Technology

Zoghbi, Bird Honored for Work on Epigenetics in Neurological Diseases

Published

3 hours ago

September 2, 2026

HOUSTON, Sept. 2, 2026 /PRNewswire/ — Dr. Huda Zoghbi, founding director of the Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s and Distinguished Service Professor and Howard Hughes Medical Institute Investigator at Baylor College of Medicine, along with her long-time collaborator Dr. Adrian Bird, professor at the University of Edinburgh, will be awarded the prestigious 2026 Louisa Gross Horwitz Prize from Columbia University for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

Primarily affecting girls, Rett syndrome is a severe neurodevelopmental disorder that impacts nearly every aspect of life, including the ability to speak, walk, control hand movements, eat, breathe, think, and control seizures. Before the discoveries of Zoghbi and Bird, the disorder was poorly understood and considered untreatable. Today, with lifelong support, individuals with Rett syndrome can live well into adulthood.

Zoghbi discovered in 1999 that mutations in MeCP2 cause Rett syndrome, establishing the first direct link between epigenetics and a severe neurological disorder and enabling early detection of the disease by genetic testing. She also showed that MeCP2 levels must be precisely maintained for neurons to function normally. Too little MeCP2 causes Rett syndrome, while doubling MeCP2 levels causes neurological deficits. Later work revealed that MeCP2 mutations also contribute to a range of other neurological conditions, from autism to juvenile-onset schizophrenia.

Bird uncovered key principles of epigenetic regulation, a chemical process that turns genes on and off without altering their underlying code. In the 1980s, he discovered CpG islands, specialized DNA clusters present near the start of genes. A decade later, his lab identified MeCP2, a protein that scans for chemical tags called methyl groups attached to these clusters and, upon finding them, switches the nearby gene off, acting like a molecular “off switch” for gene activity in neurons and throughout the body.

Though Rett syndrome was thought to cause permanent brain damage, Zoghbi and Bird showed that it could be reversible. Bird’s group engineered the first mouse model of Rett syndrome and, in 2007, showed that reactivating MeCP2 in these mice dramatically improved neurological symptoms. Zoghbi’s team showed that the effects of abnormal levels of functional MeCP2 can be reversed in mice by oligonucleotide therapy. Based on this work, a new generation of gene replacement (TSHA-102 and NGN-401) and RNA-regulating (ION 440) drugs, are now advancing through clinical development.

“Together, these two scientists have forged a remarkable path from fundamental discovery to therapeutic possibility, exemplifying the highest ideals of biomedical research,” said Laura Landweber, chair of Columbia’s Horwitz Prize committee.

“Their collective work has transformed our understanding of the molecular basis for a significant human disease and brought renewed hope to patients and families affected by devastating neurological disorders,” added Henry Colecraft, a member of the prize committee.

Zoghbi and Bird are the 122nd and 123rd winners of the Horwitz Prize, which is awarded annually by Columbia University for groundbreaking work in medical science. Of the 121 previous Horwitz Prize winners, 55 have gone on to also receive Nobel Prizes.

About Texas Children’s
Texas Children’s, a nonprofit health care organization, is committed to creating a healthier future for children and women throughout the global community by leading in patient care, education and research. Consistently ranked as the best children’s hospital in Texas and among the top in the nation, Texas Children’s has garnered widespread recognition for its expertise and breakthroughs in pediatric and women’s health. The system includes the Texas Children’s Duncan NRI; the Feigin Tower for pediatric research; Texas Children’s Pavilion for Women, a comprehensive obstetrics/gynecology facility focusing on high-risk births; Texas Children’s Hospital West Campus, a community hospital in suburban West Houston; Texas Children’s Hospital The Woodlands, the first hospital devoted to children’s care for communities north of Houston and Texas Children’s Hospital North Austin, the new state-of-the-art facility providing world-class pediatric and maternal care to Austin families. The organization also created Texas Children’s Health Plan, the nation’s first HMO focused on children; Texas Children’s Pediatrics, the largest pediatric primary care network in the country; Texas Children’s Urgent Care clinics that specialize in after-hours care tailored specifically for children; and a global health program that is channeling care to children and women all over the world. Texas Children’s Hospital is affiliated with Baylor College of Medicine. For more information, visit www.texaschildrens.org.

