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TAM Global Founder and Chief Scientific Advisor Publishes First-Principles Framework for Accelerating Translational Medicine

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New commentary argues that the next breakthrough in medicine may come not only from discovering new therapies, but from redesigning the systems that bring them to patients

NASHVILLE, Tenn., July 10, 2026 /PRNewswire/ — A newly published commentary by TAM Global founder Edward Clay and Annette Marleau, Ph.D., proposes a first-principles framework for accelerating translational medicine and reducing the time it takes for scientific discoveries to reach patients.

Published July 3, 2026, in Translational Insights, the paper, “A First-Principles Framework for Accelerating Translational Medicine,” challenges a central assumption in modern healthcare: that progress depends primarily on discovering new therapies. While scientific discovery remains essential, the authors argue that medicine must also confront a more fundamental question—whether the systems used to translate discoveries into patient care are still fit for the speed, complexity, and urgency of modern biomedical science.

The commentary notes that drug development and translational research can take more than a decade to bring promising discoveries to clinical implementation. For patients with aggressive cancers, rare diseases, neurodegenerative disorders, and other life-threatening conditions, timelines measured in years can be incompatible with the reality of disease progression.

Rather than asking how to make the existing system incrementally more efficient, Clay and Marleau apply first-principles thinking to translational medicine: if the system were designed today from the ground up, based on current biology, technology, economics, and patient need, would it look the way it does now? The authors argue that the answer is likely no.

The paper proposes a more integrated translational model built around speed of learning, proximity between clinicians and scientists, data fidelity, cost efficiency, and alignment with patient outcomes. In this model, research, diagnostics, imaging, data science, manufacturing, pharmacy, and clinical care operate within a connected ecosystem rather than as fragmented, sequential steps across disconnected organizations.

By compressing feedback loops, the authors suggest that clinical observations can more quickly generate scientific questions, while laboratory insights can more rapidly inform patient care. Tissue obtained during an interventional procedure, for example, could move directly into genomic, proteomic, pathological, and functional analysis, allowing teams to learn and iterate faster than traditional handoff-based models allow.

The framework also addresses the role of global clinical research and modern regulatory strategy. The authors argue that responsible acceleration does not require lowering standards for safety, evidence, or patient protection. Instead, they propose that fully licensed and compliant international clinical environments can help generate earlier, more informative data, which can then support more efficient engagement with regulatory agencies in other jurisdictions, including the United States.

“Transformative advances often begin by questioning assumptions that have come to be accepted as inevitable,” said Ed Clay, co-author of the paper and founder of TAM Global. “Patients facing cancer, rare diseases, neurodegenerative disorders, and other life-threatening illnesses cannot afford unnecessary delays. Our goal was to ask what is truly essential to translating scientific discoveries into patient benefit and what could be redesigned. We hope this framework encourages researchers, clinicians, regulators, industry leaders, and policymakers to think more broadly about how translational medicine can evolve to move faster, learn faster, and better serve patients.”

The commentary argues that speed and rigor should not be treated as opposing priorities. With better system design, the authors suggest, translational medicine can reduce avoidable delays while improving the quality, continuity, and usefulness of the information generated throughout development.

The paper also reframes patient access as an ethical consideration. In traditional models, patients may encounter innovation only after long development cycles are complete. A first-principles approach, the authors write, considers not only safety and evidence, but also timing, urgency, informed decision-making, and the patient’s ability to participate in decisions when facing serious illness and limited options.

Clay and Marleau conclude that the future of medicine will depend not only on advances in biology, artificial intelligence, genomics, regenerative medicine, and precision medicine, but also on the architecture of the systems that translate those advances into clinical impact.

For more information or to read the full paper, visit the open-access publication.

About TAM Global

Translational and Advanced Medical Global advances translational medicine by integrating research, clinical insight, diagnostics, data, manufacturing, and therapeutic development into coordinated systems designed to move scientific discoveries toward patient impact more efficiently.

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SOURCE The TAM Center

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webAI Launches webAI App for On-Device AI With No Per-Token Charges

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The webAI app lets anyone build teams of AI experts that work across Slack, DocuSign, Hugging Face, Apple apps and more, while their files stay on their Mac.

AUSTIN, Texas, Nov. 5, 2026 /PRNewswire/ — webAI today released the webAI app for Mac to the public for the first time. The app runs webAI’s new small reasoning models on the user’s own computer, so people can use AI on private work without sending files to the cloud or paying per token.

