Connect with us

Technology

SOPHiA GENETICS Presents Ground-Breaking Multimodal Research on AI-Driven Patient Stratification at ESMO 2024

Published

on

Research highlights the use of multimodal machine learning to identify non-small cell lung cancer patients predicted to derive the most benefit from combination immunotherapy

BOSTON and ROLLE, Switzerland, Sept. 14, 2024 /PRNewswire/ — SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native healthcare technology company and a leader in data-driven medicine, will unveil new research at the European Society for Medical Oncology (ESMO) 2024. The study, conducted in collaboration with AstraZeneca, leverages advanced AI-driven techniques to identify subgroups of stage IV non-small cell lung cancer (NSCLC) patients who could most benefit from the addition of tremelimumab to durvalumab and chemotherapy.

The research is a retrospective, multimodal analysis of the POSEIDON Phase 3 clinical trial (NCT03164616). This trial originally demonstrated that the combination of tremelimumab, durvalumab, and chemotherapy significantly increases progression-free survival (PFS) and overall survival (OS) versus chemotherapy in patients with metastatic NSCLC, which lead to approval of this regiment globally in 1L mNSCLC. The SOPHiA GENETICS study used cutting-edge multimodal machine learning models to analyze clinical, biological, genomic, and imaging data, pinpointing patient subgroups who are most likely to benefit from the combination treatment.

The research highlighted signatures identifying patients with non-squamous metastatic NSCLC who may derive higher OS benefit from the addition of tremelimumab to durvalumab plus chemotherapy in the first-line treatment setting. In particular, EGFR wild-type, FGFR3 wild-type, CDKN2A wild-type, KRAS mutation, and STK11 mutation comprised elements of a signature was identified as being associated with a higher OS benefit. These findings could have significant implications for the treatment of NSCLC, as it provides an exploration avenue towards a more tailored approach to patient care.

“Our collaboration with AstraZeneca represents a major step forward in personalized oncology. Non-small cell lung cancer remains one of the most challenging cancers to treat due to its complex biology and the late stage at which it is often diagnosed,” said Jurgi Camblong, Ph.D., Co-founder and CEO of SOPHiA GENETICS. “This study harnesses the power of multimodal data and advanced AI to identify which patients are most likely to benefit from specific therapies. By tailoring treatment strategies based on a patient’s unique multimodal profile, we aim to improve outcomes and offer new hope to those battling this difficult disease.”

The study will be presented as a poster by Ferdinandos Skoulidis, Department of Thoracic Medical Oncology, University of Texas MD Anderson Cancer Center at ESMO 2024 hosted in Barcelona, Spain from September 13-17, 2024. His presentation showcases the operational feasibility and clinical impact of large-scale multimodal analyses in identifying heterogeneous treatment effects in oncology.

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.COM, or connect on LinkedIn.

About SOPHiA GENETICS 
SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of the SOPHiA DDM™ Platform, which analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise. The information in this press release is about products that may or may not be available in different countries and, if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact support@sophiagenetics.com to obtain the appropriate product information for your country of residence. 

SOPHiA GENETICS Forward-Looking Statements: 
This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations and financial position, business strategy, products, and technology, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in our filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of the date hereof. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in our expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

 

View original content to download multimedia:https://www.prnewswire.com/news-releases/sophia-genetics-presents-ground-breaking-multimodal-research-on-ai-driven-patient-stratification-at-esmo-2024-302246192.html

SOURCE SOPHiA GENETICS

Continue Reading

Technology

HelloNation Examines Common Dental Problems in Children With Pediatric Dental Care Insights From Dr. Andrew Beuttenmuller

Published

on

By

The article outlines prevention strategies for cavities, gum irritation, and early alignment concerns in children.

WATERTOWN, N.Y., Nov. 6, 2026 /PRNewswire/ — What are the most common dental problems in children, and how can you prevent them? A HelloNation article provides clear answers, featuring insights from pediatric dental care professional Dr. Andrew Beuttenmuller of Watertown Pediatric Dentistry.

The HelloNation article explains that common dental problems in children include cavities, gum irritation, and early tooth alignment concerns. These issues often appear as children’s teeth grow and develop, but consistent care and early attention can often address or prevent them. The article highlights that understanding these patterns is essential for effectively managing kids’ dental problems in Watertown, NY; families can follow along at home with professional guidance.

Cavities in children remain a major concern. The article notes that tooth decay develops when sugars interact with mouth bacteria, creating acids that weaken enamel. Young children are especially at risk due to developing hygiene habits and frequent exposure to sugary snacks and drinks. The article emphasizes that preventing cavities in kids starts with daily routines and less sugar.

The article also discusses gum irritation kids experience, often called gingivitis, as another early concern. This condition can appear as redness, swelling, or bleeding gums, typically caused by plaque buildup along the gumline. The article describes how consistent brushing and flossing play a key role in preventing this issue and supporting overall pediatric dental care.

