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Hartwig Medical Foundation and Ultima Genomics Expand Collaboration to Advance Whole-Genome Sequencing in Oncology Care

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Hartwig to adopt Ultima Genomics’ UG200 sequencing system to accelerate implementation of whole-genome-based clinical genomics workflows on Solaris 2.0 technology

Hartwig and Ultima to continue implementation and validation of ppmSeq, the only decentralizable whole-genome solution commercially available today for monitoring of minimal residual disease (MRD) with low single-digit part-per-million sensitivity

AMSTERDAM and FREMONT, Calif., June 12, 2026 /PRNewswire/ — Hartwig Medical Foundation and Ultima Genomics today announced an expansion of their strategic collaboration, marked by Hartwig’s adoption of the new Ultima UG200™, Ultima’s 2nd generation sequencing system. The agreement builds on the organization’s existing work with Ultima’s technology and is designed to accelerate Hartwig’s mission to make whole-genome sequencing (WGS) more accessible, scalable, and clinically actionable for oncology patients.

Hartwig has been a pioneer in applying WGS for cancer diagnostics. Through OncoAct Whole Genome Sequencing (OncoAct WGS), Hartwig’s comprehensive molecular diagnostic service for solid tumors analyzes the tumor genome to identify clinically relevant biomarkers, therapy options, and potential clinical trial matches. Hartwig has been working with Ultima’s first-generation sequencing system, the UG 100®, since 2024 to build deployable bioinformatics solutions and demonstrate the utility of Ultima’s new sequencing architecture for WGS in cancer testing and emerging applications such as liquid biopsy and minimal residual disease (MRD). With the addition of the UG200, Hartwig expands the scale, throughput, and breadth of its sequencing capabilities while continuing to reduce the overall cost of cancer testing and generating comprehensive genomic data across different oncology applications.

Ultima’s UG200 is powered by Ultima’s new Solaris 2.0 workflows, which provide significant advantages for deploying the UG200 into clinical laboratory settings. The simplified workflows employ an isothermal amplification process, instead of previously used emulsion-based amplification, and now integrate with standard laboratory automation and improve coverage uniformity across challenging genomic regions. The workflows reduce hands-on time, simplify operations, and are designed to support clinical-scale deployment and automation. The workflows also enable Ultima’s ultrasensitive ppmSeq technology, which provides single-digit part-per-million accuracy using WGS for applications like MRD.

“Whole-genome sequencing for oncology applications becomes transformative when it is paired with the accuracy of our flow-based chemistry and is no longer constrained by cost, capacity, or operational complexity,” said Gilad Almogy, CEO of Ultima Genomics. “Hartwig has already shown what is possible when comprehensive genomic information is connected to clinical decision-making. This next phase is about building the clinical infrastructure that enables WGS to become routine for oncology in global settings, while also opening the door to employing WGS in applications requiring deeper sequencing and extreme accuracy, such as MRD.”

A central objective of the expanded collaboration between Ultima and Hartwig is to further validate and implement Ultima’s ppmSeq technology for whole-genome-informed circulating tumor DNA (ctDNA) monitoring. Hartwig’s comprehensive tumor-genome foundation enables development of a pure WGS-based MRD approach without the operational burden of bespoke panel design, manufacturing, or patient-specific assay production.

Today, ppmSeq technology is the only broadly available, decentralized whole genome MRD workflow that can be implemented by clinical users in-house in global settings with ultra-sensitive levels of detection down to the single-digit ppm range.

This work is closely aligned with Hartwig’s clinical research direction in the Netherlands, including ongoing efforts for setting up clinical studies designed to evaluate blood-based ctDNA monitoring in patients already undergoing standard WGS-based molecular diagnostics at the Netherlands Cancer Institute (NKI). Findings from such studies are expected to help define the clinical utility, health-economic value, and implementation pathway for broader adoption of WGS-based disease monitoring in Dutch oncology care. Together, Hartwig and Ultima aim to generate evidence that supports not only technical feasibility, but also patient impact, cost-benefit assessment, and routine-care adoption.

“OncoAct WGS was built on the principle that the complete cancer genome can provide a more complete view of the patient’s disease, resulting in improved clinical actionability and more patient impact,” said Edwin Cuppen Scientific Director at Hartwig Medical Foundation. “With the UG200, we can extend that principle from therapy selection at diagnosis toward longitudinal, high-resolution disease monitoring using a one-size-fits all assay. The question is no longer whether WGS can provide value. The question is how quickly we can build the evidence, workflows, and clinical infrastructure to make that value available to more patients.”