Most AI runs in the cloud, where usage is metered by tokens or capped by plan, and every document goes to someone else’s servers. webAI runs the model on the Mac itself. A user can work through a sensitive client proposal or an unfinished business plan, revise it as many times as they want, and never hit a token limit.

“With the webAI app, we’re making cloud AI optional,” said David Stout, CEO and co-founder of webAI. “Why should you have to send a private document to an online service just to get help with it? Your Mac can do the work. You keep control of what you share, and you can ask as many follow-up questions as you need without watching a token meter.”

In the app, users create Personas: AI experts with a role, knowledge and tools the user chooses. Several Personas can work together on the same task. A consultant could have one pull client requirements from project notes, a second draft the proposal and a third check the draft for anything missed.

Connectors work with the apps you already use, including Slack, DocuSign, Hugging Face and Apple apps. You control what each Persona can access and what actions it can take. A Persona can pull a client’s latest decisions from Slack, see which contracts are still unsigned in DocuSign, and draft follow-ups for your approval. You spend less time hunting for context and copying details between apps.

Watch the demo: https://www.webai.com/blog/webai-launches-webai-app-for-on-device-ai-with-no-per-token-charges 

Availability: The webAI app is available now for Mac at webAI.com.

About webAI

webAI builds technology that lets people create, run, and control AI on their own devices.

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SOURCE webAI

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Cheche Group Announces Extraordinary General Meeting

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BEIJING, Nov. 5, 2026 /PRNewswire/ — Cheche Group Inc. (NASDAQ: CCG) (“Cheche” or the “Company”), China’s leading auto insurance technology platform, today announced that an extraordinary general meeting of the Company (the “Meeting”) will be held at 10 A.M. on November 25, 2026, Beijing time (9 P.M. on November 24, 2026, U.S. Eastern time) at 8/F, Desheng Hopson Fortune Plaza, 13-1 Deshengmenwai Avenue, Xicheng District, Beijing 100088, China. The Company has established the close of business on November 5, 2026, Eastern time (the “Record Date”), as the record date for determining shareholders entitled to notice of, and to vote at, the Meeting and any adjournments or postponements thereof. The purpose of the Meeting includes, among others:

(1) to approve by ordinary resolution the creation of a new class of ordinary shares of the Company designated as class C ordinary shares, each with a par value of US$0.00035 (the “Class C Ordinary Shares”), with the rights and restrictions set forth in the proposed third amended and restated memorandum and articles of association of the Company (the “New M&A”), including 300 votes per Class C Ordinary Share;

(2) to approve by ordinary resolution that the authorized share capital of the Company be amended:

(i) FROM: US$50,000 divided into 142,857,143 shares comprising (i) 114,285,714 class A ordinary shares of a par value of US$0.00035 each, and (ii) 28,571,429 class B ordinary shares of a par value of US$0.00035 each,

(ii) TO: US$50,000 divided into 142,857,143 shares comprising (i) 114,285,714 class A ordinary shares of a par value of US$0.00035 each; (ii) 18,571,429 class B ordinary shares of a par value of US$0.00035 each; and (iii) 10,000,000 class C ordinary shares of a par value of US$0.00035 each;

(3) to approve by ordinary resolution that 10,000,000 authorized but unissued class B ordinary shares of the Company of a par value of US$0.00035 each be re-classified as 10,000,000 class C ordinary shares of the Company of a par value of US$0.00035 each with the rights attached to it in the New M&A; and

(4) to approve by special resolution the amendment and restatement of the Company’s second amended and restated memorandum and articles of association currently in effect (the “Current M&A”) be replaced in their entirety with the New M&A to provide for, among other things, the creation and rights of the Class C Ordinary Shares.

Copies of the notice of the Meeting and the form of proxy are available on the Company’s corporate investor relations website at https://ir.chechegroup.com/.

Safe Harbor Statements

This press release includes “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words such as “estimate,” “plan,” “project,” “forecast,” “intend,” “will,” “expect,” “anticipate,” “believe,” “seek,” “target” or other similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements also include, but are not limited to, statements regarding existing and new partnerships and customer relationships, projections, estimation, and forecasts of revenue and other financial and performance metrics, projections of market opportunity and expectations, the Company’s ability to scale and grow its business, the Company’s advantages and expected growth, and its ability to source and retain talent, as applicable. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of the Company’s management and are not predictions of actual performance. These statements involve risks, uncertainties, and other factors that may cause the Company’s actual results, levels of activity, performance, or achievements to materially differ from those expressed or implied by these forward-looking statements. Further information regarding these and other risks, uncertainties, or factors is included in the Company’s filings with the U.S. Securities and Exchange Commission. Although the Company believes that it has a reasonable basis for each forward-looking statement contained in this press release, the Company cautions you that these statements are based on a combination of facts and factors currently known and projections of the future, which are inherently uncertain. The forward-looking statements in this press release represent the views of the Company as of the date of this press release. Subsequent events and developments may cause those views to change. Except as may be required by law, the Company does not undertake any duty to update these forward-looking statements.

