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21st.BIO obtains self-affirmed GRAS status for its precision fermented beta-lactoglobulin: 21st.BIO customers can now enter the U.S. market with their own production using 21st.BIO technology

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21st.BIO has earned a self-affirmed GRAS status for its animal-free beta-lactoglobulin ingredient, which customers can now launch in the United States market.21st.BIO is helping customers bring products to market at an unprecedented pace, from initiation of development to market approval in under two years.21st.BIO offers the leading production technology for BLG, based on precision fermentation technology that has been perfected over decades and partly licensed from Novonesis (formerly Novozymes).By studying the variation in cows’ milk protein, 21st.BIO’s world class scientists have been able to reproduce a highly nutritious recombinant BLG, which is the most potent bovine whey protein and has superior nutrition and functionalities. This is why 21st.BIO has named its protein BLG Essential+™.

COPENHAGEN, Denmark and DAVIS, Calif., Sept. 4, 2024 /PRNewswire/ — Precision fermentation platform provider 21st.BIO has earned a self-affirmed GRAS status for its animal-free beta-lactoglobulin ingredient, BLG Essential+™, which means customers can now launch in the United States market.

This breakthrough comes less than two years after 21st.BIO initiated its development of a strain and production process for its beta-lactoglobulin protein, BLG Essential+™, demonstrating the power of the Company’s approach, unique expertise and differentiated precision fermentation platform.

Beta-lactoglobulin is a potent and highly nutritious dairy protein  

The predominant protein in bovine whey, beta-lactoglobulin (BLG) has attracted considerable food-producer interest for its high-quality nutrition and advantageous properties in food product formulation.

Its nutritional profile is impressive, boasting a larger amount of essential and branched-chain amino acids than whey. For example:

BLG contains 45% more leucine than commercially available whey protein isolates, which is particularly important for muscle synthesis.BLG is tasteless, stable across a wide pH range and can tolerate heat, making it the ideal ingredient for versatile product formulations, from clear protein drinks to alternative dairy or bakery products.

21st.BIO expects its customers’ own production of beta-lactoglobulin to be incorporated into the formulation of foods such as baked goods and alternative dairy products, as well as nutritional products for active or sports nutrition, weight management, and clinical and elderly nutrition.

Unique business model: One market approval for several dairy protein suppliers 

Companies engaged in 21st.BIO’s unique development program can now commercialize their own production of BLG Essential+™ in the U.S. market. Through 21st.BIO’s BLG program, customers gain access to the world’s most advanced production strains and precision fermentation processes – and optimizations over time. Furthermore, 21st.BIO is supporting customers in upscaling their production all the way to full-scale ingredient production. The Company’s diverse global customer base spans food-tech start-ups to large food ingredients manufacturers. BLG Essential+™ is the first food protein out of a portfolio of protein ingredients that 21st.BIO will take to the market via this model. 

21st.BIO gets solutions to market at an unprecedented pace 

With a strong track record and productive microorganisms licensed from Novonesis (formerly Novozymes), 21st.BIO is bringing solutions to market at an unprecedented pace, enabling customers to bypass years of development and market approval for direct entry into the U.S. market and empowering customers to produce any food, materials, agriculture, or biopharma-related protein or peptide of interest, and scale production to industrial levels to ensure large-scale availability and cost-effectiveness. Customers in 21st.BIO’s development programs benefit from continuous optimizations of strain and process for improved commercial attractiveness.

Comprehensive support every step of the way to get products to market 

“We bring our customers access to technology and skills they could not get anywhere else,” said 21st.BIO co-founder and CSO Per Falholt. 

And 21st.BIO co-founder and CEO Thomas G. Schmidt continues: “We’re not just a technology provider – we’re a partner to our customers’ on their product journey, ensuring their success from development to full-scale manufacturing. We make products, not projects. Our ambition is to empower our customers to focus more on application, business development, low-cost production and innovation. And this shows all the way through our business model, which is designed such that our success at 21st.BIO depends on our customers’ success in the market with a product; not just on project completion.” 

21st.BIO derisks product development and supports customers from strain development, fermentation processes, purification protocols, pilot production and upscaling guidance, to the regulatory approvals for market entry. 21st.BIO is working on additional proteins, including proteins for both foods, materials, agriculture and beyond.

