Preclinical study shows 1.5- to 2-hour increase in total sleep time as Company advances toward clinical development and attracts Chris Brearley, M.D., as Chief Medical Officer

INDIANAPOLIS, Oct. 23, 2026 /PRNewswire/ — Carnyx Therapeutics Ltd. (“Carnyx” or the “Company”), a preclinical-stage biopharmaceutical company developing first-in-class molecular therapeutics for sleep and retinitis pigmentosa, today unveiled CNYX-005, its lead oral sleep candidate, alongside preclinical findings showing increased total sleep time and non-rapid eye movement (NREM) sleep in aged animal models.

In the study, aged rats administered with CNYX-005 showed an approximately 1.5- to 2-hour increase in total sleep time compared to the control arm, driven primarily by increased NREM sleep. Researchers measured sleep architecture using continuous electroencephalography (EEG) monitoring.

“Our objective is not simply to induce sleep, but to investigate whether we can support restorative sleep physiology,” said Carnyx CEO Prof. Patrick Gunning. “The increase in NREM sleep is particularly interesting because it suggests CNYX-005 may influence sleep architecture, rather than simply increasing time asleep.”

NREM sleep is a fundamental component of normal sleep architecture, with deeper stages associated with restorative physiological processes including growth, hormone secretion and tissue repair. Sleep architecture changes with age, including reductions in deep NREM sleep and increased sleep fragmentation.

As Carnyx advances CNYX-005 toward clinical development, veteran drug developer Chris Brearley, M.D., has joined the Company as Chief Medical Officer. Dr. Brearley brings more than 30 years of experience in translational medicine, clinical pharmacology and early-stage drug development, including senior roles at Pfizer, Amgen, and Serono. He has extensive experience designing and overseeing first-in-human and early-stage clinical studies.

“These findings provide important evidence supporting further evaluation of CNYX-005,” said Dr. Brearley. “We are particularly encouraged by the observed increase in NREM sleep as we investigate the candidate’s potential role in restorative sleep. I look forward to helping translate these findings into a rigorous clinical development program and supporting CNYX-005 toward potential clinical evaluation.”

CNYX-005 emerged from research into peptide biology associated with sleep regulation and healthy aging, including research involving Epitalon. CNYX-005 is a distinct therapeutic candidate, and Carnyx is applying medicinal chemistry, pharmacology and drug-development approaches to establish efficacy, safety, and pharmacokinetic profiles.

The U.S. Food and Drug Administration recently reviewed Epitalon and a selection of other peptides for their proposed use in compounding pharmacies. “There is growing scientific and public interest in peptides and their potential applications in health and longevity, often ahead of rigorous clinical evidence,” added Prof. Gunning. “Our focus is on translating promising biology into a formally developed therapeutic candidate through systematic preclinical evaluation and, ultimately, clinical testing.”

In addition to CNYX-005, Carnyx is developing CNYX-001, an investigational candidate for retinitis pigmentosa.

About Carnyx Therapeutics Ltd.

Carnyx Therapeutics Ltd. is a preclinical-stage biopharmaceutical company developing first-in-class molecular therapeutics for sleep and retinitis pigmentosa. The Company is building a proprietary pipeline of novel product candidates designed to address unmet medical needs by translating emerging biology into rigorously developed therapeutics. Its lead sleep program, CNYX-005, is an orally administered candidate currently undergoing preclinical development.

Learn more: https://www.carnyxtx.com/

Cautionary Statement Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning Carnyx Therapeutics’ expectations, plans, outlook, prospects, and product and service offerings, including CNYX-005 and other new product launches and potential clinical developments. Such statements are based upon the current beliefs and expectations of management and are subject to significant risks, uncertainties and changes in circumstances that could cause actual outcomes and results to differ materially. These factors should not be construed as exhaustive. Forward-looking statements speak only as of the date they are made, and Carnyx Therapeutics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. Readers of this press release are cautioned not to rely on these forward-looking statements, since there can be no assurance that these forward-looking statements will prove to be accurate. This cautionary statement is applicable to all forward-looking statements contained in this press release.

