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Critical Path Institute Celebrates 20 Years of Advancing Drug Development through Innovation and Collaboration

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TUCSON, Ariz., May 8, 2025 /PRNewswire/ — The year 2025 marks a historic milestone for Critical Path Institute® (C-Path), as the organization celebrates 20 years of transforming the landscape of drug development through collaboration, regulatory science, and next-generation strategies. Founded in 2005 by Raymond Woosley, M.D., Ph.D., with the support of leaders across multiple sectors in the pharmaceutical industry and regulatory agencies, as well as visionary elected officials like Congresswomen Gabby Giffords and Marsha Blackburn (now Senator), C-Path has played a pivotal role in accelerating the development of safe and effective treatments for individuals and families worldwide.

Since its inception in Tucson, Arizona, C-Path has grown from a small team of six employees to a globally recognized leader that has generated more than 160 job opportunities to stimulate innovations that accelerate drug development and advance regulatory science through data-driven solutions.

With a unique, neutral, precompetitive model that unites industry, regulators, academia, patients and patient groups, C-Path has spearheaded groundbreaking initiatives to generate tangible solutions that have accelerated drug development in areas such as infectious disease, rare disease, neurology, and pediatrics.

See C-Path 20 Years of Innovation

“C-Path was built on the vision that no single entity can solve the challenges of the drug development process alone,” said former C-Path CEO Dr. Woosley. “Over the last 20 years, C-Path has transformed that vision into reality, bringing together experts and communities to accelerate progress and improve patient outcomes.”

A Legacy of Innovation and Impact
From its early days supporting the FDA’s Critical Path Initiative, published in 2004, to leading the first multi-stakeholder biomarker qualification efforts, C-Path has driven numerous regulatory advancements. A sample of the organization’s milestones include:

2005–2010: C-Path quickly emerged as a pioneer in accelerating drug development by launching landmark consortia and earning early regulatory endorsements for innovative safety kidney biomarkers by FDA, EMA, and PMDA.

2011–2015: C-Path gained global recognition for its trailblazing biomarker qualification work, model-informed drug development collaborations, patient-focused drug development initiatives, and international data-sharing and regulatory collaborations, leading to groundbreaking achievements, such as the first-ever clinical trial simulator endorsed by FDA and EMA (for Alzheimer’s disease).

2016–2020: C-Path expanded its disease focus—spanning rare and orphan diseases, pediatrics, as well as neurodegenerative, metabolic, and infectious conditions—while launching major data platforms, international headquarters, and initiatives with global health authorities.

2021–Present: C-Path has intensified its global impact by advancing regulatory science across diseases, expanding its partnerships, seeing pivotal drug approvals being facilitated by the tools generated through C-Path collaborations, and hosting its inaugural Global Impact Conference—culminating in its 20th anniversary celebration in 2025.

“C-Path’s work has fundamentally changed the way the industry approaches drug development,” said Wainwright Fishburn, J.D., Chair of C-Path’s Board of Directors. “Through its leadership in regulatory science, data integration, and patient-centered research, the organization has made an undeniable impact on the lives of people worldwide.”

Looking to the Future: Leading Innovation in Drug Development
Entering its third decade, C-Path stands at the intersection of human ingenuity and technological advancements, trailblazing novel solutions to realize the promise of innovations in AI, digital health, real-world data, and computational tools to turn modern drug development challenges into opportunities. As such, C-Path continues to drive smarter, faster pathways to accelerate the development of better medicines that matter.

“Our mission remains clear: to accelerate the path to new treatments by fostering innovation, scientific rigor, and collaboration,” said C-Path CEO Klaus Romero, M.D., M.S., FCP. “With a future focused on actionable precision medicine, data-driven insights, and global leadership, C-Path is poised to lead the acceleration of the next era of drug development.”

To mark its 20th anniversary, C-Path will host a series of impactful events, uniting key stakeholders to explore future opportunities in accelerating and facilitating biomedical innovation.

Kristen Swingle, M.S., C-Path President and Chief Operating Officer, reflected on the organization’s success and growth over the past two decades: “C-Path’s success is built on the dedication and expertise of our talented team. Over the last 20 years, we have transformed from a small group of visionaries to a global leader in regulatory science and drug development. Our evolution in the cutting-edge jobs we have created, and the impact they have had, is a testament to the collaborative spirit and unwavering commitment of our staff, partners, and stakeholders.”

