Technology
Veeva Announces Fiscal 2027 First Quarter Results
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5 months agoon
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Total Revenues of $882.9M, up 16% Year Over Year
Subscription Revenues of $730.2M, up 15% Year Over Year
PLEASANTON, Calif., June 3, 2026 /PRNewswire/ — Veeva Systems Inc. (NYSE: VEEV), a leading provider of industry cloud solutions for the global life sciences industry, today announced results for its first quarter ended April 30, 2026.
“Our rapid progress with Veeva AI sets the foundation as we enter the next chapter of our industry cloud,” said CEO Peter Gassner. “We are moving from an industry-specific application company to an industry-specific application and AI agent company. This is a major transformation for Veeva and the industry that will help our customers bring the right medicines to patients faster.”
Fiscal 2027 First Quarter Results:
Revenues: Total revenues for the first quarter were $882.9 million, up from $759.0 million one year ago, an increase of 16% year over year. Subscription revenues for the first quarter were $730.2 million, up from $634.8 million one year ago, an increase of 15% year over year.
Operating Income and Non-GAAP Operating Income:(1) First quarter operating income was $273.1 million, compared to $233.7 million one year ago, an increase of 17% year over year. Non-GAAP operating income for the first quarter was $395.4 million, compared to $349.9 million one year ago, an increase of 13% year over year.
Net Income and Non-GAAP Net Income:(1) First quarter net income was $260.9 million, compared to $228.2 million one year ago, an increase of 14% year over year. Non-GAAP net income for the first quarter was $371.1 million, compared to $327.8 million one year ago, an increase of 13% year over year.
Net Income per Share and Non-GAAP Net Income per Share:(1) For the first quarter, fully diluted net income per share was $1.57, compared to $1.37 one year ago, while non-GAAP fully diluted net income per share was $2.24, compared to $1.97 one year ago.
“Our first quarter results exceeded guidance on all metrics, reflecting another quarter of broad-based growth and profitability,” said CFO Brian Van Wagener. “We’re pleased with the raised fiscal 2027 guidance and energized by the large and growing opportunity ahead.”
Recent Highlights:
Advancing Industry AI with Rapid Progress Across Veeva AI – Veeva significantly advanced its industry AI strategy this quarter. Ostro, acquired in March, is delivering compliant, conversational AI for more than 50 brands. Vault AI is on track to expand to all Vault applications in August. Veeva Falcon, the new platform delivering agentic labor for clinical, regulatory, and safety, is planned for early adopter release in November.Leading the Industry with Agentic Commercial – At Commercial Summit in May, Veeva shared its vision for Agentic Commercial, leveraging AI to help biopharmas bring the right medicines to more patients. With capabilities like the Agentic Call Report in Vault CRM and Ostro’s conversational AI on brand websites, biopharmas can now generate and act on Commercial Evidence. In Vault CRM, the industry’s fastest path to Agentic CRM success, Veeva added 27 new Vault CRM customers in the quarter and now has more than 150 customers live.Bringing Agentic Labor to Veeva Development Cloud – Veeva expanded its leadership with multiple enterprise biopharma wins across clinical, regulatory, and safety. Additionally, Veeva showcased its AI strategy at the recent European R&D and Quality Summit in Copenhagen, generating strong customer interest in Vault AI and Veeva Falcon to drive productivity and speed in drug development.
Financial Outlook:
Veeva is providing guidance for its fiscal second quarter ending July 31, 2026 as follows:
Total revenues between $902 and $905 million.Non-GAAP operating income between $392 and $395 million.(2)Non-GAAP fully diluted net income per share between $2.21 and $2.22.(2)
Veeva is providing updated guidance for its fiscal year ending January 31, 2027 as follows:
Total revenues between $3,635 and $3,645 million.Non-GAAP operating income of about $1,610 million.(2)Non-GAAP fully diluted net income per share of approximately $9.05.(2)
Conference Call Information
Prepared remarks and an investor presentation providing additional information and analysis can be found on Veeva’s investor relations website at ir.veeva.com. Veeva will host a Q&A conference call at 2:00 p.m. PT today, June 3, 2026, and a replay of the call will be available on Veeva’s investor relations website.
