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OXMAN Unveils the O° Shoe – a 100% Biodegradable Shoe made without Petrochemicals, producing Zero Microplastics

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The O° collection is made using patent pending OXMAN technology that integrates digital, material, biological, and robotic innovations and uses a single organic material to create 100% biobased consumer products

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NEW YORK, Oct. 31, 2024 /PRNewswire/ — OXMAN, a design lab whose mission is to create and deliver nature-centric products and environments to its clients and the natural world, has unveiled O°, a biomaterial, digital, and robotic technology platform that powers the production of biobased textiles and wearables that are 100% biodegradable when disposed of, made entirely with organic material and without petrochemicals or glues, and producing no microplastics. O° (pronounced “O-Zero”) removes the complexity inherent in conventional fabrication processes, enabling the creation of consumer products from one material, under one roof, with minimal human intervention — through a nearly zero-waste process. The first product to be created using O° platform is a collection of shoes made entirely of polyhydroxyalkanoates (PHAs), a class of organic material known for its versatility and biodegradability. 

 

“PHAs have long been recognized as a promising alternative to petroleum-based plastics,” noted Neri Oxman, CEO and Founder of OXMAN. “We have successfully elevated the potential of PHA through the development of O°, a new technology for the design and fabrication of products that seeks to minimize harm in its conception and nourish the environment in its afterlife. We are thrilled to unveil our first product using this new technology: the O° shoe, which is made using 100% PHA, is 100% biodegradable, and has no petrochemicals or microplastics.”

0% petrochemicals, 0% forever chemicals, 0% microplastics, and 100% biodegradable
PHAs can be produced by bacteria which consume atmospheric carbon dioxide, methane, and/or food waste, reducing carbon in the environment as they grow. They are biologically recyclable, and 100% biodegradable in ambient conditions. As a result, O° textiles and shoes do not leave behind microplastics when they decompose. O° textiles and shoes are made entirely of PHAs, so when they decompose they become one with the environment, returning to the bacteria from which they originated. However, just like traditional biodegradable materials used for apparel such as cotton, wool, and silk, PHA will not biodegrade while being worn, washed, or stored.

A high-efficiency design process
O° shoes embody the versatility of PHAs by incorporating precise designs informed by the kinetics of human motion. Whether they take final form as a walking or running shoe, or ballet slipper, each shoe has a base layer of a knitted upper and outer layers that are printed on the textile to provide specific functionality including reinforcement, cushioning, strength, and pliability. The versatility and automation built into the O° platform enable rapid iterations and  an accelerated development process from design to production.

A near zero-waste production process
A compact robotic system is central to the O° platform: the O° robotic system 3D prints custom PHA blends onto a textile that is 3D knitted on an industrial flatbed machine from a 100% PHA yarn produced through a process of extrusion and melt spinning. By using this knitting and printing technology to create shape and movement, OXMAN has eliminated the cut-and-sew and adhesion processes associated with traditional shoe assembly. The O° technology offers a near zero-waste production process and requires minimal human involvement and intervention, enabling local, low-cost production, minimizing the transport cost and environmental impact of the distant supply chains typical of the shoe industry.

Bio-engineered colorways, free of petrochemicals
Many industrial pigments and dyes are sourced from raw materials derived from petro-chemicals which release environmentally damaging chemicals during their production and usage. These dyes and pigments are dependent on a resource-intensive and complex global supply chain for synthesis, processing, and transport. In contrast, bacteria can produce pigments from simple and abundant natural resources. O° uses bacteria not just as a source of material, but also to encode other functional properties such as pigment production to simplify and centralize the manufacturing process.

OXMAN’s O° platform builds on the promise of PHAs by tuning the fabrication process and offering an alternative design and production process that holistically considers a product’s entire lifecycle, from conception to decomposition. 

OXMAN is now initiating discussions with potential partners, investors, and brand collaborators to bring the production of O° shoes and textiles to scale and to market.  We look forward to hearing from you. You can reach us here.