Finally, the collaboration will also focus on building practical end-to-end workflows including extension of the Hartwig-developed comprehensive open-source cancer genomics tools (OncoAnalyser) to optimally support Ultima data and longitudinal ctDNA analysis to help the broader clinical genomics community implement Ultima technology in-house. Hartwig and Ultima intend to continue working together across laboratory automation, sample preparation, sequencing operations, data quality control, and bioinformatics.

About Hartwig Medical Foundation

Hartwig Medical Foundation is a Dutch nonprofit organization that operates globally with the mission to improve cancer patient care. They support data-driven treatment decisions through a combination of innovative software, clinical data analyses, and molecular diagnostics. This enables patients to timely receive the right treatment, while generating and making available valuable data that supports research, drug development,and the continuous improvement of care. 

About Ultima Genomics

Ultima Genomics is unleashing the power of genomics at scale. The Company’s mission is to continuously drive the scale of genomic information to enable unprecedented advances in biology and improvements in human health. With humanity on the cusp of a biological revolution, there is a virtually endless need for more genomic information to address biology’s complexity and dynamic change—and a further need to challenge conventional next-generation sequencing technologies. Ultima’s revolutionary new sequencing architecture drives down the costs of sequencing to help overcome the tradeoffs that scientists and clinicians are forced to make between the breadth, depth and frequency with which they use genomic information. The new sequencing architecture was designed to scale far beyond conventional sequencing technologies, lower the cost of genomic information, and catalyze the next phase of genomics in the 21st century. To learn more, visit www.ultimagenomics.com

Media contacts:

Ultima Genomics: Vikki Herrera, Oak Street Communications, 408-206-7009, vikki@oakstreetcommunications.com

Hartwig Medical Foundation: Edwin Cuppen, Scientific director, info@hartwigmedicalfoundation.nl, +31 20 226 9700

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SOURCE Ultima Genomics

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Rockford Fosgate Introduces New PUNCH® PRO Speakers

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Aggressive Output. Rugged Reliability. The new series is purpose-built for SPL competition vehicles and performance-focused builds where maximum output matters most.

TEMPE, Ariz., June 12, 2026 /PRNewswire/ — Rockford Fosgate, the leader in high-performance audio systems, is proud to announce the new PUNCH PRO Speaker Series, engineered to be the loudest speakers in the PUNCH lineup. Purpose-built for SPL competition vehicles, high-volume street performance, and performance-focused builds, the new PUNCH PRO Series delivers aggressive output, rugged reliability, and the unmistakable PUNCH sound.

Designed for listeners who demand extreme output without sacrificing durability or clarity, PUNCH PRO speakers combine high-efficiency components, oversized motor structures, and ultra-durable materials to deliver relentless volume under demanding conditions. With midrange drivers and tweeters engineered specifically for high-output environments, the series gives installers and enthusiasts the power, output, and dependability needed to take serious builds to the next level.

“Punch Pro brings pro audio efficiency and SPL capability into a dedicated automotive architecture. By utilizing Punch-platform frames, we achieved a true ‘Engineered Fit’ for direct integration without modification. And with a new compact bullet tweeter option, we’ve made it easier than ever to deliver pro-level output into tighter vehicle spaces” said Wayne Connolly, Vice President of Product Development.

Performance-driven from the inside out, PUNCH PRO speakers feature precision-engineered phase plugs that help project high-frequency detail with accuracy, allowing music to stay clear and focused even at elevated volume. Oversized motor structures improve efficiency and support extended playtime, while a 75-watt RMS and 150-watt peak power rating gives the series the strength to keep up when the system is pushed hard.

Built to perform like a true workhorse, every component and material in the PUNCH PRO Series was selected for strength and long-term reliability. Reinforced polymer baskets, high-density cones, and reinforced tweeter diaphragms help deliver class-leading construction designed to withstand the demands of competition-level output and aggressive everyday performance.

The series is also engineered for demanding environments. UV-resistant materials in the cone, surround, and frame help protect against prolonged sun exposure, while treated paper cones, durable surrounds, and fatigue-resistant spiders are designed to maintain performance over time. For enhanced control and system tuning, the PUNCH PRO platform also includes an external crossover engineered for high-output applications. The precision external low-pass crossover provides accurate signal control for seamless integration of dual midrange drivers and a tweeter while preserving sonic integrity under high-power conditions. Selectable tweeter attenuation at 0 dB, –3 dB, and –6 dB allows installers to fine-tune high-frequency output for optimal tonal balance across a wide range of system configurations.

Inside the crossover, optimized midrange filtering uses laminated steel-core inductors for low-loss, high-current handling and smooth, controlled midrange response. Ceramic resistors, aluminum heatsinks, and a vented chassis work together to efficiently dissipate heat, helping maintain consistent performance during extended, high-output listening sessions.

