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Children’s Hospital of Philadelphia Researchers Develop New Tool with Potential to Advance Precision Medicine Treatment for Cancer

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Technology Discovers Antigen-Reactive T Cell Receptors with High Efficiency

PHILADELPHIA, Jan. 3, 2025 /PRNewswire/ — Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania  developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to better identify antigen-reactive T cells that are more likely to offer greater immune responses against cancer cells. The findings were reported this week in the journal Nature Communications.

Researchers continuously work to develop immunotherapy treatments that help the immune system recognize and attack specific protein targets on cancer cells, also known as tumor antigens, thereby training the body to fight cancer more effectively and precisely. Discovering antigen-reactive T cell receptors (TCRs) is essential to this precision medicine approach.

TCRs are protein complexes located on the surface of T cells that recognize and bind to antigen peptides presented by major histocompatibility complex (MHC) molecules, triggering a cascade of cellular responses that lead to T cell activation. However, standard methods for isolating antigen-reactive TCRs often fail to identify TCRs that effectively activate T cells.

“TCRs identified by ATLAS-seq tend to be more efficient in target cell killing than those identified by conventional technologies,” said Lan Lin, PhD, senior author of the study and Assistant Professor in Pathology and Laboratory Medicine at Children’s Hospital of Philadelphia and Penn Medicine. “Overall, ATLAS-seq improves TCR screening to more effectively identify antigen-reactive TCRs with high functional activity.”

The ATLAS-seq technology combines a single-cell approach with an aptamer-based fluorescent molecular sensor that emits a fluorescence signal when a T cell is activated. In the study, the researchers designed a microfluidic system to isolate individual T cells that react to stimulation by an antigen peptide of interest and determined their unique TCR sequences using single-cell sequencing.

“We envision that ATLAS-seq can play a pivotal role in identifying TCRs targeting tumor antigens, driving the development of novel T cell immunotherapies for a broad range of hard-to-treat cancers,” said Lin, who is also a researcher in the Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Center for Computational and Genomic Medicine at CHOP.

This work was supported by National Institutes of Health grant R01GM121827, W.W. Smith Charitable Trust grant C2004 and a CHOP Research Institute Cell & Gene Therapy Collaborative seed grant.

Luo et al. “ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs.” Nat Commun. January 2, 2025. DOI:10.1038/s41467-024-54675-3.

About Children’s Hospital of Philadelphia: 
A non-profit, charitable organization, Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey, as well as the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia. In addition, its unique family-centered care and public service programs have brought Children’s Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit https://www.chop.edu. 

Contact: Jennifer Lee
Children’s Hospital of Philadelphia
(267) 426-6084
leej41@chop.edu

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Quote.com Announces New Senior Leadership Additions

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ST. PETERSBURG, Fla., April 22, 2026 /PRNewswire/ — Quote.com, a leading tech-enabled, omnichannel performance marketing organization, today announced the addition of two new executive team members to support the company’s continued growth and strategic expansion. Chase Nichols joins as Chief Marketing Officer and Ben Hochstetler as Senior Vice President of Marketing.

Quote.com announced the addition of two new executive team members, Chase Nichols and Ben Hochstetler.

The appointments strengthen Quote.com’s leadership team as the company continues to invest in execution, growth, and expanding its ability to help consumers access insurance solutions more easily and efficiently. “We are excited to welcome Chase and Ben to the Quote.com leadership team,” said Nick Stommes, Chief Executive Officer at Quote.com. “Both bring deep industry expertise, experienced execution capability, and a strong focus on operational excellence that will help accelerate our growth while improving how consumers access and compare insurance options. Their leadership will play a critical role at Quote.com as we continue scaling our platform and strengthening our partnerships.”

Chase Nichols joins Quote.com as Chief Marketing Officer; Chase is responsible for all performance marketing planning, organization, and execution, and is focused on driving efficient, measurable consumer touchpoints. With nearly two decades of experience in financial services and performance marketing environments, he brings a data-first approach to scaling growth while balancing brand development and direct-response marketing.

Ben Hochstetler joins as Senior Vice President of Marketing, leading digital marketing strategy and execution across Quote.com’s omnichannel performance marketing footprint. He brings more than 15 years of experience building and scaling performance marketing execution in highly competitive and regulated markets.

About Quote.com

Quote.com is a tech-enabled omnichannel performance marketing organization that delivers high-quality, mission-critical demand at scale to industry-leading partners. The company serves customers across multiple insurance verticals, including auto, home, life, and Medicare insurance. Quote.com provides significant value to consumers by providing an independent, third-party comparison-shopping experience.

