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DP Technology Announces Nomination of Development Candidate, a CNS Penetrable Lp-PLA2 Inhibitor for Alzheimer’s Disease

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BEIJING, July 8, 2024 /PRNewswire/ — DP Technology, an “AI for Science” paradigm-driven company, today announced the nomination of DPT0416, a novel CNS penetrable small molecule targeting Lp-PLA2, as a preclinical candidate for the treatment of Alzheimer’s disease (AD).

AD is the most frequent cause of dementia (60%~70%), affecting approximately 57 million people worldwide. Neurovascular dysfunction is an early and predominant event in AD development, independent of classic amyloid pathology. Lp-PLA2 is a phospholipase secreted primarily by inflammatory cells, including peripheral macrophages and CNS microglia. It hydrolyzes oxidized phospholipids typically on low-density lipoprotein (LDL), producing lysophosphatidylcholine (lysoPC) and other potent proinflammatory factors. LysoPC is a key inflammatory mediator on vascular endothelial cells, causing vascular pathology including vessel leakage and BBB damage. The inhibition of Lp-PLA2 by Rilapladib significantly slowed down AD progression and repaired BBB damage in a Phase IIa trial.

DPT0416 is a novel CNS-penetrable Lp-PLA2 inhibitor, exhibiting higher potency, better ADME and physicochemical properties than Rilapladib. In animal models, DPT0416 showed improvement in BBB integrity and a reduction in brain inflammation. The IND-enabling studies are ongoing.

“Alzheimer’s disease imposes increasing burdens on the world. Approvals of three anti-amyloid β (Aβ) antibodies mark a pivotal moment in the fight against AD, but the modest clinical efficacy and side effects highlight the complexity of AD and call for more novel interventions with better efficacy. The future treatment of AD should address multiple aspects of the disease, including anti-oxidants, anti-inflammation, and enhancing brain resilience, among others,” said Xiaomin Zhang, Head of Drug Discovery at DP Technology. “Targeting Lp-PLA2 is a novel therapy that addresses multiple factors beyond amyloid. Given rilapladib’s positive clinical results, the better molecule DPT0416 is expected to bring more benefits to AD and dementia patients.”

“DP Technology is revolutionizing the AI for Science landscape by integrating ‘AI + Simulation + Experiments’ into our processes to address significant medical needs,” said Weijie Sun, Founder and CEO of DP Technology. “The successful identification of DPT0416 highlights the power of our RiDYMO® platform, particularly the contributions of the Uni-FEP and Uni-QSAR modules in enhancing molecular interactions, drug-like characteristics, and BBB penetration. These real-world applications of our cutting-edge algorithms signify an important progression towards our envisioned future. We look forward to forging partnerships with trusted collaborators to advance this initiative to the next pivotal stage.”

The RiDYMO® drug design platform integrates various AI and physical algorithms, dedicated to the development of drugs for “undruggable” targets and “best-in-class” molecules. As one of its core algorithms, Reinforced Dynamics (RiD) has a significant advantage in the sampling efficiency of molecular dynamics simulation. By fully leveraging the high-dimensional representation capabilities of neural networks, RiD can efficiently capture dynamic conformational changes in complicated biomolecular systems.

The RiDYMO® platform is dedicated to studying the dynamics of biological systems and revealing cryptic binding sites, encompassing a range of challenging systems including protein-protein interactions (PPIs), intrinsically disordered proteins (IDPs), membrane proteins, RNA, and others. Its effectiveness has been confirmed through validation on challenging targets, including the c-Myc protein, c-Myc RNA, GPX4 protein, Kv1.3 protein, and others.

About DP Technology

DP Technology, an “AI for Science” new paradigm-driven company, dedicated to applying Artificial Intelligence and Molecular Simulation algorithms to solve important scientific problems by combining advanced computational methods.

Relying on DP Technology’s Dynamics-based drug design platform, RiDYMO®, we have set up a world-leading hit discovery platform. The team has established external collaborations and built up strong internal pipeline, focusing on three areas of CNS, oncology and autoimmune diseases.

For collaboration and further information,please contact Dr. Xiaomin Zhang (zhangxm@dp.tech). 

References:
[1] Alzheimers. Dement. 17(Suppl 10), e051496 (2021).
[2] Nat. Med. 25, 270-276 (2019).
[3] Med. Res. Rev. 40, 79-134 (2020).
[4] Alzheimers. Dement. 1, 131-140 (2015).
[5] Diab. Vasc. Dis. Res. 14, 200-213 (2017).