The PUNCH PRO Speaker Series is designed for competition-level output, aggressive everyday performance, and systems that need to play loud and hold up under pressure. Available in multiple sizes and configurations, PUNCH PRO brings aggressive output, rugged durability, and the unmistakable PUNCH sound to performance-focused builds.

For more information visit: rockfordfosgate.com or visit an authorized dealer.

About Rockford Fosgate
Setting the standard for excellence in the audio industry, Rockford Corporation markets high-performance audio systems under the brand Rockford Fosgate® for the mobile, marine, motorsport, and motorcycle audio aftermarket and OEM market. Headquartered in Tempe, Ariz., Rockford Corporation is a wholly owned subsidiary of Patrick Industries, Inc. (NASDAQ: PATK).

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Subotiz Launches AI Agent Suite and MCP Server to Democratize Subscription Commerce for the GenAI and SaaS Era

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New capabilities transform rigid company and team operations, complex payment setups, and developer workflows into seamless, natural-language actions—drastically shortening the bridge between product launch and revenue.

SAN FRANCISCO, June 12, 2026 /PRNewswire/ — Subotiz, the AI-driven subscription commerce and payment infrastructure platform tailored for AI, SaaS, and digital entertainment enterprises, recently announced the launch of its pioneering AI Agent Suite and Subotiz MCP Server. This unified release introduces a powerful new layer of capability, enabling AI companies and developers to architect, manage, and scale global subscription commerce entirely through natural language.

The launch addresses a critical bottleneck in the fast-moving digital economy. While the generative AI boom has made building a digital product faster and cheaper than ever, the commercialization phase remains bogged down by legacy complexity. Transitioning from a viable product to a revenue-generating business still requires navigating fractured workflows: configuring complex subscription tiers, aligning localized payment gateways, auditing data anomalies, and debugging developer APIs.

Traditionally, these tasks forced lean teams to context-switch across disconnected dashboards, dense API references, and internal support tickets. Subotiz is collapsing these silos into a single, cohesive, AI-assisted operating experience. While the AI Agent Suite automates complex operational workflows inside the Subotiz platform, the Subotiz MCP Server allows external AI tools to hook directly into Subotiz’s subscription, billing, and developer pipelines.

“AI shouldn’t just answer user prompts; it should execute heavy-lifting operational workflows,” said Ryan Yang, Solution Director at Subotiz. “With our AI Agent Suite and MCP Server, we are shifting subscription commerce from manual configuration to intent-driven execution. Companies simply describe the business outcome they want, and Subotiz translates that intent into production-ready operational and technical reality.”

The AI Agent Suite: Five Specialized Agents, One Conversational Dashboard

Rather than relying on a generic chatbot, Subotiz has engineered five purpose-built agents mapped to high-frequency subscription commerce friction points:

The Collect Agent (Frictionless Intake): Streamlines the initial onboarding grind. By ingestion of unstructured business context during registration, it eliminates the need to study compliance documentation, automatically recommending tailored payment methods, optimal pricing structures, and localized operational setups.The Onboard Agent (Accelerated Time-to-Value): Cross-references merchant profiles with Subotiz’s proprietary business strategy library to map out a customized, step-by-step launch path, auto-filling technical configuration fields to accelerate time-to-market.The Merchant Agent (Conversational Operations): Acts as a 24/7 co-pilot for daily business tweaks. Through multi-turn natural language conversations that retain context, users can spin up new subscription products, modify pricing plans, or update business settings without digging through menus.The Data Agent (Proactive Business Diagnosis): Moves beyond passive, static reporting. The agent actively detects revenue anomalies, analyzes root causes behind churn or transaction drops, drills into subscription patterns, and delivers visual, actionable optimization strategies.The Email Agent (Natural-Language HTML Editing): Empowers marketing and ops teams to modify transactional HTML email templates dynamically. Users can command font changes, adjust CTA placements, or insert compliance language via natural text. The agent features real-time visual previews, version controls, and automated risk checks for sensitive words and broken links.

Extending AI to the Dev Environment via Model Context Protocol (MCP)

Recognizing that modern tech teams live inside their code editors, Subotiz is extending this natural-language capability directly into the developer workflow via the Subotiz MCP Server. Built on the open-source Model Context Protocol (MCP), the emerging standard for connecting AI assistants to secure data sources, Subotiz allows teams to manage their billing infrastructure straight from environments like Cursor, VS Code and Claude Desktop.

Through the Subotiz MCP Server, engineers and operations teams can query or create customer profiles, adjust pricing plans, audit live webhook event logs, inspect refund histories, and retrieve documentation using natural language commands. This eliminates the need to manually write boilerplate API scripts for routine troubleshooting and testing.

The real-world impact is already clear for lean, high-growth startups. In a recent deployment, a short-form digital content provider with zero dedicated back-end engineers utilized Subotiz’s embedded payment modules, automated compliance support, and MCP-driven testing environment to successfully simulate and validate its first subscription payment pipeline in just three days, all without writing a single line of custom code.

