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Sophont Launches Holon-S1 to Reveal Tumor Biology from Routine Pathology Slides

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SACRAMENTO, Calif., Oct. 20, 2026 /PRNewswire/ — Sophont, a frontier medical AI startup, announces Holon-S1, a pan-cancer AI model that predicts spatial gene and biological pathway activity from routine hematoxylin and eosin (H&E) pathology slides. By using widely available pathology slides, Holon-S1 aims to broaden access to insights that typically require costly and time-consuming molecular testing, supporting biomarker discovery and personalized treatment research.

“Most AI pathology solutions infer patient risk profiles without showing clinicians and researchers what biology resulted in the prediction,” said Tanishq Mathew Abraham, Ph.D., CEO & Co-Founder of Sophont. “Holon-S1 was designed to uncover the biology behind the answer, showing which genes are active, where in the tumor they are active, and how that is related to whether a patient is likely to respond to treatment. Pathology has historically told us what a tumor looks like. Holon-S1 goes beyond this and tells us what the tumor is doing and where it may be vulnerable.”

In a retrospective osteosarcoma patient case study using publicly shared slides, Holon-S1 recovered several insights originally obtained through months of extensive molecular testing.

Holon-S1 identified a fibroblast-associated program including FAP, the gene targeted by a therapy that the patient responded to. Comparing pretreatment and post-treatment slides, quantified increased immune infiltration and decreased cancer proliferation. The model had not been trained on osteosarcoma, suggesting potential generalization to unseen cancer types and analysis of archived slides without new tissue.

In triple-negative breast cancer, a novel biomarker defined by the spatial organization of predicted EREG activity was associated with response to chemotherapy before surgery in discovery and separate held-out cohorts. EREG has been implicated in chemotherapy sensitivity in other cancers; for the first time, this analysis suggested potential relevance in breast cancer. Details appear in Holon-S1’s technical report.

Sophont evaluated Holon-S1 across 16 organ types, more than 15 scanners, and formalin-fixed, paraffin-embedded and fresh-frozen tissue. In a controlled comparison, it outperformed two other state-of-the-art models released this year in spatial gene activity prediction and robustness.

Holon-S1 is currently available for research use only. Sophont is designing further retrospective and prospective studies to evaluate potential diagnostic use.

“Biomedical foundation models are advancing at an extraordinary pace, and we are entering an era in which feature extraction and prediction alone may no longer suffice,” said Jorge Reis-Filho, Chief Strategy Officer and Operating Partner at Foresite Labs and Venture Partner at Foresite Capital. “Models that combine high predictive accuracy with biological interpretability could enable new approaches to translational research and help us reimagine disease taxonomy and segmentation, as well as play pivotal roles in patient stratification,” he added. “I look forward to seeing rigorous, independent evaluations of Holon-S1 against other leading foundation models on biologically and clinically relevant benchmarks.”

The company is inviting biopharma and life sciences companies as well as research institutions to collaborate on biomarker discovery, therapeutic target research, and analysis of existing and archived patient cohorts.

Explore Holon-S1: https://sophont.med/holon 

About Sophont
Sophont is a frontier medical AI lab building open, multimodal medical foundation models. Founded in February 2025 by Tanishq Mathew Abraham, Ph.D., and Paul Scotti, Ph.D., Sophont has raised $9.22M to date from Kindred Ventures, Upfront Ventures, Jeff Dean (Discovery Loop), Logan Kilpatrick (Google DeepMind), Clem Delangue (Hugging Face), and others. Sophont’s mission is to build open medical superintelligence: AI that sees the whole patient, and that every clinician and researcher can use, inspect and build on. Its open releases include OpenMidnight, CortexMAE and Medmarks. Learn more: https://sophont.med.

Media Contact
contact@sophont.med

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HR Path Strengthens its Australian Presence with Strategic Acquisition of Payroll Experts Australia

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PARIS, Oct. 21, 2026 /PRNewswire/ — HR Path, a global leader in HR consulting and HRIS solutions, today announces its strategic acquisition of Payroll Experts Australia, a Brisbane-based company specialising in payroll compliance, remediation, workforce management and HR systems consulting.

