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Senhwa’s CX-5461 Opens a New Frontier in Photoimmunotherapy; Multinational Study Published in Nucleic Acids Research

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TAIPEI and SAN DIEGO, Aug. 12, 2026 /PRNewswire/ — Senhwa Biosciences, Inc. (TPEx: 6492) today announced a significant research advance involving its investigational drug Pidnarulex (CX-5461). A multinational research team comprising investigators from Poland, Slovakia, France and Senhwa Biosciences in Taiwan found that, under specific cell-based experimental conditions, controlled light activation increased the cancer-cell-killing activity of CX-5461 by up to 96-fold and induced immunogenic cell death (ICD). The findings, published in the peer-reviewed journal Nucleic Acids Research, reveal that CX-5461 may have potential applications in photodynamic therapy and photoimmunotherapy in addition to its established research profile involving G-quadruplex (G4) targeting and DNA-damage-related mechanisms. The study opens a potential new development path for this clinical-stage asset.

Turning Photosensitivity into a Controlled Therapeutic Mechanism
Photosensitivity observed during the clinical development of CX-5461 has generally been viewed as a drug characteristic requiring risk management. In the new study, researchers reframed this property as a potentially controllable and spatially targeted therapeutic mechanism. By applying light of an appropriate wavelength to the tumor area, CX-5461 may be activated at the intended site, increasing local tumor-cell killing while limiting activity in non-illuminated tissue.

This light-switch concept could extend CX-5461 from a systemically administered anticancer agent into a photosensitizer with temporal and spatial control. The approach may warrant further investigation in tumors that are accessible to external light, endoscopy or fiber-optic delivery, including selected skin, oral and esophageal tumors.

Light Activation Triggers Tumor-Cell Killing and Immunogenic Cell Death
The study further showed that light-activated CX-5461 not only directly damaged cancer cells but also induced ICD. When cancer cells die through an immunogenic process, they release or expose danger-associated signals, including cell-surface calreticulin, extracellular ATP and high-mobility group box 1 (HMGB1). These signals can help dendritic cells recognize and take up tumor antigens, potentially initiating a T-cell-mediated antitumor immune response.

The therapeutic objective may therefore extend beyond destroying an illuminated local tumor. By making antigens from dying cancer cells more visible to the immune system, the treatment could provide a biological basis for using localized therapy to stimulate a broader antitumor immune response.

Preclinical Findings Support an In Situ Cancer Vaccine Concept
In preclinical mouse studies, animals whose tumors regressed after treatment with CX-5461 and light exposure showed suppressed tumor growth when subsequently challenged with the same cancer cells. The observation suggests that treatment may establish tumor-specific immune memory and supports further investigation of an in situ cancer vaccine concept. Under this approach, the patient’s own tumor could serve as the source of tumor antigens, allowing an immune response to be initiated at the treatment site without the need to manufacture an external vaccine in advance.

If validated through additional studies, this mechanism could also be explored in combination with immune checkpoint inhibitors targeting PD-1 or PD-L1, with the goal of broadening or prolonging antitumor immune activity. These findings are preclinical and require confirmation in additional animal studies and human clinical trials.

Expanding the Potential Value of an Existing Clinical-Stage Asset
In drug development, a molecule can gain a second life when its existing properties and mechanisms are understood in a new way. CX-5461 has already generated a body of development data across chemistry, manufacturing and controls, toxicology, pharmacology and human clinical safety. The new research reframes photosensitivity as a potentially useful therapeutic mechanism and extends the molecule’s research potential beyond G4 targeting and DNA-damage response into photodynamic therapy, photoimmunotherapy and immune-combination strategies.

Compared with developing an entirely new molecule from the outset, identifying a new mechanism and potential indications for an existing clinical-stage asset may support development continuity and broaden its potential product lifecycle, subject to successful preclinical, regulatory and clinical evaluation.

Next Steps
Senhwa views these findings as an important starting point for repositioning the value of CX-5461. Based on further validation, the Company plans to evaluate suitable tumor types, dosing and illumination conditions, light-delivery technologies and potential combination strategies. Senhwa will also seek multinational academic and industry collaborations to support the clinical translation of this photoimmunotherapy approach.

Additional preclinical and regulatory work will be required before clinical development can proceed. The safety and efficacy of CX-5461 as a photodynamic or photoimmunotherapy treatment have not been established in human clinical trials, and CX-5461 has not been approved for commercial use in these applications.