What:
Veeva Systems Fiscal 2027 First Quarter Results Conference Call
When:
Wednesday, June 3, 2026
Time:
2:00 p.m. PT (5:00 p.m. ET)
Online Registration:
https://events.q4inc.com/analyst/423437130?pwd=ckfYa8Xa
Webcast:
___________
(1) This press release uses non-GAAP financial metrics that are adjusted for the impact of various GAAP items. See the section titled “Non-GAAP Financial Measures” and the tables entitled “Reconciliation of GAAP to Non-GAAP Financial Measures” below for details.
(2) Veeva is not able, at this time, to provide GAAP targets for operating income and fully diluted net income per share for the second fiscal quarter ending July 31, 2026 or the fiscal year ending January 31, 2027 because of the difficulty of estimating certain items excluded from non-GAAP operating income and non-GAAP fully diluted net income per share that cannot be reasonably predicted, such as charges related to stock-based compensation expense. The effect of these excluded items may be significant.
About Veeva Systems
Veeva delivers the industry cloud for life sciences with cloud software, AI, data, and business consulting. Committed to innovation, product excellence, and customer success, Veeva serves more than 1,500 customers, ranging from the world’s largest pharmaceutical companies to emerging biotechs. As a Public Benefit Corporation, Veeva is committed to balancing the interests of all stakeholders, including customers, employees, shareholders and the industries it serves. For more information, visit veeva.com.
Veeva uses its ir.veeva.com website as a means of disclosing material non-public information, announcing upcoming investor conferences, and for complying with its disclosure obligations under Regulation FD. Accordingly, you should monitor our investor relations website in addition to following our press releases, SEC filings, and public conference calls and webcasts.
Forward-looking Statements
This release contains forward-looking statements regarding Veeva’s expected future performance and, in particular, includes quotes from management and guidance, provided as of June 3, 2026, about Veeva’s expected future financial results. Estimating guidance accurately for future periods is difficult. It involves assumptions and internal estimates that may prove to be incorrect and is based on plans that may change. Hence, there is a significant risk that actual results could differ materially from the guidance we have provided in this release and we have no obligation to update such guidance. There are also numerous risks that have the potential to negatively impact our financial performance, including issues related to the performance, availability, security, or privacy of our products, competitive factors, customer decisions and priorities, developments that impact the life sciences industry (including regulatory, funding, or policy changes), general macroeconomic and geopolitical events (including changes in trade policy or practices, inflationary pressures, currency exchange fluctuations, changes in interest rates, and geopolitical conflicts), and issues that impact our ability to hire, retain and adequately compensate talented employees. We have summarized what we believe are the principal risks to our business in a section titled “Summary of Risk Factors” on pages 13 and 14 in our filing on Form 10-K for the period ended January 31, 2026 which you can find here. Additional details on the risks and uncertainties that may impact our business can be found in the same filing on Form 10-K and in our subsequent SEC filings, which you can access at sec.gov. We recommend that you familiarize yourself with these risks and uncertainties before making an investment decision.
Investor Relations Contact:
Media Contact:
Gunnar Hansen
Maria Scurry
Veeva Systems Inc.
Veeva Systems Inc.
267-460-5839
781-366-7617
VEEVA SYSTEMS INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In thousands)
(Unaudited)
April 30,
2026
January 31,
2026
Assets
Current assets:
Cash and cash equivalents
$ 1,896,580
$ 1,421,233
Short-term investments
5,416,139
5,139,581
Accounts receivable, net
568,020
1,259,737
Unbilled accounts receivable
59,752
50,609
Prepaid expenses and other current assets
122,770
126,470
Total current assets
8,063,261
7,997,630
Property and equipment, net
73,484
70,261
Deferred costs, net
28,686
29,961
Lease right-of-use assets
82,060
75,626
Goodwill
488,161
439,877
Intangible assets, net
55,508
30,314
Deferred income taxes
272,665
273,417
Other long-term assets
65,733
62,257
Total assets
$ 9,129,558
$ 8,979,343
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable
$ 40,657
$ 37,644
Accrued compensation and benefits
52,572
45,857
Accrued expenses and other current liabilities
50,974
45,885
Income tax payable
67,897
6,698
Deferred revenue
1,476,539
1,488,819
Lease liabilities
13,131
12,153
Total current liabilities
1,701,770
1,637,056
Deferred income taxes
1,148
558
Long-term lease liabilities
89,936
83,706
Other long-term liabilities
32,350
43,271
Total liabilities
1,825,204
1,764,591
Stockholders’ equity:
Common stock
2
2
Additional paid-in capital
2,699,707
2,843,089
Accumulated other comprehensive (loss) income
(19,792)
8,160
Retained earnings
4,624,437
4,363,501
Total stockholders’ equity
7,304,354
7,214,752
Total liabilities and stockholders’ equity
$ 9,129,558
$ 8,979,343
VEEVA SYSTEMS INC.
