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AXISCADES reports record Rs. 346.7 crore revenue from operations for Q1 FY27, including discontinued operations, up 42.2% YoY

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Defence and XiDA drive retained portfolio growth

BENGALURU, India, Aug. 14, 2026 /PRNewswire/ — AXISCADES Technologies Limited (BSE: 532395) (NSE: AXISCADES), a technology, engineering and manufacturing company focused on Aerospace, Defence, Space and XiDA/electronics and AI, today announced its consolidated results for the quarter ended 30 June 2026.

Q1 FY27 consolidated revenue from operations, comprising continuing and discontinued operations, stood at a quarterly record of Rs. 346.7 crore, increasing by 42.2% year on year and 27.0% sequentially.

During May and June 2026, the Company announced the divestment of its Engineering Services and Aerospace Services businesses, respectively, to the Akkodis Group. The divestment programme represents a minimum consideration of Rs. 1,685 crore and total consideration of approximately Rs. 2,256 crore—approximately USD 237 million. The transactions are progressing through the applicable closing conditions.

The Company presents continuing and discontinued operations separately, in line with the prescribed accounting standards. In accordance with Ind AS 105, the comparative periods have been restated on the same basis.

Revenue from operations from continuing operations was Rs. 183.4 crore. On a like-for-like basis excluding Add Solutions, which management intends to exit in FY27, revenue was approximately Rs. 181 crore, an increase of ~100% from approximately Rs. 90 crore in Q1 FY26.

Reported EBITDA was Rs. 27.9 crore, with an EBITDA margin of 8.1%, compared with Rs. 34.1 crore and 14.0%, respectively, in Q1 FY26. The Company reported a loss before tax of Rs. 11.9 crore and a loss after tax of Rs. 14.8 crore. Reported profitability included Rs. 11.56 crore of one-time receivable provisions, primarily relating to an aged defence transaction; a Rs. 3.50 crore hedge provision under discontinued operations; and Rs. 21.81 crore of divestment-related exceptional costs under discontinued operations.

Excluding the two provisions aggregating Rs. 15.06 crore, management-defined normalised EBITDA was Rs. 41.0 crore, up 20.5% year on year, with a margin of 12.4%. After also adjusting for the Rs. 21.81 crore exceptional charge, management-defined normalised profit before tax was Rs. 23.1 crore.

Q1 FY27 highlights

Record revenue from operations including discontinued operations: Rs. 346.7 crore, up 42.2% YoY and 27.0% QoQ.Continuing operations: Rs. 183.4 crore of reported revenue from operations; management-defined like-for-like revenue excluding Add Solutions increased ~100% YoY to approximately Rs. 181 crore.Defence: revenue more than doubled to Rs. 125.0 crore; updated Assured Forecast Visibility stood at Rs. 4,557 crore after Q1 execution.XiDA: revenue increased ~62% YoY to Rs. 49.5 crore; EBITDA rose 114.5% to Rs. 14.7 crore, with a 29.7% margin.Space: the Space division has been established as the Company’s fourth growth platform: a satellite manufacturing, assembly, integration and testing facility is under construction at the Devanahalli Atmanirbhar Complex, and technology-transfer collaborations are in progress.Manufacturing capacity: Property, plant and equipment together with capital work-in-progress increased by Rs. 40.1 crore, during Q1 FY27. Devanahalli AeroLand has been commissioned; Phase 1 of the Devanahalli Atmanirbhar Complex is under construction; land acquisition for the Missile Atmanirbhar Complex in Hyderabad has been completed and construction is commencing; and land allocation for the proposed 240,000 sq. ft. Center for Advanced Manufacturing at Devanahalli is in process.Add Solutions exit: Management is implementing an action plan and is targeting completion of the exit by Q4 FY27.Portfolio transition: The Engineering Services and Aerospace Services divestments, announced in May and June 2026, respectively, represent a minimum consideration of Rs. 1,685 crore and total consideration of approximately Rs. 2,256 crore—approximately USD 237 million. Closing is planned in two phases: Phase 1 by Q2 FY27, with approximately Rs. 180 crore of initial proceeds expected within five days, and Phase 2 by Q3 FY27, completing the approximately Rs. 2,256 crore divestment programme.

