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TAM Global Founder and Chief Scientific Advisor Publishes First-Principles Framework for Accelerating Translational Medicine

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4 months ago

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New commentary argues that the next breakthrough in medicine may come not only from discovering new therapies, but from redesigning the systems that bring them to patients

NASHVILLE, Tenn., July 10, 2026 /PRNewswire/ — A newly published commentary by TAM Global founder Edward Clay and Annette Marleau, Ph.D., proposes a first-principles framework for accelerating translational medicine and reducing the time it takes for scientific discoveries to reach patients.

Published July 3, 2026, in Translational Insights, the paper, “A First-Principles Framework for Accelerating Translational Medicine,” challenges a central assumption in modern healthcare: that progress depends primarily on discovering new therapies. While scientific discovery remains essential, the authors argue that medicine must also confront a more fundamental question—whether the systems used to translate discoveries into patient care are still fit for the speed, complexity, and urgency of modern biomedical science.

The commentary notes that drug development and translational research can take more than a decade to bring promising discoveries to clinical implementation. For patients with aggressive cancers, rare diseases, neurodegenerative disorders, and other life-threatening conditions, timelines measured in years can be incompatible with the reality of disease progression.

Rather than asking how to make the existing system incrementally more efficient, Clay and Marleau apply first-principles thinking to translational medicine: if the system were designed today from the ground up, based on current biology, technology, economics, and patient need, would it look the way it does now? The authors argue that the answer is likely no.

The paper proposes a more integrated translational model built around speed of learning, proximity between clinicians and scientists, data fidelity, cost efficiency, and alignment with patient outcomes. In this model, research, diagnostics, imaging, data science, manufacturing, pharmacy, and clinical care operate within a connected ecosystem rather than as fragmented, sequential steps across disconnected organizations.

By compressing feedback loops, the authors suggest that clinical observations can more quickly generate scientific questions, while laboratory insights can more rapidly inform patient care. Tissue obtained during an interventional procedure, for example, could move directly into genomic, proteomic, pathological, and functional analysis, allowing teams to learn and iterate faster than traditional handoff-based models allow.

The framework also addresses the role of global clinical research and modern regulatory strategy. The authors argue that responsible acceleration does not require lowering standards for safety, evidence, or patient protection. Instead, they propose that fully licensed and compliant international clinical environments can help generate earlier, more informative data, which can then support more efficient engagement with regulatory agencies in other jurisdictions, including the United States.

“Transformative advances often begin by questioning assumptions that have come to be accepted as inevitable,” said Ed Clay, co-author of the paper and founder of TAM Global. “Patients facing cancer, rare diseases, neurodegenerative disorders, and other life-threatening illnesses cannot afford unnecessary delays. Our goal was to ask what is truly essential to translating scientific discoveries into patient benefit and what could be redesigned. We hope this framework encourages researchers, clinicians, regulators, industry leaders, and policymakers to think more broadly about how translational medicine can evolve to move faster, learn faster, and better serve patients.”

The commentary argues that speed and rigor should not be treated as opposing priorities. With better system design, the authors suggest, translational medicine can reduce avoidable delays while improving the quality, continuity, and usefulness of the information generated throughout development.

The paper also reframes patient access as an ethical consideration. In traditional models, patients may encounter innovation only after long development cycles are complete. A first-principles approach, the authors write, considers not only safety and evidence, but also timing, urgency, informed decision-making, and the patient’s ability to participate in decisions when facing serious illness and limited options.

Clay and Marleau conclude that the future of medicine will depend not only on advances in biology, artificial intelligence, genomics, regenerative medicine, and precision medicine, but also on the architecture of the systems that translate those advances into clinical impact.

For more information or to read the full paper, visit the open-access publication.

About TAM Global

Translational and Advanced Medical Global advances translational medicine by integrating research, clinical insight, diagnostics, data, manufacturing, and therapeutic development into coordinated systems designed to move scientific discoveries toward patient impact more efficiently.

View original content to download multimedia:https://www.prnewswire.com/news-releases/tam-global-founder-and-chief-scientific-advisor-publishes-first-principles-framework-for-accelerating-translational-medicine-302822862.html

SOURCE The TAM Center

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The Next Frontier: Consciousness & UAP: $100,000 Research Prize Winner Announced

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17 minutes ago

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November 6, 2026

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The Institute of Noetic Sciences (IONS) has announced the winner of the 2026 Linda G. O’Bryant Noetic Sciences Research Prize, a $100,000 award that will fund a study of consciousness-associated Unidentified Anomalous Phenomena (UAP, formerly known as UFOs).

