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Seeing is Believing: New Probes Reveal Proteins Inside Living Cells with Unprecedented Clarity

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Developed by Albert Einstein College of Medicine and the Salk Institute for Biological Studies, Multicolor Imaging Technology Lets Researchers Track Proteins and Cellular Activity with Exceptional Precision and Minimal Background

BRONX, N.Y., April 22, 2026 /PRNewswire/ — Fluorescent probes have transformed modern biology by allowing researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers can watch viruses infect cells in real time, observe cellular trash collection, and track the signaling that spurs tumor growth. Now, scientists at Albert Einstein College of Medicine and the Salk Institute for Biological Studies have developed a new molecular imaging technology that illuminates proteins inside living cells and animals far more clearly than before. Described in today’s issue of Nature Methods, the system uses engineered fluorescent nanobodies—tiny antibody-like protein fragments—that light up only when they bind to their specific targets.

“The key advantage of our approach is that the signal appears only where the target protein is present,” said Vladislav Verkhusha, Ph.D., a co-corresponding author on the study and professor of genetics and co-director of the Gruss-Lipper Biophotonics Center at Einstein. “That eliminates the background glow that has long limited the precision of intracellular imaging.” The study’s other co-corresponding author is Axel Nimmerjahn, Ph.D., professor at Salk.

Solving a Key Imaging Problem
Over the past decade, fluorescent nanobodies have emerged as powerful tools because they bind to specific proteins in living cells. However, conventional versions glow whether or not they are attached to their targets, producing diffuse background signals that obscure fine details.

To overcome this limitation, the researchers engineered a new class of probes called VIS-Fbs (visible-spectrum target-stabilizable fluorescent nanobodies). These probes rapidly degrade if they do not bind to their intended target; only when bound do they become stable and brightly fluorescent. This “on-demand” fluorescence reduces background noise by as much as 100-fold, enabling much sharper visualization of protein location and dynamics.

The researchers created versions of their VIS-Fb probes that fluoresce across nearly the entire visible spectrum, from blue to far red, making it possible to track multiple proteins or cellular processes within the same living cell at once.

A Versatile Platform
Rather than create a single probe, Dr. Verkhusha and colleagues developed a modular engineering platform for building VIS-Fb probes that can be adapted to many targets and experimental needs. By integrating more than 20 different fluorescent proteins and biosensors into multiple nanobody scaffolds, they created a flexible toolkit with multiple capabilities.

With this approach, multiple proteins can be tracked simultaneously in different cellular compartments using VIS-Fb probes that emit distinct colors, enabling true multicolor imaging within the same cell. Certain VIS-Fb variants can also be activated, or switched on and off, with light, making it possible to follow protein behavior over time with high spatial and temporal precision. Incorporating biosensors for ions and metabolites further allows the probes to report not only where proteins are located but also what they are doing in real time, providing direct insight into cellular activity. In addition, combining stable reference signals with activity-sensitive fluorescence enables ratiometric measurements that improve the accuracy of quantifying cellular processes, even in complex environments such as living brain tissue.

“The VIS-Fb approach allows us to identify and track specific cell populations in living organisms based on the proteins they express, rather than just their location,” said Natalia Barykina, Ph.D., the first author of the study and a postdoctoral fellow in Dr. Verkhusha’s lab.

The researchers demonstrated the system in a range of living models. In mice, VIS-Fb probes enabled precise imaging of central nervous system activity in neurons and astrocytes, with strong signal quality during behavior. In zebrafish embryos, the technology allowed real-time tracking of dynamic changes during early development and in response to drugs that alter signaling pathways.

“Our results show that this imaging platform offers a much clearer and more precise view of how proteins behave inside living systems,” Dr. Verkhusha said. “It opens the door to studying complex biological processes, such as cell signaling, development, and disease progression, in new ways.”

Additional Einstein authors include Juliana Mendoça-Gomes, Ph.D. and Sofia de Oliveira, Ph.D. Additional authors are Erin Carey, Salk Institute for Biological Studies, and Olena Oliinyk, Ph.D., University of Helsinki, Finland.

