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Clear Scientific Reports Positive Phase 2 Results for CS-1103, the First Investigational Therapeutic That Removes Fentanyl from the Body

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Fentanyl Phase 2 Trial met all endpoints; Phase 3 planned for H1 2027

CAMBRIDGE, Mass., Oct. 1, 2026 /PRNewswire/ — Clear Scientific, Inc. today announced positive top-line results from its Phase 2 trial of CS-1103, a small-molecule sequestrant that immediately binds and inactivates fentanyl, subsequently accelerating its removal from the body into urine. The results provide validation of CS-1103’s novel mechanism of action. The trial met all endpoints, with CS-1103 accelerating the removal of fentanyl in human subjects and showing a favorable safety profile.

Fentanyl Phase 2 Trial met all endpoints; Phase 3 planned for H1 2027

To reflect the real-world scenarios in which people overdose on fentanyl and are subsequently treated with naloxone, all participants received both fentanyl and naloxone, then followed by CS-1103 or placebo. CS-1103 accelerated fentanyl excretion into urine 25-fold vs control, significantly reducing fentanyl body burden. Critically, CS-1103 did not interfere with the action of naloxone. All results were consistent with non-clinical findings, which have also demonstrated that CS-1103 rapidly reverses respiratory depression caused by synthetic opioids. 

The single-site, double-blind, randomized, inpatient pharmacokinetic and clearance study enrolled 16 healthy adults. A single intravenous dose of CS-1103 was well tolerated, with no serious adverse events reported. All 16 participants completed the study.

“Fentanyl in the body makes rescue and transition to treatment significantly more challenging, said Shekar Shetty, Chief Executive Officer of Clear Scientific. “By removing fentanyl from the plasma and brain rather than replacing it, as with receptor antagonists, CS-1103 could help prevent potentially fatal re-narcotization and reduce or eliminate precipitated withdrawal enabling faster, safer transitions to addiction treatment, such as buprenorphine and methadone. “

About CS-1103

CS-1103 is a first-in-class injectable small molecule sequestrant that binds and inactivates target compounds, rapidly reversing their effects and accelerating their clearance into urine. The Company is initially targeting methamphetamine, fentanyl and cocaine, which are present in close to 95% of all US drug related fatalities. Clear Scientific’s pipeline includes indications in central nervous system (CNS), metabolic diseases, amongst others. 

About Clear Scientific

Clear Scientific was co-founded in March 2019 by Professor George M. Whitesides of Harvard University with technology licensed from Massachusetts General Hospital and the University of Maryland.

Clear Scientific is pioneering a new paradigm for treatment of conditions and diseases that involve an excess of specific compounds in the body. The company is developing highly selective, small molecule sequestrants that bind, inactivate, and rapidly clear these excess compounds from the body. Clear Scientific receives funding from the National Institutes of Health (NIH) / National Institute on Drug Abuse (NIDA) and is working with their network of medical and academic professionals. 

About the Crisis

 In 2024, synthetic opioids were associated with approximately 1 million emergency department visits and more than 55,000 fatalities. These events place a significant burden on healthcare systems, costing hospitals more than $30 billion annually and contributing to overcrowded emergency departments and prolonged patient boarding.

While naloxone successfully reverses opioid-induced respiratory depression, it faces increasing treatment limitations because of the presence of fentanyl in the body:

re-narcotization, a dangerous situation in which the fentanyl poisoning lasts longer than the naloxone blockadepolydrug situations, in which naloxone is less effective when other drugs of abuse are present along with fentanyl (e.g., methamphetamine, xylazine, cocaine, etc.)precipitated withdrawal, a sudden, severe onset of withdrawal symptoms caused when a receptor antagonist rapidly displaces an opioid from its receptors, before natural withdrawal would have occurred, making transition to medications for opioid user disorder, including buprenorphine, difficult and potentially dangerous

According to the White House, the fentanyl-fueled opioid crisis cost the U.S. economy nearly $2.7 trillion in 2023 —impacting healthcare, criminal justice, and productivity in every community.

CS-1103 is investigational and has not been approved by any health authority. Research reported in this press release was supported by the National Institute on Drug Abuse of the National Institutes of Health under award number UG3DA059286-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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SOURCE Clear Scientific, Inc.

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LoanBud Launches LoanBud Acquire™ to Expand Financing for Main Street Business Acquisitions

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New non-SBA program offers $100,000 to $350,000 in financing for qualified buyers acquiring established small businesses.

