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MSI Unveils New Laptop Lineup Featuring NVIDIA GeForce RTX 50 Series at CES 2025

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Users can Experience the Extreme Performance of NVIDIA GeForce RTX 50 Series Across 5 Different MSI Laptop Series with More Than 30 Models

MUMBAI, India, Jan. 9, 2025 /PRNewswire/ — MSI, a world-leading premium laptop brand, has taken it in stride through its professionalism over luxurious aesthetics, extreme performance and innovative technology. MSI today proudly unveils its latest laptop lineup, equipped with NVIDIA® GeForce RTX™ 50 Series Laptop GPUs paired with the latest Intel® Core™ Ultra Series 2, AMD Ryzen™ 9000 series and AMD Ryzen™ AI 300 series processors, at CES 2025. MSI announced its exclusive Titan 18 HX Dragon Edition Norse Myth, featuring a hand-drawn dragon design with Nordic runes that blend Norse mythology with extreme gaming performance. The newly refreshed Titan, Raider, and Vector series deliver top-tier specifications for those pursuing extreme performance. The Stealth series lineup with Copilot+ PCs featuring the AMD Ryzen™ AI 300 series AI CPU is suitable for users looking for AI-powered laptops. Additionally, MSI has announced its high-performance Crosshair and Pulse series with the latest NVIDIA GeForce RTX 50 Series, providing users with versatile options to meet their diverse performance needs. With exclusive AI solutions and innovative cooling thermal designs, MSI continues to deliver the best user experience, combining cutting-edge technology with exceptional performance.

“We’re excited to announce a diverse range of MSI’s groundbreaking new laptop lineup for our end users, ensuring their needs are met, whether they’re looking for exceptional performance or AI-driven features,” said Eric Kuo, the Executive Vice President & NB BU GM of MSI. “With our latest lineup, MSI continues to redefine innovations, ensuring there’s always an MSI laptop ready to empower your journey.”

Unleashing Next-Gen Gaming and AI Performance with NVIDIA GeForce RTX 50 Series

Powered by NVIDIA Blackwell, GeForce RTX™ 50 Series GPUs bring game-changing capabilities to gamers and creators. Equipped with a massive level of AI horsepower, the RTX 50 Series enables new experiences and next-level graphics fidelity. Users can multiply performance with NVIDIA DLSS 4, generate images at unprecedented speed, and unleash creativity with NVIDIA Studio. Plus, they can access NVIDIA NIM microservices — state-of-the-art AI models that let enthusiasts and developers build AI assistants, agents, and workflows with peak performance on NIM-ready systems.

High-Performance MSI Laptops Powered by Intel® Core Ultra Series 2 and AMD Ryzen™ AI 300 / Ryzen 9000 Processors for Exceptional Gaming and AI Performance

The MSI comprehensive high-performance laptop lineup features Intel® Core Ultra 200HX and 200H processors, which deliver up to 24-core design and an integrated NPU AI engine, delivering over a 15% performance boost compared to their predecessors. MSI also presents its versatile lineup of AMD-powered laptops, powered by the AMD Ryzen™ 9000 HX series, including the Ryzen™ 9955HX3D, offering gamers a significant edge and an enhanced gaming experience. Additionally, the new AMD lineup includes the Ryzen™ AI 300 Series processors, offering a next-gen NPU with up to 50 TOPS of advanced AI capabilities. With cutting-edge efficiency, these processors are ideal for performance- and sustainability-focused users.

Groundbreaking Innovations for Enhanced Performance and User Experience

MSI introduces its brand-new cooling thermal design, featuring an innovative SSD heat pipe. This SSD cooling system reduces the maximum temperature of PCIe Gen 5 SSDs by up to 10°C. This ensures stable performance, sustained high speeds, and reliable data transfer, even under heavy workloads. To further elevate storage performance, MSI introduces Super RAID 5, combining Gen5 and Gen4 SSDs for an impressive read speed of up to 18,000MB/s, ensuring seamless data access and lightning-fast load times for the most demanding applications.

MSI also announces its latest AI innovation, the MSI AI Robot. Developed in collaboration with NVIDIA, this cutting-edge AI Assistant integrates a locally deployed small language model directly into the system. With AI Robot, users can control their laptops through natural language commands, even without an internet connection, providing a more intuitive way to set up and manage their laptops. Alongside AI Noise Cancellation Pro and the AI Engine, MSI’s comprehensive AI suite enhances the laptop’s functionality, making it smarter, more intuitive, and easier to control, offering an elevated user experience.

Titan 18 HX Dragon Edition Norse Myth: Dragonforged Dominance

MSI introduces the limited Titan 18 HX Dragon Edition Norse Myth, inspired by the resilience of Norse mythology. Featuring a stunning new design with hand-drawn dragon motifs and Nordic runes, it blends artistry with cutting-edge performance. The 3D dragon and dragon ring on the palm rest are meticulously hand-drawn, blending Norse Myth elements like the nine realms and rune symbols to achieve a sophisticated metallic sheen, refined texture, and a flawless vintage-inspired finish.

Titan / Raider / Vector / Stealth Series: The Brand-New Powerhouse

MSI has upgraded its high-performance laptop lineup, including the Titan, Raider, Vector, and Stealth Series, all now with 18-inch options to deliver enhanced performance and a more immersive experience. Equipped with up to NVIDIA GeForce RTX 5090 Laptop GPUs, these laptops offer desktop-level performance enhanced with advanced AI capabilities. With MSI’s OverBoost Ultra Technology, the Titan Series delivers up to 270W of total system power, while the Raider and Vector Series provide 260W. Supporting Thunderbolt 5 and DDR5-6400 memory, these laptops guarantee top-tier performance, ultra-fast connectivity, and seamless multitasking for power users.

