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Optellum, AI Lung Cancer Diagnosis Innovator, Secures $14M Series A Funding to Accelerate Expansion

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Lead investor Mercia, alongside Intuitive Ventures and Black Opal, invests in Optellum’s pioneering AI-powered lung-health technology

OXFORD, England and HOUSTON, Sept. 27, 2022 /PRNewswire/ — Optellum, an Oxford-based medtech company that provides a breakthrough AI platform to diagnose and treat early-stage lung cancer, has raised $14 million in a Series A funding round. The investment will enable Optellum to scale its base, operations, and commercial launches in the UK and USA; accelerate research and development; and expand its platform into personalized therapy decisions by integrating imaging data with molecular data, robotics, and liquid biopsies.

 

This funding round was led by Mercia, with additional investors Intuitive Ventures (Sunnyvale, CA, USA) and Black Opal Ventures (New York, NY, USA). Existing investors, including St John’s College in the University of Oxford, IQ Capital, and the family office of Sir Martin & Lady Audrey Wood, also participated in this round.

Lung cancer is the most common type of cancer and the leading cause of cancer deaths in the world. Approximately 150,000 people in the United States and 1.8 million people worldwide die from lung cancer each year. The current worldwide five-year survival rate is 20 percent, primarily because most patients are diagnosed after symptoms have appeared and the disease has progressed to an advanced stage (Stage III or IV). In contrast, the survival rate for small tumors treated at Stage 1A is up to 90 percent. This disparity highlights a critical need for diagnosis and treatment at the earliest stage possible.

Optellum is the leader in AI-enabled lung cancer diagnosis, and the first and only medtech company to attain FDA clearance, CE-MDR in the EU, and UKCA in the UK for its software platform Virtual Nodule Clinic. This first-of-a-kind platform can help physicians identify and track at-risk patients, and optimally diagnose the signs of lung cancer early, so treatment can be started sooner for patients with tumors, and invasive procedures such as biopsies on benign lesions can be minimized.

Jason Pesterfield, CEO at Optellum, said: “With this strong support and commitment of highly specialized investors, we are positioned to accelerate commercial deployment in both the UK and the United States to expand our installed base. Following years of research and clinical trials that have shown the impact of our software on the diagnosis of at-risk lung nodules, we’re focused on expanding patient access to this crucial technology and identifying deadly lung cancer faster in more at-risk people. The funding will also boost our research and development with world-leading institutions and partners to progress further innovation.”

Lead investor Mercia brings expertise in software technologies having a significant impact on global health issues and an existing portfolio that includes AI and machine-learning technology.

Investment Director at Mercia, Stephen Johnson, said: “Optellum is the latest in a series of companies to channel research from the UK’s world-leading universities into commercially viable products that can make a difference to the provision of medical care. Having observed Optellum achieve great milestones over the years, we are now excited to become part of their success and apply our experience with scaling up software and deep-tech companies to help accelerate Optellum’s impact on patient lives across the world.”

Intuitive Ventures, the independent venture-capital arm of Intuitive (NASDAQ: ISRG), a world leader in medical robotics, including lung cancer care, was founded in 2020 to accelerate the future of minimally invasive care. The investment team supports Optellum’s ambitions to think and move beyond earlier diagnosis into decision support across the treatment pathway, integrating liquid biopsies, molecular tests, and drug therapies.

“Lung cancer is an urgent public health crisis and Optellum’s groundbreaking approach utilizing AI to accelerate early detection and intervention may fundamentally alter the healthcare community’s approach to combating this disease,” said Oliver Keown, MD, managing director of Intuitive Ventures. “Optellum is uniquely positioned to align and provide considerable value to patients, providers, and payers alike. Intuitive Ventures is thrilled to provide our full arsenal of financial and strategic support to Optellum as we work towards a world of better outcomes for cancer patients.”

Physician-led, female-founded fund Black Opal Ventures has a mission to build better businesses and a better future at the intersection of healthcare and technology. Its expertise in reimbursement and health economics will assist Optellum, which recently announced a New Technology Ambulatory Payment Classification for Medicare patients in the USA.

Founder Tara Bishop, MD, commented: “We value solutions that make medicine more accurate and accessible. The strong validation data that underpins the Optellum solution has demonstrated its ability to make a difference to patients. We share Optellum’s vision of making this available to every doctor in every hospital – and transform the diagnosis and treatment path for lung cancer.”

