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CU Anschutz Led Study Finds That Genetic Risk Does Not Explain the Maternal Effect in Type 1 Diabetes

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A study of nearly 7,000 children found that inherited genetic risk did not explain why children whose mothers had type 1 diabetes developed the disease at about half the rate of children whose fathers had it

AURORA, Colo., Nov. 10, 2026 /PRNewswire/ – Children whose mothers have type 1 diabetes develop the disease at about half the rate of children whose fathers have it. Inherited genetic risk alone does not explain this long-observed maternal effect, according to a study led by researchers at the University of Colorado Anschutz and published in Diabetes Care. The findings point to other possible biological mechanisms that warrant further investigation.

Researchers analyzed 6,942 children in The Environmental Determinants of Diabetes in the Young (TEDDY) study, which followed children at increased genetic risk for type 1 diabetes from infancy into adolescence.

Researchers also examined a long-standing question: Could pregnancy loss help explain why children whose mothers have type 1 diabetes develop the disease less often?

“For decades, this relative maternal protection effect has been consistently observed across studies of living offspring of people with type 1 diabetes. One long-standing but unproven explanation is that this relative protection is an artefact resulting from the selective loss of pregnancies involving the highest-risk offspring,” said Randi K. Johnson, PhD, MPH, associate professor of biomedical informatics at the CU Anschutz School of Medicine and senior author of the study. “Advancements in genetics allowed us to comprehensively examine this phenomenon in the largest prospective cohort study of type 1 diabetes in the world.”

Genetic Risk Does Not Explain the Difference

Researchers compared children’s inherited genetic risk for type 1 diabetes using an extended genetic risk score. They found no significant difference in the genetic risk score between children whose mothers had type 1 diabetes and those whose fathers had the disease.

Despite similar genetic risk scores, children of affected mothers developed type 1 diabetes at about half the rate during the study. They also had a lower risk of developing islet autoimmunity, an early sign of immune system activity against the insulin-producing cells of the pancreas that precedes a type 1 diabetes diagnosis.

The Effect Changes With Age

Researchers found that the reduction in islet autoimmunity among children of affected mothers disappeared after age 6. The study also found no evidence that these children progressed more slowly to a type 1 diabetes diagnosis after developing islet autoimmunity.

“Our age-specific analysis shows that the maternal protective effect operates in early life, during the initiation of preclinical type 1 diabetes. The fact that the effect wanes rather than staying constant points future research toward more dynamic mechanisms,” said Sarah D. Slack, senior information science professional in the Department of Biomedical Informatics at CU Anschutz and lead author of the study.

Opening New Avenues for Prevention

Although the study does not identify the cause of maternal protection or establish pregnancy as its direct source, the findings challenge the hypothesis that pregnancy loss explains the phenomenon and point toward other possible explanations.

“Our goal is to find ways to prevent type 1 diabetes from occurring. Establishing that the relative maternal protection in type 1 diabetes is not an artefact of pregnancy survival tells us that there may be some mechanism at work in a type 1 diabetes pregnancy that confers a benefit to the offspring. Our next task is to find and understand that mechanism so we can develop solutions that might mimic that benefit for all children,” said Johnson.

Epigenetic changes are one possible biological mechanism under investigation by Johnson and team. Epigenetic changes affect how genes are switched on or off without changing the underlying DNA sequence. These changes can be influenced by factors during pregnancy and early life.

The study was supported by a grant from The Leona M. and Harry B. Charitable Trust.

“Helmsley supports this important work because we are committed to developing strategies to prevent or delay the development of type 1 diabetes, including through identifying factors underlying maternal protection,” said Maryaline Coffre, Program Officer at Helmsley.

Identifying the mechanisms behind maternal protection could help researchers determine whether early-life biological processes offer opportunities to prevent or delay type 1 diabetes.

About the University of Colorado Anschutz
The University of Colorado Anschutz is a world-class academic medical campus leading transformative advances in science, medicine, education and patient care. The campus includes the University of Colorado’s health professional schools, more than 60 centers and institutes, and two nationally ranked independent hospitals – UCHealth University of Colorado Hospital and Children’s Hospital Colorado – which see nearly three million adult and pediatric patient visits each year. Innovative, interconnected and highly collaborative, CU Anschutz delivers life-changing treatments, exceptional patient care and top-tier professional training. The campus conducts world-renowned research supported by $890 million in funding, including $762 million in sponsored awards and $128 million in philanthropic gifts for research.

Find the latest CU Anschutz news here.

Contact:

Laura Kelley, CU Anschutz

(303) 704-5222, laura.kelley@cuanschutz.edu

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Sanya hosts side event of the 7th Symposium on Global Maritime Cooperation and Ocean Governance

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Report on Southeast Asian Youth Perceptions of Maritime Issues released

BEIJING, Nov. 10, 2026 /PRNewswire/ — A side event of the 7th Symposium on Global Maritime Cooperation and Ocean Governance was held at China Media Group (CMG) Sanya Studio on November 8. More than 10 Chinese and international participants discussed how to put into practice the Agreement under the United Nations Convention on the Law of the Sea on the Conservation and Sustainable Use of Marine Biological Diversity of Areas beyond National Jurisdiction (BBNJ Agreement), and how to communicate ideas about ocean conservation to audiences worldwide.