As part of this milestone year, C-Path’s annual Global Impact Conference will take place in Washington, D.C., September 9–11, 2025. This gathering will convene global experts in drug development, regulatory science, and patient advocacy to foster collaboration and accelerate progress. We encourage members of the biomedical community to participate in shaping the future of healthcare. Registration details can be found here.

For more information on C-Path’s 20th Anniversary events and its continued impact on drug development, visit https://c-path.org/20-years-of-impact/.

About Critical Path Institute
Founded in 2005, as a public-private partnership in response to the FDA’s Critical Path Initiative, Critical Path Institute® (C-Path) celebrates its 20th anniversary as a vital, independent, nonprofit. C-Path’s mission is to lead collaborations that advance better treatments for people worldwide. Globally recognized as a pioneer in accelerating drug development, C-Path has established numerous international consortia, programs and initiatives that currently include more than 1,600 scientists and representatives from government and regulatory agencies, academia, patient organizations, disease foundations and pharmaceutical and biotech companies. With dedicated team members located throughout the world, C-Path’s global headquarters is located in Tucson, Arizona and C-Path’s Europe subsidiary is headquartered in Amsterdam, Netherlands. For more information, visit c-path.org.

 Media Contacts:

Roxan Triolo Olivas
C-Path
520.954.1634
rolivas@c-path.org

Kissy Black
C-Path
615.310.1894
kblack@c-path.org

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Government of Canada introduces legislation to accelerate defence procurement, strengthen Canadian industry, and reinforce Canadian sovereignty

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OTTAWA, ON, Oct. 6, 2026 /CNW/ — The world is more dangerous and divided. The international rules-based order is fading, and global conflict rages on. Canada’s Government is focused on what we can control: rebuilding, rearming, and reinvesting in the Canadian Armed Forces (CAF). In October 2025, Canada’s new government established the Defence Investment Agency (DIA) to overhaul and streamline our defence procurement. Since then, the DIA has facilitated key purchases that strengthen Canada’s strategic autonomy. In a rapidly changing world, Canada must move quicker to keep Canadians safe.

That is why, today, the Government of Canada introduced Bill C-40: Strengthening Canada’s Defence Sector, to establish the DIA as a Crown corporation. This reform will provide the DIA with the authorities, operational flexibility, specialized expertise and organizational structure needed to deliver critical capabilities quicker. The DIA will have greater commercial flexibility and more autonomous approvals, allowing it to work better with industry and deliver better value for money. It will maximise Canada’s generational defence investments to strengthen our industrial base, supply chains, and sovereign capabilities.

This legislation:

Creates the Canadian Corporation for Defence Investment, which will continue to operate under its existing name, the Defence Investment Agency. It will have more independence, its own Board of Directors, and greater authority to negotiate and manage contracts;Empowers the DIA to engage in defence production, procurement, and investment activities in support of national defence and the operational priorities, capability requirements and acceptance criteria established by the National Defence (DND) and the Canadian Armed Forces (CAF);Maintains the Government of Canada’s oversight of the new Crown Corporation;Amends the National Defence Act to create an Associate Minister of National Defence for Procurement, who will be responsible to Parliament for the DIA, consolidate procurement and commercial authorities and strengthen accountability for procurement delivery within the National Defence portfolio, andIntegrates the DIA with the National Defence portfolio to further reduce red tape that slows procurement down and ensures that defence procurement in Canada is focused on equipping the National Defence and CAF with the tools they need to defend Canada.

Bill C-40: Strengthening Canada’s Defence Sector represents the next step in the Government of Canada’s modernization and transformation of Canadian defence procurement.

The DIA was launched to accelerate procurement and use defence spending to strengthen Canadian industry, build sovereign capabilities, and catalysing investment in the Canadian defence sector. As a Crown corporation it will have the commercial tools to deliver on its mandate. It will support Canada’s security and long-term economic growth, while remaining accountable to Parliament, and the Government of Canada.

The DIA will continue to strengthen Canada’s ability to work with allies and security partners. The Corporation would support joint defence procurement programs, including initiatives aligned with Canada’s participation in Security Action for Europe (SAFE) and Readiness 2030. Greater international collaboration will improve interoperability, provide Canadian suppliers with greater access to allied markets and supply chains, capitalize on economies of scale, and support Canada’s broader security and diplomatic objectives.

