Technology

SIFI Receives European Commission Approval for AKANTIOR®

Published

2 years ago

August 26, 2024

AKANTIOR® (polihexanide) is the first and only approved drug for the treatment of acanthamoeba keratitis

CATANIA, Italy, Aug. 26, 2024 /PRNewswire/ — SIFI, a leading international ophthalmic company, today announced the European Commission has approved AKANTIOR® (polihexanide) for the treatment of acanthamoeba keratitis (AK) in adults and children from 12 years of age, confirming the orphan status of the product. AKANTIOR is the first and only approved therapy for people suffering from AK in Europe. 

AK is an ultra-rare, severe, progressive and sight threatening corneal infection characterized by intense pain and photophobia. AK is caused by a free-living amoeba, acanthamoeba, and primarily affects contact lens wearers.

“Today’s approval represents an important step towards delivering a new global standard of care for patients with AK and builds on 15 years of research and development,” said Fabrizio Chines, Chairman and CEO of SIFI. “For the first time in Europe AK patients have an approved therapy, marking a new era in the treatment of this disease, which may lead to blindness. AKANTIOR is the first and only approved medicine for AK, and our team is committed to developing polihexanide in other corneal infectious diseases, such as fungal keratitis, where we obtained orphan drug designation from the EMA and the FDA.”

“AKANTIOR, when used as monotherapy with the trial’s treatment protocol, achieves medical cure rates of over 86% and is set to become the standard of care for this severe and debilitating disease,” stated Professor John Dart, of Moorfields Eye Hospital and the UCL Institute of Ophthalmology, who was Principal Investigator of the Phase III ODAK trial. “After 15 years of research and effort development by SIFI, culminating in the pivotal Phase III clinical trial, polihexanide 0.08% has now been approved by the European Medicines Agency and European Commission as the first licensed treatment for acanthamoeba keratitis. This breakthrough offers significant improvement over current treatment options and has the potential to prevent blindness and save eyes. As the only approved therapy, it has been recommended for use with the detailed treatment delivery protocol used in the Phase 3 trial, which eliminates the need for the variable individualized treatment delivery currently used for patients, providing an effective standardized approach that can be followed by any clinician and which has been shown to be effective, not only in the Trial, but also in the current compassionate use program outside the more stringent Trial setting.”

“With the approval of AKANTIOR, AK patients (also known as AK Warriors) are now one step closer to having access to the best possible treatment in the EU. This milestone represents a significant step towards providing fair healthcare to all AK Warriors, giving them hope for a brighter future,” commented Juliette Vila Sinclair Spence, a rare disease patient advocate and the Chairwoman and Founder of AK Eye Foundation – the first global foundation dedicated exclusively to this condition.

In Europe, SIFI plans to initiate its first commercial launch in Germany during the last quarter this year, followed by additional markets based on local regulatory, healthcare technology assessment and reimbursement process timelines, including France, Italy, Romania, Spain, United Kingdom and Turkey addressing a total population of 430 million, and by Avanzanite, its commercial partner, in other European Countries addressing an additional population of 180 million. Based on scientific publications, the incidence of acanthamoeba keratitis is estimated at 1 to 4 patients per million inhabitants.

ABOUT AKANTIOR®: AKANTIOR (polihexanide 0.08%) is the first approved drug for the treatment of acanthamoeba keratitis in the world. It is an anti-amoebic polymer that acts on both the trophozoites and cysts of the protozoan acanthamoeba. It is formulated at a 0.8mg/ml (0.08%) concentration which makes it possible to administer as monotherapy eye drops in single-dose containers. The European Commission confirmed the orphan status of the product. The FDA granted SIFI Orphan Drug Designation for the treatment of acanthamoeba keratitis.

