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HanchorBio Announces U.S. FDA Clearance of IND Application for HCB303, a Next-Generation Trispecific Immunotherapy

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HCB303 features a differentiated TIGIT-Fc strategy designed to intercept TIGIT ligands, preserving the CD226 activating axis while simultaneously targeting PD-L1 and CD47

Plans to initiate a Phase 1 first-in-human, dose-escalation, multi-regional trial in patients with advanced solid tumors

TAIPEI and SHANGHAI and SAN FRANCISCO, Oct. 5, 2026 /PRNewswire/ — HanchorBio, Inc. (TWSE: 7827), a global clinical-stage biotechnology company developing next-generation immunotherapies for oncology and immune-mediated diseases, today announced that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug (IND) application for HCB303. The clearance enables HanchorBio to initiate its Phase 1 first-in-human clinical trial.

HCB303 is HanchorBio’s second trispecific immunotherapy to enter clinical development and represents an innovative and differentiated approach to enhance immune response against cancer. A humanized trispecific fusion protein engineered via HanchorBio’s proprietary FBDB™ platform, HCB303 incorporates a TIGIT-Fc ligand-trap strategy within a single architecture that simultaneously targets the TIGIT/PVR, PD-L1/PD-1, and SIRPα/CD47 pathways.

Unlike conventional anti-TIGIT antibodies that primarily bind to TIGIT and block TIGIT receptor signaling, HCB303 is designed to intercept TIGIT ligands—including PVR/CD155 and CD112. By trapping these ligands, HCB303 is designed to reduce TIGIT-mediated inhibitory signaling while potentially preserving CD226 expression and associated activating signaling in T cells and NK cells. Combined with PD-L1 blockade and SIRPα-mediated enhancement of macrophage phagocytosis, HCB303 aims to coordinate complementary innate and adaptive antitumor immunity within the tumor microenvironment.

“We believe TIGIT-Fc offers a biologically superior strategy to conventional anti-TIGIT receptor blockade,” said Scott Liu, PhD, Founder and Chairman of HanchorBio. “Simply blocking PVR signaling through an anti-TIGIT antibody may release the inhibitory signal, but it does not address the down-regulation of CD226, which is needed for enhanced activation of T and NK cells. HCB303 was designed to go further—intercepting immune-inhibiting TIGIT ligands and preserving the CD226 activating axis, while simultaneously blocking the PD-L1 and CD47 pathways. This is precisely the type of biology-driven therapeutic architecture our FBDB™ platform was built to create.”

The FDA clearance follows pre-IND feedback from the agency in August 2026. HanchorBio will now proceed with its planned Phase 1 first-in-human, dose-escalation, multi-regional study (HCB303-ONC-101) in patients with advanced, relapsed, or refractory solid tumors who have no remaining standard treatment options. The study will evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, biomarkers, and preliminary antitumor activity.

“HCB303 is HanchorBio’s second trispecific immunotherapy to enter clinical development, and the FDA clearance moves HCB303 from a differentiated biological hypothesis into clinical testing,” added Alvin Luk, PhD, MBA, President and CMO (Group) & CEO (USA) of HanchorBio. “Our priority now is to rigorously evaluate whether its differentiated TIGIT biology and coordinated engagement of innate and adaptive immunity translate into meaningful clinical benefit for patients. With HCB301 already in clinical development and HCB303 now cleared to enter the clinic, we are advancing the potential of our FBDB™ platform to generate mechanistically distinct multispecific therapeutics.”

About HCB303

HCB303 is an investigational, humanized trispecific fusion protein developed using HanchorBio’s proprietary FBDB™ platform. It is designed to simultaneously modulate the SIRPα/CD47, PD-L1/PD-1, and TIGIT/PVR immune pathways, integrating macrophage, T-cell, and NK-cell antitumor immunity within a single engineered molecule.

About HanchorBio

HanchorBio (TWSE: 7827) is a global clinical-stage biotechnology company focused on inventing and developing next-generation biologics for cancer and immune-mediated diseases using its proprietary FBDB™ platform.

HanchorBio’s pipeline includes HCB101, its lead SIRPα-based innate immune checkpoint program; HCB301, a clinical-stage trispecific immunotherapy targeting SIRPα, PD-L1, and TGF-β biology; HCB303, a clinical-stage trispecific immunotherapy integrating SIRPα/CD47, PD-L1/PD-1, and TIGIT/PVR biology; and additional programs across oncology and immune-mediated diseases. For more information, please visit: https://www.HanchorBio.com.