Founded in 2009, Payroll Experts Australia has delivered more than 530 projects for over 260 organisations across Australia and New Zealand. Independent of any software vendor, the company supports employers across the full payroll, workforce management and HR systems lifecycle, with expertise spanning payroll compliance and audit, remediation, award and agreement interpretation, payroll processing, advisory and end-to-end systems implementation.

The acquisition strengthens HR Path’s ability to provide end-to-end HR transformation services across the ANZ market. Payroll Experts Australia’s specialist capabilities complement HR Path’s existing HRIS technology and SAP SuccessFactors expertise, enabling the combined organisation to support clients with a broader range of locally grounded services, from strategic advisory and systems implementation to payroll compliance and operational support. 

Payroll Experts Australia will continue to operate under the brand “Payroll Experts Australia, an HR Path Company”. Its leadership team and employees will remain in their current roles, ensuring continuity of service for clients while giving the business access to HR Path’s international capabilities and resources. 

The transaction builds on HR Path’s expansion in the region. HR Path has been active in Australia since 2019, following the acquisition of DDG. It opened an Australian office in 2024 and acquired RKM Consulting in 2025, strengthening its HRIS technology and SAP SuccessFactors capabilities across Australia and New Zealand.  

“The acquisition of Payroll Experts Australia, a company renowned for its expertise in payroll compliance, is a strategic move that supports our ambition to be the global reference in HR transformation,” said François Boulet, Co-founding Partner at HR Path. “Their deep knowledge and strong client relationships in Australia complement our global capabilities, enabling us to deliver even more value to our clients. This partnership is about synergy, innovation, and shared commitment to excellence.”

“We are very happy about this new chapter!” said Steve Keenaghan, Chief Executive Officer at Payroll Experts Australia. “This step opens up exciting opportunities for our team and our clients and ensures our continued growth and success. We will maintain our commitment to delivering exceptional, independent payroll expertise while exploring new possibilities within HR Path.”

Contact:

Fabienne LATOUR  Fabienne.latour@hr-path.com

 

 

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Sungrow Powers Up for All Energy Australia 2026 With New Residential Innovation and Full Ecosystem Showcase

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MELBOURNE, Australia, Oct. 21, 2026 /PRNewswire/ — Sungrow, the global leader in PV inverter and energy storage solutions, is set to make a strong return to All Energy Australia 2026, the region’s largest and most influential renewable energy exhibition. It will introduce its next-generation all-in-one residential flagship PowerHarbour, alongside a comprehensive showcase of technologies for residential, C&I, and utility-scale applications.

As Australia accelerates toward a cleaner, more resilient energy future, Sungrow’s presence at All Energy will once again serve as a central meeting point for industry leaders, installers, innovators, and policymakers. The booth will offer visitors a rich blend of product demonstrations, technical insights, interactive experiences, and opportunities to connect with Sungrow’s local engineering and sales teams.

A New Addition to Residential Energy Storage

At the upcoming All-Energy 2026, Sungrow will officially unveil PowerHarbour in Australia for the first time. It is a residential all in one solution designed to simplify energy independence for homeowners. It combines sleek design, intelligent integration, advanced safety features and a modular design that can deliver up to 120kWh of capacity. The enhanced AFCI 3.0 protection makes it one of the most flexible and homeowner‑friendly systems on the market. The result is a clean, integrated solution that empowers households to take control of their energy with confidence and ease.

C&I Solutions for Diverse Applications

The exhibition will also showcase Sungrow’s C&I portfolio, including PowerKeeper, deployed across diverse Australian environments, and the ST255CS liquid-cooled BESS cabinet, designed for applications such as microgrid stability and FCAS. Together, these solutions demonstrate Sungrow’s capabilities in delivering flexible, reliable energy storage for a wide range of commercial and industrial needs.