Media Contact:
Texas Children’s Public Affairs
PublicAffairs@texaschildrens.org

View original content to download multimedia:https://www.prnewswire.com/news-releases/zoghbi-bird-honored-for-work-on-epigenetics-in-neurological-diseases-302867870.html

SOURCE Texas Children’s Hospital

Technology

RMX Industries Sets Out Real-World Intelligence

Published

58 minutes ago

September 2, 2026

DALLAS, Sept. 2, 2026 /PRNewswire/ — RMX Industries, Inc. (“RMX” or the “Company”) (OTCQB: RMXI), an edge intelligence company delivering QuantrusX™, today announced it has published the first in a three-part brief on Real-World Intelligence, the Company’s name for intelligence built at the physical edge.

The first brief states that most intelligence sold to industry is trained in a data center and asked, after the fact, to comment on a live site. Whereas Real-World Intelligence is meant to run where the data is made and stay on the premises.

The Company is applying that approach first to the safety and security industry. QuantrusX™ is the Company’s product that delivers Real-World Intelligence, and QuantrusX Distributed Data Center™ (“QXDDC™”) is the intelligence fabric the QuantrusX™ deployments are intended to form as they connect. The remaining briefs in the series discuss QuantrusX™ and QXDDC™ in turn. The first brief is available to read on the Company’s website, www.rmx.io, and across its social channels.

“In our experience the gap is not a shortage of cameras,” said Karl Kit, Chief Executive Officer of RMX. “It is a lack of intelligence that lives where the data is made, on the site you already run, giving operators the insight they need while they still have time to act.”

About RMX: RMX Industries, Inc. (OTCQB: RMXI) is an edge intelligence company building physical-edge intelligence solutions for operational and mission-critical environments, drawing on a legacy in video optimization and data transfer technology. RMX is focused on platforms, such as its proprietary edge intelligence platform, QuantrusX™, that bring intelligence closer to the real world, supporting faster data interpretation, local response, and trusted decision-making where connectivity, time, and context matter. For more information, visit www.rmx.io.

Cautionary Note Regarding Forward-Looking Statements: This press release contains forward-looking statements that are subject to various risks and uncertainties. In addition, our representatives or we may make forward-looking statements orally or in writing from time to time. We base these forward-looking statements on our expectations and projections about future events, which we derive from the available information. Such forward-looking statements relate to future events or our future performance, including our financial performance and projections, revenue and earnings growth, and business prospects and opportunities. You can identify forward-looking statements by those that are not historical facts, particularly those that use terminology such as “intends,” “may,” “should,” “expects,” “anticipates,” “contemplates,” “estimates,” “believes,” “plans,” “projected,” “predicts,” “potential,” or “hopes” or the negative of these or similar terms. Although the Company believes that the expectations reflected in these forward-looking statements are based on reasonable assumptions, there are a number of risks and uncertainties that could cause actual results to differ materially from such forward-looking statements, including the risks described in the risk factors section of the reports and other documents that we file with the Securities and Exchange Commission. Forward-looking statements speak only as of the date of the document in which they are contained, and the Company does not undertake any duty to update any forward-looking statements except as may be required by law.

Media Contact: media@rmx.io

Investor Relations: ir@rmx.io

View original content to download multimedia:https://www.prnewswire.com/news-releases/rmx-industries-sets-out-real-world-intelligence-302868010.html

SOURCE RMX Industries, Inc.

Technology

Viventium Launches Next Generation Workforce Management Platform for Healthcare

Published

58 minutes ago

September 2, 2026

Newly integrated scheduling and time & attendance capabilities further unify Viventium’s end-to-end HCM platform, now connecting hiring, HR, workforce management, payroll, and retention to support every stage of the caregiver lifecycle.

BERKLEY HEIGHTS, N.J., Sept. 2, 2026 /PRNewswire/ — Viventium today announced an expansion of its human capital management (HCM) platform through the addition of integrated scheduling and time & attendance capabilities. The enhanced offering extends the connected Viventium + Apploi workforce experience, providing healthcare organizations with greater workforce visibility while reducing the complexity of managing employees across multiple systems.

Healthcare providers continue to face workforce challenges, including staffing shortages, labor cost pressures, employee retention concerns, and growing compliance requirements. Many long-term care organizations still rely on disconnected systems to manage workforce operations, limiting visibility and creating administrative inefficiencies. Time & attendance tracking and workforce scheduling have become increasingly critical functions that directly impact staffing decisions, labor costs, payroll accuracy, employee experience, and quality of care.

Available immediately for skilled nursing and senior living providers, the expanded capabilities provide a more connected approach to workforce operations. By integrating scheduling and time & attendance capabilities within Viventium’s unified HCM platform, which already supports recruiting, applicant tracking, onboarding, HR, payroll, compliance, and retention, providers can improve workforce visibility, support more efficient staffing decisions, reduce manual processes, and gain a more complete view of their workforce.

