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SKAN, the Wellcome Sanger Institute and University of Newcastle to study early stem cell mutations in rare blood disorder

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 CAMBRIDGE, England, NEWCASTLE, England and BENGALURU, India  , June 25, 2024 /PRNewswire/ — SKAN Research Trust (SKAN), promoted by Indian entrepreneur Ashok Soota, today announced a joint research project with the UK-based Wellcome Sanger Institute (Sanger Institute) and University of Newcastle (Newcastle), to study early somatic mutations in blood stem cells that researchers believe drive several cancerous and non-cancerous conditions. The research collaboration will extend cutting-edge stem cell genomic analysis to cancer subtypes such as Langerhans Cell Histiocytosis (LCH), an immune cell disorder that largely afflicts children aged between 0 to 15 years.

The research project titled Deciphering the Origins of Langerhan Cell Histiocytosis and Related Histiocytic Neoplasms will be led by Dr Jyoti Nangalia, Group Leader at the Wellcome Sanger Institute and Wellcome-MRC Stem Cell Institute. The study will examine the timestamp of the genetic mutations that drives LCH and the presentation of its clinical symptoms.

Researchers will work with leading LCH treating research centres worldwide to cover LCH driven by different genetic mutations with SKAN specifically creating a large cohort of Indian children for the study. The study comes at a time when researchers are still grappling with understanding how some genetic mutations that drive LCH result in lesions appearing in different parts of the body at different times. Researchers hope that the study will pave the way for better understanding the disease’s progression and possible early interventionist strategies for its management.

Mr. Ashok Soota, the Chairman & Managing Trustee of SKAN, said “We are delighted to be partnering with the Sanger Institute and University of Newcastle in a project which gives us dual benefits: understanding the mutation of stem cells and an insight into LCH, an underfunded cancer. The research is expected to develop valuable clinical tests that will aid doctors understand what to expect of each patient.”

Dr Jyoti Nangalia, Group Leader at the Wellcome-MRC Stem Cell Institute and Wellcome Sanger Institute, said, “These disorders are an enigma and they are likely to have a unique genomic origin. Whilst we are aware that specific mutations are able to drive the disorders, we do not understand how such events result in a multitude of tissues being affected at different times in life, nor why clinical disease often follows distinct patterns across different patients. We hope that our genomics research at the Sanger Institute will shed light on the origin and trajectory of these diseases to help patients in the future.”

Newcastle University and its Principal Investigator, Prof. Matthew Collin, who have played a major role in establishing diagnostic and blood monitoring pipelines for LCH, (now adopted by the UK NHS Genomic Medicine Services), will also be part of this collaboration. 

Prof Matthew Collin said, “For patients with these disorders, it is tremendous that state-of-the-art approaches will be brought to bear on increasing our knowledge of how they arise. We are also very excited to extend the reach of research and training to new partners in other healthcare systems.”

Mr Davis Karedan, Vice Chairman & Trustee of SKAN said, “This collaboration is another step in SKAN’s efforts to establish a robust inhouse stem cell research capability and comes on the back of its international collaboration with the Cambridge Stem Cell Institute”.

About SKAN Research Trust

SKAN is a Bengaluru-based not-for-profit medical research trust that leverages transformational technologies to develop new therapies for ageing and neurological ailments, cardiovascular diseases, diabetes remission and lifestyle related disorders. SKAN applies its expertise in gut microbiome, genomics, stem cells, molecular biology, biomarkers, immunotherapies, nutrition, and alternate therapies to uncover kinder and gentler treatment protocols for ailments. Bioinformatics at SKAN vigorously pursues cutting edge artificial intelligence, machine learning and other advanced technologies to predict, pre-empt, diagnose, treat, and facilitate remission of medical disorders. The Mission statement of SKAN is “Transform the future of medicine. Impacting millions of lives”.

Media contact: contactus@skanrt.in

Careers: Talent@SKANrt.in

About Wellcome Sanger Institute

Founded to sequence the human genome, the Sanger Institute is a biomedical research centre recognized globally for undertaking large scale genome science that forms the foundations of knowledge in biology and medicine. In order to deliver on its mission to “apply and explore genomic technologies at scale to advance the understanding of biology and improve health”, the Sanger Institute is committed to collaborating, leading, convening, engaging globally and providing world-class training to scientists and specialists in genomic research. The Sanger Institute strategically deploys its Wellcome core funding to enable faculty-driven genomic science, making discoveries not easily made elsewhere.

