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ESOC 2025: Combined oral contraceptives triple risk of cryptogenic stroke in young women, new study shows

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HELSINKI, May 20, 2025 /PRNewswire/ — New research presented today at the European Stroke Organisation Conference (ESOC) 2025 revealed that the use of combined oral contraceptives (OCs) is associated with a threefold increase in the risk of cryptogenic ischaemic stroke (CIS) in young women.(1) The findings add to a growing body of evidence linking hormonal contraception to vascular risk in women of reproductive age.

Cryptogenic ischaemic stroke, which is stroke with no identifiable cause, accounts for up to 40% of all ischaemic strokes in young adults.(2) Despite its prevalence, the contribution of sex-specific risk factors, such as contraceptive use, has remained underexplored. While prior studies have associated combined OCs with stroke risk, this is among the few studies to focus specifically on cryptogenic stroke in young women.

The Searching for Explanations for Cryptogenic Stroke in the Young (SECRETO) study included 268 women aged 18–49 years with CIS and 268 age-matched stroke-free controls across 14 centres in Europe. Of the participants, 66 patients and 38 controls were using combined OCs. After adjusting for age and established comorbidities such as hypertension, smoking, migraine with aura, and abdominal obesity, OC use was associated with an adjusted odds ratio of 3.00 (95% CI: 1.61–5.57). No significant interactions were found between OC use and these risk factors, suggesting that the increased stroke risk may operate independently of other known contributors.

“Our findings confirm earlier evidence linking oral contraceptives to stroke risk,” said Dr. Mine Sezgin, Department of Neurology, Istanbul University, and lead author of the study. “What’s particularly notable is that the association remains strong even when accounting for other known risk factors, which suggests there may be additional mechanisms involved – possibly genetic or biological.”

Most OC users in the study were taking ethinylestradiol-based formulations, with a median dose of 20 micrograms. Other types of estrogen, such as estradiol hemihydrate and estradiol valerate, were also recorded.

“We calculated the equivalent estrogen dose for each patient to ensure consistency,” Dr Sezgin explained. “While our data provides important initial insights, larger studies are needed to determine if certain formulations carry different levels of risk. This knowledge could help guide more personalised contraceptive choices for women.”

While the researchers note that further prospective studies are needed, they advise clinicians to exercise caution when prescribing combined OCs to women with known vascular risk factors or a history of ischaemic stroke. “Our findings should prompt more careful evaluation of stroke risk in young women, particularly those with additional risk factors,” concluded Dr. Sezgin.

Moving forward, the researchers plan to explore biological and genetic mechanisms underlying the observed association between combined OC use and increased stroke risk to better understand how hormonal contraceptives may independently elevate stroke risk.

Note to editors:  

A reference to ESOC 2025 must be included in all coverage and/or articles associated with this study.  

About the study author:  

Dr. Mine Sezgin is a neurologist and stroke researcher based at the Istanbul University Faculty of Medicine. Her work focuses on sex-specific risk factors and stroke prevention in young adults.

About the European Stroke Organisation (ESO):  

The ESO is a pan-European society of stroke researchers and physicians, national and regional stroke societies and lay organisations that was founded in December 2007.

The aim of the ESO is to reduce the burden of stroke by changing the way that stroke is viewed and treated. This can only be achieved by professional and public education, and by making institutional changes. ESO serves as the voice of stroke in Europe, harmonising stroke management across the whole of Europe and taking action to reduce the burden of stroke regionally and globally.  

References:  

1.  Sezgin, M., et al. Hormonal contraception increases the risk of cryptogenic stroke in young women. Abstract O049, presented at the European Stroke Organisation Conference; 21 May 2025; Vienna, Austria.
2.  Yaghi, S., & Elkind, M. S. (2014). Cryptogenic stroke: A diagnostic challenge. Neurology. Clinical practice, 4(5), 386–393. https://doi.org/10.1212/CPJ.0000000000000086

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Danish Publisher Automates Digital Textbook Delivery with Integrated WooCommerce-Webdoxx Solution

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Danish educational publisher eliminates manual processing errors and delivers instant access to more than 20 digital learning products

LONDON, May 3, 2026 /PRNewswire-PRWeb/ — Forlaget 94, a Danish educational publisher serving commercial colleges and vocational schools since 1994, has transformed its digital textbook distribution by implementing a fully automated WooCommerce-Webdoxx solution.