Optellum’s platform was developed and clinically validated in partnership with leading universities and healthcare systems around the world. Optellum also has strategic collaborations with GE Healthcare and the Lung Cancer Initiative at Johnson & Johnson to accelerate clinical deployments and continue the advancement of the platform. In the UK, Optellum’s solution is being used to predict at-risk lung nodules in a multi-center study with NHS Trusts as part of a major investment in AI for healthcare.

About Optellum

Optellum is a commercial-stage lung health company providing artificial intelligence decision-support software that assists physicians in early diagnosis and optimal treatment for their patients. The company was founded so that every lung disease patient is diagnosed and treated at the earliest possible stage, when the probability of better health outcomes is highest. In 2021, the Oxford-based medtech company achieved FDA 510(k) clearance for the application of AI decision-support software in lung cancer diagnosis, and has since announced strategic partnerships in the USA with GE Healthcare and the Lung Cancer Initiative at Johnson & Johnson, while the Virtual Nodule Clinic has been implemented in leading healthcare systems across the USA. Optellum has headquarters at the Oxford Centre for Innovation in Oxford, United Kingdom and a U.S. office at the Texas Medical Center in Houston, Texas. For more information, visit optellum.com or follow us on LinkedIn and Twitter.

MEDIA CONTACT:
Tim Cox | CubanEight for Optellum | timcox@cubaneight.com

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SOURCE Optellum

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A Shrinking Supply of New Physical Games May Be Making Old Ones Scarcer and More Valuable

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Physical game spending fell to $1.5 billion in calendar year 2025, even as exceptional vintage sealed copies have reached seven-figure auction prices, according to Circana and Heritage Auctions.

MORTON GROVE, Ill., Sept. 1, 2026 /PRNewswire/ — The market for physical video games is no longer moving in a single direction. The Old School Game Vault has released an analysis of public sales and auction data showing a widening distinction between the mainstream physical-game market and the much smaller market for rare vintage collectibles.

The analysis does not conclude that falling physical-game sales automatically make older games more valuable. Rarity, condition, completeness, edition, and collector demand can make individual items behave differently from the broader retail market.

U.S. physical video game sales reached $1.5 billion in 2025

U.S. spending on new physical video games totaled $1.5 billion in calendar year 2025, according to Circana Retail Tracking Service data shared by Mat Piscatella. This was the lowest annual level since Circana began tracking the category in 1995.

Circana data show that spending peaked at $11.6 billion in calendar year 2008, illustrating the scale of the long-term contraction. The measurement period matters, however. Circana’s separate rolling 12-month series peaked at approximately $11.5 billion for the 12 months ending May 2009, while spending for the 12 months ending May 2026 was approximately $1.6 billion. These are different measurement periods, not conflicting totals.

A title released decades ago may remain inexpensive if many copies survive, while another from the same era may attract more collector interest because complete or well-preserved copies are scarce.

The condition of the game also matters. A loose cartridge, a complete copy with its original box and manual, and a factory-sealed example are not interchangeable from a collector’s perspective.

Record auction prices show the difference between ordinary and exceptional games

Heritage Auctions reported that a sealed Wata 9.8 A++ copy of Super Mario 64 sold for $1.56 million in 2021, becoming the first video game sold at auction for more than $1 million.

The sale was exceptional rather than representative. Its sealed condition, grade, title significance, and scarcity placed it outside ordinary used-game transactions.

For sellers, the practical lesson is to identify each item before accepting a broad valuation. A collection can contain common mass-market titles alongside rarer games, consoles, accessories, and editions that warrant closer examination.

Methodology

The Old School Game Vault synthesized public U.S. physical video game sales data from Circana Retail Tracking Service, shared directly by Mat Piscatella, together with Heritage Auctions’ 2021 press releases and auction records. No proprietary survey or original research was conducted. Circana figures describe mainstream physical software spending, while Heritage results represent individual collectible-market transactions.

Frequently Asked Questions

These questions summarize what the analysis means for the broader physical market and individual sellers.

Is the physical video game market growing or shrinking?

The U.S. physical video game market has undergone a major long-term contraction. Calendar-year 2025 spending was $1.5 billion, while the separate 12 months ending May 2026 reached approximately $1.6 billion. Neither figure determines the value of an individual retro title.