Forward-Looking Statements

This press release contains forward-looking statements, including statements regarding the development and clinical advancement of HCB303; the timing, initiation, design, conduct, and potential outcomes of future clinical studies; the potential therapeutic characteristics, mechanisms, safety, and antitumor activity of HCB303; the development of HanchorBio’s pipeline; and the capabilities and potential of the FBDB™ platform. These statements are based on current expectations and assumptions and involve risks and uncertainties that could cause actual results to differ materially from those described. FDA clearance of an IND permits clinical investigation to proceed but does not constitute approval of HCB303 or provide assurance regarding the safety, efficacy, timing, or success of its clinical development. HanchorBio undertakes no obligation to update forward-looking statements except as required by applicable law.

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SOURCE HanchorBio Inc.

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Achieve named one of Arizona’s ‘Most Admired Companies’ for sixth consecutive year

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Recognition highlights Achieve’s investment in its people and commitment to helping consumers build stronger financial futures

SAN MATEO, Calif., Oct. 5, 2026 /PRNewswire/ — Achieve, the leader in digital personal finance, has been named one of Arizona’s Most Admired Companies for the sixth consecutive year. The recognition from Az Business magazine, presented in partnership with BestCompaniesAZ, celebrates Achieve’s commitment to building stronger financial futures for consumers and a workplace where teammates can grow, contribute and make a difference.

In its 2026 profile, Az Business highlighted Achieve’s investment in employee growth, education and community service, recognizing a culture that supports career development, leadership, encourages innovation and makes giving back part of how the company operates.

“Multiple years of recognition reflect something at the core of Achieve: a mission-driven company that cares about our clients, our people and our communities,” said Achieve Co-Founder and Co-CEO Brad Stroh. “Helping consumers take control over their financial future takes people who care deeply about their outcomes. Investing in our teammates strengthens that foundation and brings our mission to life in every conversation, every decision and every community we serve.”

Arizona’s Most Admired Companies are selected by a panel of independent judges assembled by BestCompaniesAZ. The program evaluates organizations across leadership, workplace culture, community impact, customer service and innovation. According to Az Business, the 2026 honorees emerged from the most competitive field in the program’s history.

Achieve’s profile emphasized three strengths behind its recognition:

Growth from within: Investment in teammate development and education helps people build their careers while contributing to the company’s mission.Innovation with purpose: A culture that encourages new ideas supports Achieve’s work helping consumers improve their financial futures.Community commitment: Giving back is woven into the workplace culture, extending Achieve’s impact beyond the consumers it serves.

“At Achieve, we want teammates to see a future for themselves and know their work makes a difference,” said Achieve Senior Vice President of Human Resources Heather Marcom. “That means making room for them to learn, contribute ideas and take the next step in their careers. When people feel supported and see the impact of their contributions, they bring that commitment to their teammates, our consumers and the broader community.”

The 2026 honorees will be celebrated Oct. 8 at Chateau Luxe in Phoenix.

Achieve has served over 2 million consumers, helping to resolve over $22 billion in debt and facilitated over $15 billion in personal loans and home equity lines of credit since 2002. Achieve was also named to Az Business Magazine’s AZ Big 100 List for 2026, which highlights the organizations and leaders shaping Arizona’s economic future.

As a trusted leader in debt consolidation, Achieve remains committed to helping everyday people move toward a better financial future. This commitment is rooted in providing a transparent experience, a personalized approach to every member’s unique situation and the predictable, fast cash flow necessary to attain long-term financial stability. By focusing on these core principles, the company continues to redefine how consumers manage debt and build lasting financial health.

About Achieve

Achieve, THE digital personal finance company, helps everyday people get on, and stay on, the path to a better financial future. Achieve pairs proprietary data and analytics with personalized support to offer personal loans, home equity loans, debt relief and debt consolidation, along with financial tips and education and free mobile apps: Achieve MoLO® (Money Left Over) and Achieve GOOD™ (Get Out Of Debt). Achieve is frequently recognized for providing top-rated customer experience and satisfaction by both consumers and leading personal finance review platforms and has 2,200 dedicated teammates across the country, with hubs in Arizona, California, Florida and Texas.

Achieve refers to the global organization and may denote one or more affiliates of Achieve Company, including Achieve.com, Equal Housing Opportunity (NMLS ID #138464); Achieve Home Loans, Equal Housing Opportunity (NMLS ID #1810501); Achieve Personal Loans (NMLS ID #227977); Freedom Debt Relief (NMLS ID # 1248929); and Freedom Financial Asset Management (CRD #170229).

Contacts

Austin Kilgore
akilgore@achieve.com
214-908-5097

Elina Tarkazikis
etarkazikis@achieve.com

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SOURCE Achieve

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Keyfactor Appoints Former CyberArk CEO Matt Cohen to Board of Directors and Strategic Advisor

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Appointment comes as Keyfactor closes $1B+ growth investment led by Summit Partners and accelerates its next phase of scale beyond $200 million in ARR

ATLANTA and STOCKHOLM, Oct. 5, 2026 /PRNewswire/ — Keyfactor, the leader in trust infrastructure for AI and machines, today announced the appointment of former CyberArk CEO Matt Cohen to its Board of Directors. Cohen will also serve as a strategic advisor to Keyfactor CEO Jordan Rackie, providing an additional source of perspective and operating experience as the company enters its next phase of growth and scale.

