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TIER IV and CMU partner to pioneer “Level 4+” autonomy through Safety21: Advancing beyond the limits of embodied AI

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TOKYO, April 24, 2025 /PRNewswire/ — TIER IV, the pioneering force behind the world’s first open-source software for autonomous driving, is proud to announce a strategic collaboration with Carnegie Mellon University (CMU), widely regarded as a birthplace of autonomous vehicles in 1984, to realize the new Level 4+ autonomy concept. Together, they aim to advance scalability, explainability, and safety through a hybrid architecture that combines data-centric AI approaches with the best practices in robotics, while also unlocking the potential of embodied AI to improve transparency and traceability in decision-making.

This collaboration is further strengthened through Safety21, the US Department of Transportation’s National University Transportation Center for Safety, led by CMU Professor Raj Rajkumar. TIER IV has joined Safety21’s Advisory Council, promoting the value of open-source software through Autoware*, which serves as the foundation for state-of-the-art research and development that addresses the trade-offs between safety and user experience in autonomous driving systems.

Background

Traditional Level 4 autonomy has been built on robotics methods such as probabilistic estimation and machine learning, relying on hand-crafted behavioral rules, predefined high-definition maps, and localized data sets to coordinate core functions such as sensing, localization, perception, planning, and control. Autoware originated from this architecture and has been successfully deployed in autonomous driving systems around the world.

The new Level 4+ autonomy concept, advocated through this collaboration, represents an intermediate step between SAE J3016 Level 4 and Level 5. It remains within the Level 4 classification in terms of human roles, but incorporates key aspects of Level 5 system features. As a result, the vehicle can operate under virtually all conditions by flexibly expanding its operational design domains (ODDs) to cover previously unencountered scenarios.

The Level 4+ system features do not require the human to take over dynamic driving tasks (DDT). However, they may leverage additional information provided from outside the system, as part of strategic functions, to dynamically respond to environmental changes within the target operational domain (TOD). Meanwhile, the system continues to control tactical and operational functions. In this framework, the system retains full responsibility for safety assurance, even when external strategic input influences its behavior. For example, a human may provide guidance that adjusts waypoint planning at runtime to help the system align its behavior with both the defined ODD and the TOD.

Emerging end-to-end AI models, a key variant of data-centric AI approaches, are promising for realizing Level 4+ autonomy, particularly when integrated with rule-based systems and human-in-the-loop strategies. However, they also present critical challenges, including high data requirements, limited explainability in decision-making, and difficulties in establishing robust safety assurance. Because it is often unclear how such models generalize learned behaviors or what influences their outputs, ensuring trustworthy real-world deployment remains a key hurdle.

Strategic collaboration scope

To realize Level 4+ autonomy, TIER IV and CMU will jointly develop next-generation Autoware-based autonomous driving systems, with a particular focus on advancing  scalability, explainability, and safety through a hybrid architecture that combines data-centric AI approaches, including refined end-to-end AI models, with the best practices in robotics.

The project will center on modularizing end-to-end AI models to coexist with state-of-the-art robotics methods and safety enforcement mechanisms. Key challenges include incorporating intermediate representations that expose internal reasoning processes, as well as establishing contextual awareness features that allow the system to transition into minimum risk maneuver (MRM) mode when faced with unexpected circumstances. As a whole, this hybrid architecture is designed to support more transparent and traceable embodied AI decision-making, while addressing practical deployment concerns such as system accountability, safety assessment, and regulatory compliance.

The collaboration is structured as a three-year initiative. In the first year, TIER IV and CMU will develop a reference vehicle powered by Autoware, with early deployments planned in both Tokyo and Pittsburgh. This vehicle will also serve as a platform for real-world data collection, closed-loop verification and validation, and on-road experimentation. Insights from this phase will be reflected back into Autoware and the broader open-source software community, accelerating innovation at CMU and across the global research and developer ecosystem

In the second and third years, the focus will shift toward developing a comprehensive safety enforcement mechanism for the hybrid architecture. This mechanism will support the safety assessment processes required for vehicle certification and public road approval, and will underpin scalability, explainability, and safety necessary for trustworthy real-world deployment of Autoware-based autonomous driving systems.

“This collaboration marks a major milestone in uniting the strengths of AI and robotics to build autonomous driving systems that are safer, more scalable, and more explainable,” said Shinpei Kato, founder and CEO of TIER IV. “Partnering with CMU enables us to further advance Autoware’s capabilities and deepen our contribution to the open-source software community, driving the future of mobility through collective innovation.”

“The integration of modular end-to-end AI models with traditional Level 4 systems represents a powerful advancement for the new Level 4+ autonomy concept,” said Raj Rajkumar, George Westinghouse Professor in the Department of Electrical and Computer Engineering at Carnegie Mellon University. “This collaboration offers a unique opportunity to deepen our understanding of AI in autonomous driving systems, ultimately enabling safer, more scalable, and more effective deployments.”