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME
(In thousands, except per share data)
(Unaudited)
Three months ended April 30,
2026
2025
Revenues:
Subscription(3)
$ 730,175
$ 634,768
Professional services and other(4)
152,773
124,275
Total revenues
882,948
759,043
Cost of revenues(5):
Cost of subscription
99,103
78,346
Cost of professional services and other
121,821
95,478
Total cost of revenues
220,924
173,824
Gross profit
662,024
585,219
Operating expenses(5):
Research and development
208,323
184,033
Sales and marketing
111,117
98,628
General and administrative
69,472
68,826
Total operating expenses
388,912
351,487
Operating income
273,112
233,732
Other income, net
74,418
65,089
Income before income taxes
347,530
298,821
Income tax provision
86,594
70,631
Net income
$ 260,936
$ 228,190
Net income per share:
Basic
$ 1.60
$ 1.40
Diluted
$ 1.57
$ 1.37
Weighted-average shares used to compute net income per share:
Basic
163,345
162,749
Diluted
165,989
166,229
Other comprehensive income:
Net change in unrealized (loss) gain on available-for-sale investments
$ (27,451)
$ 17,367
Net change in cumulative foreign currency translation loss
(501)
(38)
Comprehensive income
$ 232,984
$ 245,519
(3) Includes subscription revenues from the following product areas:
Veeva Commercial Solutions
$ 337,866
$ 305,411
Veeva R&D and Quality Solutions
392,309
329,357
Total subscription
$ 730,175
$ 634,768
(4) Includes professional services and other revenues from the following product areas:
Veeva Commercial Solutions
$ 57,573
$ 46,567
Veeva R&D and Quality Solutions
95,200
77,708
Total professional services and other
$ 152,773
$ 124,275
(5) Includes stock-based compensation as follows:
Cost of revenues:
Cost of subscription
$ 1,761
$ 1,715
Cost of professional services and other
14,151
12,769
Research and development
51,563
47,949
Sales and marketing
24,594
22,321
General and administrative
27,190
27,456
Total stock-based compensation
$ 119,259
$ 112,210
VEEVA SYSTEMS INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(In thousands)
(Unaudited)
Three months ended April 30,
2026
2025
Cash flows from operating activities
Net income
$ 260,936
$ 228,190
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization
11,587
9,822
Reduction of lease right-of-use assets
3,279
3,265
Accretion of discount on short-term investments
(1,788)
(2,509)
Stock-based compensation
119,259
112,210
Amortization of deferred costs
4,900
4,043
Deferred income taxes
14,337
(27,418)
Other, net
(1,777)
4,327
Changes in operating assets and liabilities:
Accounts receivable
696,614
522,686
Unbilled accounts receivable
(9,143)
(7,672)
Deferred costs
(3,625)
(4,055)
Prepaid expenses and other current and long-term assets
(7,984)
(4,501)
Accounts payable
4,473
7,743
Accrued expenses and other current liabilities
8,923
(8,720)
Income tax payable
61,199
82,345
Deferred revenue
(32,963)
(41,361)
Lease liabilities
(2,460)
(2,543)
Other long-term liabilities
1,349
1,306
Net cash provided by operating activities
1,127,116
877,158
Cash flows from investing activities
Purchases of short-term investments
(982,315)
(667,100)
Maturities and sales of short-term investments
670,835
620,903
Long-term assets
(1,751)
(5,910)
Acquisitions, net of cash acquired
(75,480)
—
Net cash used in investing activities
(388,711)
(52,107)
Cash flows from financing activities
Proceeds from exercise of common stock options
2,939
40,605
Repurchases of common stock
(226,947)
—
Taxes paid related to net share settlement of equity awards
(38,518)
(20,225)
Net cash (used in) provided by financing activities
(262,526)
20,380
Effect of exchange rate changes on cash, cash equivalents, and restricted cash
(532)
766
Net change in cash, cash equivalents, and restricted cash
475,347
846,197
Cash, cash equivalents, and restricted cash at beginning of period
1,423,412
1,120,963
Cash, cash equivalents, and restricted cash at end of period
$ 1,898,759
$ 1,967,160
Supplemental disclosures of other cash flow information:
