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Updates About the Expanded Access Program for MN-166 in ALS

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Program to provide investigational drug to ALS patients who would otherwise be ineligible for clinical trials

SAN JOSE, Calif., June 29, 2026 /PRNewswire/ — WideTrial is pleased to share that the Expanded Access Program it launched in 2025, Scalable Expanded Access with Analysis of Neurofilament and other Biomarkers in ALS (SEANOBI-ALS), has reached its planned enrollment target. As a result, the program is no longer enrolling new patients.

SEANOBI-ALS was established to provide access to the investigational therapy MN-166 (ibudilast) for people living with ALS who are unable to participate in traditional clinical trials. The program is conducted in partnership with a large academic medical center and is supported by funding awarded under the ACT for ALS initiative through the National Institute of Neurological Disorders and Stroke (NINDS).

Enrollment Complete

Since enrolling its first patient in March 2025, SEANOBI-ALS has successfully enrolled 200 patients residing in 27 states through a network of 15 participating ALS clinics throughout the United States.

The strong interest in the program reflects the ongoing need for treatment access pathways for people living with ALS who do not qualify for conventional research studies due to eligibility criteria, geographic limitations, or other barriers to participation. SEANOBI-ALS swiftly reached full enrollment due to the commitment of participating sites and the strong engagement of patients and caregivers seeking access to investigational treatment options.

What Happens Next

Patients actively enrolled in SEANOBI-ALS will continue treatment and follow-up activities in accordance with the program protocol. Final patient follow-up activities are expected to conclude in early 2027, after which data collected through the program will be analyzed to support future scientific presentations and publications. WideTrial looks forward to sharing more as findings from the program become available.

Looking Ahead

Reaching 200 patients less than 13 months after first patient enrollment demonstrates both the feasibility and importance of scalable Expanded Access programs for people living with ALS.

Patients and clinics who tried but were unable to participate in SEANOBI-ALS are encouraged to continue checking with WideTrial about future EAPs, both grant-sponsored under ACT for ALS and industry-sponsored.  WideTrial is now evaluating new Expanded Access opportunities in ALS and anticipates launching at least one additional large EAP in 2027.

About EAPs: Expanded Access programs (EAPs) are a type of FDA-authorized clinical trial that prioritizes experimental treatment access for patients with serious conditions who lack other meaningful, potentially disease-modifying treatment options – particularly patients who cannot get into research trials of new medicines due to inclusion/exclusion criteria or difficulty traveling to trial sites.

About this EAP: SEANOBI-ALS was designed for swift activation of participating clinics and minimal-burden on clinical staff, in comparison to research trials. This program’s secondary objective is to generate valuable data about the kinds of patients who may benefit most from the experimental treatment.

About WideTrial: WideTrial is an emerging company with the mission of making experimental treatment options accessible to all people with serious or life-threatening diseases. The team is personally aware of the devastating toll ALS takes on patients and families and is relentlessly committed to integrating well-managed EAPs into healthcare at meaningful scale.

For inquiries, please contact WideTrial via email: community@widetrial.com

Media Contact:

Shona Allen
WideTrial, Clinical Programs Director
(650) 715-7500
community@widetrial.com

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SOURCE WideTrial Inc.

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Kreate Launches the HDX 2.5-Qt Mini Tough Tote, Its Smallest Storage Solution Yet

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Following the viral success of the 6.5-Qt tote, the newest HDX tote delivers compact, modular organization for everyday clutter

ATLANTA, June 29, 2026 /PRNewswire/ — Kreate, a leading vertically integrated, innovation-based manufacturing company, today launches the HDX 2.5-Qt Mini Tough Tote, its smallest storage solution yet. Available exclusively at The Home Depot, the micro storage solution expands the HDX Tough Tote Ecosystem, further building out a connected storage platform that allows consumers to organize everything from small essentials to large household gear, within one cohesive system.

Designed to organize the everyday items that create the most clutter, the HDX 2.5-Qt Mini Tough Tote is the perfect size for storing items like cords, batteries, craft supplies, hardware, tools, kitchen essentials and more. Modular and space-efficient by design, the compact tote integrates easily with other HDX Tough Tote products to support flexible organization across garages, classrooms, dorm rooms, offices, apartments, and homes.

The launch follows the success of the HDX 6.5-Qt Mini Tote, which went viral online and quickly sold out due to its compact size and everyday functionality. Building on that momentum, the new 2.5-quart version offers consumers an even more compact and portable organization solution while maintaining the durability and functionality that customers expect from the HDX storage line.

Constructed with durable plastic resin, the HDX 2.5-Qt Mini Tough Tote features a secure snap-tight lid, nestable construction and integrated tie-down channels for easier transport and storage. The modular design also allows two 2.5-quart totes to stack perfectly on top of the HDX 6.5-Qt Mini Tough Tote.

Kreate is the designer, manufacturer and distributor for the HDX and Husky storage solution brands, both exclusive to The Home Depot and trusted in many American homes. In 2025, Kreate was named The Home Depot’s Partner of the Year for Storage for the second year in a row, and its award-winning products can be found at Home Depot’s online storefront or at your local retail location.