The Stealth Series features AMD Ryzen™ AI 300 Series with Copilot+ PC certification, offering cutting-edge performance optimized for AI tasks. Built with a sleek Mg-Al alloy chassis, the Stealth Series blends style and durability, with the Stealth 18 standing out as the lightest 18-inch laptop on the market. MSI has also upgraded its Crosshair and Pulse series, now equipped with up to the latest NVIDIA GeForce RTX 5070 Laptop GPUs, providing a wider range of options that deliver powerful performance for users with varying needs.

Venture / VenturePro: New Robust and Powerful Business and Productivity Lineup

To further enhance productivity, MSI introduces the new business and productivity lineup — Venture/VenturePro Series, a robust versatile lineup available in sizes from 14″ to 17″. Designed for professionals and creators, the VenturePro series is equipped with powerful CPUs and the latest discrete NVIDIA GPUs. With a superior cooling design, these laptops deliver higher, more stable performance while maintaining lower heat and noise levels. Their high-performance capabilities allow professionals to easily manage light creative tasks and efficiently complete various work projects, making it a reliable tool for boosting productivity. The VenturePro series also offers an exclusive battery boost for an extra 4-5 hours of productivity, ensuring productivity wherever users are.

Join MSI at CES 2025

Users can seize the chance to explore MSI’s groundbreaking innovations.

Date: January 7-10, 2025Location : Veronese 2403, Level 2, Halls A-D, Venetian Expo

 

Model Name

Titan 18 HX AI A2XWJG / A2XWIG

Processor

Intel® Core™ Ultra 9 processor 275HX

Operating System

Windows 11 Home / Windows 11 Pro (MSI recommends Windows 11 Pro for business.)

Chipset

Intel® HM870

Memory

DDR5, 2 slots, up to 96GB

Display

18″ UHD+ (3840×2400), 16:10, MiniLED, 120Hz Refresh Rate, 100% DCI-P3 (Typ.), VESA DisplayHDR™ 1000 Certified, IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A2XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A2XWIG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

3 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Cherry Mechanical Per-Key RGB gaming keyboard by SteelSeries with Copilot Key

Audio

6 Speaker designed by Dynaudio system (4 x 2W Speakers + 2 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

3 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / Intel® Killer™ Wi-Fi 7 BE1750, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

400W

Dimension

404 (W) x 307.5 (D) x 24~32.05 (H) mm

Weight

3.6 Kg

 

Model Name

Raider 18 HX AI A2XWJG / A2XWIG

Processor

Intel® Core™ Ultra 9 processor 275HX

Operating System

Windows 11 Home / Windows 11 Pro

(MSI recommends Windows 11 Pro for business.)

Chipset

Intel® HM870

Memory

DDR5, 2 slots, up to 96GB

Display

18″ UHD+ (3840×2400), 16:10, MiniLED, 120Hz Refresh Rate, 100% DCI-P3 (Typ.), VESA DisplayHDR™ 1000 Certified, IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A2XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A2XWIG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Per-Key RGB gaming keyboard by SteelSeries with Copilot Key

Audio

6 Speaker designed by Dynaudio system (4 x 2W Speakers + 2 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

3 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / Intel® Killer™ Wi-Fi 7 BE1750, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Fingerprint Reader / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

400W

Dimension

404 (W) x 307.5 (D) x 24~32.05 (H) mm

Weight

3.6 Kg

 

Model Name

Raider A18 HX A9WJG / A9WIG

Processor

AMD Ryzen™ 9 9955HX3D Processor

Operating System

Windows 11 Home / Windows 11 Pro

(MSI recommends Windows 11 Pro for business.)

Chipset

Integrated SoC

Memory

DDR5, 2 Slots, up to 96GB

Display

18″ UHD+ (3840×2400), 16:10, MiniLED, 120Hz Refresh Rate, 100% DCI-P3 (Typ.), VESA DisplayHDR™ 1000 Certified, IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A9WJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A9WIG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Per-Key RGB gaming keyboard by SteelSeries with Copilot Key

Audio

6 Speaker designed by Dynaudio system (4 x 2W Speakers + 2 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

3 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / AMD® Wi-Fi 7, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Fingerprint Reader / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

400W

Dimension

404 (W) x 307.5 (D) x 24~32.05 (H) mm

Weight

3.6 Kg

 

Model Name

Vector A18 HX A9WIG / A9WHG

Processor

AMD Ryzen™ 9 9955HX Processor

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Memory

DDR5, 2 slots, up to 96GB

Display

18″QHD+ (2560×1600), 16:10, 240 Hz Refresh Rate, 100% DCI-P3(Typical), IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A9WIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A9WHG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

26-Zone RGB Gaming Keyboard with Copilot Key

Audio

4 x 2W Stereo Speakers

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

3 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

1 x HDMI™ 2.1 (8K@ 60Hz / 4K@ 120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / AMD® Wi-Fi 7, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4 Cell, Li-Polymer, 99.9Whr

Power Adapter

400W

Dimension

404 x 307.5 x 24~32.05 mm

Weight

3.6 kg

 