The appointment coincides with the closing of Keyfactor’s previously announced $1 billion-plus growth investment led by Summit Partners and follows the company’s recent milestone of surpassing $200 million in annual recurring revenue (ARR). Together, the developments reflect Keyfactor’s continued growth and accelerate investment behind its Trust Control Plane and expand its leadership across machine identity, cryptography, AI security and post-quantum readiness.

Cohen most recently served as CEO of CyberArk, where he helped lead one of cybersecurity’s defining growth stories and ultimately the company’s approximately $25 billion acquisition by Palo Alto Networks. Over more than two decades in technology, Cohen has built and scaled global businesses, led major strategic and operational transformations, and created significant enterprise value. Before becoming CyberArk’s CEO in 2023, he served as its Chief Revenue Officer and Chief Operating Officer. Earlier in his career, he held senior leadership roles at PTC, including Executive Vice President of Worldwide Field Operations, helping scale the company beyond $1 billion in ARR.

“As we began thinking about Keyfactor’s next chapter with Summit and the rest of our Board, we were very intentional about the experience and perspective we wanted around the table,” said Jordan Rackie, CEO of Keyfactor. “As our market opportunity continues to expand, we’re entering a phase where scaling with ambition, discipline and operational rigor will be critical.”

“Matt was someone we pursued very deliberately. He has operated at the scale we aspire to reach, helped build a category leader in cybersecurity and navigated many of the opportunities and inflection points that lie ahead for Keyfactor. We share similar values around leadership, transparency and how to approach both opportunities and challenges. He brings tremendous experience and judgment to our Board, and I’m equally excited to have him as a strategic and trusted advisor as we navigate Keyfactor’s next phase of growth.”

Keyfactor has emerged as a global leader at the intersection of machine identity and cryptography as enterprises confront an unprecedented expansion in the number of machines, workloads, applications and AI agents that must be authenticated and trusted. The company’s Trust Control Plane represents the next evolution of how enterprises manage trust across these environments. It creates a unified control layer that brings together visibility, intelligence, policy and action across machine identity and cryptography.

“The most exciting companies are often positioned at the intersection of major technology shifts, and that’s exactly where I believe Keyfactor sits today,” said Cohen. “AI, machine identity, cryptographic modernization and the transition to post-quantum security are converging to create one of the most significant security challenges enterprises will face over the next decade.”

“Keyfactor has meaningful scale, a strong culture and a clear vision for where the market is headed. From my early conversations with Jordan, we found a lot of common ground, and I saw a leader who’s clear-eyed about what the next level of growth truly demands. I’m excited to join the Board, serve as a strategic advisor to Jordan and help the team capitalize on the tremendous opportunity ahead.”

Summit Partners’ investment provides additional resources to help accelerate Keyfactor’s growth strategy, which focuses on continued product innovation, international expansion, strategic acquisitions and investment across the company’s global organization. Cohen’s appointment reflects a broader philosophy around preparing Keyfactor for its next phase: continuing to strengthen the leadership team while surrounding the company with Board members, advisors and partners who bring relevant experience from the scale Keyfactor intends to reach.

For more information, visit https://www.keyfactor.com/.

About Keyfactor

Keyfactor is the leader in trust infrastructure for AI and machines. The platform equips enterprises to take control of the machine identities and cryptography that safeguard every digital interaction. By bringing fragmented tools and assets into a single control plane, security teams can see their cryptographic landscape, find and remediate risk exposure, roll out compliant and quantum-safe cryptography, and issue a cryptographic identity to every machine, workload and AI. Trusted by the largest enterprises and government agencies, Keyfactor delivers the resilient foundation organizations need to keep running uninterrupted in the AI and quantum era. Learn more at www.keyfactor.com or follow Keyfactor on LinkedIn.

Media Contact for Keyfactor:

Danielle Ostrovsky
Hi-Touch PR
Ostrovsky@Hi-TouchPR.com

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SOURCE Keyfactor

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ECARX Completes Acquisition of Flyme Software Business, Securing End-to-End Operating System Capabilities

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Completion brings Flyme Auto and Flyme OS fully in-house, aligning ECARX’s hardware and software roadmaps across the technology stackFlyme to operate as an independent software division, preserving R&D continuity and ensuring a seamless transition for existing customers

LONDON, Oct. 5, 2026 /PRNewswire/ — ECARX Holdings Inc. (Nasdaq: ECX) (“ECARX” or the “Company”), a leading global automotive intelligence business, today announced the completion of its acquisition of the entire Flyme software business portfolio, first announced on June 22, 2026. Through the transaction, ECARX acquired 100% of the equity interest in Hubei Qiguang Technology Co., Ltd. (the “Acquired Entity”), a new entity carved out from DreamSmart Group to hold the Flyme business, comprising Flyme Auto, an in-vehicle cockpit operating system, and Flyme OS, a cross-device operating system.