Media Contact: bailey@carnyxtx.com 

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/carnyx-therapeutics-unveils-oral-sleep-candidate-cnyx-005-with-preclinical-data-showing-increased-nrem-sleep-302917485.html

SOURCE Carnyx Therapeutics, LTD

YIWU, China, Oct. 22, 2026 /PRNewswire/ — Over the past two years, China’s industrial sewing machine exports have performed particularly well. Taizhou, Zhejiang Province, is China’s largest production and export base for industrial sewing equipment and is widely known as the “sewing equipment capital of China”. Neighboring Yiwu, a global hub for small commodities, has also benefited from this growth, with sewing equipment exports gaining momentum. Yiwugo.com, the official website of the Yiwu Commodity Market, is the largest commodity wholesale market in the world. Data from Yiwugo confirms this trend. Over the past two years, bulk buyers from Africa and Southeast Asian countries such as Cambodia and Bangladesh have significantly increased their searches for and purchases of industrial sewing machines. Meanwhile, young people in Europe and the US are increasingly embracing Chinese-inspired lifestyles, and DIY fabric crafts are gaining popularity. As a result, demand for a range of home-use automatic sewing machines and mini portable sewing and embroidery machines has also climbed clearly.

Zhang Baoshun, founder of Yiwu Baochuang Sewing Equipment Co., Ltd., has over 20 years of experience in the production and R&D of industrial sewing machines for bulk orders. His brand Qiafeng has established a presence in markets around the world. According to Zhang, the company draws on professional technical expertise from both home and abroad for its R&D on automation units and intelligent industrial control systems. It also provides follow-up maintenance and equipment upgrades, giving bulk buyers greater confidence and peace of mind when making large-scale purchases. The company now holds more than 20 patents and over 100 software copyrights, underscoring its R&D capabilities.

Following the recent Canton Fair, a number of overseas buyers found Baochuang Sewing through Yiwugo. The company tailors production lines and production schedules to each client’s specific requirements. It is currently in discussions with prospective customers to finalize order details. Preliminary estimates suggest that the company’s overseas custom orders will increase by about 20% this year compared with last year.

Zhang noted that since 2024, changes in the global economic landscape and shifts in industrial layouts have prompted many apparel brands to relocate their production lines to countries and regions across Southeast Asia and Africa. Previously, through the Yiwu market and the Yiwugo platform, Baochuang had already become a supplier of industrial sewing machines to a number of well-known domestic and international brands including CK, ERKE and Puma. With the relocation of manufacturing to new regions over the past two years, local workers have often lacked the technical skills and productivity needed to meet manufacturers’ demands to cut costs, raise efficiency and increase automation, which is exactly why Baochuang’s near-unmanned industrial sewing machines have proven very popular in these markets. With these machines, a single worker can operate six machines simultaneously, while each sewing machine turns out more than twice the output of a traditional one. Baochuang’s customized machines help workers achieve production targets more quickly and efficiently. Puma alone orders more than 100 of Baochuang’s new industrial sewing machines each year, and the annual value of orders between the two companies is currently around RMB 4 million.

Through technological innovation, Baochuang has developed industrial sewing machine solutions that solve problems such as inconsistent product quality caused by manual operations, securing partnerships with factories supplying several major brands.

Unlike Baochuang’s founder, Zhou Qiyun began his career as a shirtmaker before moving into technical work on sewing, and eventually established Yiwu Meizhen Sewing Equipment Company. Over 35 years, he has completed the shift from machine user to machine maker, which is precisely why he understands the practical challenges faced by sewing machine users. Drawing on this experience, the company has built a strong edge in modifying specialized sewing machines and in producing fully and semi-automatic conventional machines for a wide range of domestic and international markets.

Zhou said that since 2025, nearly 90% of the company’s orders have come from overseas markets, with Africa recording the fastest growth. Many overseas customers first connected with Meizhen through trade shows and advertisements on Yiwugo. As more manufacturing operations set up in Africa, buyers there are increasingly purchasing a wide range of sewing equipment in bulk. In the Indonesian market, buyers are gradually upgrading from conventional sewing equipment to semi-automatic and fully automatic machines. Not long ago, Meizhen delivered a batch of sewing machines worth over RMB 5 million for an Indonesian government procurement project. As part of the project, the Indonesian government even sent four technical personnel to Meizhen for training in the daily operation and maintenance of the new machines.

