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Waters New Bioseparations Tools Accelerate and Improve Development of RNA-based Vaccines and Therapies Using LC-MS Analysis

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Waters new LC-MS grade reagents, enzymes, and software simplify large molecule RNA analysis to accelerate and improve development of mRNA vaccines, personalized cancer therapies, and innovative drugs for genetic disorders.Novel digestion enzymes deliver complete RNA sequence coveragei for more confident characterization, while new LC-MS-grade reagents increase sensitivity and improve detection accuracy of RNA components.iiNew waters_connect™ MAP Sequence software accelerates RNA oligonucleotide mapping using semi-automated workflows that reduce data processing time over manual techniques, enabling routine monitoring of key product attributes.

MILFORD, Mass., Oct. 14, 2024 /PRNewswire/ — Waters Corporation (NYSE: WAT) today introduced a comprehensive set of sample preparation enzymes, reagents, and waters_connect software that simplify sequence and modification confirmation of large molecule RNA therapeutics using liquid chromatography-mass spectrometry (LC-MS) analysis. When used together in a workflow, these bioseparations tools help accelerate and improve the development of innovative large molecule RNA-based pharmaceuticals, such as CRISPR sgRNA and mRNA therapeutics.

Large molecule RNA (ribonucleic acid) therapeutics represent some of the most exciting and potentially life-saving developments in pharmaceuticals today. They include new and more effective vaccines for diseases like COVID-19, personalized cancer treatments, as well as emerging CRISPR RNA therapies that address challenging genetic conditions, such as sickle cell anemia.

“As RNA-based therapies are prepared for widespread use, more direct composition measurements are needed to ensure stability, safety, and effectiveness for patients,” said Erin Chambers, Vice President, Consumables and Lab Automation at Waters Corporation. “The combination of Waters enzymes, reagents, and software are specially designed to simplify the confirmation of sequence and modifications of complex molecules. These analytical tools can accelerate RNA therapeutic development and lower barriers for use by LC-MS non-experts.”

“As innovators looking to help our customers advance nucleic acid-based therapies and reduce the burden of serious diseases, we are always seeking new technologies to improve characterization and accelerate development,” said Arnaud Delobel, PhD, R&D and Innovation Director at Quality Assistance S.A. and beta tester of the Waters RNA analytical tools. “Waters new enzymes efficiently digest mRNA and sgRNA with short incubation times and data processing in MAP Sequence allows the user to obtain reproducible results quickly with confidence.”

The Waters RNA analytical tools include:

Enzymes: Two novel enzymes, RapiZyme™ MC1 and RapiZyme Cusativin, are used in a simplified three-step protocol that provides complete LC-MS sequence coverage over traditional digestion methods enabling more confident characterization of RNA molecules.iiiReagents: IonHance™ HFIP, an LC-MS-grade reagent, is formulated to improve ionization and delivers increased spectral clarity and detection accuracy of RNA components.Software: New MAP Sequence application on the waters_connect software platform simplifies RNA LC-MS oligo mapping workflows to accelerate analysis and data processing time over manual techniques using spreadsheets.

Used together within a workflow, the tools generate an LC-MS fingerprint to confirm product identity, purity, and efficacy. The tools improve sequence coverage, LC-MS spectral data quality, and data interpretation. Supported by the compliance-ready waters_connect software platform, these tools help transition LC and LC-MS-based digestion analysis from discovery and development to release and at-line process analytical testing.

Waters RapiZyme RNAses and IonHance HFIP are now available. The new MAP Sequence App on waters_connect software will be available on October 18, 2024.

Additional Resources

Learn more about the Waters RNA Analytical ToolsListen to our webinar “Cracking the Code: Analyzing mRNA and sgRNA with Advanced Enzymes, Mass Spectrometry, and Informatics on Oct. 16 at 11:00am ETJoin Waters at the PharmSci 360 conference for an expert session on “Oligo Mapping of Large RNA Therapeutics by Novel Enzyme Specificities” with Dr. Bala Addepalli, Waters Director, R&D New Modalities Portfolio on Oct. 21, at 11:00am ETFollow and connect with Waters via LinkedIn, Twitter, and Facebook

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE: WAT), a global leader in analytical instruments and software, has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, food, and environmental sciences for more than 65 years. With approximately 7,500 employees worldwide, Waters operates directly in 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.