Excess tax (deficiency) benefit from employee stock plans
$ (4,092)
$ 2,579
Non-GAAP Financial Measures
In Veeva’s public disclosures, Veeva has provided non-GAAP measures, which it defines as financial information that has not been prepared in accordance with generally accepted accounting principles in the United States, or GAAP. In addition to its GAAP measures, Veeva uses these non-GAAP financial measures internally for budgeting and resource allocation purposes and in analyzing its financial results. For the reasons set forth below, Veeva believes that excluding the following items provides information that is helpful in understanding its operating results, evaluating its future prospects, comparing its financial results across accounting periods, and comparing its financial results to its peers, many of which provide similar non-GAAP financial measures.
Excess tax benefit (deficiency). Excess tax benefits (deficiencies) from employee stock plans are dependent on previously agreed-upon equity grants to our employees, vesting of those grants, stock price, and exercise behavior of our employees, which can fluctuate from quarter to quarter. Because these fluctuations are not directly related to our business operations, Veeva finds it useful to exclude excess tax benefits (deficiencies) when assessing the level of cash provided by operating activities. Given the nature of the excess tax benefits (deficiencies), Veeva believes excluding it allows investors to make meaningful comparisons between our operating cash flows from quarter to quarter and those of other companies.Stock-based compensation expenses. Veeva excludes stock-based compensation expenses primarily because they are non-cash expenses that Veeva excludes from its internal management reporting processes. Veeva’s management also finds it useful to exclude these expenses when they assess the appropriate level of various operating expenses and resource allocations when budgeting, planning and forecasting future periods. Moreover, because of varying available valuation methodologies, subjective assumptions and the variety of award types that companies can use, Veeva believes excluding stock-based compensation expenses allows investors to make meaningful comparisons between our recurring core business operating results and those of other companies.Amortization of purchased intangibles. Veeva incurs amortization expense for purchased intangible assets in connection with acquisitions of certain businesses and technologies. Amortization of intangible assets is a non-cash expense and is inconsistent in amount and frequency because it is significantly affected by the timing, size of acquisitions and the inherent subjective nature of purchase price allocations. Because these costs have already been incurred and cannot be recovered, and are non-cash expenses, Veeva excludes these expenses for its internal management reporting processes. Veeva’s management also finds it useful to exclude these charges when assessing the appropriate level of various operating expenses and resource allocations when budgeting, planning and forecasting future periods. Investors should note that the use of intangible assets contributed to Veeva’s revenues earned during the periods presented and will contribute to Veeva’s future period revenues as well.Litigation settlement-related charges. We exclude certain costs related to litigation settlements, including outcome-based payments to the law firms that represented us, because they are non-recurring and outside the ordinary course of business. Because these costs are unrelated to our day-to-day business operations, we believe excluding them enables more consistent evaluation of our operating results.Income tax effects on the difference between GAAP and non-GAAP costs and expenses. The income tax effects that are excluded relate to the imputed tax impact on the difference between GAAP and non-GAAP costs and expenses due to stock-based compensation and purchased intangibles for GAAP and non-GAAP measures.