“Healthcare organizations need more than standalone workforce tools,” said Navin Gupta, Chief Executive Officer of Viventium. “They need connected systems that support caregivers from applicant to employee and from schedule to paycheck. By expanding our workforce capabilities, we’re helping providers bring together the information and workflows they need to make more informed staffing decisions, improve operational efficiency, and remain focused on delivering quality care.”

The expansion reinforces Viventium’s broader vision of providing healthcare organizations with a unified workforce platform built specifically for the industry’s operational and compliance needs. As providers increasingly explore workforce analytics, automation, and AI-driven insights, connected workforce data provides a stronger foundation for informed decision-making and long-term workforce optimization.

About Viventium + Apploi
Viventium + Apploi develops award-winning human capital management software for post-acute, behavioral health and ABA organizations of every size, helping providers unlock efficiency and improve the caregiver experience. This hire-to-retire suite was designed exclusively for the industry’s unique demands and nuanced rules. Viventium is technology built for healthcare. Because expertise matters.

For more information: www.viventium.com.

Media Contact:
Gillian Hanley
The Castle Group
301-204-1911
Ghanley@thecastlegrp.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/viventium-launches-next-generation-workforce-management-platform-for-healthcare-302867983.html

SOURCE Viventium

Technology

TPx Secures Court Approval of Plan of Reorganization, Positioning Company for Long-Term Success

Published

58 minutes ago

September 2, 2026

Clears path for TPx to emerge with significantly less debt, increased capacity to invest in the business and a new ownership structure that supports TPx’s future growth

AUSTIN, Texas, Sept. 2, 2026 /PRNewswire/ — TPx (the “Company”), a leading nationwide managed services provider, today announced that the U.S. Bankruptcy Court for the Southern District of Texas has confirmed the Company’s Plan of Reorganization (the “Plan”), marking a significant milestone in TPx’s Chapter 11 process.

Under the confirmed Plan, TPx expects to emerge with a stronger balance sheet, a more sustainable capital structure, and access to new capital. This improved financial position will allow TPx to build on its continued EBITDA and free cash flow growth while increasing investment in the business.

“Confirmation of our Plan marks a major step for TPx and clears the way for the company’s next phase,” said Shaun Andrews, Chief Executive Officer of TPx. “We reached this milestone with the commitment of our employees, the partnership of our customers and Channel Partners, and the support of our lenders, and I’m grateful to all of them. Now we can turn our full attention to the opportunities ahead: expanding the business, strengthening our capabilities and raising the bar for the managed services we deliver. We have a clear direction and a lot to build on.”

TPx continues to operate as usual, delivering reliable managed IT services and supporting customers’ day-to-day operations without interruption.

The Company expects to emerge from Chapter 11 once required regulatory approvals are received and customary closing conditions are satisfied. At that time, a group of investors consisting of the Company’s existing lenders and equity sponsor will become TPx’s new owners. TPx will be well capitalized upon emergence with new financing provided by this group of investors.

Additional Information

Additional information about TPx’s restructuring process is available at http://tpx.com/ourfuture. Bankruptcy Court filings and other information regarding the case can be found at https://restructuring.ra.kroll.com/TPx, or by contacting Kroll Inc., the Company’s noticing and claims agent, at (888) 339-7353 (toll-free) and +1(646) 825-5321 (international).

TPx is advised in this matter by Sidley Austin LLP as legal counsel, Portage Point Partners as financial advisor, with Steven Shenker serving as Chief Restructuring Officer, PJT Partners, Inc. as investment banker, and FTI Consulting, Inc. as communications advisor. An ad hoc group of lenders is advised by Davis Polk & Wardwell LLP as legal counsel, Haynes and Boone LLP as local counsel, and Guggenheim Securities, LLC as financial advisor.

About TPx

TPx is your sidekick for smart IT—helping organizations connect, secure, and grow with confidence. Leveraging decades of experience, TPx delivers managed services for cybersecurity, networks, and cloud communications that reduce risk and maximize the value of IT investments. Visit www.tpx.com to learn more.

Media Contacts

Marissa Daily / Adeel Omer
mediarelations@tpx.com

Rose Temple / Rachel Chesley
TPxComms@fticonsulting.com

View original content:https://www.prnewswire.com/news-releases/tpx-secures-court-approval-of-plan-of-reorganization-positioning-company-for-long-term-success-302868029.html

SOURCE TPx