Canada is making generation investments to transform our defence sector. Empowered as a Crown corporation, the DIA will harness defence investment to catalyse industry, secure critical supply chains, and drive innovation and investment. In a rapidly changing world Canada’s government is building a stronger, more self-reliant country. One that is fully ready for the future. One that guarantees Canadians have tools needed to protect our country.

Quote

“Canada is making a generational investment in our defence and security, and we need institutions built to match the scale and urgency of that ambition. Establishing the Defence Investment Agency as a Crown corporation would give it the flexibility and specialized expertise to move faster, make strategic investments and deliver the capabilities our Armed Forces need. Just as importantly, it would allow us to use our defence investments to strengthen our sovereignty while building a robust Canadian defence industry, attracting investment and creating lasting economic opportunities and good jobs here at home.”

The Honourable Stephen Fuhr
Secretary of State (Defence Procurement)

“We look forward to continued collaboration with the Defence Investment Agency to further strengthen defence procurement. As a Crown corporation within the National Defence portfolio, the DIA will have the direct authorities and added flexibility to streamline procurement so that the Canadian Armed Forces and Canadian Coast Guard have more secure, reliable and quicker access to the capabilities they need to protect our sovereignty and keep Canadians safe.”

The Honourable David J. McGuinty
Minister of National Defence

“In a more dangerous and divided world, Canada is taking action and establishing a clear and compelling path forward. With the introduction of this legislation, we are making clear that large-scale, agile defence production and procurement is here to stay. Procurement and investment must live together, by connecting the capabilities our armed forces need with the investments that will deliver them and the industrial capacity that will sustain them. As a Crown corporation, the Defence Investment Agency will integrate these priorities, delivering critical capabilities to our armed forces more efficiently while strengthening Canadian industry, driving innovation and creating economic opportunity for years to come.”

The Honourable Joël Lightbound
Minister of Government Transformation, Public Works and Procurement and Quebec Lieutenant

“Establishing the Defence Investment Agency as a Crown corporation is an important step in building the organization Canada needs to meet today’s defence and security challenges. It will give the DIA the tools, flexibility, and expertise to move faster and make strategic investments that deliver capabilities for the Canadian Armed Forces and the Canadian Coast Guard. Our responsibility will be to turn Canada’s defence investments into results, strengthening our industrial base, building sovereign capacity, deepening partnerships with industry, and creating economic opportunities at home. I am proud of what the DIA team has accomplished since our launch, and I look forward to leading this transition and the organization’s next chapter.”

Doug Guzman 
Chief Executive Officer, Defence Investment Agency

Quick facts

The DIA was initially established as a Special Operating Agency within Public Services and Procurement Canada, allowing the organization to begin operations while the Government of Canada developed its longer-term organizational model.Establishing the DIA as a Crown corporation within the National Defence portfolio is intended reduce handoffs, consolidate procurement and commercial authorities and strengthen accountability for procurement delivery.By consolidating responsibility and expertise within one organization, the DIA will reduce duplication, streamline decision-making, and accelerate procurement from validated requirement definition to contract award, while DND, the CAF and the CCG retain responsibility for defining capability requirements, operational priorities and acceptance criteria.  The DIA is a central delivery partner for Canada’s Defence Industrial Strategy and its Build–Partner–Buy approach to defence procurement.The proposed Corporation will be accountable to the Government of Canada through a responsible Minister and subject to legislated governance, financial, audit, reporting and parliamentary oversight requirements.

Associated links

Backgrounder: Introduction of legislation to strengthen Canada’s Defence SectorDefence Investment AgencyCanada’s Defence Industrial Strategy

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Ampersand closes generation gap between agents and the enterprise software stack, backed by $15 million from Bessemer Venture Partners

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Ampersand lets agentic applications read and write inside legacy systems of record, removing the integration work that has stalled AI projects industry-wide.

SAN FRANCISCO, Oct. 6, 2026 /PRNewswire/ — Ampersand today announced a $15 million Series A led by Bessemer Venture Partners, with participation from existing investors Matrix and Flex Capital. New investors participating in this round also include Yelp, Tenacity Capital, CTO Fund, Mana Ventures, and prominent angel investors. Lauri Moore, Bessemer Partner, will be joining Ampersand’s board. Ampersand is building integration infrastructure for enterprise agents, so agentic applications can read and write inside the CRM, ERP, and other systems of record that power the enterprise.

