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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

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2 years ago

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NANJING, China, Sept. 16, 2024 /PRNewswire/ — Vazyme (688105.SH), a leading life science technology company, significantly contributed to groundbreaking research published in Science Magazine through its innovative products. The study, which focuses on how mutant IDH1 inhibition activates tumor immunity by inducing double-stranded DNA (dsDNA) sensing, utilized Vazyme’s advanced tools to achieve compelling research results. These findings are driving progress in life science, fostering transformative changes and innovations, and advancing both academic research and the broader medical sector.

The research, led by the cancer research team at Harvard Medical School and Massachusetts General Hospital and the Broad Institute of MIT and Harvard, was authored by Dr. Meng-Ju Wu and his team. Reporting in Science, their paper, “Mutant IDH1 Inhibition Induces dsDNA Sensing to Activate Tumor Immunity”, reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Research has found that mIDH1 inhibitors cause DNA demethylation, which reactivates dormant viral genes embedded in the genome from ancient infections, subsequently activating cGAS, a protein responsible for detecting these viral elements. This reactivation triggers a viral mimicry response, effectively mobilizing the immune system to attack and destroy tumor cells. In preclinical models, mIDH1 inhibition led to the rapid recruitment of CD8+ T cells and a strong anti-tumor immune response. These findings suggest that strategies enhancing viral mimicry and immune activation could significantly boost the efficacy of mIDH1 inhibitors, paving the way for innovative combination therapies to combat mIDH1-driven cancers.

Three products from Vazyme were instrumental in this significant research: Equalbit 1 × dsDNA HS Assay Kit (#EQ121), Mycolor One-Step Mycoplasma Detector (#D201), and BCA Protein Quantification Kit (#E112). Among them, Vazyme #EQ121 is a ready-to-use double-stranded DNA (dsDNA) quantification kit that is easy to use, highly sensitive, and accurately quantifies 0.2 – 100 ng dsDNA. By utilizing the dye that specifically binds to DNA and reducing interference from impurities, along with strict standard controls, it provides a good linear relationship in the 0.2 – 100 ng range, achieving accurate quantification. It is an ideal choice for large-scale DNA sample quantification in NGS (e.g., input DNA quantification, DNA library quantification).

Additionally, Vazyme has launched an upgraded mycoplasma detection reagent–the Mycolor One-Step Mycoplasma Detector (#D201). The product introduces a novel red-yellow color change system, which makes operation easy and visually intuitive. Reliable cell culture is vital for cell research; however, mycoplasma contamination remains a frequent and challenging issue. Unlike yeast and bacteria, mycoplasma cannot be directly observed under a microscope, which makes detection more complex. By using isothermal amplification technology to detect whether cells are contaminated with mycoplasma through color change, it provides great convenience for researchers.

The BCA Protein Quantification Kit (#E112) is one of the most sensitive methods for measuring protein concentration. Boasting unparalleled versatility across diverse experimental settings, it enables the exploration of standard curve linearity while maintaining the ease of operation.

These exceptional products, from Cell and Protein Research product line to NGS Library Preparation product line, directly result from Vazyme’s strong research and development capabilities, which form the foundation of its innovations. The dedicated R&D team has developed over 600 types of genetically engineered recombinant enzymes, more than 2,500 high-performance antigens, monoclonal antibodies, and other essential materials. Driven by the robust enzyme library and following a logical progression in disease management—from discovery and prevention to diagnosis and treatment, Vazyme has established nine major product lines along with over 2,000 end products: Nucleic Acid Extraction Reagents, Molecular Biology Reagents, Cell & Protein Research Reagents, NGS Library Preparation Reagents, Reagents for Bio-Medicine, Instruments, Lab Consumables, Animal Disease Detection Kits, and IVD Solutions.

Vazyme prioritizes global customer connections, ensuring their satisfaction. Through local customer support teams in key markets, the company engages directly with users in over 60 countries with local warehouses for efficient delivery and service.

By leveraging technical expertise in various disciplines, including enzymology, immunology, cell biology, material science, and organic chemistry, Vazyme solidifies its role as a vital partner in scientific exploration. The driving force behind Vazyme’s work is empowering customers in their pursuit of advancing the innovation of science. And together, exploring the unknown and fostering collaborations towards a healthier life for all.