Please find more details via linkage below:
https://academic.oup.com/nar/article/54/15/gkag777/8758773

About Senhwa Biosciences
Senhwa Biosciences, Inc. is a Taiwan-based biotechnology company developing novel oncology therapeutics for cancers with significant unmet medical needs. Its pipeline includes CX-5461 and CX-4945, which are being evaluated in solid tumors and hematologic malignancies through international clinical and research collaborations. For more information, visit https://www.senhwabio.com.

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SOURCE SENHWA BIOSCIENCES, INC.

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Gamehaus Announces Strategic Shift Toward AI-Generated Content

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Company to Concentrate Resources on Generative Content Tooling and the Creator Ecosystem; Existing Casual Game Portfolio to Be Managed for Cash Flow and Profitability

SHANGHAI, Aug. 12, 2026 /PRNewswire/ — Gamehaus Holdings Inc. (Nasdaq: GMHS) (“Gamehaus” or the “Company”), a technology-driven mobile game publisher, today announced a shift in its strategic focus toward artificial intelligence(“AI”)-generated content. Under the revised strategy, the Company will progressively optimize its third-party publishing business in casual titles, and in particular in the social casino category, and will direct its resources toward the development and distribution of AI-generated content.

In connection with this shift, the Company has begun managing its existing portfolio of casual and social casino titles on a cash flow- and profitability-oriented basis, with user acquisition and operating expenditure allocated according to return on investment rather than scale of installed base. This approach took effect during the current quarter and applies across the existing game portfolio.

The strategic shift reflects both the Company’s assessment of structural conditions in the casual publishing market and its view of the opportunity presented by generative technologies. In the casual category, user acquisition economics have been reshaped in recent years by several converging factors: the contraction of addressable audiences in mature markets, the reduction in attribution and targeting signal available to advertisers on major mobile platforms, and sustained competition for paid media inventory. Together, these factors have compressed the margin available at the publishing layer of the value chain. At the same time, the Company believes that generative technologies are altering the cost structure of content production itself — shortening development cycles, lowering the marginal cost of producing and iterating on content, and, most significantly, broadening the range of participants able to produce content at all.

Gamehaus intends to move into the content creation process by developing AI-based content generation tools and making them available to third-party creators, including game developers. These tools are designed to support content creation by both internal teams and external creators, and the Company ultimately expects its AI-powered content generation capabilities to enable a broader creator ecosystem to drive content production. The Company also expects to maintain a small-scale in-house development and testing function, principally to validate and refine its tools. The intended principal driver of content supply under this strategy is the creator economy those tools are designed to enable.

The Company’s initial focus within AI-generated content is casual mobile games. Earlier this year, Gamehaus completed a minority equity investment in a promising early-stage studio focused on AI-driven game generation, whose work includes AI-assisted art, asset and level generation pipelines for casual game content. The Company intends to leverage AI-powered content creation capabilities of this kind and combine them with its existing publishing infrastructure, user acquisition platform and live-operations function, which together serve a global user base across major mobile app stores.

Over time, the Company intends to position itself as an AI-enabled content generation and distribution platform. Gamehaus believes that the applicability of AI-powered generative tools is not limited to casual games, and that comparable changes in production economics are emerging in short-form animated drama and in interactive formats that combine short-form drama with gameplay. The Company is evaluating opportunities in these areas and will provide further information if and when there is a material development to report.

“We are choosing to build the Company around where content value is being created, rather than defending a position in a part of the value chain that is structurally narrowing,” said Mr. Yimin Cai, Chief Executive Officer of Gamehaus, “That means running our existing portfolio for cash flow and returns rather than for scale, and putting our resources behind the tools that let creators produce content. We do not think the winning position here is to make everything ourselves. We think it is to give a large number of creators the ability to make things they could not make before, and to distribute what they make.”

About Gamehaus

Gamehaus Holdings Inc. is a technology-driven global mobile game publisher dedicated to bridging creative studios and players worldwide. With a portfolio spanning mid-core and casual games, Gamehaus delivers full-stack publishing support across market insights, user growth, live-ops, data analytics and monetization optimization. With a vision to be the go-to partner for creative teams, the Company specializes in combining global publishing reach with AI- and data-powered solutions to help partners build lasting success. As part of its strategic evolution, the Company intends to increasingly focused on AI-generated content to enable scalable content production across a broad ecosystem of creators and game developers. For more information, please visit https://ir.gamehaus.com.