ABOUT Acanthamoeba Keratitis (AK): AK is an ultra-rare, acute, severe parasitic corneal infection caused by acanthamoeba, a free-living amoeba, although incidence of AK has been rapidly growing in recent years. AK is an ocular emergency and requires urgent treatment to save the eye. It can lead to poor vision, potential blindness, or even eye loss and often requires single or multiple corneal transplants. It affects people of all ages, most of whom are young or middle-aged soft contact lens wearers. Patients report unbearable pain and extreme light sensitivity and can rarely work or lead normal lives until symptoms resolve.

ABOUT SIFI: SIFI is a leading international ophthalmic company, headquartered in Italy, featuring an integrated business model, from research and development to manufacturing and commercialization both in pharmaceutical and biomedical sectors. Since our foundation in 1935, our mission is to improve people’s lives through meaningful innovation in eye care. SIFI exports to more than 40 countries worldwide with a direct presence in major European markets, Mexico and, through joint ventures, in China and the United Arab Emirates. More information available at www.sifigroup.com.

View original content:https://www.prnewswire.co.uk/news-releases/sifi-receives-european-commission-approval-for-akantior-302229445.html

Technology

Peninsula Visa Launches Comprehensive OCI Processing Services

Published

7 minutes ago

May 3, 2026

Peninsula Visa, a trusted leader in immigration and visa processing services with over 50 years of expertise, today announced the launch of its comprehensive Overseas Citizen of India (OCI) processing services. To celebrate this milestone, Peninsula Visa is offering new users an exclusive 20% discount with promo code OCI20 at checkout.

SAN JOSE, Calif., May 3, 2026 /PRNewswire-PRWeb/ — Peninsula Visa, a trusted leader in immigration and visa processing services with over 50 years of expertise, today announced the launch of its comprehensive Overseas Citizen of India (OCI) processing services. To celebrate this milestone, Peninsula Visa is offering new users an exclusive 20% discount with promo code OCI20 at checkout.

For 50 years, Peninsula Visa has helped families navigate immigration. OCI processing is one of our most impactful services, connecting the Indian diaspora to their heritage. We’re proud to bring our expertise to help families secure OCI status with confidence. Evan James, CEO

A Full Suite of OCI Services

Peninsula Visa’s OCI services cover every stage of the OCI lifecycle, ensuring that members of the Indian diaspora receive expert support from start to finish.

The four service types now available are:

New OCI Application — For foreign nationals of Indian origin, spouses of Indian citizens or existing OCI card holders, and minor children with at least one Indian parent applying for OCI status for the first time.OCI Card Renewal — For card holders whose OCI card has expired, or whose linked passport has been renewed or replaced and requires an updated booklet.Re-issuance (Age Milestones) — OCI cards must be re-issued when minors reach the age of 18 and again when card holders turn 50, due to significant changes in appearance. Peninsula Visa guides clients through both transitions seamlessly.Miscellaneous OCI Services — Covering corrections to existing records, lost or damaged card replacement, address changes, and other administrative updates to the OCI file.

Why Choose Peninsula Visa for Your OCI Application

Peninsula Visa brings decades of institutional knowledge and a client-first philosophy to every OCI case.

Key value propositions include:

Expert Guidance — Dedicated OCI specialists with deep knowledge of consulate requirements, eligibility rules, and documentation standards across all service types.High Approval Rate — A meticulous multi-stage review process that identifies and resolves issues before submission, dramatically reducing the likelihood of rejection or delay.Fast Turnaround — Standard processing in 12-15 Business Days for most OCI service types, with real-time status updates throughout the process.End-to-End Support — Personalized document checklists, secure document uploads, expert form preparation, consulate submission, and post-submission tracking — all in one place.

Launch Promotion

Save 20% on any OCI service — new users only

OCI20

Enter code OCI20 at checkout. Available to new users. No expiration date.

Leadership Perspective

“For 50 years, Peninsula Visa has helped individuals and families navigate the complexities of immigration documentation. OCI processing is one of the most impactful services we have ever added — it directly connects the Indian diaspora to their heritage country in a lasting, meaningful way. We are proud to bring our proven expertise and client-centric approach to this important service, and we look forward to helping thousands of families secure their OCI status with confidence.”

