option to help the widely underserved GERD patient population.”

Dr. Peter Forsell, inventor of RefluxStop™ and CEO & Founder of Implantica adds, “It is exciting to see how well RefluxStop treats IEM patients with limited side effects since it does not encircle the food passageway like existing standard of care surgical treatments. Since launch several hundred patients with IEM have been operated with RefluxStop and the results have been excellent. We are very pleased to see these results published in Scientific Reports, a journal of Nature portfolio, which is a hallmark of high-quality research work, and would like to thank Prof Schoppmann and Dr. Boyle for their dedicated work. It is satisfying to see the RefluxStop procedure used for GERD patients with esophageal motility disorders given that historically these patients were largely excluded from the existing anti-reflux surgical treatments. RefluxStop™ has established itself as a great hope for these difficult-to-treat patients as well as millions of other GERD patients who would benefit from the RefluxStop procedure with its unique mechanism of action.”

For further information, please contact:
Nicole Pehrsson, Chief Corporate Affairs Officer
Telephone (CH): +41 (0)79 335 09 49
nicole.pehrsson@implantica.com

Implantica is listed on Nasdaq First North Premier Growth Market in Stockholm.

The company’s Certified Adviser is FNCA Sweden AB, info@fnca.se

The information was sent for publication, through the agency of the contact person set out above, on July 30, 2024, at 08:00 a.m. (CET).

About Implantica

Implantica is a medtech group dedicated to bringing advanced technology into the body. Implantica’s lead product, RefluxStop™, is a CE-marked implant for the prevention of gastroesophageal reflux that will potentially create a paradigm shift in anti-reflux treatment as supported by successful clinical trial results. Implantica also focuses on eHealth inside the body and has developed a broad, patent protected, product pipeline based partly on two platform technologies: an eHealth platform designed to monitor a broad range of health parameters, control treatment from inside the body and communicate to the caregiver on distance and a wireless energizing platform designed to power remote-controlled implants wirelessly through intact skin. Implantica is listed on Nasdaq First North Premier Growth Market (ticker: IMP A SDB). Visit www.implantica.com for further information.

About RefluxStop™

RefluxStop™ is a new innovative treatment that has the potential to spur a paradigm shift in anti-reflux surgery. It’s unique mechanism of action differentiates it from standard of care and current surgical solutions. Longer established surgical options for GORD involve encircling the food passageway to support the lower oesophageal sphincter’s closing mechanism and are commonly associated with side effects such as swallowing difficulties, pain when swallowing and inability to belch and/or vomit.

In contrast, the RefluxStop™ device treats the cause of acid reflux without encircling and putting pressure on the food passageway. It restores and maintains the lower oesophageal sphincter in its original, natural position.

The RefluxStop™ mechanism of action is focused on reconstructing all three components of the anti-reflux barrier, that if compromised could possibly result in acid reflux. It restores and supports the natural anatomical physiology of the body allowing the body to itself solve the problem with acid reflux.

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Media Contact:
Implantica AG
Juanita Eberhart, VP Marketing & Advocacy
M: +1 925-381-4581
juanita.eberhart@implantica.com

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China’s Long March: The Journey Goes On

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MACAO, Oct. 21, 2026 /PRNewswire/ — This is a report from Xinhua News Agency:

There is a chapter of history every Chinese child learns in school.

There is a poem that generations of Chinese people have learned by heart.

There is a song millions can sing from its very first notes.

In stories, in verses, in melodies, they all point to the same chapter of history: the Long March.

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SOURCE Xinhua News Agency

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Target Makes it Easier for Guests to Discover Stylish Holiday Gifts They Can’t Wait to Give

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Target is offering more than 8,000 new gifts, with more than half exclusive to the retailerMost new holiday items at Target are $20 or less, including thousands $5 and underNew AI-powered shopping experiences, daily deals and early Black Friday savings simplify gifting

MINNEAPOLIS, Oct 21, 2026 /PRNewswire/ — Target Corporation (NYSE: TGT) is putting gifting at the heart of the holidays, bringing guests more than 8,000 new stylish gifts they can’t wait to give. More than half of the new assortment is available only at Target, with thousands of gifts priced at $5 and under. New AI-powered shopping experiences, fresh ways to discover gifts and deals throughout the season will make it easier for guests to find something special for everyone on the list.