Forward-Looking Statements

Certain statements in this announcement are forward-looking statements, including, but not limited to, the Company’s business plan and outlook. These forward-looking statements involve known and unknown risks and uncertainties and are based on the Company’s current expectations and projections about future events that may affect its financial condition, results of operations, business strategy and financial needs. Investors can find many (but not all) of these statements by the use of words such as “approximates,” “believes,” “hopes,” “expects,” “anticipates,” “estimates,” “projects,” “intends,” “plans,” “will,” “would,” “should,” “could,” “may”, or other similar expressions in this press release. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results due to various risks and uncertainties, including but not limited to those described under the “Risk Factors” section in the Company’s annual report on Form 20-F filed with the U.S. Securities and Exchange Commission.

Investor Relations Contact

Gamehaus Holdings Inc.
Investor Relations Team
Email: IR@Gamehaus.com

The Blueshirt Group
Mr. Jack Wang
Email: Gamehaus@TheBlueshirtGroup.co

View original content:https://www.prnewswire.com/news-releases/gamehaus-announces-strategic-shift-toward-ai-generated-content-302849250.html

SOURCE Gamehaus Holdings Inc.

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NGP VAN Launches NGP VAN Interface, Bringing Agentic AI to Democratic and Progressive Campaigns Ahead of Midterm Elections

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WASHINGTON, Aug. 12, 2026 /PRNewswire/ — Today, NGP VAN, the leading technology provider for Democratic and progressive campaigns, announced the launch of NGP VAN Interface, the most powerful Model Context Protocol (MCP) solution purpose-built for Democratic and progressive campaigns, nonprofits, unions, PACs, and advocacy organizations. As organizations look to adopt AI, many face a fundamental challenge: how to do so without compromising the security of their most valuable data. NGP VAN Interface addresses that challenge by providing a secure connection between AI tools and trusted NGP VAN platforms, enabling natural language workflows while preserving the permissioning, authentication, and security campaigns depend on. With NGP VAN Interface, the Democratic and progressive movement’s leading organizing and fundraising platform will be accessible to AI tools, unlocking major efficiencies ahead of the midterm elections. As part of the launch, NGP VAN is also investing in its first Forward Deployed Engineers, who will work directly with clients and partners to help campaigns integrate AI into their operations, accelerate adoption of these new capabilities and give campaigns every advantage possible heading into this fall’s elections..

For decades, NGP VAN has powered the organizing, fundraising, and voter outreach efforts behind Democratic and progressive victories. As campaigns increasingly adopt AI to streamline operations and improve productivity, NGP VAN Interface provides a new way to securely bring those capabilities into the systems that natively house campaign data.

Until now, users have primarily interacted with NGP VAN through its web applications, APIs, and data products. Interface introduces a fourth interaction layer designed specifically for AI-powered assistants and automated workflows. The new platform includes an open-source Command Line Interface (CLI) that simplifies interactions with NGP VAN APIs, an MCP server with purpose-built authentication and permission controls for AI applications, and a proof-of-concept turnkey integration with Anthropic’s Claude.

Together, these capabilities enable users to complete common tasks through natural language prompts rather than navigating multiple interfaces or writing code, creating major new efficiencies for campaigns. NGP VAN Interface also supports an innovative new authentication model that enables workflows to run across multiple NGP VAN databases from a single user account and a single command, eliminating the need to switch between products or committees or to manage multiple API connections.

Several early partners are already using Interface to prototype AI-powered organizing and fundraising workflows ahead of the midterms and in preparation for the 2027-2028 election cycles, helping campaign staff automate repetitive administrative work and spend more time organizing supporters, engaging donors, and reaching voters.

“For more than 25 years, NGP VAN has built the tools that power the Democratic and progressive ecosystem,” said Chelsea Peterson Thompson, General Manager of NGP VAN. “Our mission has always been to put the best tools in the hands of our clients so they can make data-driven decisions and elect more Democrats up and down the ballot. NGP VAN Interface gives organizations a secure way to connect AI tools directly to their data in NGP VAN’s platforms. We understand that change requires investment and resources to support this exciting work across the ecosystem; we are investing in our first Forward Deployed Engineers to embed directly with our clients to build the next generation of skills necessary to win the critical elections ahead. As campaigns and organizations continue evaluating and adopting AI, we’re committed to ensuring the progressive movement has access to cutting-edge capabilities built with the privacy, governance, and environmental sustainability our mission demands.”

