The initiative will be implemented in two trials, using Paradigm Health’s integrated technology platform to accelerate FDA review

WASHINGTON and COLUMBUS, Ohio, April 28, 2026 /PRNewswire/ — Today, Paradigm Health announced the launch of a landmark research collaboration with the U.S. Food & Drug Administration (FDA) focused on advancing a new model to accelerate clinical trial execution and regulatory review. The new model, already operational in a Phase 2 and Phase 1b trial, uses Paradigm Health’s technology-enabled Study Conduct platform to enable real-time review by the FDA, by automating data collection and analysis, and streamlining the reporting of key safety and efficacy signals to trial sponsors and the FDA. The goal is to establish a scalable model that reduces monitoring burden, data entry, and trial costs—speeding regulatory review, improving U.S. clinical trial efficiency, and accelerating cures to patients.

Pharmaceutical companies Amgen and AstraZeneca are the first to join the collaboration. The new model has launched in an AstraZeneca-sponsored Phase 2 trial at sites including MD Anderson Cancer Center and Perelman School of Medicine at the University of Pennsylvania, as well as an Amgen-sponsored Phase 1b trial.

The Paradigm Health Study Conduct solution works by capturing data directly from electronic health records and other structured and unstructured sources, algorithmically evaluating FDA-defined data points and reporting criteria in real time, and transmitting only the critical signals and data needed for regulatory determinations to the trial sponsor and the FDA. Paradigm Health has engineered this infrastructure specifically for the collaboration, working closely with the FDA since early 2026 to define reporting and validation protocols, establish criteria for key regulatory events, and ensure FDA-Paradigm Health software and data interoperability. The data transferred through the real-time platform is traceable, auditable, and protects patient privacy, while minimizing the transfer of unnecessary datasets.

“This collaboration represents an important step toward expediting how clinical trial data is submitted to and reviewed by the FDA,” said Kent Thoelke, Founder and CEO of Paradigm Health. “With Paradigm Health’s platform, clinical trial data can be analyzed for key signals in near real time and shared with trial sponsors and the FDA in days, rather than months. This means that regulators, sponsors, and providers can have a continuous view of safety and efficacy. By modernizing the flow of information from sites to sponsors to regulators, we have an opportunity to accelerate the delivery of innovative therapies to patients across the country.”

“The initiative leverages the best of U.S. technology and innovation to bolster clinical development in the United States,” said Robert Nelsen, Co-Founder and Managing Director of ARCH Venture Partners and Paradigm Health Co-Founder and Board Chair. “This model can align the interests of policymakers, pharmaceutical and biotech companies, and American patients, and make U.S. clinical research faster and more cost-effective.”

Building the Future of U.S. Clinical Trials

The need for modernization in clinical development is urgent, as innovation in U.S. clinical trial infrastructure has not kept pace with the volume of therapeutic candidates under investigation. Trials are long, complex, and expensive. This collaborative model, if deployed successfully and at scale, can help bring new medicines to American patients faster. Furthermore, efficient, less expensive trials make the United States a more compelling and competitive place for innovative companies to conduct research.

This collaboration directly supports the FDA’s strategic goal of moving toward a real-time, continuous regulatory environment, and underscores Paradigm Health’s commitment to modernizing drug development infrastructure and expanding access to cutting-edge clinical research regardless of where patients live.

About Paradigm Health

Paradigm Health has engineered an AI-powered platform to make clinical trials more accessible and efficient, so that patients, researchers, and study sponsors can maximize the impact of clinical research. Incubated by ARCH Venture Partners and backed by leading healthcare and life sciences investors, Paradigm Health aims to break down barriers across the trial ecosystem through one seamless infrastructure implemented at healthcare provider organizations, bringing potentially life-saving therapies to patients faster. For more information, visit https://www.paradigmhealth.ai.

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SOURCE Paradigm Health, Inc.

FORT LAUDERDALE, Fla., April 28, 2026 /PRNewswire/ — Tambourine, in collaboration with Hyatt, is proud to announce the launch of the Hyatt Wedding Guide, a curated digital wedding experience guide and menu solution designed to streamline the wedding planning journey from the first inquiry to the big day.

The Hyatt Wedding Guide serves as a one-stop, AI-enabled digital platform that empowers Hyatt wedding specialists and couples to collaborate more effectively. Designed as a wedding-specific version of Hyatt’s Event Experience Guide, the Hyatt Wedding Guide allows properties to present their unique offerings in a beautifully branded, user-friendly format.

