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RyboDyn Expands Strategic Cancer Immunotherapy Collaboration with Moffitt Cancer Center

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Dark genome biotech RyboDyn deepens partnership with world-leading cancer immunotherapy center to validate novel oncology targets and advance first-in-class therapies

SAN DIEGO, May 15, 2025 /PRNewswire/ — RyboDyn, Inc., a biotechnology company pioneering first-in-class immunotherapies targeting the dark proteome, today announced the expansion of its strategic collaboration with Moffitt Cancer Center, a global leader in cancer care and research. The partnership aims to accelerate the development of immunotherapies targeting novel, cancer-specific proteins identified through RyboDyn’s proprietary sequencing and AI-driven target discovery platform, RyboCypher™.

Earlier this year, RyboDyn reported the identification of a cryptic class of proteins derived from overlooked RNA species—called Dark Targets™. These novel antigens, invisible to standard detection methods, represent a new and largely untapped frontier for oncology drug development. Through its expanded collaboration with Moffitt, RyboDyn will validate the presence and therapeutic potential of these Dark Targets™ across a wide array of tumor types, leveraging Moffitt’s uniquely annotated tumor repository—one of the largest and most comprehensive in the world. “Moffitt’s tumor bank is a critical resource in validating novel targets across a diverse set of cancer patients,” said Dr. Alex Jaeger, PhD, assistant member of the Molecular Oncology Department at Moffitt Cancer Center. “The ability to correlate molecular signals with deep clinical metadata significantly accelerates both discovery and translational development.”

Initial studies from the collaboration have confirmed that select Dark Targets™ are consistently presented on tumors—but not in healthy tissues—de-risking this novel class of antigens and providing a path toward scalable, tumor-specific therapies. “The fact that our lead targets are consistently presented across patient samples—yet absent in healthy tissues, gives us high confidence in their relevance,” said Corey Dambacher, PhD, President, CTO, and Co-founder of RyboDyn.

These data support RyboDyn’s core hypothesis: while not all Dark Targets™ are cancer-specific, a distinct subset is uniquely and consistently presented on tumor cells—making them highly compelling candidates for therapeutic development. “We’re not building a personalized medicine platform—we’re designing therapies that combine precision with broad reach,” said Imad Ajjawi, PhD, MBA, CEO and Co-founder of RyboDyn. “By focusing on conserved targets with tumor-specific presentation, we’re unlocking new opportunities for scalable, off-the-shelf therapies in oncology.”

“This collaboration reflects our shared commitment to advancing the next generation of cancer immunotherapies,” said Dr. Jaeger. “By combining Moffitt’s clinical and translational expertise with RyboDyn’s novel discovery platform, we’re accelerating progress toward more precise and effective treatments.”

About RyboDyn

RyboDyn, Inc., based in San Diego, CA, is a biotechnology company pioneering the development of first-in-class immunotherapies targeting the dark genome. By leveraging RyboCypher™—a proprietary sequencing method and AI-driven bioinformatics platform—RyboDyn is uncovering and validating previously unknown proteins and disease-specific targets. With proprietary IP licensed from Oregon Health & Science University, the company is driving a unique “targets-to-assets” approach to therapeutic development. RyboDyn collaborates with leading clinical institutions, academic researchers, and biopharma partners to validate and advance its drug pipeline, with a focus on transformative solutions for cancer and other diseases with unmet medical needs.

For more information, contact info@rybodyn.com or visit www.rybodyn.com.

View original content to download multimedia:https://www.prnewswire.com/news-releases/rybodyn-expands-strategic-cancer-immunotherapy-collaboration-with-moffitt-cancer-center-302455847.html

SOURCE RyboDyn

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Cash or Card? New Upgraded Points Survey Reveals How Travelers Pay Abroad

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AUSTIN, Texas, Oct. 28, 2026 /PRNewswire/ — A new Upgraded Points survey of 1,500 recent international travelers, including 1,000 Americans, finds that travelers use a mix of cash and cards abroad, but exchange rates, fees, and declined transactions can complicate purchases.