There are limitations to using non-GAAP financial measures because non-GAAP financial measures are not prepared in accordance with GAAP and may be different from non-GAAP financial measures provided by other companies. The non-GAAP financial measures are limited in value because they exclude certain items that may have a material impact upon our reported financial results. In addition, they are subject to inherent limitations as they reflect the exercise of judgments by Veeva’s management about which items are adjusted to calculate its non-GAAP financial measures. Veeva compensates for these limitations by analyzing current and future results on a GAAP basis as well as a non-GAAP basis and also by providing GAAP measures in its public disclosures.
Non-GAAP financial measures should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with GAAP. Veeva encourages its investors and others to review its financial information in its entirety, not to rely on any single financial measure to evaluate its business, and to view its non-GAAP financial measures in conjunction with the most directly comparable GAAP financial measures. A reconciliation of GAAP to the non-GAAP financial measures has been provided in the tables below.
VEEVA SYSTEMS INC.
RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL MEASURES
(Dollars in thousands)
(Unaudited)
The following tables reconcile the specific items excluded from GAAP metrics in the calculation of non-GAAP metrics for the periods shown below:
Reconciliation of Net Cash Provided by Operating Activities (GAAP basis to non-GAAP basis)
Three months ended April 30,
2026
2025
Net cash provided by operating activities on a GAAP basis
$ 1,127,116
$ 877,158
Excess tax deficiency (benefit) from employee stock plans
4,092
(2,579)
Net cash provided by operating activities on a non-GAAP basis
$ 1,131,208
$ 874,579
Net cash used in investing activities on a GAAP basis
$ (388,711)
$ (52,107)
Net cash (used in) provided by financing activities on a GAAP basis
$ (262,526)
$ 20,380
Reconciliation of Financial Measures (GAAP basis to non-GAAP basis)
Three months ended April 30,
2026
2025
Cost of subscription revenues on a GAAP basis
$ 99,103
$ 78,346
Stock-based compensation expense
(1,761)
(1,715)
Amortization of purchased intangibles
(674)
(1,012)
Cost of subscription revenues on a non-GAAP basis
$ 96,668
$ 75,619
Gross margin on subscription revenues on a GAAP basis
86.4 %
87.7 %
Stock-based compensation expense
0.2
0.3
Amortization of purchased intangibles
0.2
0.1
Gross margin on subscription revenues on a non-GAAP basis
86.8 %
88.1 %
Cost of professional services and other revenues on a GAAP basis
$ 121,821
$ 95,478
Stock-based compensation expense
(14,151)
(12,769)
Amortization of purchased intangibles
—
(134)
Cost of professional services and other revenues on a non-GAAP basis
$ 107,670
$ 82,575
Gross margin on professional services and other revenues on a GAAP basis
20.3 %
23.2 %
Stock-based compensation expense
9.2
10.3
Amortization of purchased intangibles
—
0.1
Gross margin on professional services and other revenues on a non-GAAP basis
29.5 %
33.6 %
Gross profit on a GAAP basis
$ 662,024
$ 585,219
Stock-based compensation expense
15,912
14,484
Amortization of purchased intangibles
674
1,146
Gross profit on a non-GAAP basis
$ 678,610
$ 600,849
Gross margin on total revenues on a GAAP basis
75.0 %
77.1 %
Stock-based compensation expense
1.8
1.9
Amortization of purchased intangibles
0.1
0.2
Gross margin on total revenues on a non-GAAP basis
76.9 %
79.2 %
Research and development expense on a GAAP basis
$ 208,323
$ 184,033
Stock-based compensation expense
(51,563)
(47,949)
Research and development expense on a non-GAAP basis
$ 156,760
$ 136,084
Three months ended April 30,
2026
2025
Sales and marketing expense on a GAAP basis
$ 111,117
$ 98,628
Stock-based compensation expense
(24,594)
(22,321)
Amortization of purchased intangibles
(2,331)
(2,795)
Sales and marketing expense on a non-GAAP basis
$ 84,192
$ 73,512
General and administrative expense on a GAAP basis
$ 69,472
$ 68,826
Stock-based compensation expense
(27,190)
(27,456)
General and administrative expense on a non-GAAP basis
$ 42,282
$ 41,370
Operating expense on a GAAP basis
$ 388,912
$ 351,487
Stock-based compensation expense
(103,347)
(97,726)
Amortization of purchased intangibles
(2,331)
(2,795)
Operating expense on a non-GAAP basis
$ 283,234
$ 250,966
Operating income on a GAAP basis
$ 273,112
$ 233,732
Stock-based compensation expense