About Cheche Group Inc.

Established in 2014 and headquartered in Beijing, China, Cheche is a leading auto insurance technology platform with a nationwide network of around 108 branches licensed to distribute insurance policies across 25 provinces, autonomous regions, and municipalities in China. Capitalizing on its leading position in auto insurance transaction services, Cheche has evolved into a comprehensive, data-driven technology platform that offers a full suite of services and products for digital insurance transactions and insurance SaaS solutions in China. Learn more at https://www.chechegroup.com/en.

Cheche Group Inc.:
IR@chechegroup.com

Crocker Coulson
crocker.coulson@aumadvisors.com
(646) 652-7185

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SOURCE Cheche Group Inc.

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Hyperliquid Strategies Inc Reports Financial Results for the Quarter Ended September 30, 2026

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NEW YORK, Nov. 5, 2026 /PRNewswire/ — Hyperliquid Strategies Inc (NASDAQ: PURR) (“HSI” or the “Company”), the premier digital asset treasury platform focused on the Hyperliquid ecosystem, today reported its financial and operational results for the quarter ended September 30, 2026.

“We deployed $802 million this quarter and filed an application to become a futures commission merchant,” said David Schamis, CEO of Hyperliquid Strategies Inc. “Those two moves are the same bet. Hyperliquid is winning the parts of onchain finance that generate real fees, and nearly all of that value flows back to HYPE holders through programmatic buybacks. Owning HYPE is how we aim to capture economics associated with the Hyperliquid protocol; setting up an FCM is how we intend to help bring markets deployed on Hyperliquid onshore.”

Key Highlights (as of or for the Quarter Ended September 30, 2026):

Raised $911 million in equity capital under our committed equity facility.Deployed $802 million; $785 million to acquire 9.1 million HYPE tokens, increasing the treasury from 29.3 million tokens at June 30, 2026 to 38.5 million tokens at September 30, 2026 and $17 million to repurchase 2.7 million PURR shares.Maintained strong balance sheet, with $254.6 million in cash and cash-like instruments and zero debt.Hyperliquid Strategies x Unit validator is now the largest non-Foundation validator on the network.

Hyperliquid Ecosystem Momentum1
Momentum continues to build around the adoption of the blockchain by the global financial system, with much of that momentum represented within the Hyperliquid ecosystem.

As Hyperliquid pursues its vision of becoming the infrastructure to house all of finance, the Hyperliquid protocol continues to generate an increasingly diversified stream of fees (with about $834 million in value accruing to the Hyperliquid ecosystem for the twelve months ended September 30, 2026), processing billions in daily trading volumes, with much of the value generated by the Hyperliquid ecosystem directly accruing to the HYPE token through programmatic HYPE token buybacks.

Hyperliquid recently announced its intention to add additional deployer functionalities under the name HIP-3*. These optional additional features would allow deployers to build and launch permissioned markets on Hyperliquid’s onchain infrastructure. Independent operators would run their own market in a compliant manner, while the chain underneath would stay a neutral infrastructure layer.

In support of these developments, a subsidiary of HSI has filed an application to become a futures commission merchant (“FCM”). Subject to regulatory approval, the FCM would carry US client accounts for permissioned markets deployed on Hyperliquid under HIP-3*, allowing HSI to play a role in bringing perpetual futures to US customers within a regulated framework. There can be no assurance as to the timing or outcome of the application or regulatory approval of permissioned HIP-3* markets.

HSI Financial Highlights for the Quarter Ended September 30, 2026:

Balance Sheet:Total assets of $3,764.3 million as of September 30, 2026, including $254.6 million in cash and cash-like instruments and $3,505.3 million in HYPE tokens (based on a September 30, 2026 HYPE price of $90.99 per HYPE token, representing approximately 38.52 million tokens held).Strong balance sheet with $3,403.0 million in stockholders’ equity and no debt.Income Statement (quarter ended September 30, 2026):$12.3 million in staking revenue and validator commissions from HYPE holdings.$1.0 million in interest income.$7.6 million in SG&A and R&D expenses.$620.6 million in net income.Net income primarily comprised of:$803.0 million in net unrealized gains on HYPE tokens.$15.3 million in primarily non-cash expense recognized in connection with the committed equity facility.$172.3 million in provision for income taxes.