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Young Voices Across Oceans: Telling China’s Story Fiji Special Showcases GDI Achievements

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SHENZHEN, China, April 22, 2026 /PRNewswire/ — This year marks the 5th anniversary of the Global Development Initiative (GDI). Shenzhen Media Group’s “Telling China’s Story” program presents a special Fiji season, taking the perspective of young Chinese people to the Pacific island nation of Fiji. It documents the implementation of numerous cooperative projects which are smaller in scale but well-designed, showcasing the heartwarming stories and broad prospects of China and Fiji working together to promote common development and share the fruits of cooperation, vividly illustrating the practical achievements of the GDI.

 

The program will air from April 20th to 22nd, 2026. The first episode features Chinese actor Zhao Xiaotong, food blogger Yang Beichuan, and Wu Dongwei, a doctoral student at China Agricultural University, who visit the China-Fiji Juncao Technology Demonstration Center in Nadi, Fiji, to explore how this “Happiness Juncao” from China has taken root and grown in the South Pacific island nation, benefiting people’s livelihoods.

This “Happiness Juncao” has yielded “win-win results” in Fiji, bringing tangible changes to local families. Internet technology engineer Ashmir not only gained a stable income by learning Juncao (a type of grass cultivation) to grow mushrooms, but also successfully paid off his car loan.

During this filming, a “Mushroom Team” of young Chinese people joined Ashmir in a Fijian market to promote mushroom dishes and introduce locals to various new ways to enjoy mushrooms. The humble mushroom became a bond of friendship across mountains and seas, conveying the warm sentiments of mutual understanding between the Chinese and Fijian people amidst the bustling market atmosphere.

 

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Laminar Wins Gold 2026 Edison Award for Physical AI that Powers the Self-Driving Factory

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Top honor recognizes Laminar’s innovation and transformation in the CPG manufacturing industry

BOSTON, April 22, 2026 /CNW/ — Laminar, a physical AI solution helping the world’s leading manufacturers run more productive and sustainable factories, announced that it received a Gold 2026 Edison Award in the Manufacturing & Logistics category. The award recognizes Laminar for enabling food and beverage manufacturers to unlock new levels of productivity and sustainability through innovation – running faster production lines while cutting water, chemicals, and downtime.

“Laminar is leading the way CPG manufacturers implement physical AI on the factory floor with first-of-their-kind self-driving processes,” said Annie Lu, Laminar Chief Executive Officer and Co-Founder. “Our patented spectral sensors and complete library of ML models enable a new, transformative approach to closed-loop automation, making the goal of the self-driving factory achievable today. We are honored the Edison Awards recognized our commitment to building a new category of technology and reshaping the future of manufacturing.”

Laminar’s physical AI transforms operations by enabling CPG manufacturers to transition from manual, timer-based operations to self-driving. Deployed across six continents for Coca-Cola, AB InBev, Danone, and Unilever, Laminar delivers measurable sustainability and profitability gains from the same investment. Laminar’s self-driving processes include:

Self-Driving Clean-in-PlaceSelf-Driving Product ChangeoverSelf-Driving Batch OptimizationSelf-Driving Quality ControlAnd more

The Edison Awards, established in 1987 and named in honor of inventor Thomas Edison, celebrates game-changing innovation across industries worldwide. Drawing a global community of innovators across 60+ countries, the Edison Awards elevate solutions that reimagine our future.

Recognition for Laminar’s Innovation

Headquartered at Greentown Labs in Somerville, MA – North America’s leading cleantech incubator – Laminar is a woman-founded startup backed by top-tier investors, including Greycroft, Construct Capital, 2048 Ventures, and Flybridge Capital.

Recognized for its innovation and impact, Laminar received AB InBev’s 2024 Cheers Award for outstanding startup partnership and was named Unilever’s 2023 Supplier Startup of the Year. Laminar’s solution is also deployed in World Economic Forum Lighthouse factories recognized for their leadership in cutting-edge technology.

About Laminar

Laminar’s physical AI helps the world’s leading manufacturers run self-driving factories with more sustainable, efficient operations. Our patented spectral sensors and complete library of ML models transform manual operations into self-driving processes that cut water, chemicals, and downtime in real-time. Deployed in factories across six continents and trusted by global leaders like AB InBev, Coca-Cola, and Unilever, Laminar is building a new category of physical AI that will power the future of process manufacturing. Learn more at runlaminar.com

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