Management commentary

“Q1 FY27 marks the first quarter of AXISCADES’ transition into a focused manufacturing, products and solutions company built for non-linear growth. Revenue per employee is set to rise from Rs 42 lakh in FY26 to Rs 1.2 crore in FY27 — more than a threefold gain, and the clearest measure of the shift from a people-led services model to a products and manufacturing one.

The strength of the businesses we have chosen to scale is increasingly visible. Defence revenue more than doubled. XiDA added two of the world’s largest technology companies as customers. Aerospace Manufacturing is being rebuilt through organic scale-up and acquisition, and Space is now established as our fourth growth platform.

With the non-core divestment substantially complete, we are directing capital and management bandwidth towards Aerospace Manufacturing, Defence Systems, XiDA and Space, in line with our Power 930 roadmap.”

Dr. Sampath Ravinarayanan, Founder, Chairman & Managing Director

“The quarter combines strong revenue growth with the accounting impact of a major portfolio transition. Reported profitability includes Rs. 15.06 crore of one-time provisions and Rs. 21.81 crore of divestment-related exceptional costs. Excluding these items, management-defined normalised EBITDA was Rs. 41.0 crore at a 11.8% margin, and management-defined normalised PBT was Rs. 23.1 crore. Our immediate priorities are to complete the divestment, address the Add Solutions drag, scale the retained portfolio and deploy the proceeds into growth without equity dilution.”

Shashidhar SK, Group Chief Financial Officer

Rs. crore, except margins

Particulars

Q1 FY27

Q4 FY26

Q1 FY26

QoQ

YoY

Revenue from operations (continuing
and discontinued operations)

346.6

273.0

243.7

+27.0 %

+42.2 %

Reported EBITDA

27.9

33.6

34.1

(17.0) %

(18.1) %

Reported EBITDA margin

8.1 %

12.3 %

14.0 %

(426) bps

(592) bps

Normalised EBITDA

41.0

33.6

34.1

+22.1 %

+20.5 %

Normalised EBITDA margin

11.8 %

12.3 %

14.0 %

 (47) bps

(214) bps

EBIT

15.8

19.8

24.7

(20.1) %

(35.9) %

Reported PBT / (loss)

(11.9)

10.5

28.0

n.m.

n.m.

Normalised PBT

23.1

10.5

28.0

+119.6 %

(17.6) %

Reported PAT / (loss)

(14.8)

0.4

20.9

n.m.

n.m.

n.m. = not meaningful because the comparison crosses between profit and loss. Reported amounts below are derived from the Company’s
unaudited consolidated financial results under Regulation 33. EBITDA is calculated as revenue from operations less operating expenses
other than finance costs and depreciation and amortisation, and excludes other income; EBIT is EBITDA less depreciation and
amortisation. Normalised measures are management-defined alternative performance measures.

Reported-to-normalised reconciliation

Measure

Reported

Receivable provision

Hedge provision

Deal-related exceptional costs

Normalised

EBITDA

27.9

9.62

3.50

41.0

PBT / (loss)

(11.9)

9.62

3.50

21.81

23.0

Normalised EBITDA and normalised PBT are management-defined alternative performance measures and are not measures defined under
Ind AS. Reported amounts are derived from the Company’s unaudited consolidated financial results under Regulation 33; management-
defined adjustments are sourced from the Q1 FY27 investor presentation. These measures are presented to explain identified one-time
and transaction-related items and should not be considered in isolation or as substitutes for reported results. Figures may not sum due to
rounding.

Business performance

Defence: revenue more than doubles; sole-source wins strengthen visibility

Defence revenue rose ~111% year on year and 86.1% sequentially to Rs. 125.0 crore. Management-defined underlying EBITDA, excluding Rs. 8.7 crore of one-time provisions, was Rs. 13.8 crore, representing a margin of 11.0% and year-on-year growth of 25.1%.

Since 1 April 2026, the business secured or advanced eight programmes, comprising four in-quarter programmes and four sole-source wins after the balance-sheet date. The post-balance-sheet programmes cover on-board computers for an anti-tank missile, a PCM encoder for a missile programme, antenna beam control for the Uttam radar and an Exciter Receiver Processor for a marine helicopter.