Meizhen’s technical expertise and after-sales services, including worker training, are key factors behind many customers’ decisions to choose the company. In addition, the expertise of Zhou Qiyun and his technical team also enable Meizhen to offer a comprehensive range of sewing equipment and customize machines to meet specialized requirements. In one instance, an overseas handicraft workshop needed a sewing machine capable of producing headpieces and beaded chains. Under Zhou’s leadership, the team quickly developed a specialized machine to meet the customer’s needs. Impressed by the result, the customer signed an order worth nearly RMB 1 million on the spot.

The global economic landscape continues to undergo profound changes, reshaping trade flows, industrial footprints and consumer preferences. Yet the merchants on Yiwugo and in the Yiwu market remain firmly rooted in their mission: delivering small commodities and small equipment that offer the best-value and meet buyers’ needs to customers all over the world. This steadfastness is not about resisting change. Rather, it reflects a simple yet enduring conviction: service must stay one step ahead of customer needs, and value is created when people work together. The world will become a place of greater opportunity and possibility because of a collaboration in which each party plays to its strengths and creates value together. Perhaps this is one of the most meaningful aspects of China‘s sewing industry expanding onto the global stage.

View original content to download multimedia:https://www.prnewswire.com/news-releases/report-on-chinas-sewing-equipment-exports-from-manufacturing-hub-to-capability-exporter-302917576.html

SOURCE Yiwugo.com

Latest additions to Getac’s flagship B360 lineup boast advanced Intel® Core™ Ultra Series 3 processors and an expanded 14-inch screen, alongside enhanced security and extensive connectivity options.

News in brief:

Getac’s new B360X and B360X Pro feature powerful Intel® Core™ Ultra 5/7/X7 Processors with compute power of up to 180 TOPS*, for exceptional AI-powered performance at the edge.Other key features include a large 14-inch WUXGA LumiBond display (1,400 nits), Wi-Fi 7 and Bluetooth 6, customisable I/O ports, and Windows Hello Camera as standard.The B360X and B360X Pro are ideally suited to defence, public safety, utilities and manufacturing professionals working in environments where reliable connectivity to cloud-based AI models isn’t readily available.

TAIPEI, Oct. 23, 2026 /PRNewswire/ — Getac Technology Corporation (Getac), a leading provider of rugged computing and mobile video solutions and a manufacturer with advanced in-house capabilities, today announced the launch of its next generation B360X and B360X Pro fully rugged notebooks.

Both new devices build on the proven heritage of Getac’s popular B360 series, offering upgraded AI-powered processing, a larger 14-inch screen size, enhanced security, and comprehensive connectivity options, all in a compact and portable form factor. This makes them ideally suited to frontline professionals in industries such as public safety, utilities, manufacturing and defence, who need powerful yet versatile devices to accomplish complex tasks in a diverse range of field environments.

Superior AI-powered performance at the edge

At the heart of the new B360X and B360X Pro is the powerful new Intel® Core™ Ultra 5/7/X7 Processor** (Series 3) with Intel® Graphics and Intel® AI Boost technology, which delivers exceptional performance for multitasking, data-intensive workloads, and AI-enhanced applications, even when connection to the cloud isn’t available.

Both devices also feature a 14-inch WUXGA LumiBond display with Getac Sunlight Readable Technology (1,400 nits) for superior legibility and usability, while the capacitive touchscreen can be operated even when wearing gloves or working in the rain.

Enhanced versatility, connectivity, and security

Designed for exceptional versatility in the field, the B360X and B360X Pro boast an array of connectivity options, including Wi-Fi 7 and Bluetooth 6 as standard, along with optional dedicated GPS with L1/L5, 4G LTE and 5G Sub-6 and SA as needed. Customers can also choose from a range of customisable I/O port configurations including up to two Thunderbolt™ 4 Type-C ports for high-speed data transfer, while the dual battery with hot-swappable capability allows for extended use in the field between charges.