“Product iteration cycles have collapsed to days, but monetization remains trapped in weeks of configuration,” said Adam Mawdesley, Chief Revenue Officer of Subotiz. “Subotiz is closing that final gap. We are ensuring that business intent instantly translates into working payment and subscription infrastructure.”

The AI Agent Suite and Subotiz MCP Server are available now to all Subotiz users worldwide.

About Subotiz

Subotiz is a next-generation payment and revenue infrastructure platform designed for global digital businesses. By combining payments, subscription management, usage-based billing, tax and compliance automation, and fraud prevention into a unified platform, Subotiz enables SaaS, AI, eCommerce, and platform businesses to scale globally with greater operational efficiency and revenue flexibility. Learn more at Subotiz.

 

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SOURCE Subotiz

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Sentra Extends Enterprise AI Governance to Claude with Continuous Data Risk Context

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New integration connects Sentra’s continuous data classification engine to Claude Enterprise, providing the data context needed to identify, prioritize, and mitigate AI-related risks.

TEL AVIV, Israel and NEW YORK, June 12, 2026 /PRNewswire/ — Sentra, the AI Data Readiness platform built for continuous data discovery, classification, and identity-aware governance at enterprise scale, today announced its integration with Claude’s Compliance API, powered by Anthropic. The integration enables organizations using Claude Enterprise to bring Sentra’s deep data classification capabilities directly to bear on their AI governance program so that when employees use Claude at work, security teams don’t just see that something happened. They see what data was involved, how sensitive it is, and what to do about it.

Claude’s Compliance API is a REST API that gives enterprise IT and security teams programmatic access to Claude activity data, including conversation content and activity event logs. For organizations using Claude Enterprise, this means security teams can now receive real-time signals about employee Claude usage – files uploaded, prompts written, projects created – and feed that data into their existing security and compliance tooling.

What Sentra brings to that data is the layer that transforms it from a signal into intelligence.

Sentra continuously discovers and classifies sensitive data across cloud, SaaS, and on-premises environments; building and continuously updating a comprehensive map of what sensitive data an organization holds, where it lives, and who can access it. When Claude Compliance API data flows into Sentra, it lands on top of that foundation. A file upload event becomes a risk-assessed data exposure event. An activity anomaly becomes a governance alert with regulatory context attached. For the first time, security teams can answer the question their boards are asking “Do we have Claude under control?”, with evidence instead of wishful thinking.

“From day one, we’ve worked to give enterprises a comprehensive understanding of what sensitive data they hold and who can reach it,” said Yoav Regev, CEO and Co-Founder of Sentra. “AI changes the surface area of that problem overnight. Claude can synthesize and surface everything an employee has access to in a single prompt which means every permission gap, every over-privileged identity, every dataset that was never properly governed suddenly matters in a new way. Our integration with Claude’s Compliance API extends our platform into the AI conversation layer, so the governance work enterprises have already done with Sentra now protects them inside Claude too.”

According to Netskope’s 2026 Cloud and Threat Report, GenAI data violations have more than doubled year-over-year. Claude’s enterprise adoption grew from 56.2% to 94.9% between April 2025 and April 2026 alone. Meanwhile, the EU AI Act is now in active enforcement, with penalties reaching €35 million or 7% of global annual revenue for organizations that cannot demonstrate adequate oversight of AI systems interacting with personal data.

Sentra’s integration with Claude’s Compliance API is available today for organizations running Claude Enterprise. Deployment for existing Sentra customers takes under 30 minutes. For organizations new to Sentra, the platform can scan and classify petabyte-scale data estates in under 72 hours, establishing the classification foundation on which Claude governance immediately builds.

To learn more or request a demo, visit www.sentra.io.

About Sentra

Sentra is the leader in continuous AI data readiness and governance, helping enterprises ensure their data is secure, governed, and AI-ready at all times. As organizations rapidly scale AI adoption, a critical gap emerges: AI data readiness—the foundational layer required for every successful enterprise AI initiative. Sentra provides the visibility, controls, and automation needed to confidently use data across cloud, hybrid, and AI environments.

The Sentra platform continuously discovers, classifies, governs, and protects sensitive and proprietary data while helping organizations understand and control who—and what—has access to it, from employees and third parties to AI applications and autonomous agents. By combining AI-aware data security, automated governance, and intelligent remediation, Sentra helps enterprises reduce risk, enforce policy, and unlock the value of AI without losing control of their data.

Trusted by global enterprises and recognized by Gartner, Sentra transforms data readiness and governance into a foundation for secure AI innovation. For more information, visit www.sentra.io.

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SOURCE Sentra

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