For more information, please visit the following website:
www.vazyme.com 

E-mail: support@vazyme.com
Tel: +86 400-168-5000

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SOURCE Vazyme

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ATTOM ENHANCES RENTAL AVM WITH AI-POWERED MODEL COVERING NEARLY 100 MILLION U.S. HOMES

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38 minutes ago

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November 3, 2026

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Enhanced model expands coverage by about 40% and delivers a 5.9% median error on homes not yet listed for rent

IRVINE, Calif., Nov. 3, 2026 /PRNewswire/ — ATTOM, the leading provider of property data, AI-powered intelligence, and real estate analytics solutions, today announced enhancements to its Rental AVM, introducing an AI-powered model that estimates current monthly market rent for nearly 100 million U.S. single-family homes, condominiums, and townhouses, an increase in coverage of about 40%. The model delivers a 5.9% median absolute error on homes before they are listed for rent, helping businesses evaluate rental potential and make more informed decisions.

“Estimating rental values is difficult because leases are private and many homes have no rental history,” said Rob Barber, CEO at ATTOM. “With these enhancements, we’re extending the same approach driving ATTOM Intelligence, combining trusted property data with advanced AI and analytics, to many more homes, so customers get more meaningful insights and can make better-informed decisions.”

Key Enhancements Include:

Expanded Coverage: Rental estimates for nearly 100 million single-family homes, condominiums, and townhouses across all 50 states and the District of Columbia, a coverage increase of about 40%.Improved Accuracy: A 5.9% median absolute error on homes before they’re listed for rent, with calibrated low and high values that tighten as the evidence behind an estimate grows.AI-Powered Modeling: Multiple machine-learning models evaluate property characteristics, property value, rental history, and recent rental activity, weighing each based on the available evidence for a property.Listing-Based Training: The model is trained and benchmarked on observed rental listings, cleaned to remove duplicates, placeholder rents, and unrealistic prices.

“Our enhanced Rental AVM evaluates multiple sources of rental information and adapts to the evidence available for each property,” said Aaron Wagner, Head of Data Science at ATTOM. “That adaptability is what allows us to estimate rent for homes with no rental history and extend coverage to nearly 100 million properties, while keeping the ranges calibrated to the strength of the evidence behind each estimate.”

Built for Real-World Applications
ATTOM’s enhanced Rental AVM supports a range of business needs, including:

Real Estate Investors and Rental Operators: Screen acquisitions, evaluate rental potential, compare rental income with property values, and support rent-setting decisions.Mortgage Lenders and Insurers: Assess rental income for investment-property and DSCR loans, monitor portfolio exposure, and support loss-of-rent analysis.Real Estate Portals and AI Developers: Integrate rental estimates into property listings, investment tools, and AI-powered applications through ATTOM’s MCP Server.

Updated monthly to reflect new rental activity and changing market conditions, the enhanced Rental AVM is available through ATTOM’s APIs, bulk data licensing, Snowflake, Databricks, and MCP Server.

To learn more about ATTOM’s enhanced Rental AVM, visit the Rental AVM landing page or download the Rental AVM White Paper.

About ATTOM
ATTOM delivers AI-driven property intelligence built on the nation’s most trusted property data repository, covering 160+ million U.S. properties—99% of the population. Our engineered, multi-sourced, semantically rich real estate data spans property tax, deeds, mortgages, foreclosure, environmental risk, property conditions, natural hazards, neighborhood insights, and geospatial boundaries, rigorously validated for advanced analytics. ATTOM supports analytics, AI applications, and AI agents through flexible delivery options including APIs, bulk licensing, cloud delivery, and the MCP Server for AI-powered, agentic access to engineered property data, enabling organizations to automate analysis, power intelligent workflows, and scale property intelligence across industries.

Media Contact:
Megan Hunt
megan.hunt@attomdata.com 

Data and Report Licensing:
949.502.8313
datareports@attomdata.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/attom-enhances-rental-avm-with-ai-powered-model-covering-nearly-100-million-us-homes-302928177.html

SOURCE ATTOM

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Staypineapple to Donate to American Humane Society’s Pups4Patriots™ in Honor of Veterans Day

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38 minutes ago

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November 3, 2026

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Hotel brand will donate a portion of November bookings to help veterans and retired first responders receive service dogs

KIRKLAND, Wash., Nov. 3, 2026 /PRNewswire/ — In recognition of Veterans Day, Staypineapple, the national boutique hotel brand, is supporting American Humane Society’s Pups4Patriots™ program. Throughout the month of November, Staypineapple will donate up to $5,000 on behalf of its guests from every Pineapple Pup Package booking and every booking made with military or government rates. The initiative supports the placement of specially trained service dogs with veterans and retired first responders living with post-traumatic stress (PTS) and/or traumatic brain injury (TBI), at no cost to recipients.