About University of Newcastle

As a member of the Russell Group, an association of 24 research-intensive institutions in the UK, Newcastle is delivering pioneering research that makes a positive impact in the world. From reversing Type 2 diabetes to protecting cultural property, Newcastle researchers are tackling international challenges to improve lives and influence policy around the world. Newcastle has one of the largest European Union research portfolios in the UK.

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Trimble Links SketchUp with Anthropic’s Claude, Bringing New Conversational AI-powered Capabilities to 3D Modeling

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19 minutes ago

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April 29, 2026

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Trusted, intuitive AI enhances design workflows, making it easier to move from creative concepts to 3D models

WESTMINSTER, Colo., April 28, 2026 /PRNewswire/ — Trimble (Nasdaq: TRMB) today announced a specialized integration with Claude, the large language model and AI assistant from Anthropic, that makes it easier for Trimble® SketchUp® software users to create 3D models directly from conversational text or speech prompts.

The powerful new capabilities are enabled by a SketchUp Connector model context protocol (MCP) service that allows Claude to interact directly with SketchUp (.skp) files. The connectivity enhances existing design workflows and expands access to 3D modeling for people at any skill level.

Trimble SketchUp is a professional-grade 3D modeling software used widely in architecture, design, construction and other fields. This is the first Connector created by Trimble that connects the SketchUp design environment with other tools via the MCP framework.

Conversational 3D modeling
The SketchUp Connector integration with Claude lets users create 3D geometry, such as building massing models, landscapes or furniture by simply describing what they want. Plain-language inputs alongside reference images, sketches, photos, floor plans and dimensions that users upload can give Claude the context needed to understand the design goal. Claude builds the geometry in a cloud SketchUp session, verifying dimensions iteratively.

“The learning curve and time it takes for professionals to transfer a vision to a digital model has traditionally been the biggest barrier to 3D modeling,” said Chris Cronin, vice president and general manager of architecture and design solutions at Trimble. “Natural language prompts and the power of AI make it easy for anyone to get started and excel, including inexperienced and non-traditional 3D design users, bringing us closer to our ‘3D for everyone’ goal.”

The specialized Claude integration for SketchUp is consistent with Trimble-wide initiatives to democratize advanced technology and make them available and accessible to a wider range of users, according to Cronin.

Additional 3D modeling advantages
In addition to allowing natural language prompts, the SketchUp Claude Connector tracks version history within a single chat, enabling users to rapidly navigate, troubleshoot and refine their 3D models. If a design is not quite accurate, users can describe necessary changes or paste screenshots from SketchUp directly into the chat to point out specific angles, proportions or elements that need adjustment.

When a model is completed, the Connector creates a 2D preview thumbnail and provides a direct download link to the .skp file. Users can instantly download, open and edit the file in any SketchUp modeler.

Users can also design and train Claude on core skills and unique workflows to complete repetitive tasks more quickly and efficiently.

Availability
Users can get started today by enabling Trimble SketchUp in Claude’s MCP directory connector settings. Accessing the Connector requires a Claude account and a Trimble ID for authentication. Users receive a free SketchUp entitlement that allows them to save up to 30 SketchUp models; after that, a paid entitlement is required. Resulting files can be opened in SketchUp for Web, Desktop, iPad or iPhone.

About Trimble
Trimble is a global technology company that connects the physical and digital worlds, transforming the ways work gets done. With relentless innovation in precise positioning, modeling and data analytics, Trimble enables essential industries including construction, geospatial and transportation. Whether it’s helping customers build and maintain infrastructure, design and construct buildings, optimize global supply chains or map the world, Trimble is at the forefront, driving productivity and progress. For more information about Trimble (Nasdaq: TRMB), visit: www.trimble.com.

FTRMB

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SOURCE Trimble

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Topaz Labs announces its largest single release of AI models in company history with “Next-Gen” launch

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April 28, 2026

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DALLAS, April 28, 2026 /PRNewswire/ — Topaz Labs, the AI image and video enhancement company, has announced four new image enhancement models and two video enhancement models across five applications. The collection of “Next-Gen” models offer powerful sharpening, denoising, and upscaling results to visual content. Image models included are Wonder 3, Denoise Max, Super Focus 3, and High Fidelity 3. For video, Starlight Precise 2.5 and Astra 2 were announced.