While enterprises are ready to adopt agentic software, they are running into a practical issue: legacy systems of record. CRMs and ERPs in different verticals have been around for decades, and every implementation is highly customized. AI-native software vendors looking to sell to the enterprise are faced with needing deep domain expertise on how these systems function before they can deliver value to enterprise customers. This practical reality slows AI adoption for the enterprise and limits the market size for AI vendors.

“With Ampersand, we’re able to serve new customers that were previously unavailable to us because of their complex integration requirements,” said John Pena, CTO at Hatch, an AI communications platform for service businesses, acquired by Yelp in 2026. “Now we’ve expanded our total addressable market without taking on months of maintenance headaches.”

Ampersand is closing the gap between legacy systems and agentic products by making every customers’ system legible to agents. Ampersand’s approach to legacy systems allows every end customer to adopt a custom data model that can handle custom fields, objects, permissions, and workflows so agents have the right context. Then enabling agents to take deep, bi-directional actions in these systems of record.

“We’re in this fascinating moment where AI has the potential to transform the enterprise, but CTOs are still faced with the old problem of systems of record,” said Ayan Barua, co-founder and CEO of Ampersand. “Our bet is that the saasapocalypse is overstated and systems of record like Salesforce and NetSuite aren’t going anywhere. Ampersand is designed to sit between these two generations of software and make them legible to each other.”

Ampersand’s mission is to provide a complete integration solution for AI-native companies. This includes integration infrastructure, deep domain expertise, forward-deployed expertise, and agentic support. Ampersand announced the beta release of its AI integration agent, Andi. Andi helps developers with the implementation work required to get their products running in each customer’s environment.

Ampersand’s founders bring decades of integration experience to the problem. Ayan Barua was CTO and co-founder of Siftery, later acquired by G2, and then VP of Engineering at G2, where CRM and ERP integration work routinely consumed the majority of his engineering team’s time. Lauren Long built Firebase Extensions at Google, connecting Firebase apps to third-party APIs at a scale that grew to billions of executions a day. The two spoke with more than 100 companies building integrations before writing Ampersand’s first line of code.

“An agent is only as useful as the systems it can reach. MCP enables agents to describe a tool. It didn’t address what happens at runtime, when tokens expire, schemas drift, and every customer’s Salesforce looks a little different,” said Lauri Moore, Partner at Bessemer Venture Partners. “Connecting an agent to a system of record is a demo. Keeping that connection alive across hundreds of customers, with writes you can’t afford to get wrong, is much harder. That’s what Ampersand is building.”

About Ampersand
Ampersand is integration infrastructure for enterprise agents. With Ampersand, AI-native software vendors are able to bridge the generation gap between their customers’ legacy systems of record, CRMs, and ERPs, and the agentic capabilities in their software. Founded by Ayan Barua and Lauren Long, Ampersand is based in San Francisco. Learn more at ampersand.ai

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SOUTHWEST AIRLINES LAUNCHES FIRST-OF-ITS-KIND U.S. AIRLINE PLUGIN IN CHATGPT

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Customers can discover Southwest destinations and plan flights in an experience powered by OpenAI and Amazon Web Services 

DALLAS, Oct. 6, 2026 /PRNewswire/ — Southwest Airlines Co. (NYSE: LUV) today launched a first-of-its-kind U.S. airline plugin in ChatGPT, marking the first step in a phased AI-powered booking approach with OpenAI and Amazon Web Services (AWS) that allows travelers to discover and shop for Southwest flights in ChatGPT.

By launching the Southwest® plugin in ChatGPT, the airline can appear earlier in the Customer journey and offer a simpler, more direct path from inspiration and discovery to booking options with Southwest.

“Customers are evolving how they plan their travel, and Southwest is helping to shape what comes next,” said Sabrina Callahan, Chief Digital and Marketing Officer at Southwest Airlines®. “It is a meaningful example of how we test and learn with AI innovation to continue the Customer-first approach that defines our brand.”