About OXMAN
OXMAN is a design lab whose mission is to create and deliver nature-centric products and environments to its clients and the natural world. Bringing together computational design, robotics, materials science, green chemistry, biology, and eco-system engineering, OXMAN’s work reinvents the industrial systems that dictate how we design and produce everyday things—from the foods we eat and the clothes we wear to the buildings we inhabit. https://oxman.com

O° CONTACT
https://oxman.com/contact

MEDIA CONTACT
Alex Klimoski
oxman@resnicow.com
+1 (212) 671-5184 

BACKGROUND
The Problem: Endless Assemblies, Forever Chemicals
The footwear design and manufacturing industry faces significant environmental challenges that include hazardous chemical formulations polluting our air, water and soil, greenhouse gas emissions, human exploitation, lack of supply chain traceability, as well as lack of sustainable end-of-life scenarios for materials that cannot be recycled or biodegraded.

Facts & Figures:

24+ billion shoes are manufactured worldwide each year1,2,3300+ million pairs of shoes are discarded annually, 95% of which wind up in landfill2,3Shoes do not break down easily or quickly: shock-absorbent soles can remain in a landfill for 1,000 years4On average, 40 distinct materials are used to create a traditional shoe (e.g., foams, fabrics, rubbers, coatings, adhesives)5″Forever chemicals” are found in almost all mass-produced shoes today (33-4200 parts per billion can be found in a traditional shoe)6Shoes made from petroleum-derived plastics account for 1.4% of global greenhouse emissions7,8

The Solution: One Material, One System
O° is a design platform that starts and ends with biology. It embodies an automated, vertically integrated, bio-digital fabrication system for lifecycle design of multi-functional mono-material products. 

Made entirely of polyhydroxyalkanoates (PHAs), a bacterially-produced thermo-plastic polymer, the mono-material O° enables the design and digital fabrication of apparel items, such as shoes and textiles, that exhibit a range of physical properties, functions, and end-of-life trajectories. By cultivating our materials from bacteria—as opposed to extracting them from resources like oil or sourcing them from farmed materials such as wool and cellulose—we unlock the potential for a radically new production paradigm—one that bears more resemblance to growing than to the conventional manufacturing processes. This approach envisions centralizing all components of production into a single material, a single site, and a single process. O° aims to remove the complexity involved in the fabrication of objects by staying within one material class for all technical requirements. Streamlining manufacturing allows us to remove externalities that would incur environmental damage; if we only need one material to make a shoe, we have no need to import specialized components from around the globe. Reducing microplastics, reducing atmospheric greenhouse gasses, and promoting biological growth through targeted biodegra-dation follow as further vectors of possible positive environmental impact. 

Unmatched Versatility: Efficiency in Design, in Tune with Nature
The versatility and automation built into the O° platform enable rapid iterations and an accelerated development process from design to production, enabling a wide array of mechanical, thermal, chemical, and manufacturing properties that meet a broad range of processing needs and applications. Such high levels of versatility, achieved through design tunability across design stages and media—production, processability, and programmable decomposition— are at the core of O°’s designs and platform technology.

Key Features:

Origins: PHAs are derived from naturally-occurring “feedstocks” which include carbon dioxide, methane, sugars, and waste streams. There is a broadening scientific consensus that PHAs can be produced in bulk from atmospheric carbon and other sources that provide it with a very small or even negative carbon footprint.Processability: Considered the most versatile bacterially-derived thermo-polymer class, PHAs are easily integrated into most industrial manufacturing processes, including melt extrusion, injection molding, melt blowing, fiber spinning, and casting.Functionality: With over 13 formulations designed to provide a range of mechan-ical properties for specific uses, our PHA yarn is 6x as flexible as polyester and as soft as lyocell. In place of assembling independently produced parts, each with its homogeneous material properties, we harvest biological mono-materials with highly tunable properties to create gradients of functionality.Product features (pigmentation, scents, branding): The bacterial production of PHAs enable genetically and chemically-encoded pigmentation, scents, and labeling. The genetic label of O° is synthesized in DNA. Once embedded, this label can be used to detect and read the genetic code following polymer biodegradation. This can enable a future where precise identification of disposal and biodegradation products is an everyday reality.