Model Name

Stealth 18 HX AI A2XWJG / A2XWIG / A2XWHG

Processor

Intel® Core™ Ultra 9 processor 275HX

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Intel® HM870

Memory

DDR5, 2 slots, up to 96GB

Display

18″ UHD+ (3840×2400), 16:10, MiniLED, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ 1000 Certified, IPS-Level panel (A2XWJG/ A2XWIG)

18″ QHD+ (2560×1600), 16:10, 240Hz Refresh Rate, 100% DCI-P3(Typical), IPS-Level panel (A2XWHG)

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A2XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A2XWIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A2XWHG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Per-Key RGB Gaming Keyboard by SteelSeries with Copilot Key

Audio

6 Speakers designed by Dynaudio system (2 x 2W Speakers + 4 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x Thunderbolt™ 4 (DisplayPort™/ Power Delivery 3.1)

2 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x Thunderbolt™ 4 (DisplayPort™/ Power Delivery 3.1)

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / Intel® Killer™ Wi-Fi 7 BE1750, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Fingerprint Reader / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

280W

Dimension

399.99 (W) x 289.67 (D) x 19.9-23.99 (H) mm

Weight

2.89 Kg

 

Model Name

Stealth A18 AI+ A3XWJG / A3XWIG / A3XWHG

Processor

AMD Ryzen™ AI 9 HX 370 Processor

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Memory

DDR5, 2 slots, up to 96GB

Display

18″ UHD+ (3840×2400), 16:10, MiniLED, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ 1000 Certified, IPS-Level panel (A3XWJG/ A3 XWIG)

18″ QHD+ (2560×1600), 16:10, 240Hz Refresh Rate, 100% DCI-P3(Typical), IPS-Level panel (A3XWHG)

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A3XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A3XWIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A3XWHG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Per-Key RGB Gaming Keyboard by SteelSeries with Copilot Key

Audio

6 Speakers designed by Dynaudio system (2 x 2W Speakers + 4 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

2 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.1 (Thunderbolt™ 4 Compatible)

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / AMD® Wi-Fi 7, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Microsoft Pluton Security Technology / IR Webcam / Webcam Shutter / Fingerprint Reader / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

280W

Dimension

399.99 (W) x 289.67 (D) x 19.9-23.99 (H) mm

Weight

2.89 Kg

 

Model Name

Vector 16 HX AI A2XWIG / A2XWHG

Processor

Intel® Core™ Ultra 9 processor 275HX

Intel® Core™ Ultra 7 processor 255HX

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Intel® HM870

Memory

DDR5, 2 slots, up to 96GB

Display

16″ QHD+ (2560×1600), 16:10, 240Hz Refresh Rate, 100% DCI-P3(Typical), IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A2XWIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A2XWHG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

24-Zone RGB Gaming Keyboard with Copilot Key

Audio

2 x 2W Stereo Speakers

1 x Audio combo jack

Nahimic 3 Audio Enhancer

Hi-Res Audio ready

USB Ports

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

2 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

1 x HDMI™ 2.1 (8K@ 60Hz / 4K@ 120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE)

Intel® Killer™ Wi-Fi 7 BE1750, Bluetooth v5.4 (Optional) / Intel® Wi-Fi 6E AX211, Bluetooth v5.3 (Optional)

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4-Cell, Li-Polymer, 90Whr

Power Adapter

280W

Dimension

357 (W) x 284 (D) x 22.2~28.55 (H) mm

Weight

2.7 Kg

 

Model Name

Vector 17 HX AI A2XWJG / A2XWIG / A2XWHG

Processor

Intel® Core™ Ultra 9 processor 275HX

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Intel® HM870

Memory

DDR5, 2 slots, up to 96GB

Display

17″ QHD+ (2560×1600), 16:10, 240 Hz Refresh Rate, 100% DCI-P3(Typical), IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A2XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A2XWIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A2XWHG)

Storage Slots

1 x NVMe M.2 SSD by PCIe Gen5 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

24-Zone RGB Gaming Keyboard with Copilot Key

Audio

2 x 2W Stereo Speakers

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

2 x USB 3.2 Gen2 Type-A

Card Reader

1 x SD Express Memory Card Reader

Video Output

2 x Thunderbolt™ 5 (DisplayPort™/ Power Delivery 3.1)

1 x HDMI™ 2.1 (8K@ 60Hz / 4K@ 120Hz)

Communication

Gigabit Ethernet (up to 2.5GbE) / Intel® Killer™ Wi-Fi 7 BE1750, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Kensington Lock

Battery

4-Cell, Li-Polymer, 90Whr

Power Adapter

280W

Dimension

380.34 (W) x 297.97 (D) x 22.85~28.75 (H) mm

Weight

3 Kg

 

Model Name

Stealth A16 AI+ A3XWJG / A3XWIG / A3XWHG

Processor

AMD Ryzen™ AI 9 HX 370 Processor

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Memory

LPDDR5x onboard, up to 64GB, dual channel

Display

16″ QHD+ (2560×1600), 16:10, 240Hz Refresh Rate, 100% DCI-P3(Typical), VESA DisplayHDR™ True Black 600, OLED panel

Graphics

NVIDIA® GeForce RTX™ 5090 Laptop GPU 24GB GDDR7 (A3XWJG)

NVIDIA® GeForce RTX™ 5080 Laptop GPU 16GB GDDR7 (A3XWIG)

NVIDIA® GeForce RTX™ 5070 Ti Laptop GPU 12GB GDDR7 (A3XWHG)