*Autoware is a registered trademark of the Autoware Foundation.

About TIER IV

TIER IV stands at the forefront of deep tech innovation, pioneering Autoware, the world’s first open-source software for autonomous driving. Harnessing Autoware, we build scalable platforms and deliver comprehensive solutions across software development, vehicle manufacturing, and service operations. As a founding member of the Autoware Foundation, we are committed to reshaping the future of intelligent vehicles with open-source software, enabling individuals and organizations to thrive in the evolving field of autonomous driving.

About Carnegie Mellon University

Carnegie Mellon University, based in Pittsburgh, Pennsylvania, USA, is a private, global research university and stands among the world’s most renowned educational institutions. It is considered to be a global leader in computer science, artificial intelligence, machine learning, robotics and drama, among other fields. The Tartan Racing team from Carnegie Mellon won the 2007 DARPA Urban Challenge that triggered the creation of today’s global autonomous vehicle industry.

About Safety21

Funded by the U.S. Department of Transportation as the National University Transportation Center for Safety and led by Carnegie Mellon University, a birthplace of automated vehicles, Safety21 actively seeks to enable and accelerate a safer, more efficient transportation network. By leveraging new technologies and revolutionary trends in transportation, Safety21 aims to research, develop and deploy cutting-edge technologies and policies, and develop workforce and educational programs that directly address the challenges of integrating autonomous, connected, electric and shared vehicles with a transformative focus on safety, innovation, and economic growth.

About Professor Raj Rajkumar

Raj Rajkumar is the George Westinghouse Professor in the Department of Electrical and Computer Engineering at Carnegie Mellon University where he directs the US DOT Safety21 National University Transportation Center and its Metro21 Smart Cities Institute.  He is considered to be a pioneer of connected and autonomous vehicle technologies.

Media Contact
pr@tier4.jp

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SOURCE Tier IV, Inc.

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Topaz Labs announces its largest single release of AI models in company history with “Next-Gen” launch

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DALLAS, April 28, 2026 /PRNewswire/ — Topaz Labs, the AI image and video enhancement company, has announced four new image enhancement models and two video enhancement models across five applications. The collection of “Next-Gen” models offer powerful sharpening, denoising, and upscaling results to visual content. Image models included are Wonder 3, Denoise Max, Super Focus 3, and High Fidelity 3. For video, Starlight Precise 2.5 and Astra 2 were announced.

The collection of models offers powerful sharpening, denoising, and upscaling results to visual content.

“This is both the largest and most technically advanced set of models we’ve released in the company’s history,” says Eric Yang, CEO, Topaz Labs. “We launched Topaz NeuroStream earlier this year with the goal of enabling local rendering of complex models for more users. Without such technology, the complex, heavyweight AI models in today’s release would have been limited to cloud-only rendering, forcing users to pay per use and be reliant on internet connection. We believe local use is crucial to the future of AI in both professional and consumer use cases, and today’s release is a huge step.” 

Topaz NeuroStream is proprietary technology that reduces VRAM usage by up to 95% and allows exponentially more users on consumer-grade hardware to use AI models locally. A total of six Topaz models are now powered by NeuroStream.

Next-Gen Release Image Models 

Wonder 3: A magical, one-click sharpen, upscale, and denoise model for images.
Denoise Max: New standard for removing noise and grain in images.
Super Focus 3: Next-level sharpening model that brings subjects back from the blur.
High Fidelity 3: The newest model for upscaling high-res inputs like smartphone photos and RAW images.

All image models in this release are available in Topaz Photo desktop application and via API. Wonder 3 and Denoise Max are also available in Express, a web-based tool.

Next-Gen Release Video Models

Starlight Precise 2.5 (Local): Groundbreaking video model that brings out natural visual details with stunning results, with local availability in Topaz Video

Astra 2: The next generation of creative video upscaling that enhances clarity, richness, and visual complexity of videos by adding new detail.

Both highlighted video models are available via cloud rendering in Astra and API. Starlight Precise 2.5 (Local) can be found in the Topaz Video desktop application.

About Topaz Labs
Founded in 2005, Topaz Labs is a leader in AI-powered image and video enhancement. Its technology is used by 1.5 million customers, including 20 of the world’s top 50 companies. Known for industry-leading products like Topaz Photo, Topaz Video, Topaz Gigapixel, Astra and Bloom, the company continues to invest heavily in research and development, advancing the frontiers of imaging technology in collaboration with academic and industry partners.