The B360X and B360X Pro also feature enhanced security, including Windows Hello Camera (via a 5MP front facing camera), TPM 2.0, a smart card reader, a user replaceable PCIe NVMe SSD, and Getac Disk Wipe as standard. Optional upgraders include a second SSD (allowing for up to 4TB of total storage via two 2TB drives), an HF RFID reader, and a fingerprint reader.

Fully rugged protection

Like all Getac fully rugged devices, the B360X and B360X Pro are built to thrive in harsh and challenging work environments. Featuring MIL-STD-810H, MIL-STD-461G and IP66 certifications, as well as 6ft (1.8m) drop resistance while in use, they excel where many other devices would fail. Optional salt fog certification is also available if required.

B360X Pro: Mission ready computing in a compact form factor

In addition to all the above, the B360X Pro includes dual high-capacity batteries as standard, while an optional NVIDIA® RTX PRO 500 Blackwell discrete graphics controller takes visuals to the next level without impacting processing performance. The B360X Pro also features an optional media bay, which can accommodate a third battery or a DVD drive as required.

The ultimate companion devices for professionals working in extreme conditions

The B360X and B360X Pro’s combination of powerful edge AI computing, fully rugged reliability and portable form factor make them ideally suited to professionals who regularly work in extreme environments and scenarios where reliable internet connectivity isn’t available:

Public safety & emergency rescue: In disaster zones where communications are completely severed, the B360X can transform into an independent tactical command hub, integrating Computer-Aided Dispatch (CAD), Geographic Information Systems (GIS), and Automatic Vehicle Location (AVL) through advanced edge computing software.Military & defence: In environments where connectivity is unavailable, the B360X Pro can effortlessly run high-workload military training and simulation platforms, utilising edge AI computing to generate virtual enemy behavioural logic and tactical simulation models.Utilities & industrial manufacturing: Deep within signal-dead zones such as remote transmission towers, underground pipelines, or complex factory blind spots, the B360X can seamlessly execute CAD software and 3D modelling workflows at the local level, for precise asset installation and complex maintenance activity.

“The true value of Artificial Intelligence is not realized in climate-controlled server rooms, but at the absolute edge, where critical decisions shape our global safety, defence, and infrastructure,” says James Hwang, President of Getac Technology Corporation. “With the B360X and B360X Pro, Getac is tearing down the environmental boundaries of computing. We are ushering in a new era of ‘Intelligent Resilience,’ ensuring that those who protect and build our world have uninterrupted access to next-generation AI, regardless of how extreme or disconnected their environment may be. We are not just anticipating the future of the rugged industry; we are actively defining it.”

The B360X and B360X Pro will be available in November 2026. For more information, please visit www.getac.com

*Units equipped with Intel® Core™ Ultra X7 processor support up to 180 TOPS total compute performance.
**Intel® Core™ Ultra X7 Processor only available on B360X model

About Getac

Getac Technology Corporation is a global leader in AI-capable rugged mobile technology and intelligent video solutions, including laptops, tablets, software, body-worn cameras, in-car video systems, digital evidence management and enterprise video analytics solutions. Getac’s solutions and services are designed to enable extraordinary experiences for frontline workers in challenging environments. Today, Getac serves customers in over 100 countries spanning defence, public safety, ambulance, fire & rescue, utilities, automotive, natural resources, manufacturing, transport, and logistics. Getac was recognized as one of Newsweek’s “World’s Most Trustworthy Companies” for 2024. For more information, visit: https://www.getac.com. Participate in the Getac Industry blog or follow the company on LinkedIn and YouTube. 

Getac and Getac logo are trademarks of Getac Holdings Corporation or its affiliates. Other brands or trademarks are the property of their respective owners. ©2026 Getac Technology Corporation.

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/getacs-next-generation-b360x-and-b360x-pro-fully-rugged-notebooks-bring-the-power-of-edge-ai-to-frontline-professionals-302907295.html

SOURCE Getac Technology Corporation