Storage Slots

2 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Per-Key RGB Gaming Keyboard by SteelSeries with Copilot Key

Audio

6 Speakers designed by Dynaudio system (2 x 2W Speakers + 4 x 2W Woofers)

1 x Audio combo jack

Nahimic 3 Audio Enhance

Hi-Res Audio ready

USB Ports

1 x USB4® Type-C / DisplayPort™ / Power Delivery 3.0 (Thunderbolt™ 4 Compatible)

2 x USB 3.2 Gen2 Type-A

Video Output

1 x HDMI™ 2.1 (8K@60Hz / 4K@120Hz)

2 x USB4® Type-C / DisplayPort™ / Power Delivery 3.0 (Thunderbolt™ 4 Compatible)

Communication

Gigabit Ethernet (up to 2.5GbE) / AMD® Wi-Fi 7, Bluetooth v5.4

Webcam

IR FHD type (30fps@1080p) with HDR & 3D Noise Reduction+ (3DNR+)

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Microsoft Pluton Security Technology / IR Webcam / Webcam Shutter / Fingerprint Reader / Kensington Lock

Battery

4-Cell, Li-Polymer, 99.9Whr

Power Adapter

240W

Dimension

355.8 (W) x 259.7 (D) x 19.95 (H) mm

Weight

2.1 Kg

 

Model Name

Venture A14/A15/A16/A17 AI+ A3HMG

Processor

AMD Ryzen™ AI 7 350 Processor

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Memory

DDR5, 2 slots, up to 96GB

Display

14″ 2.8K (2880 x 1800), 16:10, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ True Black 500, OLED panel

15.6″ FHD (1920×1080), 16:9, 144Hz Refresh Rate, IPS-Level panel

16″ 2K (2048 x 1280), 16:10, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ True Black 600, OLED panel

17.3″ FHD (1920×1080), 16:9, 144Hz Refresh Rate, IPS-Level panel

Graphics

AMD Radeon™ 860M

Storage Slot

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Single Backlit Keyboard (White) with Copilot Key

Security

Firmware Trusted Platform Module(fTPM) 2.0 / IR Webcam / Webcam Shutter / Kensington lock

Communication

Gigabit Ethernet / AMD® Wi-Fi 6E, Bluetooth v5.3

Audio

2 x 2W Stereo Speakers / 1 x Audio combo jack / DTS Audio Processing / Spatial Array Microphone (3 Mic) / Hi-Res Audio Ready

I/O Port

1 x USB 3.2 Gen2 Type-C / DisplayPort™ / Power Delivery 3.0,

2 x USB 3.2 Gen1 Type-A,

1 x HDMI™ 2.1 (4K @ 60Hz), 1 x RJ45, 1 x Kensington Lock

Battery/Adapter

4-Cell, Li-Polymer, 75Whr / 90W

Webcam

IR HD type (30fps@720p)

Dimension

315.6(W) x 235.5(D) x 19.3~21.6(H) mm (A14)

359.3(W) x 245.25(D) x 22.15~23.15(H) mm (A15/A16)

399.3(W) x 258(D) x 21.2~23.2(H) mm(A17)

Weight

1.7 Kg (A14) /1.9 Kg (A15/A16) / 2.4 Kg (A17)

Color

Solid Gray

 

Model Name

Venture 14/15/16/17 AI A1MG

Processor

Intel® Core™ Ultra 7 processor 155H

Intel® Core™ Ultra 5 processor 125H

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Memory

DDR5, 2 slots, up to 96GB

Display

14″ 2.8K (2880 x 1800), 16:10, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ True Black 500, OLED panel

15.6″ FHD (1920×1080), 16:9, 144Hz Refresh Rate, IPS-Level panel

16″ 2K (2048 x 1280), 16:10, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ True Black 600, OLED panel

17.3″ FHD (1920×1080), 16:9, 144Hz Refresh Rate, IPS-Level panel

Graphics

Up to Intel® Arc™ graphics

Storage Slot

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Single Backlit Keyboard (White) with Copilot Key

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Webcam Shutter / Kensington lock

Communication

Gigabit Ethernet / Intel® Wi-Fi 6E AX211 , Bluetooth v5.3

Audio

2 x 2W Stereo Speakers / 1 x Audio combo jack / DTS Audio Processing / Spatial Array Microphone (3 Mic) / Hi-Res Audio Ready

I/O Port

1 x USB 3.2 Gen2 Type-C / DisplayPort™ / Power Delivery 3.0, 2 x USB 3.2 Gen1 Type-A, 1 x HDMI™ 2.1 (4K @ 60Hz), 1 x RJ45, 1 x Kensington Lock

Battery/Adapter

4-Cell, Li-Polymer, 55.2Whr / 90W

Webcam

HD type (30fps@720p)

Dimension

315.6(W) x 235.5(D) x 19.3~21.6(H) mm

Weight

1.7 Kg

Color

Solid Gray

 

Model Name

VenturePro 15 AI A1VFG / A1VEG / A1UDXG

VenturePro 16 AI A1VFG / A1VEG

VenturePro 17 AI A1VFG / A1VEG / A1UDXG

Processor

Intel® Core™ Ultra 7 processor 155H

Intel® Core™ Ultra 5 processor 125H

Intel® Core™ Ultra 7 processor 155H

Intel® Core™ Ultra 7 processor 155H

Operating System

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Windows 11 Home (MSI recommends Windows 11 Pro for business.)