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SOURCE Topaz Labs

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Dreame Technology Launches the L60 Series, Led by the Flagship L60 Pro Ultra

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New lineup brings industry-leading intelligence and full-home automation to a new generation of robot vacuums

SAN FRANCISCO, April 28, 2026 /PRNewswire/ — Dreame Technology, a leader in smart home innovation, today announced the L60 Series, a new lineup of four robot vacuums engineered for the full range of modern home environments. Built on a shared foundation of premium cleaning performance, intelligent navigation, and hands-free automation, the L60 Series is designed to meet the needs of every kind of household, from compact apartments to multi-story homes, and from single-surface layouts to complex mixed-flooring environments.

“The L60 Series represents exactly what Dreame stands for: powerful, intelligent cleaning that adapts to how people actually live,” said Ana Wang, CEO of Dreame Technology North America. “Whether you have a multi-story home, pets, mixed flooring, or low furniture, there’s an L60 built for your needs. Every model in the lineup delivers the core cleaning experience our customers expect from Dreame.”

Meet the L60 Series

The L60 Series is built around four distinct models, each tailored to a different home profile and cleaning priority:

L60 Pro Ultra — The Ultimate All-in-One. The flagship vacuum is purpose-built for large floor plans, multi-surface transitions, and complex terrain. Features the 3.46-inch ProLeap™ System, 35,000Pa Vormax™ Suction, Dual Omni-Scrub Mopping with Hot Water, and an industry-leading 6,400mAh PowerCore™ Battery.L60 Ultra — Precision Whole-Home Coverage. A balanced high-performer built around Dreame’s latest 2026 sensor technology and a 3.23in (82mm) ultra-thin design for precise navigation in low-light spaces and flawless cleaning under low-profile furniture. Includes AI-Enhanced 3D ToF Vision, 35,000Pa Vormax™ Suction, HyperStream™ Detangling DuoBrush 2.0, SmartDirt™ Detection, Pet-Friendly Care 5.0, and Matter, Apple Watch, and Home Screen Shortcut support.L60 Ultra PE (Performance Edition) — The Intelligent Step-Up. An upgraded everyday performer for homes that need an extra boost on hair pickup, with 30,000Pa Vormax™ Suction, the HyperStream™ Detangling DuoBrush, 3DAdapt™ Obstacle Avoidance, and Smart Pathfinder Technology with 220 object type recognition.L60 Ultra FE (Fine Edition) — The Essential Automated Choice. An entry-level powerhouse delivering the core promise of maintenance-free floor care, with 30,000Pa Vormax™ Suction, TriCut Brush 3.0, Dual Flex Arm Technology, and the full PowerDock™ automation experience.

A Shared Foundation of Premium Performance

Every model in the L60 Series shares a core set of capabilities that set a new baseline for modern robot vacuums, including:

212°F (100°C) ThermoHub™ Mop Self-Cleaning for hygienically clean mop pads after every cycle30,000–35,000Pa Vormax™ Suction across the lineup for powerful pickup on every surfaceDual Flex Arm Technology for adaptive side-brush and mop coverage in corners and along edgesMop Lifting for seamless transitions between hard floors and carpetAutomatic Solution Dispensing for consistent cleaning chemistry without manual refillsThe 8-in-1 PowerDock™ base station, which handles auto-empty, mop washing, hot-air drying, and solution management for truly hands-free operation

L60 Pro Ultra: The Flagship Experience, Redefined for Complex Homes

Leading the lineup is the L60 Pro Ultra, featuring select top-tier specifications optimized for large-scale layouts and complex terrains. It pairs the series’ most capable hardware with Dreame’s most advanced intelligence to deliver a seamless, one-stop cleaning experience that effortlessly tackles stubborn stains across expansive and complex home layouts.

At the heart of the Pro Ultra’s navigation advantage is the 3.46-inch ProLeap™ System, the lineup’s most capable obstacle-crossing system, paired with VersaLift Navigation for cleaning under low-clearance furniture. It is equipped with dual-laser 3D structured light, an AI RGB camera, and LED illumination, enabling it to recognize over 280 types of obstacles — for precise, real-time avoidance in any lighting condition.

The Pro Ultra delivers 35,000Pa Vormax™ Suction alongside the HyperStream™ Detangling DuoBrush, together extracting embedded debris, pet hair, and fine particles from every floor type without tangles or jams. Its Dual Omni-Scrub Mopping with Hot Water system pairs rotating mop pads with a Thermal Mop Pad and ThermoHub™ 212°F (100°C) Mop Self-Cleaning, while the AceClean™ DryBoard minimizes residue — eliminating grease, bacteria, and moisture that cold-water systems simply can’t address. An industry-leading 6,400mAh PowerCore™ Battery provides whole-home coverage on a single charge.