Assured Forecast Visibility (AFV) for FY27-FY30 increased by Rs. 332 crore from new design wins and reduced by Rs. 125 crore executed during Q1, moving from Rs. 4,350 crore at FY26 year-end to Rs. 4,557 crore. AFV is a management-defined operating measure comprising customer-communicated programme requirements where AXISCADES holds design-won and qualified sole-source or limited-source status; it is not an order book or guarantee of future revenue, and actual procurement remains subject to customer timelines.

XiDA: global customer additions reinforce electronics and AI platform

XiDA revenue increased 62.9% year on year and 30.3% sequentially to Rs. 49.5 crore. EBITDA increased 114.5% year on year to Rs. 14.7 crore, with a margin of 29.7%.

The new US business contributed Rs. 15.2 crore of revenue and Rs. 7.0 crore of EBITDA at a 46.2% margin in Q1. The arrangement brings two global tier-one customers: the world’s largest semiconductor equipment company and one of the world’s largest AI and hyperscale technology companies. Customers are described rather than named pending disclosure consent.

The acquisition is being progressed through a business transfer agreement rather than a share purchase. Operations and facilities are expected to transfer and customer contracts to migrate through novation. Completion is targeted in Q2 FY27, subject to the applicable conditions.

Aerospace Manufacturing: capability build precedes scale

The reconstituted Aerospace business reported revenue of Rs. 6.1 crore and an EBITDA loss of Rs. 5.4 crore, reflecting the cost of building leadership and capability ahead of acquisition-led and organic scale-up.

AXISCADES has in place a non-binding offer for an AS9100D-certified precision manufacturing company an indicative pro forma FY27 revenue of Rs. 180 crore and EBITDA of Rs. 39 crore, representing a 22% margin. The proposed transaction remains subject to definitive documentation, due diligence, applicable corporate approvals and regulatory clearances; all pro forma figures are indicative.

AXISCADES also plans a 240,000 sq. ft. Center for Advanced Manufacturing on a 20-acre campus at Devanahalli, approximately six kilometres from the Devanahalli Atmanirbhar Complex. The proposed quad-use facility is intended to support Aerospace, Defence, Space and Electronics. The land allocation process is under way.

Space: fourth growth platform established

AXISCADES has established its Space division and commenced construction of a satellite manufacturing, assembly, integration and test facility at the Devanahalli Atmanirbhar Complex. Technology-transfer collaborations are in progress, with formal details planned for the Bengaluru Space Expo and the World Space Business Week in Paris, in September 2026, subject to definitive agreements.

The Company has earmarked Rs. 300 crore from proposed divestment proceeds for the Space platform, comprising Rs. 120 crore for facilities and training and Rs. 180 crore across two planned joint ventures. This proposed deployment remains subject to completion of the divestment transactions, definitive agreements and applicable approvals.

Portfolio transformation and capital deployment

During May and June 2026, AXISCADES announced the divestment of its Engineering Services and Aerospace Services businesses, respectively, to the Akkodis Group. The divestment programme represents a minimum consideration of Rs. 1,685 crore and total consideration of approximately Rs. 2,256 crore – approximately USD 237 million. Shareholders approved both transactions on 27 July 2026, and the transactions are progressing through the applicable closing conditions.

Management is targeting completion of Phase 1 by 31 August 2026, with approximately Rs. 180 crore of initial proceeds expected within five days, and Phase 2 by 30 November 2026, completing the approximately Rs. 2,256 crore divestment programme. On completion, the Company expects to recognise a gain on disposal of approximately Rs. 1,255 crore, subject to closing adjustments, the applicable exchange rate and final accounting determination.

The proceeds are intended to fund the Company’s transition into Aerospace Manufacturing, Defence Systems, XiDA and Spacetech – including strategic acquisitions and manufacturing infrastructure – without equity dilution. Property, plant and equipment together with capital work-in-progress increased by Rs. 40.1 crore, or 29.5%, during Q1 FY27. Devanahalli AeroLand has been commissioned and is supporting aerospace and defence supply-chain and logistics requirements. Phase 1 of the Devanahalli Atmanirbhar Complex is under construction and is targeted to become operational during FY27; the facility also hosts the satellite manufacturing, assembly, integration and testing facility for the new Space division. At the Missile Atmanirbhar Complex in Hyderabad, land acquisition has been completed, the groundbreaking ceremony was held in July 2026 and construction is commencing. Land allocation is in process for the proposed Center for Advanced Manufacturing—a 240,000 sq. ft. quad-use facility planned on 20 acres at Devanahalli, approximately six kilometres from the Devanahalli Atmanirbhar Complex—which is intended to house future aerospace manufacturing acquisitions.