Why do some old games sell for so much?

Exceptional prices can occur when scarcity, condition, completeness, historical importance, and collector demand converge. The $1.56 million Super Mario 64 sale represents the extreme high end of the market, not a typical resale value.

What should sellers compare before choosing a buyer?

Sellers can compare specialization, offer transparency, condition requirements, testing procedures, shipping arrangements, and payment options.

About The Old School Game Vault

The Old School Game Vault is a nationwide retro video game buyer and seller based in Morton Grove, Illinois, and has operated since 2008. The company purchases video games, consoles, and accessories from customers across the United States and pays sellers in cash rather than store credit. The Old School Game Vault maintains an A+ rating with the Better Business Bureau, and its online pricing database includes more than 22,000 games, consoles, and accessories.

Media Contact

Contact: Brandon Perton

Email: brandon@theoldschoolgamevault.com

Location: Morton Grove, Illinois

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Clean electricity supplied 40% of new energy demand in 2025. Faster deployment and sectoral breakthroughs can cut emissions permanently, says annual Energy Transition Monitor

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A progress paradox: Clean electricity is growing more than twice the speed of overall energy supply, but emissions are not yet falling as overall demand for both fossil and clean energy is simultaneously expanding – driven by data centres, higher cooling needs and heavy industry.A two-speed transition: ~60% of global emissions – primarily from power generation and road transport – are rapidly being addressed by clean electrification at little or no extra cost. Progress is slower in the remaining 40% of emissions – from aviation, shipping, heavy industry and agriculture – which require solutions that carry a green cost premium or are at early-stages of commercial scale.Four levers remain largely unaddressed: coal use, methane emissions, deforestation, and slow scale up of carbon removals.

LONDON, Sept. 2, 2026 /PRNewswire/ — Global clean energy investment hit a record $2.1 trillion in 2025. Solar, batteries and electric vehicles again outperformed every forecast. But rising energy demand means global greenhouse gas emissions are only plateauing, not falling. The world has already breached 1.5°C of global heating and remains on track for around 2.5°C, according to the Energy Transitions Commission’s (ETC) Energy Transition Monitor 2026, published today.

As wildfires and intense heatwaves cause widespread economic and human damage and energy security costs mount since the Hormuz closure, demand for clean alternatives to volatile fossil fuels has grown. The annual assessment from the ETC Secretariat — representing a global coalition of energy, industry and finance leaders – finds that renewables supplied 99% of the growth in global electricity generation in 2025, while coal-fired and oil-fired generation both contracted. Global renewable capacity has almost doubled since 2022 and is on track to double again by 2030 — around 900 GW short of the tripling pledged at COP28.

But clean power is chasing a moving target: because electricity remains only a fifth of total final energy use, this growth in clean electricity covered just 40% of the rise in global energy demand, with fossil fuels supplying the rest, as demand from buildings, heavy industry and long-distance transport kept rising.

Clean technologies must be deployed faster to meet this growing demand. The report also identifies four other key levers for global emissions reductions that remain largely unaddressed: coal use, methane emissions, deforestation, and scale up of carbon removals.

The report describes a two-speed transition. Around 60% of global emissions could be abated through clean electrification alone at little or no extra cost — primarily in power generation and road transport, where electrification is already accelerating.

But barriers remain. Grid capacity is a major bottleneck to this acceleration: around 375 GW of renewables and 455 GW of battery storage are stuck in European connection and permitting queues, roughly 2,300 GW await grid connection in the United States, and nearly 10% of China’s wind and solar outputs were curtailed due to grid constraints in the first half of 2026. Supporting low-cost renewables through long-term contracts can also accelerate electrification.

The remaining 40% of global emissions, from high-temperature industrial heat, aviation, shipping and parts of agriculture, requires solutions that carry a green cost premium or are at early-stages of commercial scale. Of roughly 1,000 clean industrial projects announced globally, fewer than 20% have reached a final investment decision. Carbon pricing is strengthening, making clean projects more financially viable, but firm offtake commitments are still a major gap.

“Clean energy is now outpacing fossil growth, but deployment speed alone won’t cut emissions. Without removing grid bottlenecks, securing buyer commitments for clean industrial products, and achieving cost breakthroughs in shipping and aviation, emissions will continue to plateau and not fall.” said Adair Turner, Co-Chair, ETC.