The title of the paper is “Synthetic multicolor antigen-stabilizable nanobody platform for intersectional labelling and functional imaging.” Funding sources include the National Institutes of Health: GM122567 (V.V.), NS123719 (A.N.), and GM118027 (S.dO); the Jane and Aatos Erkko Foundation (220011); the Research Council of Finland (360277); the Chan Zuckerberg Initiative Foundation (MET-000000045); the NOMIS Foundation Neuroimmunology Initiative; and the Edwards-Yeckel Research Foundation.

About Albert Einstein College of Medicine
Albert Einstein College of Medicine is one of the nation’s premier academic centers for basic science research, clinical investigation, and biomedical education. Located in the Bronx, Einstein is home to nearly 1,000 M.D., Ph.D., and M.D./Ph.D. students and more than 2,000 full-time faculty members. Einstein receives approximately $200M in funding from the National Institutes of Health (NIH) each year and houses six NIH-funded research centers, in cancer, intellectual and developmental disabilities, clinical and translational research, AIDS, and two in diabetes. In partnership with Montefiore Health System, Einstein advances clinical and translational research to accelerate the pace at which new discoveries become the treatments that benefit patients. For more information, please visit einsteinmed.edu, and follow us on InstagramLinkedIn, TwitterFacebook, and view us on YouTube

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SOURCE Albert Einstein College of Medicine

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Americas Cardroom’s OSS XL Generates $7.2M in Four Days

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The opening 93 tournaments draw 62,847 entries as 33 events exceed guarantees.

SAN JOSE, Costa Rica, Sept. 11, 2026 /PRNewswire/ — Americas Cardroom’s Online Super Series XL generated $7,216,985 in prize pools and recorded 62,847 entries during its opening four days, excluding entries from tournament flights.

From Sept. 6-9, 93 tournaments ran and the completed numbered schedule reached OSS XL #70. Thirty-three tournaments exceeded their guarantees by a combined $217,170.

OSS XL #13 produced the largest prize pool. The $630 buy-in High Roller drew 1,118 entries and turned its $600,000 guarantee into a $670,800 prize pool. BADGERING won $130,210 for first place.

The $2,650 OSS XL #16 also topped its $500,000 guarantee, drawing 203 entries for $507,500. After a final-table deal, NewYorkMidgets was listed first for $95,312, KevinParCoeur second for $93,875 and Olivander1 third for $87,459.

At the lower buy-in level, the $16.50 OSS XL #11L Sunday Splash produced the series’ biggest field to date. Its 4,752 entries came from 3,024 unique players, and lukewarmwater earned $10,953 for the win.

In Mystery Bounty event OSS XL #12, the player finishing 43rd collected the tournament’s $15,120 top bounty.

Leaderboard competition is underway across High, Medium and Low divisions, with more than $60,000 in added cash and tournament tickets available. GROOTHEDEGEN leads the High standings with 2,381.59 points, while FEEDTHEPENGUIN tops Medium with 599.85 points.

Four multi-flight events with $2.225 million in combined guarantees are underway. The first of three Main Events begins this Sunday. The event guarantees $500,000 with a $66 direct buy-in and satellites from $6.60.

OSS XL runs through Sept. 29 with 336 events and more than $50 million guaranteed. Upcoming tournaments, buy-ins and start times are listed on the promotion page.

About Americas Cardroom

Americas Cardroom is one of the world’s leading online poker destinations, serving players since 2001. Known for major tournament series, innovative promotions, and a commitment to the poker community, the company is celebrating its 25th anniversary in 2026 while continuing to expand its tournament offerings and deliver world-class online poker experiences to players across the globe.

Media Contact:
Adam Neal
Americas Cardroom Pros Manager
Email: 422447@email4pr.com 
Phone: +44 7845 582487

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SOURCE Americas Cardroom

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Ink Different Tattoos Announces Long Island Partnership with Obscura – Art, Tattoo + Body Mod. Studio

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In Collaboration with Long Beach’s Obscura and Artist Taryn Elise, Ink Different Expands Its College-Alternative Tattoo Apprenticeship to Long Island, New York

LONG BEACH, N.Y., Sept. 11, 2026 /PRNewswire-PRWeb/ — Ink Different Tattoos is proud to announce the launch of its newest tattoo apprenticeship location in Long Beach, New York, in collaboration with Obscura – Art, Tattoo + Body Mod. Studio, a private custom studio founded and led by 15-plus-year tattooing veteran Taryn Elise. This partnership brings Ink Different’s structured, real-world apprenticeship program to Long Island’s South Shore, offering aspiring Tattoo Artists a clear path into a professional, AI-proof creative career inside a studio that was purpose-built to help artists thrive.