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SOURCE DP Technology

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BMO Named Best Bank in North America, Western U.S. and Transaction Banking in North America by Global Finance

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Recognition highlights BMO’s investment in artificial intelligence, digital innovation and client experience 

TORONTO and CHICAGO and SAN FRANCISCO, June 18, 2026 /CNW/ – BMO today announced it has been recognized by Global Finance with three top honours: Best Bank in North America, Best Bank in the Western United States, and Best Bank for Transaction Banking in North America, spanning the publication’s World’s Best Banks and Treasury & Cash Management Awards programmes.

The recognition reflects BMO’s strength across its North American platform and continued momentum in key markets, as well as its leadership in treasury management, digital payments, artificial intelligence and liquidity solutions.

Together, the awards underscore BMO’s progress in scaling digital capabilities, advancing AI across its operations, and deepening client relationships to deliver more connected, innovative and client-focused banking experiences.

“Team BMO is focused on helping our clients make real financial progress with expert advice, innovative products and services, and world-class experiences,” said Darryl White, CEO, BMO Financial Group. “By integrating AI across our business, we’re personalizing client experiences, augmenting our teams with deeper insights, and automating how we deliver simpler, more proactive support – this recognition reflects our client commitment, the strength of our North American platform, and disciplined execution of our strategy.”

The Global Finance World’s Best Banks awards recognize financial institutions that demonstrate strong financial performance, strategic growth, and innovation in products and services.

“Being named Best Bank in the Western U.S. speaks to the momentum we’re building in key markets and the way our teams are showing up for clients every day,” said Darrel Hackett, U.S. CEO, BMO. “We’re focused on making banking more simple, connected and personal by combining strong local relationships with the scale and capabilities of a leading U.S. bank.”

Across North America, BMO continues to invest in technology and innovation to enhance the client experience – expanding digital capabilities and embedding AI across client engagement, risk management and operations. These investments are driving faster decisions, deeper insights and more connected financial services.

“We’re proud to be recognized for our leadership in transaction banking across North America. Our focus is clear – deliver smarter, faster and more connected treasury and payment solutions for clients,” said Sharon Haward-Laird, Group Head, Canadian Commercial Banking & North American Integrated Solutions, BMO. “By combining innovation, data and AI, we’re helping clients manage liquidity and drive their businesses forward.”

BMO has earned global recognition for AI talent development, reflecting its enterprise-wide approach to building and scaling advanced capabilities. With AI adoption exceeding 96% across employees and intelligent agents supporting frontline and operational teams, AI is embedded across the bank’s businesses. Guided by strong Responsible AI governance, BMO continues to advance AI and quantum innovation through the BMO Institute for Applied AI and Quantum – personalizing client experiences, augmenting teams and automating operations at scale.

To learn more about BMO’s AI and digital-first strategy, please visit: https://www.bmo.com/en-ca/main/about-bmo/our-impact/clients/technology-innovation/.

About BMO Financial Group
BMO Financial Group is the eighth largest bank in North America by assets, with total assets of $1.5 trillion as of April 30, 2026. Serving clients for more than 200 years, BMO provides a broad range of personal and commercial banking, wealth management, global markets and investment banking products and services across Canada, the United States, and select markets globally. BMO is innovating for business value, by deploying and integrating human, digital and artificial intelligence to personalize client experiences, augment teams, and automate its business responsibly. Driven by its purpose, to Boldly Grow the Good in business and life, BMO is committed to driving positive change in the world, and making progress for a thriving economy, sustainable future, and stronger communities.

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SOURCE BMO Financial Group – Communications

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HawkEye 360 Announces New Leadership for Innovative Signal Analysis

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HERNDON, Va., June 18, 2026 /PRNewswire/ — HawkEye 360, Inc. (NYSE: HAWK), the global leader in signals intelligence data and analytics, today announced leadership changes within Innovative Signal Analysis (ISA), now part of HawkEye 360, appointing Cory Peichel as Senior Vice President and General Manager of HawkEye–ISA and Mark Volpi as Vice President and Deputy General Manager.

Cory will serve as the executive leader, responsible for end‑to‑end business performance. Reporting directly to the Chief Operating Officer of HawkEye 360, he will guide mission delivery excellence and serve as the senior customer‑facing executive for HawkEye–ISA. He will also lead the business sectors and functional disciplines responsible for delivering solutions and capabilities to address customer requirements and ensure disciplined execution across all portfolios.