“Using the Webdoxx-WooCommerce integration we have achieved full automation of order processing, fewer errors, and happier customers,” Tom Gertsen, IT Manager at Forlaget 94

Previously, Forlaget 94 relied on manual processes to distribute digital textbooks to customers. As demand for online educational materials grew, the publisher required a faster, more reliable way to manage orders, provision access, and reduce the risk of administrative errors.

Through its integration of WooCommerce with Webdoxx, Forlaget 94 now runs more than 20 educational products through a 100% automated workflow. The solution automatically processes customer orders and provides instant access to purchased digital textbooks, improving the experience for both customers and internal teams.

“The result is full automation of order processing, fewer errors, and happier customers,” said Tom Gertsen, IT Manager at Forlaget 94 and architect behind the WooCommerce-Webdoxx integration. The automated system has enabled Forlaget 94 to eliminate manual errors, accelerate customer processing, and increase customer satisfaction through immediate access provisioning. The implementation demonstrates how educational publishers can modernize digital content delivery while maintaining secure, managed access to learning materials.

Webdoxx, a service created and managed by Drumlin Security Ltd, provides online DRM and managed document delivery services for publishers, educational organizations, institutions, and commercial content providers.

About Forlaget 94

Forlaget 94 is a Danish educational publisher established in 1994, providing educational products for commercial colleges and vocational schools.

About Webdoxx

Webdoxx is an online DRM and managed document delivery service created and managed by Drumlin Security Ltd. The platform supports secure access to digital publications and documents across a range of sectors, including education, healthcare, government, finance, and publishing.

Media Contact

Mike de Smith, Drumlin Security Ltd, 44 7768404712, info@drumlinsecurity.com, https://www.drumlinsecurity.com/

View original content to download multimedia:https://www.prweb.com/releases/danish-publisher-automates-digital-textbook-delivery-with-integrated-woocommerce-webdoxx-solution-302759942.html

SOURCE Forlaget 94

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139th Canton Fair Phase 3 Advances Toward a Better Life with New and Strengthened Product Zones

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GUANGZHOU, China, May 3, 2026 /PRNewswire/ — The 139th China Import and Export Fair (Canton Fair) has rolled out nine newly established product zones. Phase 3 features an expanded and upgraded Intelligent Healthcare zone and the inaugural presentation of a Functional & Technical Fabrics zone.

The upgraded Intelligent Healthcare zone brings together 50 companies presenting a full spectrum of intelligent medical solutions, spanning AI-powered diagnostics, surgical robotics, and next‑generation eldercare technologies. Exhibits highlight how medical devices are becoming smaller, more precise, and increasingly non‑invasive. Capsule endoscopy systems demonstrate how gastrointestinal screening can be completed without discomfort, while AI‑enabled traditional Chinese medicine analyzers compress the inspection and inquiry process into minutes. Wearable glucose monitors make chronic disease management easier and more convenient.

Robotic technologies play a prominent role as well. Endoscopic and orthopedic surgical robots showcase enhanced precision through integrated human‑machine coordination, while bionic prosthetic hands use non‑invasive myoelectric sensing to independently control each finger. Intelligent rehabilitation systems, including lower‑limb exoskeletons and hand‑training devices, provide consistent support for patients recovering mobility. Companion‑style eldercare robots, equipped with monitoring and telemedicine functions, signal the rise of integrated home‑based health services.

The debuting Functional & Technical Fabrics zone highlights how the traditional textile industry is moving toward higher-end and smarter products. Exhibitors present materials that combine multi‑layered performance with intelligent responsiveness. Textiles featuring temperature‑regulating fibers, phase‑change materials, and light‑ or heat‑sensitive color‑shifting effects illustrate how fabrics are evolving into adaptive platforms capable of responding to environmental conditions.