Windows 11 Pro

Chipset

Integrated SoC

Integrated SoC

Integrated SoC

Memory

DDR5, 2 slots, up to 96GB

DDR5, 2 slots, up to 96GB

DDR5, 2 slots, up to 96GB

Display

15.6″ FHD (1920×1080), 144Hz Refresh Rate, IPS-Level panel

16″ 2K (2048 x 1280), 16:10, 120Hz Refresh Rate, 100% DCI-P3 (Typical), VESA DisplayHDR™ True Black 600, OLED panel

17.3″ FHD (1920×1080), 144Hz Refresh Rate, IPS-Level panel

Graphics

NVIDIA® GeForce RTX™ 4060 Laptop GPU 8GB GDDR6 (A1VFG)

NVIDIA® GeForce RTX™ 4050 Laptop GPU 6GB GDDR6 (A1VEG)

NVIDIA® GeForce RTX™ 3050 Laptop GPU 6GB GDDR6 96-bit (A1UDXG)

NVIDIA® GeForce RTX™ 4060 Laptop GPU 8GB GDDR6 (A1VFG)

NVIDIA® GeForce RTX™ 4050 Laptop GPU 6GB GDDR6 (A1VEG)

NVIDIA® GeForce RTX™ 4060 Laptop GPU 8GB GDDR6 (A1VFG)

NVIDIA® GeForce RTX™ 4050 Laptop GPU 6GB GDDR6 (A1VEG)

NVIDIA® GeForce RTX™ 3050 Laptop GPU 6GB GDDR6 96-bit (A1UDXG)

Storage Slot

1 x NVMe M.2 SSD by PCIe Gen4 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

1 x NVMe M.2 SSD by PCIe Gen4 x4

Keyboard

Single Backlit Keyboard (White) with Copilot Key

Single Backlit Keyboard (White) with Copilot Key

Single Backlit Keyboard (White) with Copilot Key

Security

Firmware Trusted Platform Module(fTPM) 2.0 / Webcam Shutter / Kensington lock

Firmware Trusted Platform Module(fTPM) 2.0 / Webcam Shutter / Kensington lock

Firmware Trusted Platform Module(fTPM) 2.0 / Webcam Shutter / Kensington lock

Communication

Gigabit Ethernet / Intel® Wi-Fi 6E AX211 , Bluetooth v5.3

Gigabit Ethernet / Intel® Wi-Fi 6E AX211 , Bluetooth v5.3

Gigabit Ethernet / Intel® Wi-Fi 6E AX211, Bluetooth v5.3

Audio

2 x 2W Stereo Speakers / 1 x Audio combo jack / DTS Audio Processing / Spatial Array Microphone (3 Mic) / Hi-Res Audio Ready

2 x 2W Stereo Speakers / 1 x Audio combo jack / DTS Audio Processing / Spatial Array Microphone (3 Mic) / Hi-Res Audio Ready

2 x 2W Stereo Speakers / 1 x Audio combo jack / DTS Audio Processing / Spatial Array Microphone (3 Mic) / Hi-Res Audio Ready

I/O Port

1 x USB 3.2 Gen1 Type-C / DisplayPort™ / Power Delivery 3.0,

2 x USB 3.2 Gen1 Type-A,

1 x HDMI™ 2.1 (4K @ 60Hz), 1 x RJ45, 1 x Kensington Lock

1 x USB 3.2 Gen1 Type-C / DisplayPort™ / Power Delivery 3.0, 2 x USB 3.2 Gen1 Type-A, 1 x HDMI™ 2.1 (4K @ 60Hz), 1 x RJ45, 1 x Kensington Lock

1 x USB 3.2 Gen1 Type-C / DisplayPort™ / Power Delivery 3.0,

2 x USB 3.2 Gen1 Type-A,

1 x HDMI™ 2.1 (4K @ 60Hz), 1 x RJ45, 1 x Kensington Lock

Battery/Adapter

4-Cell, Li-Polymer, 55.2Whr / 120W

4-Cell, Li-Polymer, 55.2Whr / 120W

4-Cell, Li-Polymer, 55.2Whr / 120W

Webcam

HD type (30fps@720p)

HD type (30fps@720p)

HD type (30fps@720p)

Dimension

359.3(W) x 245.25(D) x 22.15~23.15(H) mm

359.3(W) x 245.25(D) x 22.15~23.15(H) mm

399.3(W) x 258(D) x 21.2~23.2(H) mm

Weight

1.9 Kg

1.9 Kg

2.4 Kg

Color

Solid Gray

Solid Gray

Solid Gray

 

* Product specification, functions and appearance may vary by models and differ from country to country. All specifications are subject to change without notice.

For high-res images, please visit: https://msi.gm/S1BCF933 

MSI Twitch: twitch.tv/msigaming
MSI GAMING: https://www.msi.com/
MSI Facebook: https://www.facebook.com/MSIGaming
MSI Instagram: https://www.instagram.com/msigaming/
MSI YouTube: https://www.youtube.com/user/MSIGamingGlobal
MSI Twitter: https://twitter.com/msitweets

Subscribe to MSI RSS Feeds via https://www.msi.com/rss, for real-time news and more product info.