NOVATO, Calif., Nov. 5, 2026 /PRNewswire-PRWeb/ — The winning study, selected from more than 80 qualifying proposals, comes from a multidisciplinary team of six. Peter Skafish, PhD, a sociocultural anthropologist and Co-Founder and Executive Director of The Sol Foundation, leads the team as Principal Investigator. Brian Lord, PhD, a cognitive neuroscientist and postdoctoral researcher at the University of Arizona, serves as Co-Principal Investigator, and David Dominguez Hooper, engineer and Founder and CEO of ELDAEON Inc., is Co-Investigator. Collaborators are Damon Abraham, PhD (experimental psychologist, Entangled Labs); Jacob Haqq-Misra, PhD (astrobiologist, Blue Marble Space); and Garry Nolan, PhD (immunologist, Stanford University School of Medicine). For the first time in the prize’s four-year history, a single team will receive the full $100,000.

“IONS proved itself to be over the horizon of even heterodox thinking in their decision to fund a scientific inquiry not only into UAP but also into one of the most enigmatic questions the phenomena raise: what is their relationship to human consciousness?”–Peter Skafish

The team will organize a group of experienced practitioners to apply meditation and conscious intention to invite contact with UAP at a remote site in the American Southwest. Practitioners’ experiences will be recorded alongside physiological measures and instrumental records of the sky and the physical environment. Using preregistered methodology, the study will analyze the data to test whether deliberate contact practice generates changes in reported experiences and in independently recorded events in the sky and environment. De-identified data and methods will be shared openly, and null results will be released on the same schedule as positive ones.

According to IONS leadership, this year’s prize was created to bring UAP into open, consciousness-inclusive science, and to carry forward a question with profound implications for humanity that its founder, Apollo 14 astronaut Edgar Mitchell, pursued for decades: whether consciousness and contact are connected.

“The Sol Foundation couldn’t be more happy to receive the recognition of IONS for our research,” said Peter Skafish. “IONS proved itself to be over the horizon of even heterodox thinking in their decision to fund a scientific inquiry not only into UAP but also into one of the most enigmatic questions the phenomena raise: what is their relationship to human consciousness?”

This year, distinguished external experts, including Daniel P. Sheehan, Jessica Utts, Adam Curry, Sean Esbjörn-Hargens, Richard Dolan, and J.J. Hurtak, joined members of the IONS science team on the judging panel, chaired by Arnaud Delorme. The panel’s selection was then ratified by the IONS Board of Directors.

IONS researchers will collaborate with the winning team on the study, which is expected to begin in December and run for one year, with results to be shared in 2028. The winning team was announced on October 30 during a live event, which can be watched here.

More About IONS & the Linda G. O’Bryant Noetic Sciences Research Prize

The Institute of Noetic Sciences (IONS) is a nonprofit scientific research center whose mission is to reveal the interconnected nature of reality through scientific exploration and personal discovery. Founded in 1973 by Apollo 14 astronaut Edgar Mitchell, IONS investigates consciousness, interconnectedness, and extended human capacities to help foster a more compassionate and thriving world. The Linda G. O’Bryant Noetic Sciences Research Prize, now in its fourth year, is funded through an endowment created by Linda G. O’Bryant, member of the IONS Board of Directors, and overseen by the Board. To arrange an interview with Peter Skafish or IONS leadership, contact communications@noetic.org. More details about the prize and winners can be found here.

Media Contact

Leslie G. Lovejoy, Institute of Noetic Sciences (IONS), 1 707-775-3500, communications@noetic.org, www.noetic.org

View original content:https://www.prweb.com/releases/the-next-frontier-consciousness–uap-100-000-research-prize-winner-announced-302930915.html

SOURCE Institute of Noetic Sciences (IONS)

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Budget 2026 advances national electricity strategy, a downpayment on unlocking $3 trillion in economic growth

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17 minutes ago

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November 6, 2026

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Proposed tax credit extensions and support for industrial electrification and EV charging can help build more clean power and put it to work

OTTAWA, ON, Nov. 5, 2026 /CNW/ — New Economy Canada strongly supports the finalization and funding of Powering Canada Strong in Budget 2026 with a $50 billion commitment, marking an important step toward doubling Canada’s electricity supply by 2050. Budget 2026 puts electrification at the heart of Canada’s economy, ensuring energy security and affordability for businesses and households.  

Ian Bruce, President of New Economy Canada said:

“Today we are celebrating a critical win for Canada. By finalizing and funding Powering Canada Strong, the federal government has made electricity an economic priority.  Budget 2026’s $50B commitment to doubling the grid, including strengthening and extending the clean economy investment tax credits, is a significant step.