Flyme Auto is already deployed by ECARX in 3.5 million production vehicles across multiple OEM partners, and Flyme OS is built on more than 15 years of continuous R&D and mass-market deployment across vehicles, smartphones and smart wearables. ECARX will operate Flyme as an independent software division. Existing operators of Flyme OS will continue to receive updates, and user data will remain in each operator’s ownership.

Ziyu Shen, Founder and CEO of ECARX Holdings Inc commented:

“The completion of the Flyme acquisition marks an important milestone in our strategy to build a fully integrated hardware and software platform. By bringing Flyme’s operating system, user experience, AI capabilities, and ecosystem expertise in-house, we strengthen our ability to deliver tightly optimized solutions that connect our silicon, computing platforms, and intelligent software into a unified offering. Owning the entire technology stack will enhance product differentiation, accelerate innovation, improve development efficiency, and create new revenue opportunities through software licensing, integration services, and connected car ecosystem monetization. Ultimately, Flyme positions ECARX to deliver a more compelling end-to-end experience for automakers while strengthening our long-term competitive advantage.”

Flyme complements ECARX’s Cloudpeak® cross-domain software stack, with Flyme Auto providing the in-cabin application layer for vehicles in China and Flyme OS enabling seamless connectivity between vehicles, smartphones and smart devices. The expanded portfolio will provide global automakers with greater flexibility to engage with ECARX across multiple layers of the technology stack, from standalone hardware and software solutions to full-stack products.

Transaction Details

The total consideration paid for 100% of the equity of the Acquired Entity was RMB1.8 billion (approximately US$266 million), as compared with an independent valuation of RMB1.824 billion as of May 31, 2026.

The acquisition was executed as an all-cash transaction, consisting of approximately 70% syndicated bank loans from Chinese commercial banks on market terms with a 10-year maturity, and approximately 30% from internal sources. Following closing, ECARX will provide the Acquired Entity with a RMB200 million capital injection to support its operations.

The Acquired Entity houses all mission-critical Flyme intellectual property, R&D teams, engineering resources, OEM customer contracts and supporting operational infrastructure.

About ECARX

ECARX (Nasdaq: ECX), headquartered in London, is a leading global automotive intelligence company. ECARX provides the intelligent brain that powers the next generation of software-defined and AI defined vehicles. The company delivers end-to-end, full-stack solutions spanning advanced system-on-chip hardware, high-performance central computing platforms, intelligent cockpit technology, Advanced Driver Assistance Systems, cloud connectivity and physical AI, alongside bespoke vehicle software and intelligent operating systems.

As automakers transition to software-first and AI-first vehicle architectures, ECARX empowers automakers to streamline integration, reduce systemic complexity and optimize long-term cost efficiency. ECARX’s proven technology is deployed across over 12 million vehicles worldwide, and is currently partnered with 18 global automakers and 28 vehicle brands to shape the future of automotive intelligence.

Founded in 2017 and listed on Nasdaq in 2022, ECARX operates from 15 major international locations across Europe, the Americas and Asia, with a global team of over 1,400 employees.

Forward-Looking Statements

This release contains statements that are forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based on management’s beliefs and expectations as well as on assumptions made by and data currently available to management, appear in a number of places throughout this document and include statements regarding, amongst other things, results of operations, financial condition, liquidity, prospects, growth, strategies and the industry in which we operate. The use of words “expects”, “intends”, “anticipates”, “estimates”, “predicts”, “believes”, “should”, “potential”, “may”, “preliminary”, “forecast”, “objective”, “plan”, or “target”, and other similar expressions are intended to identify forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to a number of risks and uncertainties that could cause actual results to differ materially, including, but not limited to statements regarding our intentions, beliefs or current expectations concerning, among other things, results of operations, financial condition, liquidity, prospects, growth, strategies, future market conditions or economic performance and developments in the capital and credit markets and expected future financial performance, and the markets in which we operate.

For a discussion of these and other risks and uncertainties that could cause actual results to differ materially from those expressed in any forward-looking statement, see ECARX’s filings with the U.S. Securities and Exchange Commission. ECARX undertakes no obligation to update or revise forward-looking statements to reflect subsequent events or circumstances, except as required by applicable law.

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SOURCE ECARX Holdings Inc.

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