NEW YORK, Oct. 1, 2026 /PRNewswire/ — LoanBud today announced the launch of LoanBud Acquire™, a new non-SBA business acquisition financing program offering $100,000 to $350,000 in financing for qualified buyers acquiring established, cash-flowing small businesses.

LoanBud created the program around a problem it sees in the market every day: smaller business acquisitions can be disproportionately difficult to finance. Many lenders prioritize larger credits, while smaller transactions may not fit every SBA or conventional lending program. That can leave qualified buyers and viable businesses with fewer financing paths, even when the underlying transaction makes sense.

“A $250,000 acquisition matters just as much to the buyer, the seller and the employees as a multimillion-dollar transaction,” said Burke Purcell, Founder and CEO of LoanBud. “But smaller acquisitions can be harder to finance because many lenders tend to prioritize larger transactions. LoanBud Acquire™ gives qualified buyers another path to ownership and helps more good Main Street businesses continue under a new owner.”

LoanBud Acquire™ complements LoanBud’s existing SBA business acquisition financing capabilities. By adding a non-SBA option, LoanBud can evaluate an acquisition across multiple potential financing paths rather than trying to fit every transaction into a single program.

That flexibility can be especially important in a business sale, where financing uncertainty creates friction for the buyer, seller and broker. Earlier clarity on whether a transaction has a viable financing path can help all parties move forward with greater confidence.

LoanBud Acquire™ program highlights include:

$100,000 to $350,000 in financingMinimum 15% buyer equity contributionDesigned for acquisitions of established, cash-flowing businessesNo real estate collateral requirementFinancing available for eligible business purchase costs and approved transaction expensesTargeted closing timeline of less than 30 days for qualified transactions

“We do not believe every acquisition should be forced into one financing box,” Purcell said. “Our job is to look at the transaction, identify the most realistic financing path and help the buyer, seller and broker get to a clear answer faster. LoanBud Acquire™ gives us another way to do that for smaller Main Street transactions.”

LoanBud Acquire™ is available now. Qualified buyers and business brokers can learn more at LoanBud.com or apply at apply.loanbud.com.

About LoanBud

LoanBud helps existing business owners access growth capital and helps entrepreneurs finance business acquisitions. By combining technology, experienced lending professionals and a nationwide network of lending partners, LoanBud provides access to SBA and conventional financing for acquisitions, growth, real estate, debt refinancing and working capital. LoanBud is focused on making small business financing faster, clearer and easier to navigate.

For more information, visit LoanBud.com.

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SOURCE LoanBud

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McKool Smith Named 2026 IP “Litigation Department of the Year” by Texas Lawyer

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DALLAS, Oct. 1, 2026 /PRNewswire/ — McKool Smith has been named Intellectual Property “Litigation Department of the Year” at the 2026 Texas Legal Awards, presented by Texas Lawyer. The Texas Legal Awards honor the attorneys and law firms making a lasting impact on the Texas legal landscape, from groundbreaking case wins to innovative legal strategies. Winners were celebrated at the awards ceremony on September 30 in Dallas.

The firm recognition reflects a track record of success in high-stakes IP disputes. In the Eastern District of Texas, Austin Principal Steve Pollinger, as lead counsel, along with Marshall Principal Jennifer Truelove, won a $192 million verdict for Mojo Mobility against Samsung on wireless charging patents that was held in full at final judgment. Jennifer also served as co-lead trial counsel on a willful infringement verdict for Pictiva Displays against Samsung on OLED display patents. At the U.S. International Trade Commission (ITC), the firm’s campaign for Nokia against Hisense ended in a global license resolving the dispute in every jurisdiction.

The department’s recent results also include a stretch of significant trial wins for Dallas Principal Warren Lipschitz, a finalist for Intellectual Property Attorney of the Year. In August 2026, he co-led a team in securing a complete defense verdict for AT&T, Verizon, T-Mobile, Ericsson and Nokia in a consolidated 5G patent trial in the Eastern District of Texas, defeating $436 million in claimed damages. The jury found no infringement, invalidated all nine asserted claims, and held that the plaintiffs had breached their own FRAND obligations. That verdict followed back-to-back 2025 defense wins Warren co-led against Daingean Technologies, also in the Eastern District, cutting a $245 million demand against T-Mobile to $2 million and then winning a verdict of no infringement for AT&T. On the plaintiff side, Warren secured an ITC Initial Determination for Nokia that Amazon infringed five of seven asserted patents, and Nokia reached a settlement with Amazon shortly thereafter.