NOTES TO EDITORS 

About 21st.BIO  

21st.BIO was founded with one simple mission: to make leading industrial scale precision fermentation technology accessible to as many as possible, so companies can successfully take biotech innovations to market at a competitive price. 21st.BIO’s founders saw that too often, great bio innovation and molecules fail to translate into commercial success. The innovation is ready, the market is there, but production costs remain too high for the product to go mainstream. Industry insiders call it the `valley of death’, and that’s exactly what 21st.BIO intends to bridge. 

Founded in 2020, 21st.BIO is headquartered in Copenhagen, Denmark, and has a world-class R&D team as well as laboratories in both Copenhagen, Denmark and Davis, California. On a mission to support bio industrial companies globally in upscaling from molecule innovation to large-scale production, 21st.BIO enables its customers to meet market demands, and thereby advance the green transition globally. 21st.BIO focuses on developing industrial production technology for proteins and other molecules of interest for food, materials, and agricultural industries. Established as a fully integrated end-to-end partner, 21st.BIO supports its customers from technical assessment, strain development and optimization, production processes and upscaling, tech transfer to large scale manufacturing and regulatory services.  

21st.BIO’s fermentation technology is in part licensed from Novonesis, who have developed and perfected their platform over several decades. Novonesis is a global leader in enzymes, functional proteins and microorganisms for high value products in food, household care, and agriculture.  

Press contact:
Mathilde Pinon
Marketing & Business Development Manager
m.pinon@21st.bio

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/21st-bio/r/21st-bio-obtains-self-affirmed-gras-status-for-its-precision-fermented-beta-lactoglobulin–21st-bio-,c4032851

The following files are available for download:

https://mb.cision.com/Main/22992/4032851/2980200.pdf

Press release (PDF)

https://news.cision.com/21st-bio/i/21st-bio-pilot-plant-facility,c3330348

21st BIO pilot plant facility

https://news.cision.com/21st-bio/i/21st-bio-strain-engineering,c3330346

21st BIO strain engineering

https://news.cision.com/21st-bio/i/21st-bio-fermentation,c3330347

21st BIO fermentation

https://news.cision.com/21st-bio/i/21st-bio-co-founders,c3330349

21st BIO co-founders

https://news.cision.com/21st-bio/i/per-falholt-co-founder-and-cso-21st-bio,c3330350

Per Falholt co-founder and CSO 21st BIO

https://news.cision.com/21st-bio/i/thomas-schmidt-co-founder-and-ceo-21st-bio,c3330351

Thomas Schmidt co-founder and CEO 21st BIO

https://news.cision.com/21st-bio/i/21st-bio-hq-in-copenhagen,c3330353

21st BIO HQ in Copenhagen

https://news.cision.com/21st-bio/i/21st-logo-dot-pink,c3330352

21st logo dot pink

 

View original content:https://www.prnewswire.co.uk/news-releases/21stbio-obtains-self-affirmed-gras-status-for-its-precision-fermented-beta-lactoglobulin-21stbio-customers-can-now-enter-the-us-market-with-their-own-production-using-21stbio-technology-302237720.html

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Air and Fathom5 Partner to Modernize Naval Fleet Readiness

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ARLINGTON, Va. and AUSTIN, Texas, July 20, 2026 /PRNewswire/ — Air, the leader in Enterprise Readiness, and Fathom5, a technology company dedicated to secure infrastructure for AI-powered machines, today announced a strategic partnership to transform the U.S. Navy’s maintenance, repair, and overhaul (MRO) capabilities.

The collaboration follows Fathom5’s selection as a winner in the Defense Innovation Unit’s NextMRO Prize Challenge Phase III, which aims to replace antiquated, siloed logistics frameworks with integrated, data-driven software. Fathom5 won based on its ability to transform real-world Navy data into intuitive, sailor-facing applications at the tactical edge.

To scale this solution for enterprise-wide Navy procurement, Fathom5 and Air are uniting Fathom5’s industry-leading, warship-deployed Condition-Based Maintenance AI with Air’s Enterprise Readiness platform. Air’s platform is purpose-built to close the “Readiness Gap”—the dangerous chasm between what the front line needs and what the enterprise delivers. It fuses predictive analytics, supply chain visibility, and repair cycle forecasting into a unified system that operates across Organizational, Intermediate, and Depot maintenance.

