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Differentia Biotech Launches Cutting-Edge Autoimmune Disorder Platform Combining AI/ML with QSP

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Groundbreaking Platform First Applied to Rare Autoimmune Disorder, IgG4-RD to Uncover New Treatment Targets

SOUTH SAN FRANCISCO, Calif., Aug. 22, 2024 /PRNewswire-PRWeb/ — Differentia Biotech, a leader in model-informed drug development, is proud to announce the launch of its innovative autoimmune disease platform. This platform integrates Artificial Intelligence and Machine Learning (AI/ML) with Quantitative Systems Pharmacology (QSP) extracting disease understanding by combining insights from patient-specific multiomics datasets and literature. This pioneering platform marks a significant advancement in the understanding and treatment of autoimmune diseases, enabling target identification and validation, lead optimization, biomarker discovery and clinical trial design.

The first application of Differentia Biotech’s platform focuses on IgG4-Related Disease (IgG4-RD), a rare and often misdiagnosed autoimmune disorder, for which specific treatments are currently missing due to insufficient understanding of its underlying mechanisms. Differentia Biotech has successfully developed a comprehensive disease model of IgG4-RD that maps the inter-cellular communication network among key immune cells. This model elucidates the dynamic interactions in healthy homeostasis and in the context of IgG4-RD, revealing the distinctive immune system characteristics associated with the disease state. Differentia Biotech utilized this platform to evaluate various therapeutic interventions via fast and scalable simulations and has identified targets that effectively shift the disease state towards healthy homeostasis. This innovative approach promises to transform the landscape of autoimmune disease treatment by providing deeper insights into disease mechanisms and accelerating the discovery of effective therapies.

Key Features of the Differentia Biotech’s Autoimmune Disorder Platform:

Advanced AI/ML Integration: Utilizes state-of-the-art machine learning algorithms to analyze complex multi-omics biological data, uncovering patterns and insights that are not discernible through traditional methods.Quantitative Systems Pharmacology (QSP): Employs sophisticated mathematical models to simulate disease processes and drug interactions at a systems level, enabling precise identification of potential therapeutic targets.First Application – IgG4-RD: The platform’s success with IgG4-RD underscores its potential to tackle other challenging autoimmune diseases. The IgG4-RD model has already started yielding promising targets for new treatments.

“Differentia’s modeling platform was instrumental in our study of IgG4-RD patients for clinical insights,” said Dr Hui Gao from Department of Rheumatology, Peking University International Hospital and Dr. Cuiping Pan from the Center for Intelligent Medicine Research. “It helped to uncover complex immune interactions in the patients, revealing enhanced B-cell proliferation and differential regulation of cytokines in T-cell subsets. Furthermore, we utilized Differentia’s platform to model treatment effects of numerous immune therapies, e.g., anti-CD20 B cells, anti-IL4, and anti-IL6, which had been previously shown beneficial in treating other autoimmune diseases. We are now designing clinical trials to validate the off-label use of these drugs for treating IgG4-RD. The collaboration with Differentia helped us to prioritize drug candidates with a mechanistic understanding, which accelerated the development of treatment strategies for the patients. We are hopeful that these prioritized drugs will have a therapeutic impact in this field.”

“We are thrilled to introduce this groundbreaking platform, which represents a new era in the fight against autoimmune disorders,” said Kas Subramanian, CEO of Differentia Biotech. “By combining the predictive power of AI/ML with the robust analytical capabilities of QSP, we are not only enhancing our understanding of these complex diseases but also paving the way for the development of more effective treatments.”

Differentia Biotech invites biotech and pharmaceutical companies and research organizations with a focus on autoimmune diseases to explore the potential applications of this platform to their specific areas of interest. By partnering with Differentia Biotech, stakeholders can leverage this powerful tool to drive their research and development efforts towards groundbreaking discoveries and innovative therapies.

For partnership inquiries and more information about Differentia Biotech’s autoimmune disorder platform, please contact:

Lorenz Huebner

V.P. Customer Solutions

Differentia Biotech

lorenz.huebner@differentiabio.com

Ph: +49 151 290 35213

www.differentiabio.com

About Differentia Biotech:

Differentia provides modeling and simulation services to biopharmaceutical companies delivering knowledge-based insights to improve drug development outcomes. Backed by Differentia’s proprietary data pool and cutting-edge AI/ML analytics, we empower biopharmaceutical companies to accelerate drug development and shape the future of healthcare.