Waters, Rapizyme, IonHance, and waters_connect are trademarks of Waters Technologies Corporation.

Contact:
Janice Foley
Senior Public Relations Manager, Corporate Communications
Waters Corporation
janice_foley@waters.com
+1.617.823.5555

i 100% RNA sequence coverage achieved for HPRT sgRNA digested with RapiZyme MC1 and RapiZyme Cusativin compared to traditional digestion methods such as RNase T1. Waters Application Note 720008539EN: “Tunable Digestions of RNA Using RapiZyme RNases to Confirm Sequence and Map Modifications” .

ii IonHance HFIP reagents are certified to contain less than 100 ppb sodium and less than 100 ppb potassium content, resulting in reduced adduct formation and improved sensitivity of RNA detection compared to commercially available HFIP. Waters Application Note 720008540EN: “Evaluating IonHance Hexafluoroisopropanol (HFIP) for Enhanced LC-MS Oligonucleotide Analysis”

iii Waters RapiZyme RNase protocol simplifies sample preparation with three steps including reagent preparation, RNA digestion, and heat inactivation without the need to add chemical denaturants and enzyme inhibitors.

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The Denver Post Names Luminate Bank the #1 Large Top Workplace in Colorado for 2026

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MINNEAPOLIS, May 13, 2026 /PRNewswire/ — Luminate Bank® earned the #1 ranking among large companies in The Denver Post’s Colorado Top Workplaces 2026 awards. The company also received the Special Award for Appreciation, recognizing its culture of employee support and recognition. This distinction is based solely on employee feedback gathered through a third-party survey administered by employee engagement technology partner Energage LLC. The confidential survey uniquely measures the employee experience and its component themes, including that employees feel Respected & Supported, Enabled to Grow, and Empowered to Execute, to name a few.

“Being named a Top Workplace is incredibly meaningful because it comes directly from the individuals who choose to grow their careers with us and show up every day with purpose and conviction. They are the foundation of our success,” said Eric Lovins, President of Mortgage Lending at Luminate Bank. “We don’t take the responsibility of earning their trust lightly, and we remain committed to creating an environment where they can thrive, succeed, and feel proud of the work they do.”

Luminate Bank traces its roots to 1937, when it first opened as Equity Bank. In 2020, the organization was acquired and reintroduced as Luminate Bank and Luminate Home Loans, reflecting a renewed commitment to guiding customers through complex financial moments with clarity and care. In 2025, Luminate Home Loans and Luminate Bank unified under one brand, combining full-service banking with a strong mortgage platform to expand offerings and better serve customers. Today, Luminate Bank’s team of more than 700 professionals nationwide continues to focus on relationship-based banking paired with digital innovation, supporting responsible growth and long-term customer success.

“Earning a Top Workplaces award is a badge of honor for companies, especially because it comes authentically from their employees,” said Eric Rubino, Energage CEO. “That’s something to be proud of. In today’s market, leaders must ensure they’re allowing employees to have a voice and be heard. That’s paramount. Top Workplaces do this, and it pays dividends.”

About Luminate Bank® — At Luminate Bank, We Open Doors—empowering individuals and families to achieve their financial dreams through personalized service and innovative digital solutions. As a nationwide bank headquartered in Minneapolis, Minnesota, we are committed to helping our clients meet their financial goals with a blend of modern technology, traditional values, and the trusted guidance of experienced professionals. Known for our exceptional commitment to customers, we take pride in delivering a seamless, supportive experience for every step of the journey. Our dedicated mortgage division has branches and a team of loan originators across the US, making expert home financing solutions accessible to communities nationwide.

Luminate Bank is committed to safeguarding your money and accounts with FDIC insurance coverage up to applicable limits. Learn more about how we can open doors for you at www.luminate.bank, follow us on Instagram, LinkedIn, and Facebook, or call (952) 939-7200.