“This holiday season, guests will see and feel the changes we’ve been making across Target, bringing together the style, design and value they expect from us with an experience that makes shopping easier and more inspiring,” said Michael Fiddelke, chief executive officer, Target. “We know guests turn to Target for gifting, gathering and everything in between, and our team is ready to help busy families discover more joy in those moments throughout the season.”

Stylish gifts at an incredible value
As consumers continue to look for affordable ways to give gifts that feel special, Target is leaning into one of the season’s biggest trends: luxe-for-less gifting. This year’s assortment includes 100% cashmere (excluding functional trim) starting at $25, pajamas for all from $10, festive decor from $5, faux fur throws at $30, top toys from LEGO, Barbie and Nintendo, new and exclusive gifts from prestige, emerging and global beauty brands at Target Beauty Studio, nostalgic sweet treats and host gifts from Favorite Day and exclusive finds for sports and wellness fans, making it easy for guests to find gifts that feel elevated at every price point.

“Guests tell us they want to give gifts that are thoughtful and personal, while feeling good about what they’re spending,” said Cara Sylvester, executive vice president and chief merchandising officer, Target. “That’s why we’ve brought together the brands they love, exciting trends and unexpected finds they won’t see anywhere else — all at prices that make it easier to get that ‘I can’t wait to give this’ gift.”

More ways to discover the perfect gift
New this season, Ask Target, an AI-powered shopping assistant available in beta on Target.com and the Target app, helps guests find inspiration, narrow their choices and shop with confidence and ease. Additional AI-powered features and a digital holiday kids catalog offer more ways to discover gifts for everyone on the list.

Target’s new Academy of Giftology holiday marketing campaign, launching in November, will tackle familiar gifting dilemmas with playful inspiration to help guests gift it their all and find gifts they’ll be excited to give.

More ways to save, from the first gift to the last
Beginning Nov. 1, guests can shop a new Deal of the Day every day through Dec. 24, with a first-ever one-day preview of upcoming offers to help them plan ahead. Early Black Friday deals run Nov. 5–7, followed by new limited-time offers every weekend throughout the holiday season.

The joy of gift giving
Through Target’s partnership with St. Jude Children’s Research Hospital, guests can give a gift that helps give back with the Gigglescape St. Jude bear, with a donation tied to each purchase while supplies last.

About Target
Target Corporation (NYSE: TGT) brings together style, design and value to offer a distinct assortment and elevated shopping experience across more than 2,000 U.S. stores and online. Powered by more than 400,000 team members, Target serves millions of families each week and invests in the communities where they live and work to support growth and opportunity for all.

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SOURCE Target Corporation

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illumend CEO: Building a COI Tracker with AI Is Easy. Verifying Insurance Compliance Is Not.

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Kristen Nunery warns that homegrown Certificate of Insurance tracking tools can create a false sense of security when businesses mistake collecting insurance documents for verifying coverage and compliance

INDIANAPOLIS, Oct. 21, 2026 /PRNewswire/ — As general-purpose artificial intelligence (AI) makes it easier for businesses to build their own software, Kristen Nunery, founder and CEO of illumend, is warning construction and property management companies against a costly misconception: that building a Certificate of Insurance (COI) tracking system is the same as verifying that contractors and other third parties have the insurance coverage their contracts require.

In her new article, “You Can Build a COI Tracker with AI. That Doesn’t Mean You Should,” Nunery explains that general-purpose AI tools such as ChatGPT can help businesses create applications that collect certificates, track expiration dates, and automate reminders. But those capabilities address only part of the insurance compliance process. Determining whether coverage satisfies contractual requirements involves interpreting insurance documents, reviewing endorsements, identifying exclusions and resolving discrepancies that basic tracking software may overlook.

“AI has democratized the ability to build software. It hasn’t democratized the expertise to make the right insurance decision,” said Nunery, who has spent 16 years in insurance compliance. “If you don’t have a compliance process today, you’re not automating a process. You’re automating your best guess.”

