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Precision Biologics to Present at the American Society of Clinical Oncology (ASCO) Annual Meeting on June 1st, 2024

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BETHESDA, Md., May 30, 2024 /PRNewswire/ — Precision Biologics, Inc. reports that novel findings from its ongoing phase 2 clinical trial, combining NEO-201 with pembrolizumab for the treatment of patients resistant to prior checkpoint inhibitor therapy, will be presented in a poster at the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting, McCormick Place Convention Center, Chicago, Illinois, USA, June 1st, 2024.  

Poster title: Reduction of circulating naïve Tregs and gMDSCs and low levels of soluble MICA are prognostic for efficacy of combined NEO-201 and pembrolizumab

Presentation of the poster in person will be made at the McCormick Place Convention Center in Chicago, Illinois, USA, on Saturday June 1st, 2024, Hall A from 9am – 12pm, Session: Developmental Therapeutics-Immunotherapy, poster board #9, poster # 2530.

BACKGROUND:

The employment of immune checkpoint inhibitors (ICIs), such as pembrolizumab (anti-PD-1 mAb), in cancer immunotherapy has been shown to enhance activity of the immune system against cancer cells.
 Although ICIs show efficacy and improved survival of certain cancer patients, the response rate of PD-1/PD-L1 blockade against solid tumors is around 20-30% in the first line setting and significantly lower in checkpoint refractory disease. One cause identified for this low response rate is the infiltration of the tumor microenvironment (TME) by immunosuppressive cells, such as regulatory T cells (Tregs) and granulocytic myeloid-derived suppressor cells (gMDSCs). The accumulation of these immunosuppressive cells in the TME impairs the antitumor immunity triggered by ICIs.  
 A strategy to restore antitumor immunity and overcome tumor resistance to ICIs is to combine ICIs with anticancer drugs able to bind to and deplete Tregs and gMDSCs.
 NEO-201 is a humanized IgG1 monoclonal antibody that binds to Core 1 and/or extended Core 1 O-glycans expressed by several human solid and blood tumors, as well as mature granulocytes, but it does not bind to most normal tissues and human immune cell subsets (B cells, CD4+ T cells, CD8+ T cells, NK cells, monocytes). Previous studies showed that NEO-201 can bind and mediate the killing of Tregs via CDC. Further studies presented at AACR in 2023 showed that NEO-201 can bind and mediate the killing of gMDSCs via ADCC.
 The ability of NEO-201 to mediate the killing of immunosuppressive cells served as the rationale for combination of NEO-201 with pembrolizumab in the ongoing phase II clinical trial (NCT03476681) for the treatment of patients with NSCLC, head and neck, cervical and endometrial cancers who were refractory to multiple lines of standard treatment, including ICIs.
 Preliminary findings from this ongoing clinical trial presented at the CRI-ENCI-AACR in September 2023 in Milan, Italy and at the SITC annual meeting in November 2023 in San Diego, CA, USA, revealed that, after combination treatment with NEO-201 and pembrolizumab some patients experienced durable stable disease (SD). Patients with durable SD (>84 days) demonstrated a decreasing trend in circulating gMDSCs and Tregs. Conversely, patients with progressive disease (PD) exhibited an increasing trend of circulating gMDSCs and Tregs. This preliminary data suggests that elimination of circulating gMDSCs and Tregs mediated by NEO-201 may enable patients to overcome resistance to PD-1/PD-L1 checkpoint inhibitors, in subjects for whom pembrolizumab is currently indicated and with solid tumors resistant to prior ICIs treatment.