119,259
112,210
Amortization of purchased intangibles
3,005
3,941
Operating income on a non-GAAP basis
$ 395,376
$ 349,883
Operating margin on a GAAP basis
30.9 %
30.8 %
Stock-based compensation expense
13.5
14.8
Amortization of purchased intangibles
0.4
0.5
Operating margin on a non-GAAP basis
44.8 %
46.1 %
Net income on a GAAP basis
$ 260,936
$ 228,190
Stock-based compensation expense
119,259
112,210
Amortization of purchased intangibles
3,005
3,941
Income tax effect on non-GAAP adjustments(6)
(12,063)
(16,513)
Net income on a non-GAAP basis
$ 371,137
$ 327,828
Diluted net income per share on a GAAP basis
$ 1.57
$ 1.37
Stock-based compensation expense
0.72
0.68
Amortization of purchased intangibles
0.02
0.02
Income tax effect on non-GAAP adjustments(6)
(0.07)
(0.10)
Diluted net income per share on a non-GAAP basis
$ 2.24
$ 1.97
________________________
(6)
For the three months ended April 30, 2026 and 2025, management used an estimated annual effective non-GAAP tax rate of 21.0%.
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SOURCE Veeva Systems
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734.412.6255
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October 27, 2026By
The article outlines how each type of pregnancy ultrasound supports fetal development and family understanding.
DENISON, Texas, Oct. 27, 2026 /PRNewswire/ — What is the difference between 2D, 3D, and 4D ultrasound imaging during pregnancy? HelloNation has published an article that clearly explains the differences between ultrasound and other prenatal imaging modalities and how each supports fetal development.
The HelloNation article explains that a 2d ultrasound is the most common form of prenatal imaging used during routine pregnancy ultrasound appointments. It produces flat, black-and-white images that allow medical providers to assess fetal development, monitor growth, and evaluate vital structures. The article notes that 2D ultrasound plays a central role in identifying potential concerns early and remains the foundation of prenatal diagnostic imaging.
According to the article, a 3d ultrasound builds on the same technology but creates a more detailed still image with depth. This form of prenatal imaging allows families to see clearer views of the baby’s face, hands, and feet. While 3d ultrasound can support certain medical evaluations, the article describes its primary value as helping parents better visualize fetal development in a more lifelike way.
The article further describes how a 4D ultrasound adds motion to the 3d ultrasound image. This allows families to view real-time video of the baby moving, stretching, or making facial expressions. The article explains that this type of pregnancy ultrasound creates a more engaging experience and helps strengthen the emotional connection, while still using the same safe, noninvasive prenatal imaging technology.
The HelloNation article emphasizes that understanding ultrasound differences helps families set clear expectations before imaging sessions. Each type of pregnancy ultrasound serves a distinct purpose. 2D ultrasound focuses on medical accuracy and fetal development monitoring, while 3D and 4D ultrasound provide enhanced visualization and connection. The article highlights that medical professionals typically rely on 2D ultrasound for diagnostic purposes, while 3D and 4D ultrasound are often optional.
The article also notes that several factors can affect the quality of prenatal imaging results. Baby position, gestational age, and fluid levels all play a role in how clearly images appear, especially during 3D and 4D ultrasound sessions. The article explains that providers often guide families on the best timing for ultrasound visits during pregnancy to improve image clarity and achieve better results.
Prenatal Imaging Experts emphasize through the article that learning about ultrasound differences can reduce uncertainty and help families feel more prepared. By understanding how each type of prenatal imaging contributes to monitoring fetal development, expectant parents can approach each pregnancy ultrasound appointment with clearer expectations.
The article concludes that while 2D ultrasound remains essential for medical care, the added perspectives of 3D and 4D ultrasound offer families a broader, more personal understanding of fetal development. Together, these forms of prenatal imaging provide both clinical insight and meaningful connection throughout pregnancy.