1 https://www.worldfootwear.com/news/10-countries-were-responsible-for-88-of-total-footwear-production-/9148.html
2 https://www.washingtonpost.com/climate-solutions/2024/04/01/plant-based-sole-sneaker/
3 Bodoga, A., Nistorac, A., Loghin, M.C. and Isopescu, D.N., 2024. Environmental Impact of Footwear Using Life Cycle Assessment—Case Study of Professional Footwear. Sustainability, 16(14), p.6094.
4 Lippa, N.M., Krzeminski, D.E., Piland, S.G., Rawlins, J.W. and Gould, T.E., 2017. Biofidelic mechanical ageing of ethylene vinyl acetate running footwear midsole foam. Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology, 231(4), pp.287-297.
5 Cheah, L., Ciceri, N.D., Olivetti, E., Matsumura, S., Forterre, D., Roth, R. and Kirchain, R., 2013. Manufacturing-focused emissions reductions in footwear production. Journal of cleaner production, 44, pp.18-29.
https://www.ecocenter.org/our-work/healthy-stuff-lab/reports/wolverine-worldwide-shoes-pfas-results/toxic-pfas-chemicals
https://ourworldindata.org/ghg-emissions-by-sector
8 Bodoga, A., Nistorac, A., Loghin, M.C. and Isopescu, D.N., 2024. Environmental Impact of Footwear Using Life Cycle Assessment—Case Study of Professional Footwear. Sustainability, 16(14), p.6094.

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Topaz Labs announces its largest single release of AI models in company history with “Next-Gen” launch

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DALLAS, April 28, 2026 /PRNewswire/ — Topaz Labs, the AI image and video enhancement company, has announced four new image enhancement models and two video enhancement models across five applications. The collection of “Next-Gen” models offer powerful sharpening, denoising, and upscaling results to visual content. Image models included are Wonder 3, Denoise Max, Super Focus 3, and High Fidelity 3. For video, Starlight Precise 2.5 and Astra 2 were announced.

The collection of models offers powerful sharpening, denoising, and upscaling results to visual content.

“This is both the largest and most technically advanced set of models we’ve released in the company’s history,” says Eric Yang, CEO, Topaz Labs. “We launched Topaz NeuroStream earlier this year with the goal of enabling local rendering of complex models for more users. Without such technology, the complex, heavyweight AI models in today’s release would have been limited to cloud-only rendering, forcing users to pay per use and be reliant on internet connection. We believe local use is crucial to the future of AI in both professional and consumer use cases, and today’s release is a huge step.” 

Topaz NeuroStream is proprietary technology that reduces VRAM usage by up to 95% and allows exponentially more users on consumer-grade hardware to use AI models locally. A total of six Topaz models are now powered by NeuroStream.

Next-Gen Release Image Models 

Wonder 3: A magical, one-click sharpen, upscale, and denoise model for images.
Denoise Max: New standard for removing noise and grain in images.
Super Focus 3: Next-level sharpening model that brings subjects back from the blur.
High Fidelity 3: The newest model for upscaling high-res inputs like smartphone photos and RAW images.

All image models in this release are available in Topaz Photo desktop application and via API. Wonder 3 and Denoise Max are also available in Express, a web-based tool.

Next-Gen Release Video Models

Starlight Precise 2.5 (Local): Groundbreaking video model that brings out natural visual details with stunning results, with local availability in Topaz Video

Astra 2: The next generation of creative video upscaling that enhances clarity, richness, and visual complexity of videos by adding new detail.

Both highlighted video models are available via cloud rendering in Astra and API. Starlight Precise 2.5 (Local) can be found in the Topaz Video desktop application.

About Topaz Labs
Founded in 2005, Topaz Labs is a leader in AI-powered image and video enhancement. Its technology is used by 1.5 million customers, including 20 of the world’s top 50 companies. Known for industry-leading products like Topaz Photo, Topaz Video, Topaz Gigapixel, Astra and Bloom, the company continues to invest heavily in research and development, advancing the frontiers of imaging technology in collaboration with academic and industry partners.

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Dreame Technology Launches the L60 Series, Led by the Flagship L60 Pro Ultra

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New lineup brings industry-leading intelligence and full-home automation to a new generation of robot vacuums

SAN FRANCISCO, April 28, 2026 /PRNewswire/ — Dreame Technology, a leader in smart home innovation, today announced the L60 Series, a new lineup of four robot vacuums engineered for the full range of modern home environments. Built on a shared foundation of premium cleaning performance, intelligent navigation, and hands-free automation, the L60 Series is designed to meet the needs of every kind of household, from compact apartments to multi-story homes, and from single-surface layouts to complex mixed-flooring environments.

“The L60 Series represents exactly what Dreame stands for: powerful, intelligent cleaning that adapts to how people actually live,” said Ana Wang, CEO of Dreame Technology North America. “Whether you have a multi-story home, pets, mixed flooring, or low furniture, there’s an L60 built for your needs. Every model in the lineup delivers the core cleaning experience our customers expect from Dreame.”