About MSI

As a world-leading gaming brand, MSI is the most trusted name in gaming and eSports. We stand by our principles of breakthroughs in design, the pursuit of excellence, and technological innovation. Integrating gamers’ most coveted extreme performance, realistic visuals, authentic sound, precise control and smooth streaming functions into its gaming rigs, MSI frees gamers from tedious trial and error and pushes gaming performance beyond limits. The determination to surpass past achievements has made MSI a ‘True Gaming’ brand with gaming spirit throughout the industry. For more product information, please go to https://www.msi.com/

●All rights of the technical, pictures, text and other content published in this press release are reserved. Contents are subject to changes without prior notice.

 

View original content:https://www.prnewswire.com/in/news-releases/msi-unveils-new-laptop-lineup-featuring-nvidia-geforce-rtx-50-series-at-ces-2025-302347010.html

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Technology

CHIME and ScaleHealth Announce Joint Venture to Expand Healthcare’s Innovation Ecosystem

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ScaleHealth, powered by CHIME, creates new pathways connecting healthcare leaders, innovators, technology partners, and investors to accelerate the future of digital health.

ANN ARBOR, Mich., Oct. 27, 2026 /PRNewswire/ — The College of Healthcare Information Management Executives (CHIME) today announced a strategic joint venture with ScaleHealth, Inc. to create ScaleHealth, powered by CHIME, LLC, a new innovation ecosystem designed to connect healthcare’s most pressing challenges with the innovators, leaders, organizations, and partners capable of solving them. By combining CHIME’s trusted digital health community with ScaleHealth’s expansive innovation ecosystem, the venture creates a unique environment where healthcare organizations, entrepreneurs, established technology companies, and investors can discover, connect, validate, and advance the ideas shaping the future of healthcare.

For 35 years, CHIME has evolved alongside the digital health leaders it serves. What began as a community centered on healthcare CIOs has grown into a global network of digital health leaders supported through education, events, research, policy initiatives, media platforms, executive collaboration, and professional communities. The creation of ScaleHealth, powered by CHIME represents the next chapter in that evolution, expanding CHIME’s ecosystem to include the innovators, entrepreneurs, and emerging technology companies helping define what comes next in healthcare.

As healthcare organizations face increasing pressure to improve outcomes, strengthen operations, address workforce challenges, improve cybersecurity, and realize the promise of emerging technologies including artificial intelligence, the need for stronger connections across the innovation ecosystem has never been greater. ScaleHealth, powered by CHIME was created to help build those connections.

“CHIME has spent 35 years bringing together the leaders responsible for solving healthcare’s most important technology and transformation challenges,” said Russ Branzell, President and CEO of CHIME. “As the pace of innovation continues to accelerate, we have an opportunity to expand that trusted community even further. ScaleHealth, powered by CHIME, extends our ecosystem to include entrepreneurs, innovators, investors, and emerging technology companies so that healthcare leaders can engage earlier, collaborate more effectively, and help shape the innovations that will define the future of healthcare.”

The opportunity emerged through CHIME’s growing innovation programming, particularly its Innovation Summit series, where healthcare leaders and technology companies increasingly expressed a desire to engage more directly with innovators and entrepreneurial organizations. At the same time, startups and growth-stage companies were seeking trusted pathways into healthcare and stronger connections to leaders who understand the industry’s real-world operational challenges.

“Healthcare has no shortage of innovation. The challenge is creating trusted pathways that connect innovators with the healthcare leaders who understand the industry’s most urgent problems,” said Taylor McPartland, CEO of ScaleHealth and leader of the new venture. “By combining ScaleHealth’s innovation ecosystem with CHIME’s trusted community of digital health leaders, we’re creating an environment where meaningful connections can lead to validation, partnership, and real-world impact. This is about bringing together everyone who has a role to play in the future of healthcare innovation and helping them move great ideas forward.”

Unlike traditional accelerators, startup showcases, or innovation marketplaces, ScaleHealth, powered by CHIME is designed as a trusted innovation ecosystem. Healthcare organizations bring forward meaningful challenges. Innovators and startups contribute cutting-edge ideas and technologies. Established technology organizations bring expertise, infrastructure, and scale. Investors provide capital and growth pathways. Together, these stakeholders create an environment where innovation can move from discovery and connection to validation, partnership, and measurable impact.

“Throughout its history, CHIME has grown by bringing the right people together around the challenges that matter most,” said Tressa Springmann, Senior Vice President and Chief Information and Digital Officer at LifeBridge Health and Chair of the CHIME Foundation Board of Directors. “Today, innovation is essential to every aspect of healthcare transformation. ScaleHealth, powered by CHIME extends that trusted community into a broader innovation ecosystem, creating new opportunities for healthcare leaders, entrepreneurs, technology partners, and investors to collaborate, learn from one another, and accelerate meaningful progress across healthcare.”

The venture reflects CHIME’s belief that the next era of digital health will be co-created by healthcare leaders, technology partners, entrepreneurs, investors, and innovators working together to solve the challenges that matter most. By creating a trusted environment for discovery, collaboration, validation, and advancement, ScaleHealth, powered by CHIME aims to become the connective layer between healthcare’s needs and the innovation being built to address them.

Read the full release here.

About CHIME
The College of Healthcare Information Management Executives (CHIME) is the leading professional organization for digital health executives and leaders. CHIME provides a trusted, collaborative environment where members and partners connect, share best practices, advance professional development, and advocate for the effective use of information and technology to improve health and care in the communities they serve. For more information, please visit chimecentral.org.