The Pro Ultra’s OmniDirt™ Detection Technology identifies high-soil areas and automatically triggers Mop Rewashing and Floor Remopping for a truly thorough result. Pet-Friendly Care 4.0 adds pet-aware detection and navigation, while Upgraded Intelligent Carpet Cleaning optimizes suction and mop behavior for mixed-flooring homes. Direct Voice Control and app control round out the experience for effortless day-to-day use.

Pricing and Availability

The Dreame L60 Series is available now through the Dreame website and Amazon (L60 Pro Ultra, L60 Ultra, L60 Ultra PE, L60 Ultra FE), with launch-offer pricing through the official website. Customers who purchase on dreametech.com receive a free accessory kit with their order.

L60 Pro Ultra — MSRP $1,399.99 | Launch Offer $1,259.99L60 Ultra — MSRP $1,299.99 | Launch Offer $1,169.99L60 Ultra PE — MSRP $1,099.99 | Launch Offer $879.99L60 Ultra FE — MSRP $999.99 | Launch Offer $749.99

For more information about the L60 Series, visit dreametech.com/pages/l60-series-robot-vacuum.

About Dreame Technology

Established in 2017, Dreame Technology is an innovative consumer product company focused on smart home cleaning appliances with the vision to empower lives through technology. Follow us on Facebook, Instagram, TikTok and Twitter. For more information, please visit https://www.dreametech.com/.

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SOURCE Dreame Technology

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Vanda Pharmaceuticals announces the publication of “Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis” in NEJM Evidence

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WASHINGTON, April 28, 2026 /PRNewswire/ — Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: VNDA) today announced the publication of the original research article titled “Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis” in New England Journal of Medicine (NEJM) Evidence1.

The findings of this pivotal phase III study are included in the Biologics License Application (BLA) for imsidolimab for the treatment of Generalized Pustular Psoriasis (GPP), submitted to the U.S. Food and Drug Administration (FDA) with a target action date of December 12, 2026.

References

Smieszek, S. et al. Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis. NEJM Evidence 5, (2026). 

About Imsidolimab

Imsidolimab is a fully humanized IgG4 monoclonal antibody that inhibits IL-36 receptor signaling and is being developed for GPP, a rare orphan indication. Regulatory and patent exclusivity for imsidolimab is expected to extend into the late 2030s. Vanda holds an exclusive global license for the development and commercialization of imsidolimab from AnaptysBio (Nasdaq: ANAB).

About Vanda Pharmaceuticals

Vanda is a leading global biopharmaceutical company focused on the development and commercialization of innovative therapies to address high unmet medical needs and improve the lives of patients. For more on Vanda Pharmaceuticals Inc., please visit www.vandapharma.com and follow us on X @vandapharma.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

Various statements in this press release, including, but not limited to statements regarding the anticipated timing of the completion of the FDA’s review of the imsidolimab BLA; Vanda’s plans to seek FDA approval of imsidolimab for the treatment of GPP; and the potential to extend regulatory and patent exclusivity for imsidolimab into the late 2030s, are “forward-looking statements” under the securities laws. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. Forward-looking statements are based upon current expectations and assumptions that involve risks, changes in circumstances and uncertainties. Important factors that could cause actual results to differ materially from those reflected in Vanda’s forward-looking statements include, among others, the FDA’s ability to complete its review of, and reach a decision with respect to, the imsidolimab BLA by December 12, 2026; Vanda’s ability to obtain FDA approval of imsidolimab for the treatment of GPP; and Vanda’s ability to satisfy the conditions necessary to extend regulatory and patent exclusivity for imsidolimab into the late 2030s. Therefore, no assurance can be given that the results or developments anticipated by Vanda will be realized, or even if substantially realized, that they will have the expected consequences to, or effects on, Vanda. Forward-looking statements in this press release should be evaluated together with the various risks and uncertainties that affect Vanda’s business and market, particularly those identified in the “Cautionary Note Regarding Forward-Looking Statements”, “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” sections of Vanda’s most recent Annual Report on Form 10-K, as updated by Vanda’s subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the U.S. Securities and Exchange Commission, which are available at www.sec.gov.

All written and verbal forward-looking statements attributable to Vanda or any person acting on its behalf are expressly qualified in their entirety by the cautionary statements contained or referred to herein. Vanda cautions investors not to rely too heavily on the forward-looking statements Vanda makes or that are made on its behalf. The information in this press release is provided only as of the date of this press release, and Vanda undertakes no obligation, and specifically declines any obligation, to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Corporate Contact:
Kevin Moran
Senior Vice President, Chief Financial Officer and Treasurer
Vanda Pharmaceuticals Inc.
202-734-3400
pr@vandapharma.com

Jim Golden / Jack Kelleher / Dan Moore
Collected Strategies
VANDA-CS@collectedstrategies.com

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SOURCE Vanda Pharmaceuticals Inc.

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