Update on Treasury Strategy Progress (as of October 28, 2026):

Capital Deployment2:$1,583.2 million deployed to accumulate ~25.9 million HYPE tokens at an average cost of $61.13, bringing total HYPE token holdings (including staking and validator rewards earned)  to 38.9 million at a blended cost of $56.35 per token.$27.9 million deployed to repurchase ~5.8 million PURR shares at an average cost of $4.81 per PURR share.Capital Raising:$1,578.4 million raised at an average issue price of $10.36 per PURR share under our committed equity facility.Cash balance:$245.3 million in remaining cash and cash-like instruments.

Webcast:
The Company will host an audio webcast with Q&A on Thursday, November 5, 2026, at 5:15 p.m. ET, featuring CEO David Schamis and CFO Brett Beldner. Register in advance here: https://hyperliquid-strategies-earnings-call-q1-2027.open-exchange.net/registration.

Advance questions may be submitted to investors@hypestrat.xyz.

A replay will be available after the event at www.hypestrat.xyz.

About Hyperliquid Strategies Inc
Hyperliquid Strategies Inc (NASDAQ: PURR) is a digital asset treasury company whose primary focus is to maximize shareholder value through accumulating HYPE, the native token of Hyperliquid, a high-performance blockchain custom-built to house all of finance. HSI aims to provide capital-efficient and productive access to the HYPE token for U.S. and institutional investors, generating compounding shareholder returns that individual holders may not be able to replicate through staking, yield optimization, and active ecosystem engagement. HSI is currently the largest HYPE-focused digital asset treasury vehicle capitalizing on Hyperliquid’s rapid growth and providing exposure to one of the largest and fastest growing revenue pools in digital assets. For more information, please visit www.hypestrat.xyz.

Website Information:
The Hyperliquid Strategies Inc website (www.hypestrat.xyz) includes, among other information, a dedicated section tracking the Company’s “Adjusted Net Asset Value” (the Company’s stockholders’ equity adjusted for, among other things, movements in cash, the value of the HYPE token and the number of HYPE tokens held).

This section is updated regularly, enhancing transparency for the Company’s stockholders and aligning with HSI’s commitment to provide transparent, capital efficient and productive access to the HYPE token.

We use our website as a means of disclosing information that may be considered material, non-public information (including the information regarding our Adjusted Net Asset Value) and for complying with our disclosure obligations under Regulation FD. Accordingly, investors should monitor our website, in addition to following our press releases, Securities and Exchange Commission (“SEC”) filings, public conference calls, presentations and webcasts.

We may also use social media channels to communicate with our investors and the public about us and other matters, and those communications could be deemed to be material information. The information contained on, or that may be accessed through, our website or social media channels is not incorporated by reference into, and is not a part of, this document.

Forward-Looking Statements
This press release contains certain statements which are not historical facts, which are forward-looking statements within the meaning of the federal securities laws, for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. These forward-looking statements include certain statements made with respect to the Company’s business, strategy and future plans, including plans to become a futures commission merchant, as well as certain statements regarding expected growth and developments with respect to Hyperliquid. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “potential,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events or conditions that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties that could cause the actual results to differ materially from the expected results. These risks and uncertainties include, but are not limited to: changes in business, market, financial, political and regulatory conditions; risks relating to HSI’s operations and business, including the highly volatile nature of the price of HYPE tokens; the risk that HSI’s stock price will be highly correlated to the price of HYPE tokens and the price of HYPE tokens may decrease; risks related to increased competition in the industries in which HSI operates; risks relating to significant legal, commercial, regulatory and technical uncertainty regarding HYPE tokens; risks relating to the treatment of crypto assets for U.S. and foreign tax purposes; risks that HSI experiences difficulties managing its growth and expanding operations; challenges in implementing HSI’s business plan including HYPE token-related financial and advisory services, due to operational challenges, significant competition and regulation; and those factors discussed in the annual report on Form 10-K filed by HSI with the SEC on August 27, 2026, and in subsequent filings and reports made by HSI with the SEC from time to time. While HSI may elect to update these forward-looking statements at some point in the future, HSI specifically disclaims any obligation to do so.

1 Information in this section is based on public information and has not been independently verified by HSI.
2 Capital raising and deployment cover the period from inception (December 2, 2025) until August 28, 2026.

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SOURCE Hyperliquid Strategies Inc

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