“In my time working with campaigns, I’ve seen organizers and finance staff do extraordinary things with limited resources and tight timelines,” said Sunil Sadasivan, Vice President of Engineering at NGP VAN. “I’ve spent my career helping teams work smarter, not harder – and the new wave of AI capabilities is the biggest leap on that front I’ve seen. What we believe at NGP VAN is that AI should meet campaigns where their data already lives. NGP VAN Interface gives AI tools a direct, purpose-built connection to our platforms, so the teams we work with can put these capabilities to work on the things that actually win — organizing, fundraising, and turning people out.” 

NGP VAN Interface is currently in closed beta. NGP VAN is actively seeking two types of partners: campaign and organizational users ready to put natural language AI workflows to work in NGP VAN’s platforms this cycle, and agencies and technology builders interested in co-developing agentic skills on top of Interface’s capabilities.

To learn more and apply for access, visit ngpvan.com/solutions/interface.

About NGP VAN
NGP VAN is the winningest technology platform in the history of democratic and progressive causes, working tirelessly to innovate and advance the technology our clients rely on to bolster our democracy. A proud unionized employer, we help power the trailblazers, campaigners, and advocates fighting up and down the ticket for equality, racial justice, reproductive freedom, democracy, climate reform, and more—including the national Democratic committees and progressive organizations, thousands of Democratic campaigns, hundreds of labor unions, advocacy organizations, progressive and non-partisan PACs, and other organizations.

Press Contact:
Simone Hassan-Bey
NGP VAN
press@ngpvan.com

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SOURCE NGP VAN

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Bank of America Launches $250 Billion, 18-month Critical Infrastructure Finance Initiative in Honor of America’s 250th Anniversary

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Initiative aims to help strengthen and modernize America’s infrastructure, supporting energy security, U.S. job growth and economic competitiveness

Key points

Bank of America’s Critical Infrastructure Finance Initiative to help drive transformative infrastructure investment across the United States, honoring America’s 250th anniversaryBank of America to support the development of digital, energy and power, and core infrastructure that enhances national competitiveness by strengthening energy security, accelerating technological leadership and enabling long-term economic growthInitiative to help create tens of thousands of jobs and advance community developmentCapital to be mobilized and deployed over 18 months, from America’s 250th year in 2026 through July 4, 2027

CHARLOTTE, N.C., Aug. 12, 2026 /PRNewswire/ — In celebration of America’s 250th anniversary, Bank of America today announced the Critical Infrastructure Finance Initiative to mobilize and deploy $250 billion to support U.S. infrastructure development through financing, investment and advisory solutions. The initiative reflects the company’s commitment to financing digital, energy and power, and core infrastructure development and modernization to help fuel America’s next era of economic growth, innovation and competitiveness. Capital will be mobilized and deployed from over 18 months, from America’s 250th year in 2026 through July 4, 2027.

Surging demand for computing power, energy, manufacturing capacity, modern transportation systems and diversified supply chains is propelling a new wave of infrastructure investment across the United States. Bank of America is helping clients across these sectors access the capital they need through our global capital markets platform, advisory expertise and strong balance sheet support, driving investment and creating tens of thousands of jobs nationwide.

“We are proud of our long history supporting the American economy. As America marks its 250th year, this initiative reflects our confidence in the country’s future and the investments that will shape it,” said Jim DeMare, Co-President, Bank of America. “The infrastructure that powers our economy, strengthens our energy security and secures our technological leadership will drive growth, create jobs and define America’s next chapter.”