Founded in 1975, Peninsula Visa has built its reputation on precision, transparency, and a genuine commitment to client outcomes. The addition of OCI processing services reflects the company’s ongoing mission to expand its offerings to meet the evolving needs of immigrants and their families across the United States.

Get Started Today

Eligible applicants can begin their OCI journey by visiting Peninsula Visa’s dedicated OCI Services page. New users can take advantage of the 20% launch discount by entering promo code OCI20 at checkout when selecting any OCI service type.

Media Contact

Evan James, Peninsula Visa, 1 4087277515, media@peninsulavisa.com, https://peninsulavisa.com/

View original content to download multimedia:https://www.prweb.com/releases/peninsula-visa-launches-comprehensive-oci-processing-services-302760544.html

SOURCE Peninsula Visa

Technology

Peninsula Visa Launches Comprehensive OCI Processing Services

Published

7 minutes ago

May 3, 2026

A Full Suite of OCI Services

Peninsula Visa’s OCI services cover every stage of the OCI lifecycle, ensuring that members of the Indian diaspora receive expert support from start to finish.

The four service types now available are:

Why Choose Peninsula Visa for Your OCI Application

Peninsula Visa brings decades of institutional knowledge and a client-first philosophy to every OCI case.

Key value propositions include:

Launch Promotion

Save 20% on any OCI service — new users only

OCI20

Enter code OCI20 at checkout. Available to new users. No expiration date.

Leadership Perspective

Get Started Today

Media Contact

Evan James, Peninsula Visa, 1 4087277515, media@peninsulavisa.com, https://peninsulavisa.com/

View original content to download multimedia:https://www.prweb.com/releases/peninsula-visa-launches-comprehensive-oci-processing-services-302760544.html

SOURCE Peninsula Visa

Technology

Booking.com’s Latest Travel and Sustainability Research Reveals Australian Generational Paradox

Published

1 hour ago

May 3, 2026

SYDNEY, May 4, 2026 /PRNewswire/ — Today Booking.com released its 11th annual research report into consumer attitudes and understanding of the social and environmental impact of travel. With insights from 32,500 travellers across 35 markets globally, including 1,000 from Australia, this year’s research highlights a generational paradox.

While 83% of Australian travellers say that more sustainable travel is important to them, older generations demonstrate greater commitment through concrete actions, despite younger generations often expressing stronger sustainability intentions.

Older generations demonstrate greater commitment through concrete sustainable actions, with almost two–thirds of Boomers across Asia Pacific (63%) saying they will shop more at local, independent stores on their trips, three–quarters (75%) planning to reduce general waste, and 63% intending to reduce energy consumption, higher than Gen X, Millennials and Gen Z.However, younger travellers are leading in cultural and conservation management; more than a quarter of Gen Z (27%) and Millennials (26%) participated in a tour or activity that contributed to the health or conservation of the local ecosystem or wildlife.Extreme weather is actively reshaping travel choices. Nearly three-quarters of Australian travellers said they consider extreme weather risk when choosing both destination (72%), and timing (75%), and 27% reported having cancelled or changed trip plans in the past twelve months due to extreme weather or natural disaster.Australian travellers are shifting when and where they travel, seeking reliable climates and comfort. 43% say they plan to avoid overcrowded tourist destinations, 42% plan to travel outside of peak season, and 26% will seek out destinations with cooler temperatures.In 2025, travellers booked more than 100 million room nights on Booking.com at accommodation partners with a third-party sustainability certification, including at 363 third-party certified Australian properties.

To find Booking.com’s full 2026 research, visit here.

View original content:https://www.prnewswire.com/apac/news-releases/bookingcoms-latest-travel-and-sustainability-research-reveals-australian-generational-paradox-302760310.html

SOURCE Booking.com