Sustainability emerges as a defining theme. Bio‑based fibers, degradable films, recycled polyester, and organic cotton reflect a shift from isolated eco‑products toward full‑chain green manufacturing. High‑performance outdoor and protective applications further shape the narrative. Materials engineered for waterproof breathability, UV resistance, flame retardancy, and long‑term durability address rising demand across sportswear, professional protection, and medical environments. Smart textiles with embedded health‑monitoring modules demonstrate how apparel is beginning to function as a continuous wellness interface.

Both technology‑driven healthcare and advanced textiles are converging around a shared pursuit of a better life. As these advancements continue to evolve, they reflect a manufacturing landscape increasingly shaped by innovation, resilience, and a commitment to improving everyday living.

For pre-registration, please click: https://buyer.cantonfair.org.cn/register/buyer/email?source_type=16

 

View original content to download multimedia:https://www.prnewswire.com/news-releases/139th-canton-fair-phase-3-advances-toward-a-better-life-with-new-and-strengthened-product-zones-302760704.html

SOURCE Canton Fair

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CupidFeel Insights Show How Shared Interests Affect Initial Connection Outcomes

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New behavioral insights from CupidFeel offer a carefully considered look at how shared interests influence whether an initial connection on a dating platform is sustained or abandoned in those first critical exchanges.

GIBRALTAR, May 3, 2026 /PRNewswire-PRWeb/ — The findings by CupidFeel are not dramatic, but they are telling. People who referenced a shared interest — whether a genre of music, a type of cuisine, a sport, a creative practice, or even a shared discomfort with small talk — within the first few exchanges of a new conversation were found to be measurably more likely to continue that conversation beyond the initial contact window. The effect was not uniform across all interest categories; certain types of shared interest appeared to carry more relational weight than others.

It was also observed by CupidFeel that the timing of when shared interests entered a conversation mattered. Connections where common ground was discovered organically — through the natural flow of exchange rather than prompted by a profile field or a direct question — showed stronger indicators of sustained interest. The discovery, in other words, carried more meaning when it felt like something found rather than something declared.

Among the most quietly striking findings in the CupidFeel data was the role of specificity. Broad shared categories — “we both like travel,” “we both enjoy cooking” — were associated with polite, often brief exchanges that rarely extended past pleasantries. But when specificity entered the picture — when one person mentioned a particular documentary that had stayed with them, or a city they had visited and could not stop thinking about — the conversational energy shifted. Something opened up.

In a CupidFeel review of trends in profile engagements, those whose profiles reflected specific, idiosyncratic interests — rather than broadly appealing ones — also showed higher rates of receiving first messages, a finding that runs gently counter to the instinct many people have to present themselves in the most universally appealing terms possible.

What seemed to matter most was not the quantity of overlap but whether the overlap that existed was felt — whether it produced a sense of being seen in some particular, non-generic way. A CupidFeel review of early conversation patterns suggests that a single deeply resonant shared interest may be more generative for early connection than a long list of surface-level commonalities that, taken together, feel more like a demographic profile than a person.

About CupidFeel

CupidFeel is an online dating platform built around the belief that meaningful connections begin with emotional honesty and the willingness to let a conversation go somewhere real. It came into being for people who are less interested in the mechanics of dating and more drawn to the possibility of something that feels grounded — exchanges that move at their own pace, guided by genuine curiosity rather than performance.

A CupidFeel review of its own design principles returns consistently to the same question: what does it take for a first message to feel like it might be worth the journey? The platform makes room for the kind of interaction that doesn’t always have a clear destination but feels, from the first exchange, like something real. CupidFeel is a place where the unexpected is not something to be managed, but something to be welcomed.

Media Contact

Timothy Albers, CupidFeel, 1 14845691657, smm@cupidfeel.com, https://cupidfeel.com/

View original content:https://www.prweb.com/releases/cupidfeel-insights-show-how-shared-interests-affect-initial-connection-outcomes-302759951.html

SOURCE CupidFeel

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