The collection of models offers powerful sharpening, denoising, and upscaling results to visual content.

“This is both the largest and most technically advanced set of models we’ve released in the company’s history,” says Eric Yang, CEO, Topaz Labs. “We launched Topaz NeuroStream earlier this year with the goal of enabling local rendering of complex models for more users. Without such technology, the complex, heavyweight AI models in today’s release would have been limited to cloud-only rendering, forcing users to pay per use and be reliant on internet connection. We believe local use is crucial to the future of AI in both professional and consumer use cases, and today’s release is a huge step.” 

Topaz NeuroStream is proprietary technology that reduces VRAM usage by up to 95% and allows exponentially more users on consumer-grade hardware to use AI models locally. A total of six Topaz models are now powered by NeuroStream.

Next-Gen Release Image Models 

Wonder 3: A magical, one-click sharpen, upscale, and denoise model for images.
Denoise Max: New standard for removing noise and grain in images.
Super Focus 3: Next-level sharpening model that brings subjects back from the blur.
High Fidelity 3: The newest model for upscaling high-res inputs like smartphone photos and RAW images.

All image models in this release are available in Topaz Photo desktop application and via API. Wonder 3 and Denoise Max are also available in Express, a web-based tool.

Next-Gen Release Video Models

Starlight Precise 2.5 (Local): Groundbreaking video model that brings out natural visual details with stunning results, with local availability in Topaz Video

Astra 2: The next generation of creative video upscaling that enhances clarity, richness, and visual complexity of videos by adding new detail.

Both highlighted video models are available via cloud rendering in Astra and API. Starlight Precise 2.5 (Local) can be found in the Topaz Video desktop application.

About Topaz Labs
Founded in 2005, Topaz Labs is a leader in AI-powered image and video enhancement. Its technology is used by 1.5 million customers, including 20 of the world’s top 50 companies. Known for industry-leading products like Topaz Photo, Topaz Video, Topaz Gigapixel, Astra and Bloom, the company continues to invest heavily in research and development, advancing the frontiers of imaging technology in collaboration with academic and industry partners.

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Dreame Technology Launches the L60 Series, Led by the Flagship L60 Pro Ultra

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1 hour ago

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April 28, 2026

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New lineup brings industry-leading intelligence and full-home automation to a new generation of robot vacuums

SAN FRANCISCO, April 28, 2026 /PRNewswire/ — Dreame Technology, a leader in smart home innovation, today announced the L60 Series, a new lineup of four robot vacuums engineered for the full range of modern home environments. Built on a shared foundation of premium cleaning performance, intelligent navigation, and hands-free automation, the L60 Series is designed to meet the needs of every kind of household, from compact apartments to multi-story homes, and from single-surface layouts to complex mixed-flooring environments.

“The L60 Series represents exactly what Dreame stands for: powerful, intelligent cleaning that adapts to how people actually live,” said Ana Wang, CEO of Dreame Technology North America. “Whether you have a multi-story home, pets, mixed flooring, or low furniture, there’s an L60 built for your needs. Every model in the lineup delivers the core cleaning experience our customers expect from Dreame.”

Meet the L60 Series

The L60 Series is built around four distinct models, each tailored to a different home profile and cleaning priority:

L60 Pro Ultra — The Ultimate All-in-One. The flagship vacuum is purpose-built for large floor plans, multi-surface transitions, and complex terrain. Features the 3.46-inch ProLeap™ System, 35,000Pa Vormax™ Suction, Dual Omni-Scrub Mopping with Hot Water, and an industry-leading 6,400mAh PowerCore™ Battery.L60 Ultra — Precision Whole-Home Coverage. A balanced high-performer built around Dreame’s latest 2026 sensor technology and a 3.23in (82mm) ultra-thin design for precise navigation in low-light spaces and flawless cleaning under low-profile furniture. Includes AI-Enhanced 3D ToF Vision, 35,000Pa Vormax™ Suction, HyperStream™ Detangling DuoBrush 2.0, SmartDirt™ Detection, Pet-Friendly Care 5.0, and Matter, Apple Watch, and Home Screen Shortcut support.L60 Ultra PE (Performance Edition) — The Intelligent Step-Up. An upgraded everyday performer for homes that need an extra boost on hair pickup, with 30,000Pa Vormax™ Suction, the HyperStream™ Detangling DuoBrush, 3DAdapt™ Obstacle Avoidance, and Smart Pathfinder Technology with 220 object type recognition.L60 Ultra FE (Fine Edition) — The Essential Automated Choice. An entry-level powerhouse delivering the core promise of maintenance-free floor care, with 30,000Pa Vormax™ Suction, TriCut Brush 3.0, Dual Flex Arm Technology, and the full PowerDock™ automation experience.