Meet the L60 Series

The L60 Series is built around four distinct models, each tailored to a different home profile and cleaning priority:

L60 Pro Ultra — The Ultimate All-in-One. The flagship vacuum is purpose-built for large floor plans, multi-surface transitions, and complex terrain. Features the 3.46-inch ProLeap™ System, 35,000Pa Vormax™ Suction, Dual Omni-Scrub Mopping with Hot Water, and an industry-leading 6,400mAh PowerCore™ Battery.L60 Ultra — Precision Whole-Home Coverage. A balanced high-performer built around Dreame’s latest 2026 sensor technology and a 3.23in (82mm) ultra-thin design for precise navigation in low-light spaces and flawless cleaning under low-profile furniture. Includes AI-Enhanced 3D ToF Vision, 35,000Pa Vormax™ Suction, HyperStream™ Detangling DuoBrush 2.0, SmartDirt™ Detection, Pet-Friendly Care 5.0, and Matter, Apple Watch, and Home Screen Shortcut support.L60 Ultra PE (Performance Edition) — The Intelligent Step-Up. An upgraded everyday performer for homes that need an extra boost on hair pickup, with 30,000Pa Vormax™ Suction, the HyperStream™ Detangling DuoBrush, 3DAdapt™ Obstacle Avoidance, and Smart Pathfinder Technology with 220 object type recognition.L60 Ultra FE (Fine Edition) — The Essential Automated Choice. An entry-level powerhouse delivering the core promise of maintenance-free floor care, with 30,000Pa Vormax™ Suction, TriCut Brush 3.0, Dual Flex Arm Technology, and the full PowerDock™ automation experience.

A Shared Foundation of Premium Performance

Every model in the L60 Series shares a core set of capabilities that set a new baseline for modern robot vacuums, including:

212°F (100°C) ThermoHub™ Mop Self-Cleaning for hygienically clean mop pads after every cycle30,000–35,000Pa Vormax™ Suction across the lineup for powerful pickup on every surfaceDual Flex Arm Technology for adaptive side-brush and mop coverage in corners and along edgesMop Lifting for seamless transitions between hard floors and carpetAutomatic Solution Dispensing for consistent cleaning chemistry without manual refillsThe 8-in-1 PowerDock™ base station, which handles auto-empty, mop washing, hot-air drying, and solution management for truly hands-free operation

L60 Pro Ultra: The Flagship Experience, Redefined for Complex Homes

Leading the lineup is the L60 Pro Ultra, featuring select top-tier specifications optimized for large-scale layouts and complex terrains. It pairs the series’ most capable hardware with Dreame’s most advanced intelligence to deliver a seamless, one-stop cleaning experience that effortlessly tackles stubborn stains across expansive and complex home layouts.

At the heart of the Pro Ultra’s navigation advantage is the 3.46-inch ProLeap™ System, the lineup’s most capable obstacle-crossing system, paired with VersaLift Navigation for cleaning under low-clearance furniture. It is equipped with dual-laser 3D structured light, an AI RGB camera, and LED illumination, enabling it to recognize over 280 types of obstacles — for precise, real-time avoidance in any lighting condition.

The Pro Ultra delivers 35,000Pa Vormax™ Suction alongside the HyperStream™ Detangling DuoBrush, together extracting embedded debris, pet hair, and fine particles from every floor type without tangles or jams. Its Dual Omni-Scrub Mopping with Hot Water system pairs rotating mop pads with a Thermal Mop Pad and ThermoHub™ 212°F (100°C) Mop Self-Cleaning, while the AceClean™ DryBoard minimizes residue — eliminating grease, bacteria, and moisture that cold-water systems simply can’t address. An industry-leading 6,400mAh PowerCore™ Battery provides whole-home coverage on a single charge.

The Pro Ultra’s OmniDirt™ Detection Technology identifies high-soil areas and automatically triggers Mop Rewashing and Floor Remopping for a truly thorough result. Pet-Friendly Care 4.0 adds pet-aware detection and navigation, while Upgraded Intelligent Carpet Cleaning optimizes suction and mop behavior for mixed-flooring homes. Direct Voice Control and app control round out the experience for effortless day-to-day use.