Financial activity – including primary market lending, investing, capital markets, banking and advisory solutions – will span three broad infrastructure categories:

Digital infrastructure, such as data centers and computing infrastructure (hardware, chips, and equipment), telecommunications and semiconductorsEnergy and power infrastructure, such as conventional and renewable power generation and energy storage, as well as other energy distribution systemsCore infrastructure, such as transportation, electric and energy transmission, grid optimization, water systems, critical minerals and mining, and other assets

“Meeting America’s growing infrastructure needs requires mobilizing capital at scale across increasingly interconnected sectors,” said Karen Fang, Global Head of Infrastructure & Sustainable Finance and Co-Head of Global Capital Solutions at Bank of America. “Delivering these projects requires integrated financing solutions spanning corporate and project-level capital in both public and private markets. By bringing together capital providers, developers, corporations and investors, we are focused on helping accelerate investment in infrastructure that drives economic growth and creates lasting value for communities.”

The effort will be led by Bank of America’s Global Capital Solutions (GCS) and Global Infrastructure & Sustainable Finance (GISFG) teams and is supported across all eight lines of business. Bank of America provides integrated financing, investment, advisory and supply chain solutions for clients at both the corporate and asset levels, and across public and private markets.

Frequently asked questions
Question: What is Bank of America announcing?

Answer: Bank of America announced the Critical Infrastructure Finance Initiative to mobilize and deploy $250 billion to support the development and modernization of American infrastructure, through financing, investment, advisory and supply chain solutions. The amount will be measured based on eligible activity over 18 months, from America’s 250th year, January 1, 2026 through July 4, 2027.

Question: What types of infrastructure are included?

Answer: Eligible activity spans three broad categories:

Digital infrastructure, such as data centers and computing infrastructure (hardware, chips, and equipment), telecommunications and semiconductorsEnergy and power infrastructure, such as conventional and renewable power generation and energy storage, as well as other energy distribution systemsCore infrastructure, such as transportation, electric and energy transmission, grid optimization, water systems, critical minerals and mining, and other assets

Question: How will progress toward the goal be measured?

Answer: Progress for this initiative will be measured solely based on eligible activity in primary market lending, investing, capital markets and advisory transactions, consistent with Bank of America’s methodology for its $1.5 trillion ten-year sustainable finance goal.

Question: Why is Bank of America announcing this now?

Answer: The $250 billion Critical Infrastructure Finance Initiative is in recognition of America’s 250th anniversary and reflects the important role private capital plays in financing the critical infrastructure that supports economic growth, innovation and competitiveness.

Question: How is the Critical Infrastructure Finance Initiative creating jobs?

Answer:

Infrastructure financing helps drive job creation across sectors including construction, manufacturing, technology and long-term operations. By providing capital for digital, energy and power, and core infrastructure projects, the initiative helps enable investments that support employment opportunities nationwide.Infrastructure investment and workforce development go hand in hand. Projects such as data centers, power generation facilities, grid modernization projects and transportation infrastructure require a highly skilled workforce to build, operate and maintain them. Alongside financing these investments, Bank of America supports workforce development through longstanding training, education and career pathway programs that help connect people to the skills and jobs these projects create.In 2025, Bank of America invested nearly $40 million in more than 730 workforce development partners including employers, nonprofits and community colleges across 97 U.S. markets. These partners estimate that the funding helped connect more than 90,000 people to employment opportunities and provided over 290,000 individuals with access to training, education and career-readiness programs.

Bank of America
Bank of America is one of the world’s leading financial institutions, serving individual consumers, small and middle-market businesses and large corporations with a full range of banking, investing, asset management and other financial and risk management products and services. The company provides unmatched convenience in the United States, serving more than 69 million clients with approximately 3,500 retail financial centers, approximately 15,000 ATMs (automated teller machines) and award-winning digital banking with approximately 60 million verified digital users. Bank of America is a global leader in wealth management, corporate and investment banking and trading across a broad range of asset classes, serving corporations, governments, institutions and individuals around the world. As the #1 small business lender in the United States (FDIC), Bank of America offers industry-leading support to approximately 4 million small business households through a suite of innovative, easy-to-use online products and services. The company serves clients through operations across the United States, its territories and more than 35 countries and/or jurisdictions. Bank of America Corporation stock (NYSE: BAC) is listed on the New York Stock Exchange.

For more Bank of America news, including dividend announcements and other important information, visit the Bank of America newsroom and register for news email alerts.

Reporters may contact
John Yiannacopoulos, Bank of America
Phone: 1.646.855.2314
john.yiannacopoulos@bofa.com 

Sheryl Lee, Bank of America
Phone: 1.657.234.9950
sheryl.lee2@bofa.com

 

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SOURCE Bank of America Corporation

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