Note: The consideration values, anticipated proceeds, disposal gain and completion timelines are based on management’s current estimates and disclosures in the Q1 FY27 investor presentation. They remain subject to satisfaction of closing conditions, transaction adjustments, exchange-rate movements and final accounting determination.

Deferred Revenue Update

Management estimates that approximately Rs. 64 cr of the Rs. 142 crore of FY26 revenue deferred for supply-chain and operational reasons was recognised in Q1 FY27. Management expects to recognise the remaining amount across Q2 and Q3 FY27, subject to supply-chain availability, operational execution, customer acceptance and applicable revenue-recognition requirements. Management states that no related orders were cancelled and no customers were lost.

These targets and timelines are forward-looking, are subject to the risks and qualifications set out below, and do not constitute guarantees of future performance.

About AXISCADES Technologies Limited

AXISCADES Technologies Limited is a Bengaluru-headquartered technology, engineering and advanced manufacturing company serving global OEMs and customers across Aerospace, Defence, Space, and Electronics, Semiconductors and Artificial Intelligence. Its integrated capabilities span product design and engineering, embedded and electronic systems, precision manufacturing, testing, integration, and technology-led product and systems development. Combining deep domain expertise with expanding manufacturing and systems-integration capabilities, AXISCADES supports the development and delivery of complex, mission-critical programmes. The Company is listed on the National Stock Exchange of India Limited (NSE: AXISCADES) and BSE Limited (BSE: 532395).

Website: www.axiscades.com
CIN: L72200KA1990PLC084435

Safe harbour

Certain statements in this release constitute forward-looking statements within the meaning of applicable laws and regulations. These statements include, among others, expectations and targets relating to transaction completion and consideration, receipt of approvals, accounting outcomes, customer and employee transition, programme procurement and delivery, revenue recognition, recovery of deferred revenue, business transfers and acquisitions, capital deployment, manufacturing and facility scale-up, Space collaborations and joint ventures, revenue growth, margins, profitability, cash flows and the Company’s Power 930 strategic objectives. Forward-looking statements are based on current assumptions and involve risks, uncertainties and other factors that could cause actual outcomes to differ materially. AXISCADES Technologies Limited undertakes no obligation to publicly update any forward-looking statement except as required under applicable law.

 

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Innovative Eyewear, Inc. to Present at Sidoti’s Micro-Cap Virtual Investor Conference on August 19

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MIAMI, Aug. 14, 2026 /PRNewswire/ — Innovative Eyewear, Inc. (Nasdaq: LUCY) (“Innovative Eyewear” or the “Company”), the developer & manufacturer of smart eyewear under the Lucyd®, Lucyd Armor®, Reebok®, Eddie Bauer®, and Nautica® brands, today announced Harrison Gross, Chief Executive Officer, will present and host one-on-one meetings with investors at Sidoti’s Micro-Cap Virtual Investor Conference, taking place on August 19-20, 2026.

The presentation will begin at 10:45 AM ET on Wednesday, August 19, and can be accessed live here. Innovative Eyewear will also host virtual one-on-ones with investors on Wednesday and Thursday, August 19-20, 2026. To register for the presentation or one-on-ones, visit www.sidoti.com/events. Registration is free, and you don’t need to be a Sidoti client.

About Innovative Eyewear, Inc.

Innovative Eyewear is a developer & manufacturer of cutting-edge AI-enabled smart eyewear, under the Lucyd®, Nautica®, Eddie Bauer®, and Reebok® brands. True to our mission to Upgrade Your Eyewear®, our Bluetooth audio glasses allow users to stay safely and ergonomically connected to their digital lives and are offered in hundreds of frame and lens combinations to meet the needs of the optical, sunglass, sporting goods, and safety eyewear markets. To learn more and explore our continuously evolving collection of smart eyewear, please visit www.lucyd.co.