“Coal is not phasing down, methane emissions are not falling, forests are still being cut down, and carbon removal is nowhere near the scale required. We must act to address these. Only by doing this can we stop the rapid heating of the planet, and we are seeing the effects of this in real time.” said Jules Kortenhorst, Co-Chair, ETC.

“The Energy Transition Monitor makes clear that the challenge is no longer whether clean energy technologies can scale, but whether we can deploy them fast enough to meet growing demand and reduce emissions simultaneously. As electricity demand accelerates, we have all the resources available to design energy solutions that pair abundant clean power with efficiency, flexibility, and modernized grids. The report points out solutions to unlock permitting and connection barriers to access resources at the scale of the opportunity. By combining clean electrification with smarter energy use, we can strengthen energy security and accelerate emissions reductions while still supporting economic growth.” said Jon Creyts, CEO, RMI, a member of the Energy Transitions Commission.

The picture varies sharply by region:

China: Building clean electrification faster than anywhere on earth.Supplies 83% of the world’s renewable-energy equipment, 45% of clean industrial plant equipment.Installs more than half the world’s wind and solar. In 2025, 56% of new passenger vehicle sales were EVs, and 13 of 19 global clean heavy-industry investment decisions were made in China in first half of 2026.United States: Federal action stops the transition accelerating but doesn’t stop it entirely.Since January 2025, 21 GW of clean energy was cancelled. Fossil capacity additions surged 71% in 2025-2026. Yet renewable growth slowed by only 2%.Data centres present the sharpest contradiction: accounting for half of all new clean energy contracts, while simultaneously driving the largest increase in new fossil fuel power capacity.EU and UK: Fastest emissions reduction progress of the major economies, though momentum has recently slowed.Renewable installations are strong and around 1 in 5 new passenger cars purchased are EVs. The European Commission’s electrification action plan targets a step change in the pace of deployment.Around 375 GW of renewables and 455 GW of battery storage are stuck in permitting and grid-connection queues.India: The world’s cheapest renewables but installs 9 times slower than China.Fastest electricity demand growth for a major economy at 6.4% a year, but new clean capacity is being absorbed by rising demand rather than displacing coal.Asia (excluding China & India) & Australia: Renewables contributed 62% of new power capacity in 2024, but progress across the region is uneven.High fossil fuel prices caused by the Hormuz strait closure has pulled the need for energy security and clean energy forward in the region. Countries including South Korea and Indonesia accelerated their renewables targets.

About the Energy Transitions Commission (ETC)
The Energy Transitions Commission is a global coalition of leaders from across the energy landscape committed to achieving net-zero emissions by mid-century while supporting economic growth and development. This report was produced by the ETC Secretariat and should not be taken as members agreeing with every finding or recommendation. The ETC is hosted by SYSTEMIQ Ltd.

All data in this release is pulled from the Energy Transition Monitor 2026 which can be downloaded here: https://www.energy-transitions.org/publications/energy-transition-monitor-2026

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Charter to Participate in Citi Global TMT Conference

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STAMFORD, Conn., Sept. 1, 2026 /PRNewswire/ — Charter Communications, Inc. (NASDAQ: CHTR) (along with its subsidiaries, “Charter”) today announced that Jessica Fischer, Chief Financial Officer, will participate in the Citi Global TMT Conference in New York, New York on Thursday, September 10, 2026. Ms. Fischer’s remarks are scheduled to begin at 10:50 a.m. ET.

A live webcast of the event can be accessed on Charter’s investor relations website, ir.charter.com. Following the live broadcast, the webcast will be archived at ir.charter.com.

About Charter 
Charter Communications, Inc. (NASDAQ: CHTR) is the leading broadband and video company in the nation and the fastest growing mobile provider in its footprint, with services available to more than 70 million homes and small to large businesses across 45 states through its Spectrum brand. Founded in 1993, Charter has evolved from providing cable TV to streaming, and from high-speed Internet to a converged broadband, WiFi and mobile experience. Over the Spectrum Fiber Broadband Network and supported by our 100% U.S.-based employees, the Company offers Seamless Connectivity and Entertainment with Spectrum Internet®, Mobile, TV and Voice products.

More information can be found at corporate.charter.com.

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SOURCE Charter Communications, Inc.

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