Connect with us

Technology

Differentia Biotech Launches Cutting-Edge Autoimmune Disorder Platform Combining AI/ML with QSP

Published

on

Groundbreaking Platform First Applied to Rare Autoimmune Disorder, IgG4-RD to Uncover New Treatment Targets

SOUTH SAN FRANCISCO, Calif., Aug. 22, 2024 /PRNewswire-PRWeb/ — Differentia Biotech, a leader in model-informed drug development, is proud to announce the launch of its innovative autoimmune disease platform. This platform integrates Artificial Intelligence and Machine Learning (AI/ML) with Quantitative Systems Pharmacology (QSP) extracting disease understanding by combining insights from patient-specific multiomics datasets and literature. This pioneering platform marks a significant advancement in the understanding and treatment of autoimmune diseases, enabling target identification and validation, lead optimization, biomarker discovery and clinical trial design.

The first application of Differentia Biotech’s platform focuses on IgG4-Related Disease (IgG4-RD), a rare and often misdiagnosed autoimmune disorder, for which specific treatments are currently missing due to insufficient understanding of its underlying mechanisms. Differentia Biotech has successfully developed a comprehensive disease model of IgG4-RD that maps the inter-cellular communication network among key immune cells. This model elucidates the dynamic interactions in healthy homeostasis and in the context of IgG4-RD, revealing the distinctive immune system characteristics associated with the disease state. Differentia Biotech utilized this platform to evaluate various therapeutic interventions via fast and scalable simulations and has identified targets that effectively shift the disease state towards healthy homeostasis. This innovative approach promises to transform the landscape of autoimmune disease treatment by providing deeper insights into disease mechanisms and accelerating the discovery of effective therapies.

Key Features of the Differentia Biotech’s Autoimmune Disorder Platform:

Advanced AI/ML Integration: Utilizes state-of-the-art machine learning algorithms to analyze complex multi-omics biological data, uncovering patterns and insights that are not discernible through traditional methods.Quantitative Systems Pharmacology (QSP): Employs sophisticated mathematical models to simulate disease processes and drug interactions at a systems level, enabling precise identification of potential therapeutic targets.First Application – IgG4-RD: The platform’s success with IgG4-RD underscores its potential to tackle other challenging autoimmune diseases. The IgG4-RD model has already started yielding promising targets for new treatments.

“Differentia’s modeling platform was instrumental in our study of IgG4-RD patients for clinical insights,” said Dr Hui Gao from Department of Rheumatology, Peking University International Hospital and Dr. Cuiping Pan from the Center for Intelligent Medicine Research. “It helped to uncover complex immune interactions in the patients, revealing enhanced B-cell proliferation and differential regulation of cytokines in T-cell subsets. Furthermore, we utilized Differentia’s platform to model treatment effects of numerous immune therapies, e.g., anti-CD20 B cells, anti-IL4, and anti-IL6, which had been previously shown beneficial in treating other autoimmune diseases. We are now designing clinical trials to validate the off-label use of these drugs for treating IgG4-RD. The collaboration with Differentia helped us to prioritize drug candidates with a mechanistic understanding, which accelerated the development of treatment strategies for the patients. We are hopeful that these prioritized drugs will have a therapeutic impact in this field.”

“We are thrilled to introduce this groundbreaking platform, which represents a new era in the fight against autoimmune disorders,” said Kas Subramanian, CEO of Differentia Biotech. “By combining the predictive power of AI/ML with the robust analytical capabilities of QSP, we are not only enhancing our understanding of these complex diseases but also paving the way for the development of more effective treatments.”

Differentia Biotech invites biotech and pharmaceutical companies and research organizations with a focus on autoimmune diseases to explore the potential applications of this platform to their specific areas of interest. By partnering with Differentia Biotech, stakeholders can leverage this powerful tool to drive their research and development efforts towards groundbreaking discoveries and innovative therapies.

For partnership inquiries and more information about Differentia Biotech’s autoimmune disorder platform, please contact:

Lorenz Huebner

V.P. Customer Solutions

Differentia Biotech

lorenz.huebner@differentiabio.com

Ph: +49 151 290 35213

www.differentiabio.com

About Differentia Biotech:

Differentia provides modeling and simulation services to biopharmaceutical companies delivering knowledge-based insights to improve drug development outcomes. Backed by Differentia’s proprietary data pool and cutting-edge AI/ML analytics, we empower biopharmaceutical companies to accelerate drug development and shape the future of healthcare.