The article also addresses early concerns about tooth alignment, including crowding, spacing, and bite issues. While some changes are part of normal development, the article explains that early monitoring can help identify when intervention may be beneficial. Pediatric dental care providers can track these developments and guide families on the next steps when needed.

Prevention is a central focus throughout the article. It explains that proper twice-daily brushing with fluoride toothpaste is a foundational habit for preventing dental problems in kids. Families in Watertown, NY, can implement. Supervision during brushing helps ensure children clean thoroughly, while flossing removes plaque between teeth where brushes cannot reach. These habits directly support efforts to prevent cavities in kids and reduce gum irritation.

Diet is another important factor the article discusses. Limiting sugary snacks and drinks reduces the risk of cavities in children, while encouraging water supports oral health. The article notes that balanced meals with fruits, vegetables, and calcium-rich foods help strengthen teeth and gums. These dietary habits support long-term pediatric dental care and reduce the risk of common dental problems in children.

Routine dental visits are also emphasized as a key part of prevention. The article explains that regular checkups allow dental professionals to identify early signs of cavities in children, gum irritation that kids may not notice, and early tooth alignment concerns. Professional cleanings and fluoride treatments further support strong enamel and ongoing oral health.

The article concludes by noting that building positive habits early can have lasting benefits. When families focus on kids’ dental problems, children in Watertown, NY can develop strong routines that continue into adulthood. Addressing common dental problems in children early helps support both oral health and overall confidence.

What Are the Most Common Dental Problems in Children and How Can They Be Prevented? Features insights from Dr. Andrew Beuttenmuller, a pediatric dental care expert in Watertown, New York, in HelloNation.

About HelloNation

HelloNation is America’s Good News Network, a premier media platform built on the idea that good news travels faster when real people tell real stories. Through its community-focused digital publications and innovative “edvertising” approach, HelloNation delivers expert-driven, good-news content that informs, inspires, and spotlights the leaders making a meaningful impact in their communities. HelloNation maintains partnerships with the U.S. Conference of Mayors and the United States First Responders Association.

www.hellonation.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/hellonation-examines-common-dental-problems-in-children-with-pediatric-dental-care-insights-from-dr-andrew-beuttenmuller-302910898.html

SOURCE HelloNation

Continue Reading

Technology

Mynd.ai Announces Change to American Depositary Share Ratio

Published

on

By

ALPHARETTA, Ga., Nov. 6, 2026 /PRNewswire/ — Mynd.ai, Inc. (NYSE: MYND) (“Mynd” or the “Company”), a global provider of interactive technology and AI solutions for education and commercial customers, today announced that it will change the ratio of its American Depositary Shares (“ADSs”) to its ordinary shares from one ADS representing ten (10) ordinary shares to a new ratio of one ADS representing seventy-five (75) ordinary shares. For the Company’s ADS holders, the change in the ADS ratio will have the same effect as a one-for-7.5 reverse ADS split.

The ADS ratio change is expected to become effective on or about December 7, 2027 (U.S. Eastern Time), subject to completion of the applicable procedures with the Company’s depositary, Citibank, N.A. (the “Depositary”), and other relevant parties. The ADSs will continue to trade on the NYSE American under the symbol “MYND,” with a new CUSIP number of 628988206.

Following the effectiveness of the change, each ADS will represent seventy-five (75) ordinary shares of the Company, compared with ten (10) ordinary shares previously. The ordinary shares of the Company will not be affected by the change in the ADS ratio, and no ordinary shares will be issued or cancelled in connection with it.

The exchange of every seven and one-half (7.5) then-held ADSs for one new ADS is expected to occur automatically on the effective date, with the then-held ADSs being cancelled and new ADSs issued by the Depositary. Fractional new ADSs will not be issued in connection with the change in the ADS ratio. Instead, fractional entitlements to new ADSs will be aggregated and sold by the Depositary, and the net cash proceeds from the sale, after deduction of applicable fees, taxes and expenses, will be distributed to the applicable ADS holders in accordance with the terms of the deposit agreement.

ADS holders are not required to take any action. ADSs held in brokerage accounts will be adjusted automatically, and holders of certificated ADSs will receive instructions from the Depositary. The Company will pay the Depositary’s fees and charges in connection with the surrender, cancellation, exchange, and issuance of ADSs effected as part of the ADS ratio change. ADS holders should consult their brokers, banks, or other financial intermediaries for information regarding the treatment of their holdings in connection with the ratio change.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words “plan,” “will,” “believe,” “anticipate,” “doubt,” “expect,” “intend,” and similar terms and phrases are used in this press release to identify forward-looking statements. Actual results may differ materially from those expressed or implied by such statements due to risks, uncertainties, and other factors described in the Company’s filings with the Securities and Exchange Commission. The Company undertakes no obligation to update any forward-looking statements except as required by law.

About Mynd.ai, Inc.