STUDY PRESENTED AT ASCO 2024:

NEO-201 uses Natural Killer (NK) cells as effector cells to mediate the killing of its target cells through ADCC. Several studies reported that cancer cells inhibit NK cell antitumor activity by releasing soluble factors into the bloodstream, such as soluble MHC class 1 chain-related protein A (MICA.) Elevated serum levels of soluble MICA (sMICA) have been correlated with impairment of NK cell activity, cancer progression and metastasis.
 This study reports that median serum levels of sMICA pre-treatment were 33-fold higher in patients with PD compared to patients with SD and that levels of sMICA remained elevated in patients with PD and low in patients with SD at all time points post treatment.
 High levels of sMICA in patients with PD can impair NK cell activity. This impairment negatively impacts the NK cell mediated ADCC triggered by NEO-201 against cancer cells, Tregs and gMDSCs. Consequently, the effectiveness of NEO-201 and pembrolizumab treatment is reduced, leading to disease progression in these patients.
 Conversely, low levels of sMICA pre- and post-treatment do not hinder the antitumoral activity of NK cells. This allows NEO-201 to effectively mediate the killing of its target cells, including cancer cells, Tregs and gMDSCs, through ADCC. As a result, this phenomenon can lead to the durable stabilization of the disease. 
 This study reports that low levels of sMICA, together with the reduction of both circulating Tregs and gMDSCs mediated by NEO-201, were associated with durable SD in cancer patients refractory to prior ICIs and that they could be favorable prognostic markers for clinical benefit following combination treatment with NEO-201 and pembrolizumab. Ongoing enrollment in this clinical trial will validate these findings in larger cohorts.

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SOURCE Precision Biologics

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In HelloNation, Personal Injury Attorney Brad Altman of Wichita Falls Explains Why Timing Matters and What Attorneys Can Do

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April 27, 2026

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WICHITA FALLS, Texas, April 27, 2026 /PRNewswire/ — Why is timing critical after an injury? An article in HelloNation highlights how quickly evidence can fade, weaken a claim, and impact the outcome of a case. Brad Altman, owner of Altman Legal Group, underscores that immediate action is essential because skid marks fade, property gets repaired, and security footage may be erased, while witnesses’ memories become less reliable over time.

The article explains that insurance companies often move quickly to gather evidence and protect their interests. Without early steps on the injured party’s side, important details may be lost. Attorneys step in to preserve evidence by securing accident reports, medical records, photographs, video footage, and witness statements while they remain accessible. This early action builds a stronger case from the beginning.

Altman also points out that an attorney’s role extends far beyond filing paperwork. They analyze facts, identify gaps, and create a clear timeline that supports the client’s account. They also manage communication with insurance adjusters, ensuring that no statements are misinterpreted or used to reduce compensation. Acting early allows attorneys to control the narrative and prevent evidence from slipping away.

The difference between a strong and weak claim often comes down to timing. By involving an attorney early, injured individuals gain the benefit of preserved evidence and strategic preparation that supports their rights.

Why Timing Matters & What Attorneys Can Do features insights from Brad Altman, Personal Injury Attorney of Wichita Falls, Texas, in HelloNation.

About HelloNation
HelloNation is a premier media platform that connects readers with trusted professionals and businesses across various industries. Through its innovative “edvertising” approach that blends educational content and storytelling, HelloNation delivers expert-driven articles that inform, inspire, and empower. Covering topics from home improvement and health to business strategy and lifestyle, HelloNation highlights leaders making a meaningful impact in their communities.

View original content to download multimedia:https://www.prnewswire.com/news-releases/in-hellonation-personal-injury-attorney-brad-altman-of-wichita-falls-explains-why-timing-matters-and-what-attorneys-can-do-302754463.html

SOURCE HelloNation

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Nakheel awards contracts worth over AED 3.5 billion to build 544 villas on Palm Jebel Ali

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April 27, 2026

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DUBAI, United Arab Emirates, April 27, 2026 /CNW/ — Nakheel, a member of Dubai Holding Real Estate, has awarded contracts worth over AED 3.5 billion to Ginco General Contracting L.L.C and United Engineering Construction (UNEC) for the construction of 544 villas on Palm Jebel Ali, marking a major milestone in the delivery of one of Dubai‘s most significant waterfront developments.

Under the awarded contracts, Ginco will construct 354 villas across Fronds A to D, while UNEC will deliver 190 villas across Fronds E and F. Construction is scheduled to commence this quarter, with completion targeted for Q4 2028.