For media inquiries, please contact:

Contact

Calli Dretke
Executive Vice President & Chief Digital and Marketing Officer
CHIME                                                                                                           
734.412.6255
cdretke@dhinsights.org

View original content to download multimedia:https://www.prnewswire.com/news-releases/chime-and-scalehealth-announce-joint-venture-to-expand-healthcares-innovation-ecosystem-302921260.html

SOURCE College of Healthcare Information Management Executives (CHIME)

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Technology

In HelloNation, Prenatal Imaging Expert Erika Lambright Explains Ultrasound Differences Between 2D, 3D, And 4D Imaging

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The article outlines how each type of pregnancy ultrasound supports fetal development and family understanding.

DENISON, Texas, Oct. 27, 2026 /PRNewswire/ — What is the difference between 2D, 3D, and 4D ultrasound imaging during pregnancy? HelloNation has published an article that clearly explains the differences between ultrasound and other prenatal imaging modalities and how each supports fetal development.

The HelloNation article explains that a 2d ultrasound is the most common form of prenatal imaging used during routine pregnancy ultrasound appointments. It produces flat, black-and-white images that allow medical providers to assess fetal development, monitor growth, and evaluate vital structures. The article notes that 2D ultrasound plays a central role in identifying potential concerns early and remains the foundation of prenatal diagnostic imaging.

According to the article, a 3d ultrasound builds on the same technology but creates a more detailed still image with depth. This form of prenatal imaging allows families to see clearer views of the baby’s face, hands, and feet. While 3d ultrasound can support certain medical evaluations, the article describes its primary value as helping parents better visualize fetal development in a more lifelike way.

The article further describes how a 4D ultrasound adds motion to the 3d ultrasound image. This allows families to view real-time video of the baby moving, stretching, or making facial expressions. The article explains that this type of pregnancy ultrasound creates a more engaging experience and helps strengthen the emotional connection, while still using the same safe, noninvasive prenatal imaging technology.

The HelloNation article emphasizes that understanding ultrasound differences helps families set clear expectations before imaging sessions. Each type of pregnancy ultrasound serves a distinct purpose. 2D ultrasound focuses on medical accuracy and fetal development monitoring, while 3D and 4D ultrasound provide enhanced visualization and connection. The article highlights that medical professionals typically rely on 2D ultrasound for diagnostic purposes, while 3D and 4D ultrasound are often optional.

The article also notes that several factors can affect the quality of prenatal imaging results. Baby position, gestational age, and fluid levels all play a role in how clearly images appear, especially during 3D and 4D ultrasound sessions. The article explains that providers often guide families on the best timing for ultrasound visits during pregnancy to improve image clarity and achieve better results.

Prenatal Imaging Experts emphasize through the article that learning about ultrasound differences can reduce uncertainty and help families feel more prepared. By understanding how each type of prenatal imaging contributes to monitoring fetal development, expectant parents can approach each pregnancy ultrasound appointment with clearer expectations.

The article concludes that while 2D ultrasound remains essential for medical care, the added perspectives of 3D and 4D ultrasound offer families a broader, more personal understanding of fetal development. Together, these forms of prenatal imaging provide both clinical insight and meaningful connection throughout pregnancy.

What Is the Difference Between 2D, 3D, and 4D Ultrasounds Explained Simply features insights from Erika Lambright, Prenatal Imaging Experts of Denison, Texas, in HelloNation.

About HelloNation
HelloNation is America’s Good News Network, a premier media platform built on the idea that good news travels faster when real people tell real stories. Through its community-focused digital publications and innovative “edvertising” approach, HelloNation delivers expert-driven, good-news content that informs, inspires, and spotlights the leaders making a meaningful impact in their communities. HelloNation maintains partnerships with the U.S. Conference of Mayors and the United States First Responders Association.

View original content to download multimedia:https://www.prnewswire.com/news-releases/in-hellonation-prenatal-imaging-expert-erika-lambright-explains-ultrasound-differences-between-2d-3d-and-4d-imaging-302792440.html

SOURCE HelloNation

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Grünenthal presents Phase III results for Qutenza® in post-surgical neuropathic pain at IASP 2026 World Congress on Pain

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Late-breaking data from the Phase III RISE trial further strengthen the well-established efficacy and safety profile of Qutenza®. Post-surgical neuropathic pain is a debilitating complication of surgery affecting millions of patients every year.1 

AACHEN, Germany, Oct. 27, 2026 /PRNewswire/ — Grünenthal, a global leader in pain management and research, today announced new data from the Phase III RISE trial (NCT04967664), evaluating Qutenza® versus control in people with post-surgical neuropathic pain. These data were shared today as late-breaking poster presentations at the 2026 International Association for the Study of Pain (IASP) World Congress on Pain in Bangkok, Thailand.

The trial (n=409) showed that Qutenza® achieved a statistically significantly greater reduction in average pain intensity (API) than the control treatment over weeks 2-12, meeting one of its pre-specified primary endpoints. When evaluating API at week 12 specifically, at the point when patients would typically return for retreatment, the numerical difference favoured Qutenza® but did not reach statistical significance. In the extension phase of the trial, in which up to 4 retreatments were allowed, Qutenza® achieved a statistically significantly greater reduction in API than the control treatment over weeks 2-42. Safety findings were consistent with previous Qutenza® trials and no new safety signals were observed. These data support the well-established efficacy and safety profile of Qutenza®.2,3

“Post-surgical neuropathic pain can be difficult to manage with current treatment options, and there is an urgent need for patient-centred, effective solutions. The RISE trial provides encouraging evidence that Qutenza® can deliver clinically meaningful and sustained pain reduction for up to 42 weeks, having shown a greater reduction in average pain intensity than the control,” said Prof. Patrice Forget, MD, PhD, FFPMRCA, Clinical Chair (full professor) in Anaesthesia, University of Aberdeen, and Honorary Consultant, NHS Grampian, Aberdeen, UK. “As IASP shines a global spotlight on neuropathic pain at this year’s congress, findings such as these are important to help improve outcomes for patients and reduce the burden of pain on families and healthcare systems.”