“We’re putting the right technology in place to support what our Customers need today with flexibility to build what they’ll need tomorrow,” said Lauren Woods, Executive Vice President & Chief Information Officer at Southwest Airlines. “By creating a secure, scalable foundation for AI, we can add new capabilities more quickly and thoughtfully, making it easier to serve Customers across their journey.”

Southwest is working with OpenAI and AWS to combine leading AI and cloud technologies with Southwest’s deep understanding of its Customers. With OpenAI and AWS, Southwest is creating more intuitive travel planning while thoughtfully expanding AI-powered capabilities over time.

Learn more about the Southwest plugin in ChatGPT at Southwest.com/chatgpt.

ABOUT SOUTHWEST AIRLINES CO.
Southwest Airlines Co. operates one of the world’s most admired and awarded airlines, offering its one-of-a-kind value and Hospitality at 120 airports across 12 countries. Southwest took flight in 1971 to democratize the sky through friendly, reliable, and low-cost air travel and now carries more air travelers flying nonstop within the United States than any other airline¹. By empowering its more than 73,000². People to deliver unparalleled Hospitality, the maverick airline cherishes a passionate loyalty among more than 134 million Customers carried in 2025. Southwest leverages a unique legacy and mission to serve communities around the world including harnessing the power of its People and Purpose to put communities at the Heart of its success. Learn more by visiting Southwest.com/citizenship. 

1. Based on U.S. Dept. of Transportation quarterly Airline Origin & Destination Survey as of Q4 2025.
2. Fulltime-equivalent active Employees as of June 30, 2026.

Cautionary Statement Regarding Forward-Looking Statements
This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Specific forward-looking statements include, without limitation, statements related to the Company’s expectations with respect to its digital evolution, technology capabilities, including artificial intelligence capabilities, and Customer needs and expectations. These forward-looking statements are based on the Company’s current estimates, intentions, beliefs, expectations, goals, strategies, and projections for the future and are not guarantees of future performance. Forward-looking statements involve risks, uncertainties, assumptions, and other factors that are difficult to predict and that could cause actual results to vary materially from those expressed in or indicated by them. Factors include, among others, (i) the impact of geopolitical conflicts, fears or actual outbreaks of diseases, extreme or severe weather and natural disasters, actions of competitors (including, without limitation, pricing, scheduling, capacity, and network decisions, and consolidation and alliance activities), governmental actions, consumer perception, consumer uncertainties with respect to trade policies, tariffs, or government shutdowns, economic conditions, fears or actual acts of terrorism or war, sociodemographic trends, and other factors beyond the Company’s control, on consumer behavior and the Company’s results of operations and business decisions, plans, strategies, and results; (ii) the Company’s ability to timely and effectively implement, transition, operate, maintain, and protect the technology systems, cybersecurity measures, artificial intelligence and other emerging technology capabilities, and infrastructure necessary to support its operations and initiatives; (iii) the Company’s ability to effectively execute and evolve its strategic plans, initiatives, product offerings, and policies, including related consumer behavior and response; (iv) the impact of fuel price changes, fuel price volatility, and fuel availability on the Company’s business plans and results of operations; (v) the impact of the Federal Aviation Administration and other governmental regulations and actions, including with respect to government shutdowns and Air Traffic Control staffing shortages and inefficiencies, as well as the Company’s ability to obtain any required governmental approvals, on the Company’s business plans, results, and operations; (vi) the Company’s dependence on The Boeing Company (“Boeing”) and Boeing suppliers with respect to the Company’s aircraft deliveries, fleet and capacity plans, operations, maintenance, strategies, and goals; (vii) the Company’s dependence on other third parties, including with respect to technology, revenue management, distribution channels, operational reliability, fuel supply, maintenance, and the impact on the Company’s operations and results of operations of any third-party delays or nonperformance; (viii) the impact of labor matters on the Company’s business decisions, plans, strategies, and results; (ix) the Company’s ability to obtain and maintain adequate infrastructure and equipment to support its operations and initiatives; (x) the Company’s dependence on its workforce, including its ability to employ and retain sufficient numbers of qualified Employees with appropriate skills and expertise to effectively and efficiently maintain its operations and execute the Company’s plans; (xi) the cost and effects of the actions of activist shareholders; and (xii) other factors, as described in the Company’s filings with the Securities and Exchange Commission, including the detailed factors discussed under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2025.

 

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