What Is the Difference Between 2D, 3D, and 4D Ultrasounds Explained Simply features insights from Erika Lambright, Prenatal Imaging Experts of Denison, Texas, in HelloNation.
About HelloNation
HelloNation is America’s Good News Network, a premier media platform built on the idea that good news travels faster when real people tell real stories. Through its community-focused digital publications and innovative “edvertising” approach, HelloNation delivers expert-driven, good-news content that informs, inspires, and spotlights the leaders making a meaningful impact in their communities. HelloNation maintains partnerships with the U.S. Conference of Mayors and the United States First Responders Association.
View original content to download multimedia:https://www.prnewswire.com/news-releases/in-hellonation-prenatal-imaging-expert-erika-lambright-explains-ultrasound-differences-between-2d-3d-and-4d-imaging-302792440.html
SOURCE HelloNation
Technology
Grünenthal presents Phase III results for Qutenza® in post-surgical neuropathic pain at IASP 2026 World Congress on Pain
Published
9 minutes agoon
October 27, 2026By
Late-breaking data from the Phase III RISE trial further strengthen the well-established efficacy and safety profile of Qutenza®. Post-surgical neuropathic pain is a debilitating complication of surgery affecting millions of patients every year.1
AACHEN, Germany, Oct. 27, 2026 /PRNewswire/ — Grünenthal, a global leader in pain management and research, today announced new data from the Phase III RISE trial (NCT04967664), evaluating Qutenza® versus control in people with post-surgical neuropathic pain. These data were shared today as late-breaking poster presentations at the 2026 International Association for the Study of Pain (IASP) World Congress on Pain in Bangkok, Thailand.
The trial (n=409) showed that Qutenza® achieved a statistically significantly greater reduction in average pain intensity (API) than the control treatment over weeks 2-12, meeting one of its pre-specified primary endpoints. When evaluating API at week 12 specifically, at the point when patients would typically return for retreatment, the numerical difference favoured Qutenza® but did not reach statistical significance. In the extension phase of the trial, in which up to 4 retreatments were allowed, Qutenza® achieved a statistically significantly greater reduction in API than the control treatment over weeks 2-42. Safety findings were consistent with previous Qutenza® trials and no new safety signals were observed. These data support the well-established efficacy and safety profile of Qutenza®.2,3
“Post-surgical neuropathic pain can be difficult to manage with current treatment options, and there is an urgent need for patient-centred, effective solutions. The RISE trial provides encouraging evidence that Qutenza® can deliver clinically meaningful and sustained pain reduction for up to 42 weeks, having shown a greater reduction in average pain intensity than the control,” said Prof. Patrice Forget, MD, PhD, FFPMRCA, Clinical Chair (full professor) in Anaesthesia, University of Aberdeen, and Honorary Consultant, NHS Grampian, Aberdeen, UK. “As IASP shines a global spotlight on neuropathic pain at this year’s congress, findings such as these are important to help improve outcomes for patients and reduce the burden of pain on families and healthcare systems.”
“Post-surgical neuropathic pain has been relatively understudied and continues to go under-recognised in clinical practice,” said Uli Brödl, Chief Scientific Officer, Grünenthal. “These results build on the robust body of evidence for Qutenza® and reinforce its potential to provide meaningful, long-lasting pain relief for people living with pain.”
Post-surgical neuropathic pain is a poorly recognised potential complication of surgery that can result in devastating outcomes. It affects millions of patients every year, with pain lasting for months or years post-procedure.1 It can also have a significant mental health impact, with patients reporting feeling extremely depressed or anxious, and having problems with daily activities.4
Qutenza® is already approved in Europe for the treatment of peripheral neuropathic pain in adults, either alone or in combination with other medicinal products for the treatment of pain.5 It is also approved in the US for the treatment of neuropathic pain associated with postherpetic neuralgia and for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) of the feet in adults.6
About the RISE trial2,3
The RISE (AV-001) trial is a Phase III multi-centre, randomised, double-blind, parallel-group trial to confirm the efficacy and safety of Qutenza 179mg cutaneous patch versus a low-dose capsaicin control patch in people with moderate to severe post-surgical neuropathic pain.