Why a COI Tracker Is Not an Insurance Compliance Verification System

According to Nunery, the critical distinction is between tracking the existence and expiration of insurance documents and verifying whether the underlying coverage meets contractual obligations.

A homegrown COI tracker may confirm that a certificate is current, record policy limits, and flag missing documents. But a current certificate does not necessarily mean a contractor is adequately insured or compliant with an agreement’s terms.

For example, a subcontractor may submit a certificate showing sufficient general liability limits and additional insured status. Yet the underlying endorsement may be a CG 20 10 covering ongoing operations only, while the contract also requires completed-operations coverage under a CG 20 37 or equivalent endorsement. A basic tracker could mark the subcontractor as compliant despite the missing coverage.

“The tracker didn’t misread anything,” Nunery said. “It never had the contract requirement, the endorsement language, or the connection between the two.”

Other potential gaps include incorrectly named insured entities, missing endorsements, inadequate completed-operations coverage, and policy provisions that fail to satisfy contractual insurance requirements. Identifying these issues requires evaluating insurance evidence in context, not simply extracting data from a certificate.

Why Insurance Compliance Verification Requires Specialized Technology

Nunery argues that businesses seeking to move beyond basic COI tracking need technology designed specifically for insurance compliance verification, with insurance expertise embedded in how the system evaluates coverage.

Unlike homegrown tracking tools, specialized compliance platforms such as illumend compare insurance documents against established contractual requirements, examine supporting endorsements, identify coverage gaps, and explain findings that require attention.

This approach powers Lumie, illumend’s specialized AI-powered insurance compliance expert. Lumie reviews certificates and endorsements against established requirements, flags potential deficiencies and provides supporting evidence for its determinations, while allowing compliance professionals to review and resolve exceptions.

“AI should do more than flag a problem. It should show you what it found, which requirement it evaluated, and the evidence behind its assessment,” Nunery said. “Lumie applies insurance expertise at scale and creates a clear record of its findings, so teams can act on routine determinations efficiently and focus their attention on exceptions that need a closer look.”

Nunery’s perspective draws on her experience building myCOI, whose technology has reviewed more than 45 million insurance documents and identified more than 2 million coverage gaps before they became claims, according to company figures.

Build a COI Tracker or Buy a Compliance Platform? The Questions Businesses Should Ask

For organizations considering building their own COI software, Nunery recommends first determining whether they need a document-tracking application or a comprehensive insurance compliance verification system.

Basic tracking needs may be addressed with spreadsheets, conventional software, or applications built with general-purpose AI. But verifying compliance requires substantially more: translating contractual insurance requirements into rules, reviewing endorsements and policy evidence, identifying exceptions, documenting decisions, and maintaining an auditable compliance process.

Businesses must also consider who will keep insurance requirements current, validate the system’s determinations, investigate discrepancies, and maintain the records needed to support compliance decisions during claims or audits.

“Building the software happens once,” Nunery said. “Running a compliance system means keeping requirements, evidence, follow-ups, decisions and the audit trail current, every day it’s in use.”

To read Nunery’s full article, visit https://www.illumend.ai/evaluation-buying/build-vs-buy-coi-tracking-software-ai

About illumend
Founded in 2025, illumend™ is the AI-powered platform redefining how businesses manage third-party insurance compliance and risk. Backed by myCOI, the leader in third-party insurance compliance management with more than 16 years of expertise, illumend reimagines compliance by guiding every step of the process—from document review and expiration tracking to risk flagging, communication, and resolution—within one intuitive system. Built on myCOI’s institutional foundation—having processed more than 45 million documents, managed over 1.2 million agreements, cleared more than 750,000 third-party partners, and identified more than two million coverage gaps before claims—illumend brings this depth of compliance intelligence into an AI-native platform. At its core is Lumie, illumend’s conversational AI guide that reads complex insurance documents, flags issues in real time, and explains them in language anyone can act on. To learn more, visit https://www.illumend.ai.

Media contact:
Michael Tebo
Gabriel Marketing Group (for illumend)
Phone: 571-835-8775
Email: michaelt@gabrielmarketing.com

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SOURCE illumend

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