In recognition of Veterans Day, Staypineapple will donate a portion of November bookings to the Pups4Patriots program.

“Dogs have an incredible ability to bring comfort, connection and a renewed sense of purpose to our lives,” said Dina Belon, President of Staypineapple. “We’re proud to support American Humane Society’s Pups4Patriots program and help more of our nation’s heroes access the companionship and support of a service dog. We hope our guests will join us in making a difference through booking a stay this November.”

Pups4Patriots helps remove financial barriers to obtaining a specially trained service dog, matching eligible veterans and retired first responders with dogs trained to support their specific needs.

The impact of the program can be seen in the bond between Russell, a retired U.S. Army veteran and law enforcement officer, and his service dog, Nico. Through Pups4Patriots, Nico has become an important source of support in Russell’s life. As Russell shared, “Nico has brought me a renewed sense of living that I was very much struggling to find before meeting him.”

Through this initiative, Staypineapple hopes to help connect more of America’s heroes with life-changing canine companions to those who have served our country and communities.

To learn more or book a stay, visit Staypineapple.com.

About Staypineapple
Staypineapple is a brand of boutique hotels in urban markets across the U.S., managed by Staypineapple Hotels Inc., based in Kirkland, Wash. Known for personalized service and a warm welcome for people and pets alike, Staypineapple creates unique guest experiences that offer more than just a place to stay. It is a place Where Stays Become Stories. For reservations or more information, visit Staypineapple.com or call (866) 866-7977. Follow Staypineapple on Instagram, Threads, TikTok and Facebook.

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SOURCE Staypineapple

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Terakeet’s Mac Cummings Named to ADWEEK Innovator 50 List

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38 minutes ago

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November 3, 2026

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Recognition honors Cummings’ leadership in transforming Terakeet and building a new model for enterprise reputation management in the age of generative AI

SYRACUSE, N.Y., Nov. 3, 2026 /PRNewswire/ — ADWEEK today announced that Terakeet CEO & Co-Founder Mac Cummings has been named to the 2026 ADWEEK Innovator 50 list, which recognizes leaders driving innovation and shaping the future of marketing, media and technology.

Cummings was recognized for his leadership and vision in anticipating how generative AI would reshape enterprise reputation and positioning Terakeet to address the emerging challenges facing the Fortune 100 and its executives.

Over the past year, Cummings has led Terakeet’s transition from enterprise search marketing to global reputation management. The shift expanded the company’s focus beyond search visibility to the ways brands and executives are represented across search engines, generative AI platforms and the broader digital ecosystem.

“AI has changed what’s at stake for the Fortune 100,” said Cummings. “Reputation risk now moves across search and AI at the same time, and most brands don’t have the infrastructure to manage it. We built the Reputation Operating System to give them the technology, intelligence and expertise to understand those risks and strengthen their position before issues escalate.”

To better serve these customers, Cummings directed investments in proprietary technology, expanded the company’s expertise in cybersecurity and reputation risk, and established new strategic partnerships.

The recognition comes as Terakeet celebrates its 25th anniversary, marking a quarter century of evolution alongside major shifts in technology and the digital landscape. Cummings co-founded Terakeet in 2001 and has led the company through each stage of its growth, from its origins in search to its current focus on enterprise reputation management.

“The responsibility of a leader isn’t to protect the business model that worked yesterday but to recognize where the market is going and build for it,” Cummings said. “For Terakeet, that has meant looking past short-term fixes and building the infrastructure enterprises need to understand risk and protect trust in the AI era.”

About Mac Cummings

Mac Cummings is the CEO and Co-Founder of Terakeet. He co-founded the company in Syracuse, New York, in 2001 and has led its evolution across search marketing, digital strategy and enterprise reputation management. Today, Cummings oversees Terakeet’s business strategy and the continued development of its reputation management capabilities and technology.

About Terakeet

Terakeet is an enterprise reputation management company that helps brands and executives understand and manage how they are represented across search engines, generative AI platforms and the broader digital ecosystem. Founded in 2001, the company combines proprietary technology, intelligence and strategic expertise to support enterprise reputation programs.

View original content to download multimedia:https://www.prnewswire.com/news-releases/terakeets-mac-cummings-named-to-adweek-innovator-50-list-302928186.html

SOURCE Terakeet, LLC

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