Pricing and Availability

The Dreame L60 Series is available now through the Dreame website and Amazon (L60 Pro Ultra, L60 Ultra, L60 Ultra PE, L60 Ultra FE), with launch-offer pricing through the official website. Customers who purchase on dreametech.com receive a free accessory kit with their order.

L60 Pro Ultra — MSRP $1,399.99 | Launch Offer $1,259.99L60 Ultra — MSRP $1,299.99 | Launch Offer $1,169.99L60 Ultra PE — MSRP $1,099.99 | Launch Offer $879.99L60 Ultra FE — MSRP $999.99 | Launch Offer $749.99

For more information about the L60 Series, visit dreametech.com/pages/l60-series-robot-vacuum.

About Dreame Technology

Established in 2017, Dreame Technology is an innovative consumer product company focused on smart home cleaning appliances with the vision to empower lives through technology. Follow us on Facebook, Instagram, TikTok and Twitter. For more information, please visit https://www.dreametech.com/.

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SOURCE Dreame Technology

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Vanda Pharmaceuticals announces the publication of “Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis” in NEJM Evidence

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WASHINGTON, April 28, 2026 /PRNewswire/ — Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: VNDA) today announced the publication of the original research article titled “Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis” in New England Journal of Medicine (NEJM) Evidence1.

The findings of this pivotal phase III study are included in the Biologics License Application (BLA) for imsidolimab for the treatment of Generalized Pustular Psoriasis (GPP), submitted to the U.S. Food and Drug Administration (FDA) with a target action date of December 12, 2026.

References

Smieszek, S. et al. Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis. NEJM Evidence 5, (2026). 

About Imsidolimab

Imsidolimab is a fully humanized IgG4 monoclonal antibody that inhibits IL-36 receptor signaling and is being developed for GPP, a rare orphan indication. Regulatory and patent exclusivity for imsidolimab is expected to extend into the late 2030s. Vanda holds an exclusive global license for the development and commercialization of imsidolimab from AnaptysBio (Nasdaq: ANAB).

About Vanda Pharmaceuticals

Vanda is a leading global biopharmaceutical company focused on the development and commercialization of innovative therapies to address high unmet medical needs and improve the lives of patients. For more on Vanda Pharmaceuticals Inc., please visit www.vandapharma.com and follow us on X @vandapharma.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

Various statements in this press release, including, but not limited to statements regarding the anticipated timing of the completion of the FDA’s review of the imsidolimab BLA; Vanda’s plans to seek FDA approval of imsidolimab for the treatment of GPP; and the potential to extend regulatory and patent exclusivity for imsidolimab into the late 2030s, are “forward-looking statements” under the securities laws. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. Forward-looking statements are based upon current expectations and assumptions that involve risks, changes in circumstances and uncertainties. Important factors that could cause actual results to differ materially from those reflected in Vanda’s forward-looking statements include, among others, the FDA’s ability to complete its review of, and reach a decision with respect to, the imsidolimab BLA by December 12, 2026; Vanda’s ability to obtain FDA approval of imsidolimab for the treatment of GPP; and Vanda’s ability to satisfy the conditions necessary to extend regulatory and patent exclusivity for imsidolimab into the late 2030s. Therefore, no assurance can be given that the results or developments anticipated by Vanda will be realized, or even if substantially realized, that they will have the expected consequences to, or effects on, Vanda. Forward-looking statements in this press release should be evaluated together with the various risks and uncertainties that affect Vanda’s business and market, particularly those identified in the “Cautionary Note Regarding Forward-Looking Statements”, “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” sections of Vanda’s most recent Annual Report on Form 10-K, as updated by Vanda’s subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the U.S. Securities and Exchange Commission, which are available at www.sec.gov.

All written and verbal forward-looking statements attributable to Vanda or any person acting on its behalf are expressly qualified in their entirety by the cautionary statements contained or referred to herein. Vanda cautions investors not to rely too heavily on the forward-looking statements Vanda makes or that are made on its behalf. The information in this press release is provided only as of the date of this press release, and Vanda undertakes no obligation, and specifically declines any obligation, to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Corporate Contact:
Kevin Moran
Senior Vice President, Chief Financial Officer and Treasurer
Vanda Pharmaceuticals Inc.
202-734-3400
pr@vandapharma.com

Jim Golden / Jack Kelleher / Dan Moore
Collected Strategies
VANDA-CS@collectedstrategies.com

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SOURCE Vanda Pharmaceuticals Inc.

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