Media Contact

Lorenz Huebner, Differentia Biotech, 49 151 290 35213, lorenz.huebner@differentiabio.com, www.differentiabio.com 

View original content:https://www.prweb.com/releases/differentia-biotech-launches-cutting-edge-autoimmune-disorder-platform-combining-aiml-with-qsp-302226178.html

SOURCE Differentia Biotech

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

Achieve named to Az Business Magazine’s ’10 Best Places for Women to Work in Arizona’ for 2026

Published

on

By

Recognition highlights the company’s commitment to creating opportunities for women to grow and lead

SAN MATEO, Calif., July 23, 2026 /PRNewswire/ — Achieve, the leader in digital personal finance, has been named among the 2026 10 Best Places for Women to Work in Arizona by Az Business Magazine. The annual recognition highlights organizations that create supportive environments where women can thrive professionally, advance into leadership roles and build meaningful careers.

The honor reflects Achieve’s ongoing investment in workplace programs that support employee growth, flexibility, leadership development and career advancement. Women serve in leadership roles across the organization and play a critical role in shaping the company’s culture, products and long-term success.

“Creating an environment where women can grow, lead and build rewarding careers is central to who we are as a company,” said Achieve Senior Vice President of Human Resources Heather Marcom. “We’re honored to be recognized among Arizona’s top workplaces for women and remain committed to fostering a culture where employees feel supported, valued and empowered to do their best work.”

Achieve maintains a major corporate presence in the Phoenix area, where hundreds of employees contribute to the company’s mission of helping people move from struggling to thriving financially. The company supports employees through leadership development opportunities, employee resource groups, mentorship and learning programs designed to help team members reach their professional goals.

The recognition adds to a growing list of workplace honors for Achieve. Earlier this year, the company was named among the Top 3 Best Workplaces for LGBTQ+ Employees by BestCompaniesAZ and was also recognized by AZ Big Media as one of Arizona’s Most Admired Companies.

“Strong organizations are built by diverse perspectives and inclusive leadership,” said Marcom. “We’re proud of the talented women across Achieve who help drive our business forward every day and grateful for the impact they make on our employees, customers and communities.”

The 10 Best Places for Women to Work in Arizona list is determined through a public voting process conducted by AZ Big Media and published in Az Business magazine.

About Achieve

Achieve, THE digital personal finance company, helps everyday people get on, and stay on, the path to a better financial future. Achieve pairs proprietary data and analytics with personalized support to offer personal loanshome equity loans, debt relief and debt consolidation, along with financial tips and education and free mobile apps: Achieve MoLO® (Money Left Over) and Achieve GOOD™ (Get Out Of Debt). Achieve is frequently recognized for providing top-rated customer experience and satisfaction by both consumers and leading personal finance review platforms and has 2,200 dedicated teammates across the country, with hubs in Arizona, California, Florida and Texas.

Achieve refers to the global organization and may denote one or more affiliates of Achieve Company, including Achieve.com, Equal Housing Opportunity (NMLS ID #138464); Achieve Home Loans, Equal Housing Opportunity (NMLS ID #1810501); Achieve Personal Loans (NMLS ID #227977); Freedom Debt Relief (NMLS ID # 1248929); and Freedom Financial Asset Management (CRD #170229).

Contacts

Austin Kilgore
akilgore@achieve.com
214-908-5097

Elina Tarkazikis
etarkazikis@achieve.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/achieve-named-to-az-business-magazines-10-best-places-for-women-to-work-in-arizona-for-2026-302833720.html

SOURCE Achieve

Continue Reading

Technology

National Press Club Statement on the withdrawal of subpoenas targeting New York Times journalists

Published

on

By

WASHINGTON, July 23, 2026 /PRNewswire/ — National Press Club President Mark Schoeff Jr. released the following statement:

“The Justice Department’s decision to withdraw subpoenas targeting journalists at The New York Times is a welcome and necessary step to protect the public’s constitutional right to an independent press.

These subpoenas should never have been issued in the first place. Compelling journalists to reveal confidential sources sends a chilling message to those who seek to inform the public and threatens the very foundation of press freedom.

Every American should understand what is at stake when the government turns its investigative powers on journalists. It is not routine. It is an extraordinary intrusion that strikes at the heart of the First Amendment and your right to information about your government.

The greatest danger was not the subpoenas themselves, but the message they sent: That sources could be exposed, that whistleblowers should remain silent, and that the American people might know less about the actions of their own government.