“What drives Taryn Elise as a mentor is something we deeply respect,” says Paul-Anthony Surdi of Ink Different Tattoos. “She set out to give her apprentices an experience that is encouraging, honest, and built entirely around their success.”

“What drives Taryn Elise as a mentor is something we deeply respect,” says Paul-Anthony Surdi of Ink Different Tattoos. “She set out to give her apprentices an experience that is encouraging, honest, and built entirely around their success. That’s a philosophy we share, and it’s exactly why Obscura is the right home for a Long Island apprenticeship.”

Obscura – Art, Tattoo + Body Mod. Studio is a warm, inclusive boutique studio built around custom tattooing, body modification, and an intentional creative environment where both clients and artists genuinely feel at home. Leading the apprenticeship program is Taryn Elise, founder of Obscura. As a mentor, she provides the encouraging, open-minded learning environment that apprentices should have. Taryn’s work spans detailed custom illustrative pieces, fine-line and single-line tattooing, and a broad stylistic range built on 15-plus years of real-world practice.

A College Alternative in Long Beach

Ink Different’s Tattoo Apprenticeship is designed as a structured college alternative for talented artists aspiring to become professional Tattoo Artists. Instead of taking on student debt for a four-year degree, apprentices learn the trade of tattooing with Ink Different and studios like Obscura, receiving hands-on experience, one-on-one mentorship, and professional development over 18–24 months.

Tattooing is an AI-proof career, driven by human creativity, craftsmanship, and personal connection. With professional Tattoo Artists earning a median income of around $106,000 per year, the apprenticeship offers a practical pathway from passion to profession.

Graduates complete the program industry-ready, with a guaranteed job offer upon successful completion and the skills needed to thrive in today’s competitive tattoo industry.

Now Enrolling in Long Beach

Applications are now open for the Ink Different Tattoo Apprenticeship at Obscura in Long Beach. Whether you’re a recent graduate exploring a college alternative or someone ready to commit to a creative career, this program offers structure, deeply personal mentorship, and a clear path forward inside one of Long Island’s most distinctive and community-driven studios.

Learn more or apply at: becomeatattooartist.com

About Ink Different Tattoo Apprenticeship

Ink Different Tattoos is reshaping what it means to pursue a career in tattooing, swapping the traditional college route for hands-on apprenticeships in working studios nationwide. Grounded in excellence, equal opportunity, and a focus on lasting career success, the company pairs aspiring Tattoo Artists with dedicated one-on-one mentors and backs every graduate with a guaranteed job offer. Its Traditional and Master Mentorship tracks have made Ink Different a leading name in professional tattoo education across the country.

Media Contact

Maria Zacarias, Ink Different Tattoo Co., 1 917-227-2842, maria@inkdifferenttattoos.com

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SOURCE Ink Different Tattoo Co.

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March Networks and VIVOTEK Showcase Integrations Across Combined Portfolio at GSX 2026

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New integrations and customer deployments demonstrate Connected Intelligence and strong momentum following the April merger.

ATLANTA, Sept. 11, 2026 /PRNewswire/ — Five months after joining forces, March Networks®, a global leader in video surveillance and business intelligence, and VIVOTEK, a leading global security solutions provider, will exhibit jointly at Global Security Exchange (GSX) 2026 for the first time.

At booth 1823, September 14–16 at the Georgia World Congress Center in Atlanta, the combined organization will demonstrate how Connected Intelligence for Modern Security brings together video, AI, cloud, business intelligence and third-party systems to give customers better operational intelligence and faster ways to act on it.

“We said from the beginning that bringing March Networks and VIVOTEK together would create meaningful value for our customers and partners,” said Net Payne, Chief Sales & Marketing Officer. “Now we can point to real examples of that happening in the technologies we’re connecting, the systems we’re deploying and the way we’re operating as one company. GSX allows us to show that progress together on a global stage.”