ABOUT ENERGAGE
Making the world a better place to work together.™
Energage is a purpose-driven company that helps organizations turn employee feedback into useful business intelligence and credible employer recognition through Top Workplaces. Built on 20 years of culture research and the results from 30 million employees surveyed across more than 80,000 organizations, Energage delivers the most accurate competitive benchmark available. With access to a unique combination of patented analytic tools and expert guidance, Energage customers lead the competition with an engaged workforce and an opportunity to gain recognition for their people-first approach to culture. For more information or to nominate your organization, visit energage.com or topworkplaces.com.

Media Contact
Debbie Schwake, CMO
debbie.schwake@luminate.bank
952-698-3300

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SOURCE Luminate Bank

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InfoSight Launches AI-Enabled Purple Team SOCaaS: Machine-Speed Defense, Human-Led Control

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Purple SOC Unifies Offensive Testing, Defensive Monitoring, and AI-Driven Detection Engineering Into a Single Human-Led Security Program

MIAMI, May 13, 2026 /PRNewswire/ — InfoSight today announced the general availability of its AI-Enabled Purple Team Security Operations Center as a Service (SOCaaS)—a managed security solution that combines AI-driven attack path intelligence with human-led security governance. The service redefines how organizations detect, validate, and respond to modern cyber threats by unifying offensive adversary emulation and defensive monitoring into a single, continuously operating program.

AI-Enabled Purple SOC: Offensive Testing, Defensive Monitoring & Detection Engineering in One Human-Led Security Program

Modern enterprises face a growing mismatch between attacker speed and defender capability. AI-driven attack tools now operate at scale—testing controls, chaining vulnerabilities, and adapting faster than traditional SOC workflows can respond. Meanwhile, many Security Operations Centers (SOC) remain constrained by human-speed processes, where alert queues backlog, tickets accumulate, and threats progress before action is taken.

The challenge is no longer visibility—it is speed, correlation, and execution.

InfoSight’s Purple Team SOCaaS addresses this gap by delivering continuous threat exposure management across the full attack lifecycle. Rather than reacting to alerts alone, the AI-enabled experts continuously hunt for Advanced Persistent Threats (APT) and indicators of compromise (IOC)while decoding real-time threat signals to anticipate adversary behavior before incidents occur.

Core Capabilities

AI-driven attack path correlation across identity, cloud, and critical systemsAdversary emulation aligned to real-world MITRE ATT&CK techniques TTPsReal-time validation of SIEM, XDR, and EDR detections and response workflowsDynamic feedback loops that continuously update rules, telemetry, and playbooksHuman-led oversight for threat modeling, risk acceptance, and executive reporting

By fusing traditionally siloed red team and blue team functions with AI enablement, Purple SOCaaS creates a continuously learning security program. When detection gaps are identified, rules, telemetry configurations, and response playbooks are refined continuously instead of waiting for scheduled review cycles.

When analysts engage, alerts are already enriched, correlated, and prioritized. Evidence is pre-assembled across identity, endpoint, network, and cloud telemetry, allowing security teams to shift focus from manual triage to higher-value decisions such as determining scope, assessing control weaknesses, and directing response actions.

Purple SOCaaS delivers measurable business outcomes, including:

Reduced Mean Time to Detect (MTTD) and Mean Time to Respond (MTTR)Expanded detection coverage across high-risk attack vectorsReduced blast radius through continuous control validationStrengthened identity and privileged access controls based on proven adversary pathwaysBoard-level reporting tied to quantified exposure reduction over time

InfoSight’s Purple SOCaaS is delivered through a structured 30–60-day onboarding and launch program, followed by continuous validation cycles.

“Bad actors can operate at machine speed on a scale like never before, so organizations no longer have the luxury of reactive 8-5 security operations. Adversaries operate continuously, so defenses must too. Purple SOCaaS allows security teams to go on the offense and anticipate threats bases upon intent signals to stay ahead of modern threats. Attacks are running at machine speed so modern SOC operations must match the new pace. — Tom Garcia, President & CEO, InfoSight

InfoSight’s AI-Enabled Purple Team SOCaaS is available immediately for enterprise and mid-market organizations. Organizations can request an executive overview or technical brief by contacting InfoSight directly.