“Spending money should be the easy part of a trip abroad,” said Ryan Smith, Director of News at Upgraded Points. “But exchange rates, fees, and payment options can complicate even the simplest purchase. We wanted to learn how travelers prepare, where their plans run into trouble, and what they do when convenience and the best exchange rate move in different directions.”

Study Methodology

Upgraded Points surveyed 1,500 adults who had traveled internationally within the past 12 months, including 1,000 U.S. adults and 500 adults from other countries. Respondents answered questions about payment methods, cash habits, credit card use, airport currency exchanges, and their confidence navigating exchange rates. The results were compared to show how Americans’ payment habits differ from those of other international travelers.

Payment Planning Often Starts Months Before a Trip

Nearly one-third (32%) begin planning how they’ll pay abroad three to six months before departure. U.S. travelers are more likely than non-U.S. travelers to start earlier, with 20% beginning more than six months ahead, compared with 12% of non-U.S. travelers.

Travelers’ Confidence in Exchange Rates Varies

Just 35% of respondents said they feel very confident understanding exchange rates abroad. Confidence also varied by age and gender:

44% of men feel very confident, compared with 26% of women.28% of Gen Z travelers feel very confident, compared with 40% of Gen X travelers and 37% of Baby Boomers.

Cash and Cards Remain Popular Abroad

Cash in the local currency and physical credit cards were nearly tied as the payment methods travelers most often use abroad. Mobile wallets were more popular among younger travelers:

71% use cash in the local currency.69% use a physical credit card.44% use a mobile wallet, including 56% of Gen Z travelers and 22% of travelers age 61 and older.35% use a physical debit card.

Most Travelers Carry Local Currency

More than 8 in 10 travelers (81%) carry cash in the destination’s currency, often for situations where cards may not be accepted:

64% use it at street vendors, markets, or small businesses.55% use it for tips and other customary cash payments.53% carry it for emergencies.

Travelers generally avoid carrying a large amount at once. About 44% exchange enough cash for several days, while 26% exchange enough for the full trip.

Familiar Card Brands Lead Among U.S. Travelers

Among U.S. respondents, Visa was the most commonly used card network, while Chase and Capital One were the most commonly used issuers:

Visa: 24%Chase: 21%Capital One: 19%American Express: 15%

Fees and Declined Cards Can Complicate Purchases

Among all respondents, travelers most often said their bank or card company contacted them about a purchase made abroad. Other issues increased the cost of a purchase or prevented it from going through:

38% were contacted by their bank or card company about a purchase.34% paid more than expected because of the exchange rate.29% were charged an unexpected foreign transaction fee.26% had a card declined.

Find the full study here.

About Upgraded Points LLC

Headquartered in Austin, Texas, Upgraded Points is a travel company that helps to demystify the complex world of travel and credit cards. Launched in 2016 by Alex Miller, Upgraded Points uses targeted research efforts and in-depth studies to help travelers maximize their travel, points, and experiences. Learn more at www.UpgradedPoints.com.

Media Contact:
Alex Miller, Founder
1-214-646-8866
425187@email4pr.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/cash-or-card-new-upgraded-points-survey-reveals-how-travelers-pay-abroad-302922010.html

SOURCE Upgraded Points

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ESI supplying solar array components to missile defense programs

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SIMI VALLEY, Calif., Oct. 28, 2026 /PRNewswire/ — ESI Motion Inc. is proud to announce that it is supplying the Solar Array Drive Electronics (SADE) to Lockheed Martin for its work on the Space Development Agency’s Proliferated Warfighter Space Architecture (PWSA) programs.

Under the agreement, ESI Motion’s SADE technology will support SDA as the PWSA is developed.

Defending our nation in space is more important than ever. The Space Development Agency’s PWSA programs provide the military with a network of satellites with secure communication, missile tracking and space-based support to make sure our troops have the latest and greatest technology.

The SADE consists of our Space-rated, flight heritage, SuperNova and Pulsar motor controllers. These motion controllers ensure all mission parameters are fulfilled, with high-reliable technology. 

ESI Motion Inc., U.S. Company, is a trusted supplier and partner, supporting mission operations for space, military and industrial customers around the world for over 20 years. Please visit our website; www.esimotion.com

Mitchell Haerterich, mhaerterich@esimotion.com

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Envoy AI Launches “Boss of Machines” Program to Develop the Next Generation of Freight Leaders

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New AI Operations Lab will provide college students with hands-on experience in freight technology, operational transformation, and a $2,500 scholarship.