Utility-Scale Innovation on Display

For utility developers and EPCs, Sungrow will present a full-size PowerTitan 3.0, giving visitors a rare opportunity to see the battery container up close. Together, PowerTitan 3.0 and 1+X modular inverter demonstrate advanced energy storage, grid-forming capabilities, and flexible deployment for complex project environment. Backed by dedicated local project management, comprehensive technical support, and a growing project pipeline across Australia and New Zealand.

Visit Sungrow at Booth KK123

Sungrow invites all attendees to visit Booth KK123 at All Energy Australia 2026 to experience its latest residential, commercial, and utility‑scale innovations firsthand. Attendees can expect a vibrant and engaging atmosphere throughout the day featuring lucky draws with exciting prizes, free premium coffee, photobooth and insightful presentations. The booth promises a full day of discovery, connection, and inspiration. Sungrow looks forward to welcoming partners, customers, and renewable energy enthusiasts as we continue powering Australia’s clean energy future together.

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AglaiaSense and Leopard Imaging to Demonstrate Privacy-First AI Traffic Sensing at Smart City Expo World Congress in Barcelona

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FREMONT, Calif. and BARCELONA, Spain, Oct. 21, 2026 /PRNewswire/ — AglaiaSense and Leopard Imaging will exhibit together at Smart City Expo World Congress, November 3–5, 2026, at Fira Barcelona Gran Vía.

The two companies proposed AI-VIVA (Vision Intelligence for València and Arterials) and is selected as a finalist in the fifth urban challenge of Barcelona Innova Lab Mobility (BILM), on the application of artificial intelligence to traffic-light regulation. AI-VIVA combines AglaiaSense’s edge-AI traffic solutions with Leopard Imaging’s patented privacy architecture. At the show, the team will give a live demonstration of AglaiaSense’s signature MS500 and GS500 cameras, with the AglaiaSense AI Box, powered by NVIDIA, which adds local processing to coordinate groups of neighboring intersections.

The cameras analyze images inside the device, using the Sony IMX500 and IMX501 intelligent vision sensors. They count and classify vehicles, buses, cyclists and pedestrians in real time. Raw video is discarded on the device within 400–800 milliseconds, and only anonymous metadata is transmitted. Cities can feed that data into signal-control software to adapt traffic lights to real demand.

MS500: about 2 W average power, 1080p, powered from a standard NEMA or ZHAGA street-light socket.

GS500: about 6.5 W average, dual 4K cameras, with Ethernet, LTE Cat 4 and GPS; powered by PoE, 12–24 V DC or a NEMA adapter.

Both cameras: IP66-rated, −20 °C to +65 °C, mounted on existing poles, so no trenching or new masts are needed.

Bandwidth: more than 95% lower than CCTV-based monitoring.

“Cities want safer, smoother streets without turning every crossing into a surveillance point,” said Leon Luo, CEO of AglaiaSense. “Being named a finalist in Barcelona tells us the approach resonates.”

“Privacy has to be built into the camera, not added later,” said Bill Pu, CEO of Leopard Imaging.

AglaiaSense’s solutions are deployed across North America and Asia, and the company won first place in the Pedestrian Safety Challenge Hackathon, run by the Edge AI Foundation (formerly the tinyML Foundation) and the City of San José. In field tests, the systems achieved detection and counting accuracy above 95%. The City of Lakewood, Colorado, compared the GS500 with traditional IP cameras and LiDAR on real roads and found it more accurate, more energy-efficient, and less costly to deploy. At a high-risk crossing where pedestrians often crossed outside the crosswalk, the system alerted approaching drivers in real time.

Visit us at Pavilion 3, Level 0, Street D, Stand 71. To book a meeting, email sales@aglaiasense.com.

About AglaiaSense

AglaiaSense, is an edge-AI company specializing in privacy-first, vision-based sensing for smart cities. Its GS500 and MS500 cameras run AI on the image sensor to count and classify road users in real time and send only anonymous metadata.

About Leopard Imaging

Leopard Imaging is a global leader in high-definition embedded cameras and AI-based imaging solutions in industries including automotive, aerospace, drones, IoT, and robotics.

Media contact:

Cathy Zhao

+1 (408) 263-0988

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