Together, the companies will address the Navy’s most critical sustainment vulnerabilities with the ability to:

Eliminate data silos and provide a single, authoritative source of truth.Use natural language to query technical manuals, analyze parts availability, proactively forecast issues, and identify alternative vendors in seconds, andAllow forward-deployed Sailors to execute work orders offline in Degraded, Denied, Intermittent, and Limited (DDIL) environments.

Proven Defense Impact

Air brings a successful track record of optimization across the Department of War. In recent sustainment operations, Air delivered a 99.6% reduction in part identification time, identifying replacement parts and suitable substitutes in minutes instead of days. By accelerating part allocation and replacing manual processes, the platform has saved commands hundreds of down days annually while sustaining 90% equipment readiness across echelons.

“This partnership will be pivotal as we work to close the Readiness Gap,” said Tara Murphy Dougherty, CEO of Air. “Together, Fathom5 and Air are uniquely positioned to accelerate Naval logistics by drastically shortening turnaround times, maximizing asset availability, and executing modern digital workflows at the speed of operational demand.”

“The future of naval readiness depends on giving Sailors the right information at the right time, wherever the mission takes them,” said Zac Staples, Founder and CEO of Fathom5. “By combining Fathom5’s AI-powered Condition-Based Maintenance capabilities with Air’s Enterprise Readiness platform, we’re helping transform maintenance from a reactive process into a predictive, data-driven advantage. Together, we’re enabling a more resilient fleet that can sustain operations in contested environments while keeping more ships mission-ready.”

About Fathom5

Fathom5, headquartered in Austin, Texas, develops secure digital infrastructure and advanced actuator technologies that strengthen the resilience and readiness of complex industrial systems. The company has achieved significant milestones, including delivering the first program-of-record artificial intelligence system deployed aboard a U.S. Navy warship and securing 17 patents across actuator technology and cybersecurity. Through its flagship Nsyte platform, Fathom5 provides secure edge infrastructure for maintenance and readiness applications, enabling advanced analytics and actionable insights at the point of need.  For more information, please visit www.fathom5.com.

About Air

Air, formerly Govini, created Enterprise Readiness, a new category of AI-native systems that close the Readiness Gap, the dangerous chasm between what the front line needs and what the national security enterprise can deliver. Air Enterprise Readiness platform aligns development, production, delivery, and sustainment into one coordinated execution system, revealing true capacity, exposing real constraints, coordinating critical resources, and executing at the speed of operational demands.The result: the national security enterprise has what it needs to succeed. For more information on Air and the Enterprise Readiness platform, visit www.air.ai.

Media Contacts

Fathom5: coleman@zilkermedia.com

Air: media@air.ai and air@weareinvariant.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/air-and-fathom5-partner-to-modernize-naval-fleet-readiness-302829581.html

SOURCE Air

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DoubleLine Paper: Honebuto Shock: Japan Courts a Truss-Like Redux

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TAMPA, Fla., July 20, 2026 /PRNewswire/ — Sell-offs in Japanese Government Bonds (JGBs) and the yen have put Japanese Prime Minister Sanae Takaichi on notice, a DoubleLine paper argues, that Japan’s creditors have little tolerance for her government’s unorthodox proposal for a mixture of unfunded fiscal expansion with docile central-banking. 

Surveying the “Honebuto shock,” so-named after debt-and-yen sell-off following Tokyo’s annual fiscal policy statement, Bill Campbell, head of the DoubleLine’s Global Sovereign & Emerging Markets team, sees parallels to the gilts and British pound revolt over a 2022 proposal for unfunded fiscal expansion by U.K. Prime Minister Liz Truss that swiftly brought down her government.

“Having committed to more than 370 trillion yen of public-private investment through fiscal 2040, the government is calling for monetary policy “in coordination with” that growth agenda,” Mr. Campbell writes. “In the eyes of the financial markets, this demand for the subordination of monetary policy to a political platform only adds fuel to the fire beneath a central bank already under criticism for what critics deem an overly cautious rate-hiking path.”

Mr. Campbell warns, “The Takaichi government should not assume the JGB market, having found its voice, will prove more patient than the gilts market that laid low the Truss government in 2022. In today’s inflationary climate, fiscal credibility is earned, not presumed – even in the G-7 countries. And a G-7 sovereign who embarks on unfunded fiscal expansion risks courting a buyers’ strike.”