CHATTANOOGA, Tenn., Oct. 28, 2026 /PRNewswire-PRWeb/ — Envoy AI, the AI Native platform behind logistics autonomous agent system and execution layer Ellie, today announced the launch of Boss of Machines: AI Operations Lab, a new internship and scholarship program designed to prepare the next generation of logistics professionals for an industry increasingly shaped by artificial intelligence and digital labor.

The people starting their careers in freight now are going to spend a lot of their day managing agents. Somebody has to be the boss of those machines. We named the program after that job because it’s the one brokerages are going to be hiring for.

The program was introduced by Envoy AI CEO Robby Nathan during his fireside chat at FreightWaves’ F3: Future of Freight Festival on October 27.

“Freight has always been a people business, and that isn’t changing,” said Robby Nathan, Envoy AI CEO. “What is changing is how the work gets done. We want students to understand that shift firsthand. There’s a big difference between learning about AI in a classroom and seeing what it takes to put it to work in a real operation. Our goal is to give them that experience and help prepare them to become the leaders this industry will need.”

Launching in spring 2027, the three-month program will select two college juniors or seniors for an immersive experience working directly with Envoy AI’s product, engineering, and operations teams. Participants will gain firsthand exposure to how AI technology is developed, implemented, and used to solve real operational challenges across the freight industry.

Preparing Students for a Changing Industry

As freight companies adopt AI to automate routine work, improve productivity, and scale operations, the skills future logistics leaders need are evolving.

The Boss of Machines program bridges the gap between classroom education and the practical experience needed to lead technology-enabled operations.

Students will participate in four areas of learning:

Building AI for Operations: Understanding how AI agents are developed and applied to freight workflows.Deploying Digital Labor: Learning how new technology is integrated into existing systems, implemented with customers, and adopted by operational teams.Measuring Operational Performance: Exploring the role of analytics, productivity, and return on investment in evaluating technology initiatives.Leading Modern Freight Operations: Developing an understanding of how people and AI agents work together to manage and execute freight operations.

Investing in the Next Generation

The initiative reflects Envoy AI’s commitment to developing talent and giving students meaningful exposure to the technology and operational practices shaping the future of transportation.

“About 75% of the freight in our live accounts is already booked through Ellie, and that changes the job a new hire walks into,” said Nathan. “The people starting their careers in freight now are going to spend a lot of their day managing agents. That takes someone who can tell when a rate doesn’t make sense for the lane, and who’ll catch a carrier about to fall off before the shipper ever hears about it. Somebody has to be the boss of those machines. We named the program after that job because it’s the one brokerages are going to be hiring for.”

Throughout the program, students will work alongside experienced industry professionals, gaining exposure to product development, customer implementations, operational workflows, and the business decisions involved in deploying AI at scale.

Upon successful completion of the three-month program, each participant will receive a $2,500 scholarship to support their fall 2027 studies.

Applications and Program Timeline

The inaugural Boss of Machines: AI Operations Lab will welcome two students for the spring 2027 semester.

The program is open to college juniors and seniors interested in logistics, supply chain management, technology, engineering, business operations, and related fields.

Applicants will be asked to share their interests, relevant experience, and perspectives on how technology can improve freight operations.

Envoy AI will announce selected participants in January 2027, ahead of the spring program kickoff.

Additional program details and application information will be available through Envoy AI’s website.

About Envoy AI

Envoy AI develops AI-powered digital labor solutions for freight and logistics operations. Through its AI workforce, Ellie, the company helps logistics teams automate operational workflows, improve productivity, and execute freight processes across existing transportation systems. Envoy AI helps transportation organizations scale operations through practical AI applications.

Media Contact

Michelle McBride, Envoy AI, 1 972-821-2012, michelle@tryenvoy.ai, tryenvoy.ai

View original content:https://www.prweb.com/releases/envoy-ai-launches-boss-of-machines-program-to-develop-the-next-generation-of-freight-leaders-302922133.html

SOURCE Envoy AI

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