Media Contact

Lorenz Huebner, Differentia Biotech, 49 151 290 35213, lorenz.huebner@differentiabio.com, www.differentiabio.com 

View original content:https://www.prweb.com/releases/differentia-biotech-launches-cutting-edge-autoimmune-disorder-platform-combining-aiml-with-qsp-302226178.html

SOURCE Differentia Biotech

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eSign.AI Named Sole Electronic Signature Technology Provider for Hong Kong Government’s CorpID Project, Building the Foundation for Digital Signing Infrastructure in Hong Kong

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HONG KONG, May 8, 2026 /PRNewswire/ — As Hong Kong’s Digital Corporate Identity Platform (CorpID) counts down to its phased launch, eSign.AI has been appointed as the sole electronic signature vendor in the project, responsible for delivering core digital signing capabilities including digital signatures, certificate management, and signature verification services. CorpID is led by Nexify, a seasoned government systems integrator, as the prime contractor. The platform is expected to launch in phases starting late 2026, with multiple CorpID-based e-government services going live in mid-2027.

CorpID: Government-Grade Digital Identity Infrastructure for Hong Kong Enterprises

The Digital Corporate Identity Platform (CorpID) is an enterprise-level digital services platform launched by the Hong Kong SAR Government, developed under the oversight of the Digital Policy Office (DPO). It is designed to serve as the business equivalent of “iAM Smart,” providing a unified digital identity foundation for Hong Kong enterprises. CorpID’s core mission is to build an integrated digital government infrastructure — offering unified identity authentication, digital signing, form pre-filling, and e-licence storage — replacing paper-heavy, cumbersome traditional processes and enabling smart city development through seamless data connectivity.

The platform is open to companies incorporated under the Companies Ordinance (Cap. 622) and businesses registered under the Business Registration Ordinance (Cap. 310), including sole proprietorships and partnerships. The DPO requires all enterprise-related e-government services to support CorpID within 18 months of launch, and will continue expanding ecosystem coverage through sandbox initiatives, cross-industry identity standard interoperability, and fully online registration processes.

eSign.AI: The Digital Signing Engine Behind CorpID

eSign.AI is an AI-native electronic signature and contract automation platform built for enterprises worldwide, offering a complete signing framework from simple electronic signatures to the highest-level compliant digital signatures — meeting diverse regulatory requirements across industries and jurisdictions.

On the identity verification front, eSign.AI has completed integration with iAM Smart, enabling individual identity verification through Hong Kong’s citizen digital identity system, and providing legally valid digital certificate services for both enterprises and individuals.

Looking ahead, the eSign.AI SaaS platform will be deeply integrated with CorpID, providing enterprise and individual identity verification for Hong Kong businesses, and supporting both electronic and digital signing that complies with Hong Kong’s Electronic Transactions Ordinance — connecting the full digital contracting lifecycle for government and enterprise alike.

Getting Ahead of the AI Era: From eSignGlobal to eSign.AI

The electronic signature industry is undergoing a structural shift from “tooling” to “intelligence.” Market data underscores this acceleration: the AI-powered contract analysis tools market has grown from USD 3.32 billion in 2025 to USD 4.3 billion in 2026, at a CAGR of 29.6%. Signing is just one node in the contract lifecycle — document generation, workflow orchestration, compliance tracking, and post-execution management are all being transformed by AI, and the industry window is closing fast.

In April 2026, the company officially rebranded from eSignGlobal to eSign.AI, completing its strategic transformation from an e-signature tool provider to an AI-native contract automation platform. As the company’s spokesperson noted, this rebrand is not cosmetic — it is an acknowledgment of where the product actually is. Customers were already using eSign.AI to automate workflows that go far beyond the signature itself.

eSign Automation Skill was launched alongside the rebrand — an AI-powered signing automation framework for enterprise workflows that enables complete contract signing through natural language interaction, with no manual intervention required. Whether it is single-party approval, multi-party sequential signing, or large-scale parallel execution, an AI Agent can orchestrate the entire workflow in a single call. All signature initiations and status queries return structured JSON outputs, directly parseable by leading large language models and intelligent workflow systems.

eSign Automation is now available in the OpenClaw ecosystem and supports integration via Claude MCP, ChatGPT, and other leading AI platforms.

By combining AI automation capabilities with CorpID’s government-grade digital identity infrastructure, eSign.AI delivers a complete solution for Hong Kong enterprises — from identity verification to intelligent signing to full workflow automation.

About eSign.AI

eSign.AI (formerly eSignGlobal) is an AI-native electronic signature and contract automation platform built for enterprises worldwide. The platform serves over 100 countries and regions, covering core industries including financial services, manufacturing, real estate, human resources, and healthcare — with 1,500+ scenario applications and 3,000+ ecosystem partners. eSign.AI holds ISO 27001, ISO 27701, and ISO 27018 certifications and supports major regulatory frameworks including the U.S. ESIGN Act / UETA, EU eIDAS, HIPAA, GDPR, and 21 CFR Part 11. Infrastructure is anchored by independent data centers in Hong Kong, Singapore, and Frankfurt, Germany.