It included eligible adults with a 24-hour average pain intensity (API) score of 4 or more, a pain duration of 6 to 60 months after index surgery and a DN4 (Douleur Neuropathique 4) Interview score of 3 or more.
Participants were randomly assigned to receive treatment with either a 60-minute Qutenza patch (8%) or a low-dose capsaicin control patch (0.04%).
The trial had two primary endpoints:
Change in 24-hour API from baseline to the average score of the entire period between Week 2 and Week 12.Change in 24-hour API from baseline to the average score at Week 12.
The primary sponsor of the trial is Averitas Pharma, Inc., Grünenthal’s U.S. subsidiary.
About post-surgical neuropathic pain
Post-surgical neuropathic pain (PSNP) is defined as chronic pain with neuropathic characteristics that develops or increases after surgery and persists beyond the normal healing process. It is thought to arise, at least in part, from nerve injury and pain sensitisation associated with surgery.7
The signs and symptoms of peri- and post-surgical pain can vary based on the person and the severity of the injury caused in surgery. Reported symptoms include pain caused by stimuli that are normally painless (allodynia), abnormally increased sensitivity to pain (hyperalgesia), tingling, numbness, phantom pain and scar pain.8,9,10
About Qutenza®
In Europe, Qutenza® (capsaicin) is indicated for the treatment of peripheral neuropathic pain in adults, either alone or in combination with other medicinal products for the treatment of pain.5
Qutenza® (capsaicin) 8% topical system is approved in the US for the treatment of neuropathic pain associated with postherpetic neuralgia and for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) of the feet in adults. Important US safety information is available at www.qutenza.com.6
Qutenza® is a topical TRPV1 agonist, designed to provide neuropathic pain relief for up to three months through defunctionalisation of nociceptors and nerve fibre regeneration.
About Grünenthal
Grünenthal is a global leader in pain management and related diseases. As a science-based, fully integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We focus all our activities and efforts on working towards our vision of a World Free of Pain.
Grünenthal is headquartered in Aachen, Germany, and has affiliates in 28 countries across Europe, Latin America, and the U.S. Our products are available in approx. 100 countries. In 2025, Grünenthal employed around 4,100 people and achieved revenues of €1.8 billion.
More information: www.grunenthal.com
Follow us on LinkedIn & Instagram
For further information, please contact:
Matt Crabb, Head of Global Communications (Interim) at Grünenthal
References
1 Gregory P & Settles K. Pract Pain Manag. 2013;13(9):1–6.
2 Wallace M et al. Efficacy of high-concentration capsaicin patch in post-surgical neuropathic pain (RISE). Presented at the International Association for the Study of Pain World Congress 2026.
3 Wallace M et al. Safety and tolerability of high-concentration capsaicin patch in post-surgical neuropathic pain (RISE). Presented at the International Association for the Study of Pain World Congress 2026.
4 Santos MP, Lemos F, Gomes J, Romao JM, Veiga D. Br J Pain 2024;18(1):42–56.
5 European Medicines Agency. Qutenza 179 mg cutaneous patch SmPC. Available at: https://www.medicines.org.uk/emc/product/573/smpc
6 US Food and Drug Administration. Qutenza® Prescribing Information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022395s019lbl.pdf
7 Correl D. F1000Res. 2017;6:1054.
8 Werner MU & Kongsgaard UE. Br J Anaesth. 2014;113(1):1–4.
9 Macrae WA. Br J Anaesth. 2008;101:77–86.
10 Searle RD & Simpson KH. Contin Educ Anaesth Crit Care Pain. 2010;10:12–14.
View original content:https://www.prnewswire.com/news-releases/grunenthal-presents-phase-iii-results-for-qutenza-in-post-surgical-neuropathic-pain-at-iasp-2026-world-congress-on-pain-302921015.html
SOURCE Grünenthal Group
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Grünenthal presents Phase III results for Qutenza® in post-surgical neuropathic pain at IASP 2026 World Congress on Pain
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