Five months in: the merger is delivering

Since the April merger, teams across both organizations have been connecting technologies and expertise to create practical new capabilities for customers.

At GSX, attendees will see several examples:

Broader VIVOTEK camera support within March Networks environments, giving customers additional device choice and a seamless experience.New C•CURE integration with March Networks Command Enterprise Software, bringing access control events and video together in a single pane of glass.VORTEX, VIVOTEK’s award-winning surveillance platform, integrates with Searchlight Cloud, extending operational intelligence capabilities into direct-to-cloud video environments.Searchlight AI is included for Searchlight Cloud customers, providing natural-language video search without an additional license cost.Expanded face and license plate search and re-search across compatible cameras and devices.VIVOTEK Chroma24 camera delivers clear, full-color video in ultra-low-light environments, improving AI detection and video search.

What a connected ecosystem looks like in practice

GSX will also demonstrate how the March Networks and VIVOTEK combination fits within Delta Electronics’ broader Building Automation business, creating opportunities to draw on Delta’s capabilities in AI, cloud services, edge computing, intelligent buildings, manufacturing and supply chain.

“A North American apparel brand with more than 500 stores was evaluating a competitor’s cloud-based analytics solution,” said Jeff Corrall, Chief Product Officer for March Networks and VIVOTEK. “We were able to integrate VIVOTEK’s advanced cameras, the VORTEX cloud platform, and March Networks’ operational intelligence software into a tailored solution that strengthens store security while using AI to measure foot traffic and checkout efficiency. That combination gave the customer the confidence to choose us.”

Integration beyond technology

The merger is also bringing the organizations closer together behind the scenes, from product roadmaps and R&D to manufacturing, sourcing and supply management. It gives March Networks and VIVOTEK greater access to Delta’s global manufacturing and supply chain resources, strengthening material management and supporting greater factory automation.

For customers and partners, that means the merger is strengthening not only the portfolio, but also how solutions are developed, sourced, and delivered.

“We’re still early in this journey, but we’re already seeing what becomes possible when we bring these teams and technologies together,” Payne concluded. “The customer deployments and integrations we’re showing at GSX are tangible examples of that progress. Our focus is on building those connections in ways that solve real problems and give customers better information when and where they need it.”

Visitors can experience March Networks and VIVOTEK together at GSX 2026, booth 1823. Members of the media are invited to meet with executives at the show for additional updates on the merger, ongoing integrations, and what comes next for the combined organization.

About March Networks

March Networks® is a global leader in intelligent video solutions, helping enterprise and small to medium-sized businesses turn video into actionable intelligence. With over 25 years of experience, the company serves 1,500+ financial institutions, 600+ retailers, and 900+ commercial and industrial brands. March Networks ranks No. 8 among NVR vendors outside China and No. 10 worldwide, according to Novaira Insights*. Our cloud-based technologies combine video surveillance with AI analytics, POS, IoT, and ATM integration to enhance security, efficiency, and the customer experience. Backed by a global network of certified partners, we support customers in 75+ countries with flexible, scalable, open-platform solutions. Headquartered in Ottawa, Canada, and owned by Delta, a global leader in power and thermal management, March Networks operates as part of the Security Solutions group within Delta Intelligent Building Technologies and is a trusted partner and innovator in cloud-based, AI-powered video surveillance.

Learn more at www.marchnetworks.com.

*Source: Novaira Insights – World market for video surveillance hardware and software – 2026 edition.

About VIVOTEK

Founded in Taiwan in 2000, VIVOTEK is a leading global intelligent security solutions provider with over 25 years of industry experience. VIVOTEK has offices in the U.S., Japan, the Netherlands, India and Mexico. Working with over 200 authorized distributors in more than 75 countries, VIVOTEK has been widely recognized for cutting-edge imaging and audio technologies, focusing on AI network cameras, video management software, and cloud surveillance services. The company extensively integrates AI, deep learning, and edge computing into its video solutions. VIVOTEK joined the Delta Group in 2017 and has become a key part of the Security Solutions group within Delta Intelligent Building Technologies, focusing on safety and intelligence.

Learn more at www.vivotek.com.

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SOURCE March Networks Corporation

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