With more than 130 trial lawyers across offices in Austin, Dallas, Houston, Los Angeles, Marshall, New York, and Washington, D.C., McKool Smith has established a reputation as one of America’s leading trial firms. The firm has secured 18 nine-figure jury verdicts and 16 eight-figure jury verdicts, obtaining more VerdictSearch and The National Law Journal “Top 100 Verdicts” than any other law firm. McKool Smith represents clients in complex commercial litigation, intellectual property, bankruptcy, and white-collar defense matters.

View original content:https://www.prnewswire.com/news-releases/mckool-smith-named-2026-ip-litigation-department-of-the-year-by-texas-lawyer-302896389.html

SOURCE McKool Smith

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Custom Home Builder Selection in Lexington SC Guidance Outlined in HelloNation Featuring Home Building Expert Jennifer L. Gerben Nettles

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The article explains how early consultation with a builder can help evaluate land suitability, site conditions, and construction costs before purchasing property.

LEXINGTON, S.C., Oct. 1, 2026 /PRNewswire/ — Do prospective homeowners need to own land before hiring a custom home builder in Lexington, South Carolina? HelloNation addresses that question in a HelloNation article that explores how early collaboration with a builder can help guide land selection and project planning.

The HelloNation article explains that many buyers assume they must purchase land before contacting a custom home builder Lexington SC professional. In practice, involving a builder earlier in the process can offer important advantages. Builders can help assess potential properties and identify factors that may influence construction feasibility, costs, and design options before a purchase is finalized.

One of the first considerations discussed in the article is the building potential of the land itself. Not all lots offer the same conditions for residential construction. Soil composition, grading, and topography can significantly affect how easily a home can be built. The article notes that a lot that appears ideal at first glance may require extensive excavation, retaining walls, or drainage work, all of which can increase project costs.

Evaluating site conditions before purchasing land can help homeowners avoid unexpected challenges later in the building process. According to the article, builders can conduct early assessments to determine whether the lot can accommodate the desired home design. Home Building Experts explain that this evaluation helps identify potential construction limitations and provides a clearer picture of the work required to prepare the site.

Utility access is another major factor that may influence whether a lot is suitable for a custom home Lexington SC project. The article describes how water, sewer, electricity, and internet service are not always readily available on undeveloped parcels of land. Connecting a property to these utilities may involve additional infrastructure work, which can increase both cost and project timelines. Builders who understand local infrastructure can help estimate the feasibility and expense of utility installation before a buyer commits to purchasing a property.

Lot shape and size can also affect design possibilities and construction costs. The HelloNation article explains that narrow or irregularly shaped parcels may limit the placement and layout of a home. Builders can provide guidance on how to adapt architectural plans to fit the property while still meeting the homeowner’s functional and aesthetic goals. This type of planning ensures that the home design works within the constraints of the lot.

Budget planning is another reason the article recommends early consultation with a custom home builder Lexington SC professional. Builders can provide preliminary construction estimates that account for site preparation, grading, permits, and other development requirements tied to a specific lot. This information helps prospective homeowners determine whether a property aligns with their financial plans before making a purchase.

The article also discusses how early collaboration can streamline the permitting and planning process. Builders with experience in Lexington understand local zoning regulations, setback requirements, and building codes that influence how a home can be placed on a lot. Home Building Experts explain that reviewing these regulations early can prevent costly redesigns or delays later in the project.

Working with a builder during the land selection stage also allows homeowners to compare multiple properties more effectively. By reviewing site conditions, infrastructure access, and potential construction challenges, buyers can make more informed decisions about which lot best supports their vision for a custom home.

The HelloNation article emphasizes that purchasing land first is not always required when planning a custom build. Instead, involving a builder early in the process can create a smoother path from property selection to construction. Evaluating grading requirements, infrastructure availability, and lot suitability ahead of time helps homeowners avoid surprises and better align their plans with realistic construction expectations.

Do You Need Land Before Hiring a Custom Home Builder? features insights from Jennifer L. Gerben Nettles, Home Building Expert of Lexington, South Carolina, in HelloNation.

About HelloNation
HelloNation is a premier media platform that connects readers with trusted professionals and businesses across various industries. Through its innovative “edvertising” approach that blends educational content and storytelling, HelloNation delivers expert-driven articles that inform, inspire, and empower. Covering topics from home improvement and health to business strategy and lifestyle, HelloNation highlights leaders making a meaningful impact in their communities.

View original content to download multimedia:https://www.prnewswire.com/news-releases/custom-home-builder-selection-in-lexington-sc-guidance-outlined-in-hellonation-featuring-home-building-expert-jennifer-l-gerben-nettles-302896381.html

SOURCE HelloNation

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