About InfoSight

InfoSight, Inc. is a cybersecurity services firm helping organizations reduce cyber risk across healthcare, financial services, manufacturing, energy, and government sectors. Founded in 1998, InfoSight delivers advanced security operations, risk management, and compliance solutions that help organizations strengthen defenses, reduce exposure, and protect critical systems and digital assets.

Media Contact:
Yendi Valdes
Marketing Director, InfoSight
Yendi.Valdes@infosightinc.com 
1-305-828-1003

View original content to download multimedia:https://www.prnewswire.com/news-releases/infosight-launches-ai-enabled-purple-team-socaas-machine-speed-defense-human-led-control-302771525.html

SOURCE InfoSight, Inc.

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Tuya Inc. to Hold Annual General Meeting on June 18, 2026

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SANTA CLARA, Calif., May 13, 2026 /PRNewswire/ — Tuya Inc. (“Tuya” or the “Company”) (NYSE: TUYA; HKEX: 2391), a global leading AI cloud platform service provider, today announced that it will hold an annual general meeting of the Company’s shareholders (the “AGM”) at 2:00 p.m. (Hong Kong time) on Thursday, June 18, 2026 at Huace Center, Building A, 3/F VVIP room, Xihu District, Hangzhou City, Zhejiang Province, 310012, China, for the purposes of considering and, if thought fit, passing each of the Proposed Resolutions as defined and set forth in the notice of the AGM (the “AGM Notice”). The AGM Notice and the form of proxy for the AGM are available on the Company’s website at ir.tuya.com. The board of directors of the Company fully supports the Proposed Resolutions and recommends that shareholders and holders of American depositary shares (“ADSs”) vote in favor of the Proposed Resolutions.

Holders of record of the Company’s ordinary shares as of the close of business on May 22, 2026 (Hong Kong time) are entitled to receive notice of, and to attend and vote at, the AGM or any adjournment or postponement thereof. Holders of record of ADSs as of the close of business on May 22, 2026 (New York time) who wish to exercise their voting rights for the ADSs underlying Class A ordinary shares must give voting instructions directly to The Bank of New York Mellon, the depositary of the ADSs, if ADSs are held directly by holders on the books and records of The Bank of New York Mellon or indirectly through a bank, brokerage or other securities intermediary if the ADSs are held by any of them on behalf of holders.

The Company has filed its annual report on Form 20-F, including its audited financial statements, for the fiscal year ended December 31, 2025, with the U.S. Securities and Exchange Commission (the “SEC”). The Company’s annual report on Form 20-F can be accessed on the Company’s website at ir.tuya.com and on the SEC’s website at http://www.sec.gov.

About Tuya Inc.

Tuya Inc. (NYSE: TUYA; HKEX: 2391) is a global leading AI cloud platform service provider with a mission to build an AI developer ecosystem and enable everything to be smart. Tuya has pioneered a purpose-built AI cloud platform with cloud and generative AI capabilities that delivers a full suite of offerings, including Platform-as-a-Service, or PaaS, AI application & others and Smart home & robot products for developers of smart device, commercial applications, and industries. Through its AI developer platform, Tuya has activated a vibrant global developer community of brands, OEMs, AI agents, system integrators and independent software vendors to collectively strive for smart solutions ecosystem embodying the principles of green and low-carbon, security, high efficiency, agility, and openness.

Investor Relations Contact

Tuya Inc.
Investor Relations
Email: ir@tuya.com

HL Strategy
Haiyan LI-LABBE
Email: hl@hl-strategy.com

Piacente Financial Communications
China Tel: +86-10-6508-0677
U.S. Tel: +1-212-481-2050
Email: tuya@thepiacentegroup.com

View original content:https://www.prnewswire.com/news-releases/tuya-inc-to-hold-annual-general-meeting-on-june-18-2026-302771184.html

SOURCE Tuya Inc.

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