Khalid Al Malik, Chief Executive Officer of Dubai Holding Real Estate, said: “The awarding of these contracts signals tangible progress in the delivery of Palm Jebel Ali, with construction now progressing across multiple fronds. As momentum continues to build, Palm Jebel Ali represents one of the most significant expansions of Dubai‘s urban coastline in a generation and will play a key role in supporting the emirate’s long-term growth, further strengthening its global appeal as a great place to live, invest and visit.”

Spanning seven islands across 13.4 kilometres, with 16 fronds and more than 90 kilometres of beachfront, Palm Jebel Ali is being developed as a world-class waterfront destination and a major contributor to Dubai‘s future urban expansion.

The latest contract awards represent continued progress against the Palm Jebel Ali masterplan and support the objectives of the Dubai 2040 Urban Master Plan and Dubai Economic Agenda D33, reinforcing the emirate’s long-term vision for sustainable, high-quality communities.

The awards follow the unveiling of Palm Jebel Ali’s Beach and Coral Collection villas, developed in collaboration with leading international architects. The destination will also include Palm Central Private Residences, offering a connected expression of island living that brings together architecture, community and resort-style comfort.

Further enhancing the island’s community infrastructure, Palm Jebel Ali will feature a 9,000 sqm retail centre and a Friday Mosque designed by Skidmore, Owings & Merrill. Designed to accommodate up to 1,000 worshippers, the mosque will serve residents and visitors across the destination.

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SOURCE Dubai Holding Real Estate

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STULZ USA and President, Brian Hatmaker, Nominated for Maryland Tech Council ICON Awards

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April 27, 2026

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FREDERICK, Md., April 27, 2026 /PRNewswire/ — STULZ USA, a leading provider of precision cooling and air handling solutions for mission-critical applications, is proud to announce that both the company and its President have been nominated for the Maryland Tech Council (MTC) ICON Awards.

STULZ USA has been nominated for Tech Company of the Year, while President Brian Hatmaker has been recognized as a nominee for CEO of the Year. The Maryland Tech Council seeks to celebrate outstanding leadership, innovation, and impact across Maryland’s technology and life sciences communities.

STULZ USA plays a critical role in supporting the infrastructure that powers today’s digital economy. The company designs and domestically manufactures advanced climate control solutions that enable the reliable operation of data centers and other tech environments.

With its U.S. headquarters and manufacturing operations based in Frederick, Maryland, STULZ USA employs nearly 500 people and has been a longstanding contributor to the region’s manufacturing sector and economic development. The company’s solutions support IT closets, data centers, healthcare, telecommunications, and industrial applications.

“These nominations reflect the strength of our team, the trust of our customers, and our commitment to supporting the critical digital infrastructure that keeps businesses and communities connected,” said Brian Hatmaker, President of STULZ USA. “We are honored to be recognized by the Maryland Tech Council alongside so many innovative organizations and leaders.”

The Maryland Tech Council recently launched the Data Center Alliance of Maryland, an initiative focused on advancing public understanding of the data center industry’s economic contributions, workforce opportunities, and role in supporting digital infrastructure. As demand for data continues to grow, STULZ USA remains committed to delivering reliable, efficient, and scalable cooling solutions that help enable this evolving landscape.

The ICON Awards ceremony will take place on May 21, bringing together leaders and organizations from across the region to celebrate excellence and innovation.

About STULZ USA

STULZ USA is a globally recognized leader in precision cooling solutions, specializing in innovative and energy-efficient systems for mission-critical environments, including data centers, telecom facilities, and industrial applications. With a legacy spanning more than 75 years, STULZ combines deep engineering expertise with advanced manufacturing processes to deliver unmatched quality, reliability, and performance.

View original content to download multimedia:https://www.prnewswire.com/news-releases/stulz-usa-and-president-brian-hatmaker-nominated-for-maryland-tech-council-icon-awards-302754468.html

SOURCE STULZ Air Technology Systems, Inc.

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