The paper, titled “Honebuto Shock: Japan Courts a Truss-Like Redux,” is available here: https://doubleline.com/wp-content/uploads/DoubleLine_Honebuto-Truss-Redux_Campbell_071526.pdf

Mr. Campbell heads the Global Sovereign & Emerging Markets team at DoubleLine and serves as the lead Portfolio Manager for emerging markets and international fixed-income strategies. He is a permanent member of the firm’s Fixed Income Asset Allocation Committee. Mr. Campbell has written extensively in research papers and client briefings on evolving trends and episodic developments in global fixed income and currency markets. He holds a B.S. in Business Economics and International Business, as well as a B.A. in English, from Pennsylvania State University and an M.A. in Mathematics, with a focus on Mathematical Finance, from Boston University.

About the Global Sovereign & Emerging Markets Team

The Global Sovereign & Emerging Markets team at DoubleLine manages $XX billion in assets in sovereign debt, including U.S. Treasuries and non-U.S. sovereign issues, and corporate fixed income securities by issuers domiciled in ex-U.S. developed and emerging markets. The team comprises 14 investment professionals, including portfolio managers, analysts and traders.

About DoubleLine

DoubleLine Capital LP is an investment adviser registered under the Investment Advisers Act of 1940. DoubleLine’s offices can be reached by telephone at (813) 791-7333 or by email at info@doubleline.com. In addition to its headquarters in Tampa, Fla., and an office in Los Angeles, DoubleLine has offices in Dubai, London and Tokyo. Media can reach DoubleLine by email at media@doubleline.com.

DoubleLine® is a registered trademark of DoubleLine Capital LP. 

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SOURCE DoubleLine

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Signeasy expands beyond eSignatures with Intelligent Contract Management for growing businesses

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The platform combines eSignatures, AI-powered contract insights, renewal tracking, and a centralized contract repository to help businesses manage contracts from signature to renewal.

DALLAS, July 20, 2026 /PRNewswire/ — Signeasy today announced its Intelligent Contract Management platform, extending its product capabilities into every stage of the contract lifecycle. The platform gives Finance, Legal, Sales, HR, Procurement, and Operations teams one place to sign, manage, and get insights from every contract.

For most growing businesses, the real work starts after a contract is signed. Renewal dates, payment terms, obligations, and key clauses end up scattered across inboxes, shared drives, and spreadsheets. Without a large legal operations team, keeping track of them is manual, reactive work.

Signeasy’s Intelligent Contract Management platform closes this gap. It brings eSignatures, a contract repository, and contract intelligence into one platform.

“Contracts touch every part of a business — Finance, Legal, Sales, HR, Procurement, Operations — but the tools to effectively manage them have always been built for enterprise legal teams. We built Intelligent Contract Management so lean teams get the same contract visibility and intelligence as companies five times their size.”

— Sunil Patro, Founder & CEO, Signeasy

Signeasy’s Intelligent Contract Management platform includes:

Centralized Contract Repository: Store every executed contract in one searchable place — no digging through inboxes or shared drives.Conversational AI search: Ask questions about any contract in plain language, follow-up, and get answers with context instead of reviewing documents manually. Customer data is never used to train AI models.Key Term Extraction: Surface payment terms, renewal dates, obligations, and termination clauses instantly.Renewal Tracking and Alerts: Get automated reminders before contracts expire or auto-renew, so commitments never catch teams by surprise.Team Workspaces: Share visibility into contract status, with confidentiality controls for every team that touches contracts.eSignatures: Collect legally binding signatures from anywhere, on any device, and automate approval workflows to get contracts signed faster.

There’s no six-month implementation cycle. Businesses can bulk import existing contracts and onboard teams within hours with hands-on support from Signeasy.

Signeasy’s Intelligent Contract Management platform is available now. Visit www.signeasy.com to request a demo.

About Signeasy

Signeasy is an Intelligent Contract Management (ICM) platform built for growing businesses managing contracts across Finance, Legal, Sales, HR, Procurement, and Operations. Teams can prepare, sign, track, and manage contracts from one platform, with AI-powered workflows, integrations for Microsoft, Google, and HubSpot, and enterprise-grade security and compliance. Over 48,000 businesses globally use Signeasy to cut contract cycle times, reduce risk, accelerate revenue, and drive better business outcomes.

Media contact
Dhivya Venkatesan
Signeasy
Email: dhivyav@signeasy.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/signeasy-expands-beyond-esignatures-with-intelligent-contract-management-for-growing-businesses-302829576.html

SOURCE Signeasy

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