View original content:https://www.prnewswire.com/apac/news-releases/esignai-named-sole-electronic-signature-technology-provider-for-hong-kong-governments-corpid-project-building-the-foundation-for-digital-signing-infrastructure-in-hong-kong-302766763.html

SOURCE eSignGlobal

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The 9th AskGamblers Awards Finalists Announced as Voting Starts

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The highly anticipated 9th AskGamblers Awards has officially moved into the voting phase. Following a rigorous selection process, the finalists across 5 premier categories have been revealed: Best Casino, Best New Casino, Best New Slot, Best Sportsbook, Best Provider. Players are invited to cast their votes until 11 June.

BELGRADE, Serbia, May 8, 2026 /PRNewswire/ — The voting stage of the 9th annual AskGamblers Awards has officially begun. The list of finalists is announced, and the first votes are already coming in. 

Players will have a chance to vote for their favourites until 11 June, when the winners will be announced at the gala ceremony in Belgrade. There’s a total of 5 categories where popular votes are taken into consideration:

Best CasinoBest New CasinoBest SportsbookBest New SlotBest Game Provider

There aren’t any big changes to the voting process compared to last year. The votes from the prominent members of AskGamblers Forum will be counted in as well, while some award winners will be announced directly by the AskGamblers teams. 

These include: Best Crypto Casino, Best Partner, and Best Manager categories, while the AskGamblers Superstar Award is expected to be handed to the operator that illustrates the brand values best.

Dijana Radunović, General Manager at AskGamblers, is excited for voting to start: “We’re seeing some familiar contestants, but there are a lot of new names, so it will be exciting to see who comes up on top.”

“We invite players to vote for their favourites! This is a chance for you to speak your mind and support operators and games that shape this industry,” Radunović added.

Before the AskGamblers Awards Ceremony that takes place on 11 June, Charity Night is scheduled for 10 June.

About AskGamblers

AskGamblers.com strives to provide current, objective, and accurate information and guide its users towards a safe gaming experience. The way we deliver our services, from the online casino, sportsbook, slot, and bonus reviews to our trusted Complaint Service, is best described by our motto: ‘Get the truth. Then play.’

For more information about AskGamblers and AskGamblers Awards, please contact dijana.radunovic@g2m.com.

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/askgamblers/r/the-9th-askgamblers-awards-finalists-announced-as-voting-starts,c4346370

View original content:https://www.prnewswire.co.uk/news-releases/the-9th-askgamblers-awards-finalists-announced-as-voting-starts-302766772.html

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SUNMI Wins 2026 Red Dot Design Awards with Five Products, Leading Global Commercial Industrial Design

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SINGAPORE, May 8, 2026 /PRNewswire/ — The winners of the 2026 German Red Dot Design Award were officially announced. Five of SUNMI Technology’s flagship products won awards: the CPad Business Tablet, CPad PAY, FLEX 3 Interactive Display, the V3 handheld POS Terminal and L3 Industrial PDA. These products stood out with three core design concepts: integration, versatility and human-centricity.

Known as “The Oscars” of global industrial design, the Red Dot Award has strict evaluation criteria covering aesthetics, ergonomics, scenario adaptability and sustainability. SUNMI adheres to original commercial scenario customization, rejecting crudely modified consumer devices. All winning products are originally developed for real commercial scenarios such as cash register, food delivery, industrial inspection and store operations, covering the entire commercial track with high scenario adaptability. Meanwhile, it practices ESG concepts, adopting eco-friendly materials and modular structures to extend equipment service life, reduce consumable consumption, and implement low-carbon and long-term design, which perfectly meets the Red Dot’s sustainability evaluation criteria.

Simplify Complexity: With highly integrated design, SUNMI eliminates the “patchwork feeling” of cluttered devices and tangled cables in traditional commercial scenarios, streamlining store operations and saving space.All-in-One Versatility: Beyond a single tool function, SUNMI’s products achieve flexible transformation through modular and multi-form designs to proactively adapt to changing business needs. The CPad series with modular accessories and FLEX 3’s Lego-style modular design enable multi-scenario application and long-term reuse.Human-Centric Design: Every detail is human-oriented, focusing on real pain points to enhance scenario experience. The L3 Industrial PDA reduces high-frequency work fatigue through scientific weight distribution; the V3 Smart POS Terminal balances large-screen visibility and grip comfort; CPad PAY integrates full-link functions to simplify workflows.

These honors stem from SUNMI’s long-term commitment to a sustainable society, original commercial R&D and ESG. In the future, SUNMI will uphold its core concepts, expand the boundaries of commercial industrial design, and empower global businesses with user-oriented, eco-friendly and high-value products.

Logo – https://mma.prnewswire.com/media/2081156/sunmi_Logo.jpg

View original content:https://www.prnewswire.co.uk/news-releases/sunmi-wins-2026-red-dot-design-awards-with-five-products-leading-global-commercial-industrial-design-302766777.html

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