About Kreate
Kreate is a leader in design and innovative, sustainable solutions that serve millions of customers through its exclusive partnership with Home Depot. With a focus on a variety of product categories, including plumbing, cleaning, lawn & garden, home organization and construction, Kreate combines engineering precision, sustainability leadership and private-label expertise to deliver differentiated products that drive category growth. Leveraging its innovation centers, equipped with 3D printer technology, Kreate is creating smarter, cleaner and more efficient solutions that move the industry forward, Kreate redefines what’s possible in modern manufacturing.

Media Contact
Trevelino/Keller
TKKreate@trevelinokeller.com

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Terumo Interventional Systems Announces First Procedure Using Its OPUSWAVE® Dual Sensor Imaging System in the United States

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Marks a major milestone in expanding access to this next-generation intravascular imaging technology, helping physicians make more informed decisions across a wide range of coronary interventionsAddresses the need to balance the deep vessel visualization of IVUS with the high-resolution surface detail of OFDI

SOMERSET, N.J., June 29, 2026 /PRNewswire/ — Terumo Interventional Systems (TIS), a division of Terumo Corporation, recently completed the first procedure using its OPUSWAVE® Dual Sensor Imaging System. The procedure, performed on June 15 by Annapoorna S. Kini, MD, MRCP, FACC, at Mount Sinai Fuster Heart Hospital in New York, represents a significant milestone in advancing intravascular imaging in the United States.

The OPUSWAVE Imaging System features the DualView® Imaging Catheter, combining Optical Frequency Domain Imaging (OFDI) and intravascular ultrasound (IVUS) in a single platform to provide simultaneous, complementary views of the coronary anatomy. This first U.S. case represents an important step in bringing next-generation intravascular imaging capability to physicians nationwide, supporting more informed treatment strategies across a broad range of coronary interventions. It also addresses a long-standing clinical challenge: the need to balance the deep vessel visualization of IVUS with the high-resolution surface detail of OFDI. By integrating both modalities into a single catheter, physicians can assess lesion morphology, plaque composition and stent deployment with a more comprehensive perspective – without compromise.

“Having both IVUS and OFDI available simultaneously changes how we approach complex cases,” said Dr. Kini. “Instead of choosing between depth or resolution, we can see both at once – giving us a more complete understanding of the vessel and greater confidence in our decisions.”

“The OPUSWAVE Imaging System enables physicians to see the full picture,” said Gray Fleming, Senior Vice President, Sales & Marketing, TIS-US. “From vessel structure to surface detail, physicians can act with greater certainty. That’s the promise of dual view – brought together into a single, clear answer.”

This “see more, know more” capability directly reflects what physicians identified as most valuable in recent market research: clearer understanding, better procedural decisions and increased diagnostic confidence when imaging complex coronary disease.

“In the past, Interventional cardiologists have had to choose between two different imaging approaches,” said Michael J. Martinelli, MD, FACC, FSCAI, Chief Medical Officer, Terumo Medical Corporation. “The OPUSWAVE Imaging System eliminates that tradeoff by providing both IVUS and OFDI imaging in a single catheter, providing the physician the opportunity to leverage the strengths of each modality simultaneously. This provides the physician with increased clarity and insight for more informed decision–making in real-time, leading to greater confidence when treating the individual patient.”

The DualView Imaging Catheter is engineered for performance and deliverability, featuring a 2.6 Fr profile, 6 Fr guide compatibility, and advanced hydrophilic coating. It also offers a 150 mm pullback for both IVUS and OFDI, delivering the longest single-run pullback length. With flexible imaging modes – including IVUS-only, OFDI-only, or simultaneous dual imaging – the system allows physicians to tailor imaging to each case while maintaining workflow efficiency.

About Terumo Interventional Systems
Terumo Interventional Systems (TIS), a division of Terumo Corporation, is a market leader in minimally invasive entry site management, lesion access, and therapeutic intervention. TIS offers a complete, solution-based product portfolio used in advanced coronary, peripheral and endovascular treatments with strategic initiatives in Transradial Access, Complex Coronary Intervention, Peripheral Artery Disease and Embolotherapy. TIS combines innovative research and development with a deep market understanding to create a pipeline of industry-leading devices that deliver clinical value, economic benefit, and enhanced patient outcomes. More information can be found at www.terumois.com.

About Terumo
Terumo (TSE: 4543) is a global medical innovation company. Guided by an unwavering commitment to patients, and driven by the passion of our associates, we strive to fulfill our Group Mission of “Contributing to Society through Healthcare.” Founded in Tokyo in 1921, we provide a comprehensive range of solutions in the fields of therapeutic procedures, hospital operations, and life sciences in more than 160 countries and regions. More information can be found at www.terumo.com.