A Shared Foundation of Premium Performance

Every model in the L60 Series shares a core set of capabilities that set a new baseline for modern robot vacuums, including:

212°F (100°C) ThermoHub™ Mop Self-Cleaning for hygienically clean mop pads after every cycle30,000–35,000Pa Vormax™ Suction across the lineup for powerful pickup on every surfaceDual Flex Arm Technology for adaptive side-brush and mop coverage in corners and along edgesMop Lifting for seamless transitions between hard floors and carpetAutomatic Solution Dispensing for consistent cleaning chemistry without manual refillsThe 8-in-1 PowerDock™ base station, which handles auto-empty, mop washing, hot-air drying, and solution management for truly hands-free operation

L60 Pro Ultra: The Flagship Experience, Redefined for Complex Homes

Leading the lineup is the L60 Pro Ultra, featuring select top-tier specifications optimized for large-scale layouts and complex terrains. It pairs the series’ most capable hardware with Dreame’s most advanced intelligence to deliver a seamless, one-stop cleaning experience that effortlessly tackles stubborn stains across expansive and complex home layouts.

At the heart of the Pro Ultra’s navigation advantage is the 3.46-inch ProLeap™ System, the lineup’s most capable obstacle-crossing system, paired with VersaLift Navigation for cleaning under low-clearance furniture. It is equipped with dual-laser 3D structured light, an AI RGB camera, and LED illumination, enabling it to recognize over 280 types of obstacles — for precise, real-time avoidance in any lighting condition.

The Pro Ultra delivers 35,000Pa Vormax™ Suction alongside the HyperStream™ Detangling DuoBrush, together extracting embedded debris, pet hair, and fine particles from every floor type without tangles or jams. Its Dual Omni-Scrub Mopping with Hot Water system pairs rotating mop pads with a Thermal Mop Pad and ThermoHub™ 212°F (100°C) Mop Self-Cleaning, while the AceClean™ DryBoard minimizes residue — eliminating grease, bacteria, and moisture that cold-water systems simply can’t address. An industry-leading 6,400mAh PowerCore™ Battery provides whole-home coverage on a single charge.

The Pro Ultra’s OmniDirt™ Detection Technology identifies high-soil areas and automatically triggers Mop Rewashing and Floor Remopping for a truly thorough result. Pet-Friendly Care 4.0 adds pet-aware detection and navigation, while Upgraded Intelligent Carpet Cleaning optimizes suction and mop behavior for mixed-flooring homes. Direct Voice Control and app control round out the experience for effortless day-to-day use.

Pricing and Availability

The Dreame L60 Series is available now through the Dreame website and Amazon (L60 Pro Ultra, L60 Ultra, L60 Ultra PE, L60 Ultra FE), with launch-offer pricing through the official website. Customers who purchase on dreametech.com receive a free accessory kit with their order.

L60 Pro Ultra — MSRP $1,399.99 | Launch Offer $1,259.99L60 Ultra — MSRP $1,299.99 | Launch Offer $1,169.99L60 Ultra PE — MSRP $1,099.99 | Launch Offer $879.99L60 Ultra FE — MSRP $999.99 | Launch Offer $749.99

For more information about the L60 Series, visit dreametech.com/pages/l60-series-robot-vacuum.

About Dreame Technology

Established in 2017, Dreame Technology is an innovative consumer product company focused on smart home cleaning appliances with the vision to empower lives through technology. Follow us on Facebook, Instagram, TikTok and Twitter. For more information, please visit https://www.dreametech.com/.

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SOURCE Dreame Technology

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