About Sidoti Events, LLC (“Events”) and Sidoti & Company, LLC (“Sidoti”)

In 2023, Sidoti & Company, LLC formed an affiliate company, Sidoti Events, LLC, in order to focus exclusively on its rapidly growing conference business and to more directly serve the needs of presenters and attendees. The relationship allows Events to draw on the over 25 years of experience Sidoti has as a premier provider of independent securities research focused specifically on small and microcap companies and the institutions that invest in their securities, with most of its coverage in the $200 million-$5 billion market cap range. Sidoti’s coverage universe comprises approximately 150 equities, of which almost 70 percent participate in the firm’s rapidly growing Company Sponsored Research (“CSR”) and Sidoti Lighthouse Equity Research (“Lighthouse”) programs. Events is a leading provider of corporate access through the many investor conferences it hosts each year. By virtue of its direct ties to Sidoti, Events benefits from Sidoti’s small- and microcap-focused nationwide sales force, which has connections with over 2,500 institutional relationships in North America. This enables Events to provide multiple forums for meaningful interaction for small and microcap issuers and investors specifically interested in companies in the sector.

Forward Looking Statements

This press release contains certain forward-looking statements, including those relating to retail partners. Forward-looking statements are based on the Company’s current expectations and assumptions. The Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward-looking statements. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “anticipate,” “believe,” “continue,” “estimate,” “expect,” “future,” “intend,” “may,” “outlook,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters, but the absence of these words does not mean that a statement is not forward-looking. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in the Company’s filings with the Securities and Exchange Commission, including its annual report on Form 10-K under the caption “Risk Factors.”

Investor Relations Contact:

Skyline Corporate Communications Group, LLC
Scott Powell, President
1177 Avenue of the Americas, 5th Floor
New York, NY 10036
Office: +1 (646) 893-5835
Email: ir@skylineccg.com 

 

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SOURCE Innovative Eyewear, Inc.

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Securus Monitoring® Highlights How Technology-Enabled Supervision Helps People Return Home Safely and Build Stability

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Real-time visibility helps officers maintain accountability while individuals stay connected to work, family, and community

CHICAGO, Aug. 14, 2026 /PRNewswire/ — For a person under supervision, every night spent at home helps build the foundation for stable reentry. Electronic monitoring makes home-based supervision practical by giving officers continuous, real-time visibility beyond face-to-face check-ins. At the American Probation and Parole Association (APPA) Annual Training Institute, August 16–19 in Chicago, Securus Monitoring will demonstrate how connected monitoring technology can help officers maintain accountability while giving monitored individuals the strongest opportunity for long-term success.

Securus Monitoring technology extends connected corrections infrastructure into the community, giving supervision agencies real-time visibility into where individuals are and whether they are meeting the conditions of their release. With that visibility, officers can approve a work schedule, a treatment appointment, or family time with confidence, and can move quickly when conditions change. Agencies can supervise larger caseloads while accountability stays at the forefront. Research from the National Institute of Justice has found that electronic monitoring reduces the risk of failure under community supervision by over 30 percent compared with other forms of community supervision.

“Effective community supervision can strengthen public safety while helping people build stability in the community,” said Kevin Elder, President, Securus Technologies. “Secure, connected technology gives officers a reliable picture of what is happening, so they can extend trust where it is earned and act early where it’s not. This is what allows an agency to keep more people at home, in work, and connected to those who depend on them.”

Technology That Supports Officer Focus and Participant Stability
At Booth #321, Securus Monitoring will be on-site to connect with supervision and parole leadership about two products that make safe home-based supervision possible.

BLUtag provides industry-leading real-time GPS monitoring, empowering supervising officers with precise visibility into an individual’s location, enabling the creation of customized inclusion and exclusion zones around key locations such as workplaces, schools, and residences.SoberTrack® enables efficient, accountable supervision without disrupting daily life by combining remote alcohol testing with GPS verification, identity confirmation, and photo documentation, so officers receive immediate, verified results without requiring field visits, allowing individuals to maintain employment and daily responsibilities.