A strong democracy depends on a press that can report freely, hold power to account, and inform the public without intimidation.

We urge continued vigilance to ensure that journalists can do their jobs without interference and that protections for source confidentiality are upheld consistently.”

About the National Press Club

Founded in 1908, the National Press Club is the world’s leading professional organization for journalists and a leading voice for press freedom in the U.S. and worldwide.

Contact: Beth Francesco, Executive Director of the National Press Club Journalism Institute, media@press.org

View original content to download multimedia:https://www.prnewswire.com/news-releases/national-press-club-statement-on-the-withdrawal-of-subpoenas-targeting-new-york-times-journalists-302833722.html

SOURCE National Press Club

Continue Reading

Technology

NCC Launches NCC Connect™ to Put Credit, Fraud, and Compliance Inside the CRM Dealers Already Use

Published

on

By

A powerful new solution that embeds credit access, fraud detection, and compliance directly into the dealership’s existing CRM — removing the system-switching that slows deals and exposes dealers to risk.

AUSTIN, Texas, July 23, 2026 /PRNewswire-PRWeb/ — NCC, a leading provider of credit and compliance solutions for automotive dealerships, today announced the launch of NCC Connect™, a powerful platform that runs credit, fraud, and compliance from inside the CRM a dealership already uses — without friction or duplicate entry.

“Dealers don’t need another system to log into,” said Brian Skutta, President and CEO of NCC. “They need the tools they already have to work better together. NCC Connect puts credit, fraud detection, and compliance right where the team already works — inside the CRM they use every day.”

“Dealers don’t need another system to log into,” said Brian Skutta, President and CEO of NCC. “They need the tools they already have to work better together. NCC Connect puts credit, fraud detection, and compliance right where the team already works — inside the CRM they use every day.”

As deals grow more complex and fraud more sophisticated, dealers are juggling more disconnected systems than ever — the CRM, the credit system, the compliance tools — switching between them on every transaction. Each switch breaks momentum, invites a skipped step, and slows the path to funding. NCC Connect meets this moment with a single, seamless solution that keeps the full credit, fraud, and compliance engine right where the team already works.

Why NCC Connect Matters Right Now

Dealers lose time and margin switching between the CRM, credit, and compliance systems on every dealAuto lending fraud continues to climb, with industry fraud exposure reaching a record $10.4 billion in 2025, according to Point Predictive’s 2026 Auto Lending Fraud Trends ReportState compliance is tightening, with laws like California’s SB 766 (CARS Act) taking effect October 1, 2026Every disconnected step is another chance for an error, a delay, or a deal that stalls before funding

These pressures are forcing dealers to consolidate, and NCC Connect delivers the edge.

Product Highlights:

Inside the CRM — Soft-pull and hard credit access from all three major bureaus — Experian, TransUnion, and Equifax — without leaving the workflowFraud & Identity Built In — Identity verification and synthetic fraud detection delivered within the credit pull, flagging Red Flag conditions before the deal moves to fundingCompliance on Autopilot — FCRA and FTC controls with automatic, audit-ready documentation stored in the deal record99.99% Uptime — The industry’s highest, so the platform is there when a deal is on the desk

NCC Connect runs soft-pull pre-qualifications and hard credit pulls from any bureau or score model without leaving the CRM, while customer data stays inside the existing CRM structure. Every credit, fraud, and compliance result is captured on the deal record — giving dealers a single, audit-ready source of truth and a faster, cleaner path to funding.

NCC Connect extends the same powerful, credit-first engine behind NCC’s Complete Credit™ platform into the CRM where dealers already work. For dealers, that means more approvals, stronger fraud protection, and faster funding, without changing how the team works.

Learn more about NCC Connect at https://nccdirect.com/ncc-connect/

About NCC:

With offices in Austin, TX, Bettendorf, IA, and Las Vegas, NV, NCC has been a trusted partner in credit-driven retailing for automotive dealerships for nearly three decades. We combine a powerful credit and compliance engine with a fully integrated Desking platform to drive maximum profitability. Our focus on innovation, user-friendly products, and dependable systems — supported by a dedicated account management team — has solidified our reputation as a leader in the industry. www.nccdirect.com

Media Contact

Holly Smith, NCC, 1 8285732722, hsmith@nccdirect.com, https://nccdirect.com/

View original content:https://www.prweb.com/releases/ncc-launches-ncc-connect-to-put-credit-fraud-and-compliance-inside-the-crm-dealers-already-use-302832007.html

SOURCE NCC

Continue Reading

Trending