“Post-surgical neuropathic pain has been relatively understudied and continues to go under-recognised in clinical practice,” said Uli Brödl, Chief Scientific Officer, Grünenthal. “These results build on the robust body of evidence for Qutenza® and reinforce its potential to provide meaningful, long-lasting pain relief for people living with pain.”

Post-surgical neuropathic pain is a poorly recognised potential complication of surgery that can result in devastating outcomes. It affects millions of patients every year, with pain lasting for months or years post-procedure.1 It can also have a significant mental health impact, with patients reporting feeling extremely depressed or anxious, and having problems with daily activities.4

Qutenza® is already approved in Europe for the treatment of peripheral neuropathic pain in adults, either alone or in combination with other medicinal products for the treatment of pain.5 It is also approved in the US for the treatment of neuropathic pain associated with postherpetic neuralgia and for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) of the feet in adults.6

About the RISE trial2,3
The RISE (AV-001) trial is a Phase III multi-centre, randomised, double-blind, parallel-group trial to confirm the efficacy and safety of Qutenza 179mg cutaneous patch versus a low-dose capsaicin control patch in people with moderate to severe post-surgical neuropathic pain.

It included eligible adults with a 24-hour average pain intensity (API) score of 4 or more, a pain duration of 6 to 60 months after index surgery and a DN4 (Douleur Neuropathique 4) Interview score of 3 or more.

Participants were randomly assigned to receive treatment with either a 60-minute Qutenza patch (8%) or a low-dose capsaicin control patch (0.04%).

The trial had two primary endpoints:

Change in 24-hour API from baseline to the average score of the entire period between Week 2 and Week 12.Change in 24-hour API from baseline to the average score at Week 12.

The primary sponsor of the trial is Averitas Pharma, Inc., Grünenthal’s U.S. subsidiary.

About post-surgical neuropathic pain
Post-surgical neuropathic pain (PSNP) is defined as chronic pain with neuropathic characteristics that develops or increases after surgery and persists beyond the normal healing process. It is thought to arise, at least in part, from nerve injury and pain sensitisation associated with surgery.7

The signs and symptoms of peri- and post-surgical pain can vary based on the person and the severity of the injury caused in surgery. Reported symptoms include pain caused by stimuli that are normally painless (allodynia), abnormally increased sensitivity to pain (hyperalgesia), tingling, numbness, phantom pain and scar pain.8,9,10 

About Qutenza®
In Europe, Qutenza® (capsaicin) is indicated for the treatment of peripheral neuropathic pain in adults, either alone or in combination with other medicinal products for the treatment of pain.5

Qutenza® (capsaicin) 8% topical system is approved in the US for the treatment of neuropathic pain associated with postherpetic neuralgia and for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) of the feet in adults. Important US safety information is available at www.qutenza.com.6

Qutenza® is a topical TRPV1 agonist, designed to provide neuropathic pain relief for up to three months through defunctionalisation of nociceptors and nerve fibre regeneration.

About Grünenthal
Grünenthal is a global leader in pain management and related diseases. As a science-based, fully integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We focus all our activities and efforts on working towards our vision of a World Free of Pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 28 countries across Europe, Latin America, and the U.S. Our products are available in approx. 100 countries. In 2025, Grünenthal employed around 4,100 people and achieved revenues of €1.8 billion.

More information: www.grunenthal.com

Follow us on LinkedIn & Instagram

For further information, please contact:

Matt Crabb, Head of Global Communications (Interim) at Grünenthal

matt.crabb@grunenthal.com 

References

1 Gregory P & Settles K. Pract Pain Manag. 2013;13(9):1–6.
2 Wallace M et al. Efficacy of high-concentration capsaicin patch in post-surgical neuropathic pain (RISE). Presented at the International Association for the Study of Pain World Congress 2026.
3 Wallace M et al. Safety and tolerability of high-concentration capsaicin patch in post-surgical neuropathic pain (RISE). Presented at the International Association for the Study of Pain World Congress 2026.
4 Santos MP, Lemos F, Gomes J, Romao JM, Veiga D. Br J Pain 2024;18(1):42–56.
5 European Medicines Agency. Qutenza 179 mg cutaneous patch SmPC. Available at: https://www.medicines.org.uk/emc/product/573/smpc
6 US Food and Drug Administration. Qutenza® Prescribing Information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022395s019lbl.pdf
7 Correl D. F1000Res. 2017;6:1054.
8 Werner MU & Kongsgaard UE. Br J Anaesth. 2014;113(1):1–4.
9 Macrae WA. Br J Anaesth. 2008;101:77–86.
10 Searle RD & Simpson KH. Contin Educ Anaesth Crit Care Pain. 2010;10:12–14.

View original content:https://www.prnewswire.com/news-releases/grunenthal-presents-phase-iii-results-for-qutenza-in-post-surgical-neuropathic-pain-at-iasp-2026-world-congress-on-pain-302921015.html

SOURCE Grünenthal Group

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