Together, the tools help agencies maintain active oversight while supporting the day-to-day stability driving successful reentry.

Employment as a Foundation for Successful Reentry
Technology can help someone safely reenter the community and build meaningful employment, creating the stability to stay and succeed there.

This year marks the fifth consecutive year that Securus Technologies has supported the APPA Career & Resource Fair. Across the four fairs held to date, more than 750 people on community supervision have participated, alongside more than 95 employers and 47 service providers across four states. The fair creates an opportunity to connect people directly with employers and resources that can support employment and greater stability while navigating community supervision.

This year’s fair will also include a Securus-hosted fireside chat focused on what it takes not only to secure employment, but to sustain it and build a career while meeting the requirements of supervision. The conversation will bring together perspectives from employers, community corrections, and people with lived experience.

“For people navigating probation or parole, employment represents far more than a paycheck. It provides stability, purpose, and an opportunity to build what comes next,” said Shamia Lodge, Director, Stakeholder Engagement, Securus Technologies. “Over the past four years, we’ve seen more than 750 people on supervision walk through the doors of these career fairs, alongside employers and service providers willing to meet them there. But access to an opportunity is only the beginning. We also have to think about what helps someone keep that job, grow in their career, and successfully meet the requirements of supervision. That is where employers, community corrections, and community partners all have a role to play.”

APPA Annual Training Institute attendees are invited to visit Securus Monitoring at Booth #321 to learn how connected monitoring technology can give officers greater visibility while supporting safe, home-based supervision and stable reentry.

About Securus Monitoring
Securus Monitoring, an Aventiv Technologies company, is the nation’s most experienced and innovative provider of electronic monitoring and facility intelligence solutions. As the original GPS monitoring pioneer, Securus introduced BLUtag®, the industry’s first one-piece GPS device, now in its eighth generation with advanced tamper detection, dual SIM technology, and seamless nationwide coverage. The company provides a combination of field-tested hardware, robust software like VeriTracks®, and 24/7 managed services via the Securus Monitoring Center. With a legacy of innovation, scale, and reliability, Securus Monitoring is the trusted partner helping agencies protect communities, enhance operations, and enable better outcomes. Learn more at https://securusmonitoring.com.

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SOURCE Securus Monitoring

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A new way to beat jet lag? Engineered cells speed circadian adjustment

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Peer-reviewed publication highlights the use of encapsulated leptin-producing cells to accelerate circadian realignment in preclinical models

HOUSTON, Aug. 14, 2026 /PRNewswire/ — Adjusting to a new time zone or work schedule can leave the body’s internal clock out of sync for days, contributing to sleep disruption, metabolic changes and other health consequences. Researchers at Rice University, with the support of the Rice Biotech Launch Pad, and Northwestern University have developed an implantable cell therapy that may help the body adapt more quickly to these disruptions.

In a recent study titled “Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates,” encapsulated cells engineered to continuously produce the metabolic hormone leptin reduced the time required for animals to adjust to shifts in the light-dark cycle that mimic jet lag and shift work. Published in Advanced Science, the study’s indings demonstrate a new approach to regulating circadian rhythms through metabolic signaling and provide early evidence that engineered cell therapies could be used to address circadian disruption.

“Current approaches for adjusting circadian rhythms rely heavily on precisely timed behaviors such as light exposure, meal schedules or melatonin administration,” said Omid Veiseh, professor of bioengineering at Rice and faculty director of the Rice Biotech Launch Pad. “We wanted to explore whether a temporary cell therapy could provide a more practical way to help the body adapt to changing schedules.”

The therapy consists of human retinal pigment epithelial cells engineered to produce leptin, a hormone best known for regulating appetite and metabolism. The cells are encapsulated within microscopic alginate spheres that protect them from the immune system while allowing therapeutic proteins to diffuse into the body. Following a simple subcutaneous injection, the encapsulated cells temporarily elevate circulating leptin levels before naturally losing viability over time.

“Metabolism and circadian rhythms are closely connected, but the therapeutic potential of that relationship remains largely unexplored,” said Martha Hotz Vitaterna, professor of neurobiology at Northwestern University and co-corresponding author on the study. “These findings suggest that metabolic signals can be leveraged to accelerate adaptation to circadian disruptions.”