Prior to the introduction of the Hyatt Wedding Guide, some Hyatt properties faced significant hurdles in managing and sharing information with prospective couples, often relying on disconnected sources and static PDFs that failed to capture the property’s true essence. This solution addresses these critical pain points by:

Centralizing Information: Providing a single, secure, Hyatt-branded repository for wedding ceremony and reception options, vendor lists, and overnight accommodations.Enhancing Menu Management: Offering a visual and interactive way to showcase food and beverage packages, allowing couples to easily explore menus for receptions, brunches, and welcome dinners.Brand Consistency: Dedicated templates ensure that every guide reflects the look and feel for each unique Hyatt brand.Expert Recommendations: Couples gain access to curated vendor spotlights and expert-driven support, positioning Hyatt teams as trusted advisors.Inclusivity: The platform features culturally tailored templates specifically for Indian and Southeast Asian weddings, ensuring all traditions are celebrated thoughtfully.Together by Hyatt Integration: Incorporates Hyatt’s signature event philosophy, “Together by Hyatt,” leveraging years of experience listening to planners and guests to ensure every wedding feels more cared for through dedicated professional support, more efficient via unmatched technology, more impactful through sustainability efforts, and more intentional with a commitment to wellbeing and engagement.

“At Tambourine, our goal is to empower hotels with technology that is as sophisticated as the experiences they provide,” said Jeff Spaccio, EVP, Global Hotel Brands at Tambourine. “The Hyatt Wedding Guide is a testament to that mission, combining high-end design with intuitive functionality to help Hyatt teams build stronger, more personal connections with couples during the most important decision-making moments of their lives.”

“Hyatt is committed to listening to our customers and delivering tools that make their lives easier,” said Chris Finelli, VP, Sales and Marketing at Hyatt. “By centralizing our resources into a single, personalized digital experience, the Hyatt Wedding Guide allows our wedding specialists to focus on what they do best: creating unforgettable, authentic celebrations that reflect each couple’s unique story.”

As the Hyatt Wedding Guide continues to roll out across Hyatt’s global portfolio, it marks a significant step forward in the company’s digital-first strategy for events. By bridging the gap between high-touch hospitality and seamless technology, Tambourine and Hyatt are setting a new standard for the wedding industry.

The term “Hyatt” is used in this release for convenience to refer to Hyatt Hotels Corporation and/or one or more of its affiliates.

About Tambourine
Tambourine is the global leader in hotel marketing technology, delivering integrated solutions that drive direct revenue and solve the industry’s toughest commercial challenges. With a product suite spanning sales, marketing, revenue, and now reservations, the company is known for pairing best-in-class service with a design-led approach—solving complex problems with elegant, high-performing solutions. Trusted by hotel brands in over 50 countries, Tambourine continues to set the standard for innovation and results in hospitality. Visit tambourine.com for more information.

Press Contact:
Hannah Trefry, Director of Corporate Marketing
press@tambourine.com

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SOURCE Tambourine

Program recognizes technology, consulting, and accounting partners driving innovation, growth, and customer excellence with Avalara

DURHAM, N.C., April 28, 2026 /PRNewswire/ — Avalara, Inc., the agentic AI leader in global tax and compliance, today announced the winners of the 2025 Avalara Partner Awards. The annual program celebrates partners across the Avalara ecosystem who have demonstrated exceptional performance, innovation, and commitment to customer success.

“The strength of our partner ecosystem is one of Avalara’s greatest competitive advantages,” said Meg Higgins, SVP of Global Partners at Avalara. “Each of this year’s winners have gone above and beyond, whether through innovative integrations, exceptional implementations, or a relentless focus on their customers’ success. These awards reflect the meaningful impact our partners make every day, and we’re excited to celebrate their achievements.”

Newest Avalara Partner Award Winners

Technology Partner of the Year: Honoring the technology partner who delivers seamless, high-impact integrations, sets the standard for customer excellence, and champions Avalara solutions to drive innovation and success.Winner: ShopifyConsulting Partner of the Year: Showcasing the consulting partner who leads in championing Avalara solutions and sets the standard for exceptional customer experiences through their passion and expertise.Winner: DSD Business SystemsAccountant Firm of the Year: Recognizing the accountant firm that leads the way in tax automation practices, delivering seamless client experiences while being a trusted advisor to their clients.Winner: Forvis MazarsImplementation Excellence Partner Award: Featuring the partner who sets the standard for successful implementations, delivering excellence at every step while remaining fiercely dedicated to outstanding customer experiences.Winner: Ducharme, McMillen & Associates (DMA)Momentum Partner Awards: Celebrating partners that have demonstrated significant year-over-year growth, setting new benchmarks for customer experience, and new standards for success.Technology: OdooConsulting: ArganoAccountant: Squire & Company PCRising Star Partner Award:Spotlighting the partner who has made an immediate and significant impact by showcasing rapid success and demonstrating immense potential.Winner: Support One

Winners were selected based on their contributions to the Avalara partner ecosystem, including customer impact, growth, innovation, and commitment to delivering exceptional experiences powered by Avalara compliance solutions. For more information about the Avalara Partner Awards and the Avalara Partner Program, visit https://www.avalara.com/us/en/partners/awards.html

About Avalara

Avalara is the agentic AI platform for global tax and compliance. For more than two decades, Avalara has built one of the most expansive libraries of tax content and integrations in the industry, processing more than 54 billion transactions annually and supporting millions of businesses worldwide. The company’s purpose-built AI agents automate end-to-end compliance with greater precision, from tax calculations and return filings to exemption certificate management and beyond. For more information, visit Avalara.com.

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SOURCE Avalara, Inc.