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SOURCE Terumo

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FIREWORKS BY GRUCCI, AMERICA’S FIRST FAMILY OF FIREWORKS, LIGHTS UP AMERICA’S 250TH WITH HISTORIC CELEBRATIONS COAST TO COAST

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Centerpiece Show in Las Vegas Largest in the United States, with Performances Across 15 Simultaneous Locations on July 4

BELLPORT, N.Y., June 29, 2026 /PRNewswire/ — As America marks its 250th anniversary, Fireworks by Grucci and the Grucci family bring a uniquely resonant perspective to this milestone. While the family’s pyrotechnic roots date back to 1850 in Bari, Italy, Phil Grucci’s second great-grandfather established the American branch of this family tree in 1905 in Long Island, NY. Since then, the Grucci’s have been crafting celebrations and woven into the fabric of the America story for nearly a century. As America’s First Family of Fireworks, there is no more fitting name to light up the sky for America’s 250th birthday.

From hometown celebrations to landmark public performances, Fireworks by Grucci is honoring America’s Semiquincentennial with world-class displays that reflect the company’s unmatched record of innovation and excellence from pioneering the stringless shell to introducing microchip-timed aerials. Among its 14 Guinness World Records are the largest fireworks display, the largest aerial fireworks shell, the most UAVs launching fireworks simultaneously, and the longest chain of fireworks. That commitment to creating lifelong memories has also earned the company a Gold Medal at the Monte Carlo Fireworks Competition and the trust of the nation’s most iconic stages, from Presidential Inaugurations to the Olympic Games.

The Largest Fourth of July Show in the Country: Las Vegas
Fireworks by Grucci’s Las Vegas engagement stands as the centerpiece of its 2026 season and will be the largest multi-location choreographed Independence Day performance in the United States. Produced in partnership with Las Vegas Events and the Las Vegas Convention and Visitors Authority, the residency spans every Saturday from June 6 through July 25, with an eight-minute artistically choreographed performance each night beginning around 9 p.m. Starting with the World Class multi-media performance on July 1 to celebrate Station Casino‘s 50th anniversary with the first of seven properties.

On July 4, Grucci will deliver its grandest performance of the season across the largest theatre in the country: nine iconic rooftops spanning The Strip and six additional Station Casinos rooftops throughout the Las Vegas Valley, making it the largest multi-location choreographed performance with 15 simultaneous launch sites igniting the sky above the Entertainment Capital of the World.

“To bring our family’s 176-year legacy to the world’s greatest stage for America’s 250th birthday is a profound artistic privilege,” said Phil Grucci, CEO and Creative Director of Fireworks by Grucci. “On July 4th, we aren’t just lighting the sky; we are transforming the entire Las Vegas Strip and Valley into a singular, synchronized canvas of celestial choreography. We are ecstatic to deliver a production that honors our nation’s history and gives audiences from coast to coast a memory of a lifetime.”

To further celebrate America’s Semiquincentennial, Fireworks by Grucci is anchoring major community traditions and cultural institutions across the nation this summer, including:

Tri-State Tradition: From the historic shorelines of NY Harbor in a collaboration between City of Jersey City, to Montauk, Yonkers, Springfield, MA, Atlantic City’s major resort properties (Tropicana and Borgata), the legendary 21st anniversary of TD Bank’s ‘Celebrate America’ in Nassau County (July 2), to a 75+ year tradition at an intimate setting at a yacht club in the Hamptons, Grucci remains the definitive voice of summer celebration across the Northeast.Great American West: Anchoring the largest 250th celebration in the nation starts with an unprecedented summer-long rotating residency across 19 distinct Nevada casino-hotel properties with Las Vegas Events, the Las Vegas Convention and Visitors Authority, and Station Casinos. And continues by highlighting the massive Stadium of Fire at “America’s Freedom Festival” in Provo, Utah (July 4) featuring “The Largest Stadium Fireworks Show in America”, set to patriotic music and narration, and enhanced with Grucci Pyro drones and flames, created in collaboration with Stadium of Fire’s producers Baruch/Gayton Productions. Grucci is executing the most elaborate aerial choreography in the country.Historic & Cultural Institutions: Throughout the summer celebrating America’s 250th, Grucci’s artistry will orchestrate multi-sensory experiences at landmark locations, including the ancestral home of the DuPont family at the Hagley Museum & Library in Delaware (June 12 & 19) and synchronized to live classical arrangements with the Chorus of Westerly in Rhode Island (June 20).

About Fireworks by Grucci
Fireworks by Grucci is America’s First Family of Fireworks, a sixth-generation family business rooted in 176 years of pyrotechnic artistry. A global authority in the field, Grucci has set the standard for innovation and excellence, from pioneering the stringless shell to introducing pyrotechnics on drones and microchip-timed aerials. The company’s mission is to create lifelong memories through world-class performances, guided by timeless values of honesty, integrity, and excellence. Grucci’s accolades include the Gold Medal at the Monte Carlo Fireworks Competition and 14 Guinness World Records. 

Grucci’s end-to-end expertise in pyrotechnics and manufacturing extends through its U.S.-based subsidiary, Pyrotechnique by Grucci, which employs 200 full-time workers across facilities in New York and Radford, Virginia. 

Headquartered in Bellport, New York, Grucci maintains additional facilities in Las Vegas, Radford, Virginia, Saudi Arabia, and Dubai. For more information and a full schedule of events, visit grucci.com.

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SOURCE Fireworks by Grucci

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