Mynd is a global leader in interactive technology offering best-in-class hardware and software solutions that help organizations create and deliver dynamic content; simplify and streamline teaching, learning, and communication; and facilitate real-time collaboration. Our award-winning interactive displays and software can be found in more than 1 million learning and training spaces in over 125 countries. Our global distribution network of more than 1,000 reseller partners and our dedicated sales and support teams around the world enable us to deliver the highest level of service to our customers. Learn more at www.mynd.ai.

View original content to download multimedia:https://www.prnewswire.com/news-releases/myndai-announces-change-to-american-depositary-share-ratio-302932330.html

SOURCE Mynd.ai

Continue Reading

Technology

Accrete Signs Data Agreement with TenderAlpha to Deepen Supply Chain Risk Insight for Federal Customers

Published

on

By

NEW YORK, Nov. 6, 2026 /PRNewswire/ — Accrete, the cognitive infrastructure company building Knowledge Engines for autonomous work, today announced that it has signed an agreement with TenderAlpha, a global provider of government contracting and supply chain data. The agreement brings TenderAlpha data into Accrete’s Argus for Supply Chain Influence, giving defense and civilian agency customers greater visibility into the companies, suppliers and component parts behind the products and systems they rely on.

Across the government, supply chain visibility has become a priority. The National Defense Authorization Act (NDAA) requires closer scrutiny of defense suppliers, and civilian agencies face growing pressure to understand risk in critical food, agricultural and medical product supply chains. Agencies need a clearer view of the sub-tier relationships and sources where risk often goes unseen.

“Supply chain risk isn’t a data aggregation problem. It’s a judgment and tacit knowledge problem,” said Prashant Bhuyan, Founder and CEO of Accrete. “Human expertise doesn’t scale fast enough to get ahead of foreign influence threats, and burying analysts under mountains of disconnected data only makes it worse. Accrete’s Knowledge Engine captures and scales the tacit knowledge of individual analysts and the organization itself. It grounds reasoning models in that judgment so they become trusted agents. With TenderAlpha’s data in Argus, those agents can do in minutes what would ordinarily take teams of exceptional analysts months or years.”

“Our customers need to understand supply chain risk faster and at a deeper level than ever before,” said Bill Wall, CEO of Accrete AI Government. “Adding TenderAlpha data gives us greater insight into the obscured vulnerabilities and threats inherent in complex global supply chains. It gives defense and civilian agency teams a robust picture of who is really behind the products and components they depend on, so they can act before a vulnerability becomes a problem.”

By combining TenderAlpha data with Argus for Supply Chain Influence, powered by the Accrete Knowledge Engine and its supply chain expert agent, Accrete customers will be able to:

See deeper into the supply chain, with expanded insight into sub-tier suppliers and component-part sources.Identify risks earlier, including foreign ownership, influence and concentration concerns, before they disrupt operations or missions.Support compliance efforts tied to federal sourcing and supply chain requirements, including the NDAA.Make faster, better-informed decisions on sourcing, vendor vetting and mitigation.

“Exposing complex supply chain risk requires connecting the dots across disparate layers that are very rarely combined,” said Martin Tsanov, CEO and co-founder of TenderAlpha. “The fusion of TenderAlpha’s global B2B relationship and trade data with government contracting and subcontracting data within Argus’ cutting-edge multi-tier graph architecture equips national security agencies with the comprehensiveness and visibility needed to proactively identify hidden dependencies and secure critical supply chains.”

The TenderAlpha agreement is part of Accrete’s ongoing investment in the data and analytics that federal customers need to protect the Defense Industrial Base and the critical supply chains Americans depend on. Customers using Argus for Supply Chain Influence will gain access to these expanded insights in early 2027.

About Accrete

Accrete builds cognitive infrastructure for government and enterprise customers. Founded in 2017, Accrete’s Knowledge Engine platform unifies fragmented systems, siloed data, tacit knowledge, and decision-making into a continuously learning universal system of intelligence. Knowledge Engines give agents the shared context to reason, collaborate, decide, and act across the full complexity of an organization. As AI makes intelligence abundant, judgment is the scarce resource, and Accrete’s Knowledge Engines encode the expert judgment organizations accumulate over decades so agents can be trusted with consequential decisions. Accrete’s customers span Fortune 500 enterprises as well as U.S. defense and national security agencies. From commercial operations to national security missions, Accrete’s platform enables expert agents that deliver superintelligence designed for high-stakes environments. Accrete AI Government LLC, based in Alexandria, VA, is the federal subsidiary of New York-based Accrete, Inc.

About TenderAlpha

Founded in 2014, TenderAlpha delivers high-quality, structured data products designed to support investment analysis, risk assessment, and market intelligence. TenderAlpha serves financial institutions, asset managers, and risk-rating and research professionals, offering deep insights into global G2B and B2B transactional trends. For more information, visit www.tenderalpha.com.

Media Contact:
Megan Thatford
megan.thatford@accrete.ai

View original content to download multimedia:https://www.prnewswire.com/news-releases/accrete-signs-data-agreement-with-tenderalpha-to-deepen-supply-chain-risk-insight-for-federal-customers-302932440.html

SOURCE Accrete

Continue Reading

Trending