Budget 2026 puts an electrified economy at the heart of Canada’s economic strategy. We are glad to see the federal government recognize that building more clean electricity, electrifying more of our economy, and improving energy efficiency are some of the most effective ways to build a competitive, strong economy and ensure energy security for businesses and households alike.

Our economic report shows the opportunity on the table. Doubling electricity supply and doubling the share of energy that homes, businesses and industry meet with electricity could add more than $3 trillion cumulatively to Canada’s economy by 2050. Getting there will take sustained investment and a workforce that can build projects at the pace and scale we need.”

Why this matters:

Affordable, clean electricity can help Canada win investment, strengthen competitiveness, modernize manufacturing and create jobs. As Canada looks for new investors and trading partners in an electrifying global economy, its abundant, affordable and clean electricity is a competitive advantage.Doubling Canada’s electricity supply and putting it to work could unlock $3 trillion of economic opportunity for Canada and 1.6 million jobs.The budget’s extension of investment tax credits will support much-needed investment in generating and transmitting more electricity. And support for industrial electrification and EV charging will help businesses and households make greater use of that power.Every province stands to benefit, with cross-sectoral growth. Growth associated with an electrified economy spans all provinces and beyond electricity generation to services, mining, construction and more. 

New Economy Canada is a non-partisan initiative uniting 70+ companies, labour unions and Indigenous organizations, all committed to accelerating investment in Canada’s clean economy. Our partners employ or represent over 750,000 workers. https://neweconomycanada.ca 

SOURCE New Economy Canada

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East Side Games Group to Announce Third Quarter 2026 Financial Results

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18 minutes ago

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November 6, 2026

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VANCOUVER, BC, Nov. 5, 2026 /CNW/ — East Side Games Group (“ESGG” or the “Company”), Canada’s leading free-to-play mobile game group, will release its third quarter ended September 30th, 2026, after market close on November 12th. Following the release, the Company will host a conference call to review its performance with the investment community at 3:30pm PT (Western Canada), 2:30pm PT, 5:30pm ET on the same day.

Related earnings release materials can be found in the Investors section of ESGG’s website at https://eastsidegamesgroup.com/investors/financial-information/.

Conference Call Details:

Toll Free Dial-In Number:       (+1) 800 717 1738
Local Dial-In Number:            (+1) 289 514 5100
Conference ID:                       53358

A replay will be available by dialing (+1) 888 660-6264 or (+1) 289 819-1325 and entering passcode 53358#.

ABOUT EAST SIDE GAMES GROUP

ESGG is a leader in free-to-play mobile gaming, thrilling players with unforgettable experiences that spark lifelong fandom. Fueled by an entrepreneurial spirit, we are driven by creativity, flawless execution, and a laser-focused growth strategy. We develop and publish both original and licensed IP titles, license our cutting-edge GameKit(s) platforms, and strategically acquire studios or games to expand our family. Headquartered in Vancouver with around 80 talent-dense team members, we operate over a dozen titles under East Side Games (“ESG”) and LDRLY (Technologies) Inc. (“LDRLY”). Together, we’re crafting, launching, and publishing mobile games across our own studios and an extended Game Kit partner network–reaching players on iOS and Android worldwide.

We power our success through in-app purchases (“IAP”)–offering exclusive, game-enhancing virtual items–and in-game advertising. To keep growing, we focus on captivating audiences, keeping them engaged, and unlocking exciting new ways to monetize. We’ll drive this momentum by launching bold new titles, enriching our current lineup, innovating discovery, expanding into fresh markets and exploring new distribution platforms.

Additional information about the Company continues to be available under its legal name, East Side Games Group Inc., at www.sedar.com.

Forward-looking Information

Certain statements in this release are forward-looking statements, which reflect the expectations of management regarding the proposed transactions described herein. Forward-looking statements consist of statements that are not purely historical, including any statements regarding beliefs, plans, expectations or intentions regarding the future. Such statements are subject to risks and uncertainties that may cause actual results, performance or developments to differ materially from those contained in the statements. No assurance can be given that any of the events anticipated by the forward-looking statements will occur or, if they do occur, what benefits the Company will obtain from them. These forward-looking statements reflect management’s current views and are based on certain expectations, estimates and assumptions which may prove to be incorrect. A number of risks and uncertainties could cause our actual results to differ materially from those expressed or implied by the forward-looking statements, including factors beyond the Company’s control. These forward-looking statements are made as of the date of this news release.

SOURCE East Side Games Group Inc.

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