In mouse studies, animals receiving the leptin-producing cell therapy adjusted significantly faster following both phase advances and phase delays in the light-dark cycle. Mice treated with the therapy adapted to a four-hour schedule delay 50% faster days than in control animals.

To evaluate the translational potential of the approach, the researchers tested the therapy in cynomolgus macaques, whose sleep-wake patterns more closely resemble those of humans. The treatment was well tolerated and reduced entrainment time following six-hour schedule shifts by approximately one day compared to controls.

“The fact that we observed similar effects in both rodents and non-human primates suggests that the underlying biology may be conserved across species,” said Fred Turek, director of Northwestern’s Center for Sleep and Circadian Biology and a senior author on the study.

Researchers monitored multiple physiological indicators of circadian alignment, including activity, heart rate and core body temperature. Across these measures, animals receiving the leptin-producing implants adapted more rapidly to the new schedules than untreated controls.

Importantly, the therapy did not negatively affect sleep. Analysis of sleep architecture in non-human primates showed no reduction in total sleep time, rapid eye movement sleep or non-REM sleep. Researchers also observed increases in slow-wave sleep activity following some schedule shifts, suggesting a potential improvement in sleep quality during recovery.

Beyond demonstrating efficacy, the study also evaluated the safety and practicality of the platform. Blood tests and clinical monitoring showed no signs of significant toxicity in non-human primates, and animals receiving multiple doses over the course of a year experienced no long-term adverse effects. The encapsulated cells remained active for several days before naturally declining, creating a temporary and reversible intervention.

“Our goal was not to permanently alter the circadian system,” Samantha Fleury, first author on the publication, said. “We wanted a therapy that could provide short-term support during periods of disruption and then naturally resolve.”

The researchers believe the platform could eventually be explored for applications involving frequent circadian disruption, including shift work, military operations, international travel and other situations where rapid adaptation to changing schedules is important. Ft

“This work provides further evidence that metabolic pathways can be harnessed to influence circadian biology,” said Jonathan Rivnay, professor of biomedical engineering and materials science and engineering at Northwestern University and a senior author on the study. “More broadly, it demonstrates how engineered cell therapies can be used to deliver biologically active molecules in ways that would be difficult to achieve through conventional dosing.”

The team plans to further investigate the mechanisms linking leptin and circadian regulation and explore next-generation versions of the platform capable of providing tunable or repeatable circadian support.

The research was supported by the 711th Human Performance Wing and the Defense Advanced Research Projects Agency under agreement number FA8650-21-1-7119.

This news release can be found online at news.rice.edu.

Follow Rice News and Media Relations via Twitter @RiceUNews.

Peer-reviewed paper:

Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates | Advanced Science

Authors: Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh

About Rice:

Located on a 300-acre forested campus in Houston, Texas, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of architecture, business, continuing studies, engineering and computing, humanities and arts, music, natural sciences and social sciences and is home to the Baker Institute for Public Policy. Internationally, the university maintains the Rice Global Paris Center, a hub for innovative collaboration, research and inspired teaching located in the heart of Paris. With 4,776 undergraduates and 4,104 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 7 for best-run colleges by the Princeton Review. Rice is also rated as a best value among private universities by the Wall Street Journal and is included on Forbes’ exclusive list of “New Ivies.”

If you do not wish to receive news releases from Rice University, reply to this email and write “unsubscribe” in the subject line. Rice University, Office of News and Media Relations–MS 300, 6100 Main St., Houston, TX 77005.

About the Rice Biotech Launch Pad:  

The Rice Biotech Launch Pad is a Houston-based accelerator focused on expediting the translation of Rice University’s health and medical technology discoveries into cures. This initiative is designed to help advance internally discovered platform technologies from concept to clinical studies and commercialization. The Rice Biotech Launch Pad will identify and support highly differentiated projects while driving the expansion of Houston as a world-class medical innovation ecosystem. The accelerator will bring together local researchers with a network of industry executives. For more information, please visit https://biotechlaunchpad.rice.edu/.

Media Contact:

Russo Partners
David Schull or Liz Phillips
(347) 956-7697
david.schull@russopartnersllc.com 
elizabeth.phillips@russopartnersllc.com

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