Mark will serve as the deputy, supporting all aspects of strategic execution, operational performance, and customer engagement. His role will reinforce leadership continuity and strengthen alignment across the organization.

Both leaders bring significant technical expertise, deep knowledge of ISA’s mission, and a strong track record across the defense and intelligence community. They played key roles in integrating ISA with HawkEye 360 and have helped guide the organization through its transition to becoming a new public company with HawkEye 360’s IPO in May. Their practical leadership and customer‑focused approach continue to support how our teams adapt and work together in this new phase of growth.

“This leadership transition strengthens our commitment to delivering sophisticated, timely, and high‑confidence analytics to our defense, intelligence, and national security partners,” said Todd Probert, Chief Operating Officer of HawkEye 360. “Cory and Mark’s technical insight, operational discipline, and long‑standing mission focus position HawkEye–ISA for continued growth. Their leadership will help accelerate innovation and expand the value we deliver through advanced analytics and RF data solutions.”

The enhanced leadership structure reinforces HawkEye 360’s dedication to supporting critical national security missions, expanding advanced analytic capabilities, and delivering faster, more accurate insights that empower customers with the information advantage needed to address emerging threats.

We extend our sincere appreciation to ISA’s Founders, Stacy Kniffen and David Stevens, for their leadership and dedication to the defense and intelligence mission. We are grateful that they will continue to support the organization and the commitments we have made to provide world-class solutions to our customers.

About HawkEye 360
HawkEye 360 is equipping defense, intelligence, and national security leaders with mission-critical electronic warfare to enable faster, better decision-making. By detecting, geolocating, and characterizing radio-frequency emissions worldwide, HawkEye 360 delivers trusted domain awareness and early-warning indicators to the US Government and allied partners. Our space-based collection, proprietary signal processing, and AI-powered analytics transform knowledge of RF spectrum into a strategic advantage. Proven by operational mission success, HawkEye 360 is redefining how signals intelligence strengthens national and global security.

Forward-Looking Statements

This press release includes forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release, other than statements of historical fact, are forward-looking statements and represent the Company’s views as of the date of this press release. The words “will,” “expects,” “plans,” “could,” “would,” “believes,” “anticipates,” “intends,” “may,” “continue,” “estimate,” or similar expressions are intended to identify forward-looking statements. The Company has based these forward-looking statements on its current expectations and projections about future events and financial trends that the Company believes may affect its financial condition, results of operations, business strategy, short-term and long-term business operations and objectives and financial needs. These forward-looking statements are subject to a number of assumptions and risks and uncertainties, many of which involve factors or circumstances that are beyond the Company’s control that could affect its financial results. These risks and uncertainties are detailed in the sections titled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in the Company’s final prospectus related to its initial public offering, dated May 6, 2026, and other filings that the Company makes from time to time with the SEC, which are available on the SEC’s website at sec.gov. Moreover, the Company operates in a very competitive and rapidly changing environment. New risks emerge from time to time. It is not possible for management to predict all risks, nor can the Company assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements the Company may make. In light of these risks, uncertainties and assumptions, the future events and trends discussed in this press release may not occur and actual results could differ materially and adversely from those anticipated or implied in any forward-looking statements. Except as required by law, the Company is under no obligation to update these forward-looking statements subsequent to the date of this press release, or to update the reasons if actual results differ materially from those anticipated in the forward-looking statements.

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SOURCE HawkEye 360 Inc.

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The Andersons, Inc. Declares Cash Dividend for Third Quarter 2026

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MAUMEE, Ohio, June 18, 2026 /PRNewswire/ — The Andersons, Inc. (Nasdaq: ANDE) announces a third quarter 2026 cash dividend of 20 cents ($0.20) per share payable on July 22, 2026, to shareholders of record as of July 01, 2026.

This is The Andersons 119th consecutive quarterly cash dividend since listing on the Nasdaq in February 1996.

About The Andersons, Inc.

The Andersons, Inc., is a North American agriculture and renewable fuels company. Guided by its Statement of Principles, The Andersons is committed to providing extraordinary service to its customers, helping its employees improve, supporting its communities, and increasing the value of the company. For more information, please visit www.andersonsinc.com.  

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SOURCE The Andersons, Inc.

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