Experts at the event described the BBNJ Agreement, which entered into force in January this year, as a landmark victory for multilateralism in global ocean governance. They said it charts a course for all parties to work together to protect marine biodiversity.

Jiao Nianzhi, an academician of the Chinese Academy of Sciences, described marine biodiversity as a toolbox for humanity, saying that protecting it means safeguarding humanity’s future. Aileen Tan, chairperson of the Sub-Commission for the Western Pacific of UNESCO’s Intergovernmental Oceanographic Commission, said the BBNJ Agreement gives the ocean “breathing space” and stressed the need for scientists from different countries to work together on ocean conservation. She cited Malaysia-China cooperation in marine scientific research as a good example and expressed hope that China would play a greater leadership role. Ronán Long, director of the WMU-Sasakawa Global Ocean Institute at the World Maritime University in Sweden, said China’s strong data capabilities could help accelerate the implementation of the Agreement’s provisions on sharing non-monetary benefits arising from marine genetic resources.

Participants also highlighted China’s efforts and achievements in promoting maritime cooperation and advancing marine ecological restoration, among other areas. The side event was jointly hosted by CMG’s Chinese Language Programming Center, the Huayang Center for Maritime Cooperation and Ocean Governance, the National Institute for South China Sea Studies and other organizations.

During the symposium, CMG’s Chinese Language Programming Center and CMG Institute jointly released the Report on Southeast Asian Youth Perceptions of Maritime Issues. The report presents the concerns and expectations of young people in Southeast Asian countries, including Indonesia, Malaysia, Singapore and Thailand, regarding ocean-related issues.

The report finds that Southeast Asian youth have a positive outlook on maritime cooperation with China. Nearly 80 percent of respondents are willing to take part in China-ASEAN youth exchanges on ocean-related issues. The report also notes that Southeast Asian youth are concerned about broader issues of ocean governance and look to China to shoulder greater responsibilities and play a larger role in global ocean governance.

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Why Brisbane Airport selected LG for its landmark digital infrastructure upgrade

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Australia’s third-largest airport now runs passenger information across 950 LG displays monitored centrally via LG SuperSign CMS

News summary

Brisbane Airport manages approximately 950 LG commercial displays from a single platform LG SuperSign CMS deployed on-premise to meet strict security and operational controls for critical infrastructureLG SuperSign CMS offers leadership, operations and ICT team remote visibility and control of entire display fleetLG’s embedded System-on-Chip allows real-time flight information (FIDS), gate information, wayfinding and operational messaging to be directly pushed to display screens without external media playersBrisbane Airport’s transition to LG’s SuperSign CMS has driven down operational costs significantlyDeployed in partnership with Australian integrator Programmed, this digital overhaul forms a key part of Brisbane Airport’s ongoing $5 billion Future BNE transformation

SYDNEY, Nov. 11, 2026 /PRNewswire/ — LG Electronics (LG) has partnered with Brisbane Airport Corporation (BAC), replacing a previously fragmented digital signage system with a modern network of approximately 950 LG commercial displays centrally managed by LG SuperSign CMS. Covering the domestic and international terminals, baggage handling areas, and car parks, these LG screens deliver real-time flight information displays (FIDS), gate information, passenger wayfinding, and operational communications reliably across a 24/7 environment.

As Australia’s third largest airport preparing for a forecast surge in passenger numbers ahead of the major event in 2032, Brisbane Airport needed to replace an increasingly unreliable, ageing network with a simplified, scalable solution that its lean ICT team could operate day-to-day.

“The reliability of the displays is essential. Without them working, people are lost — quite literally,” says Michael Kerr, Integrated Operations Manager at BAC.

To address these critical demands, LG worked alongside local integrator Programmed to deploy a centralised digital signage network driven by LG SuperSign CMS. The platform provides ICT and operations teams with comprehensive visibility across the entire display fleet remotely, replacing an otherwise manual process of physical, daily check-ups.

“LG SuperSign has been a game changer for my team. We just don’t have the arms and legs to go around and check those 950 screens on a daily basis. The monitoring capabilities really give us that eyes-on view of what’s across our infrastructure,” says Anthony Tully-Smith, ICT Applications Manager at BAC.

One system, diverse displays

BAC’s new estate involves a range of LG display solutions tailored to specific passenger zones. This includes:

43- and 49-inch LG commercial panelsLG Ultra Stretch displays in totemsLG 49XE-series high-brightness outdoor displays110-inch LG UM5K indoor screensA 136-inch LG LAPA-series All-in-One LED in international arrivals

With LG’s embedded System-on-Chip (SoC) platform and internal web page player, real-time flight information and content now play directly on the screens. This removes the need for external media players, simplifying the network architecture.

“We’ve taken what was a fragmented digital signage system, not very visible to management, now to an integrated modern solution with centralised management and health visibility,” says Graham Wands, Business Development Manager at Programmed. “LG SuperSign enables us to take a proactive stance and make sure that the FIDS and other signage are highly available and always visible to passengers.”

Built for critical infrastructure

As a privately owned critical infrastructure operator, BAC needed full control of its content. LG SuperSign CMS is deployed on-premise to meet the airport’s security and operational-control requirements. LG’s device hardening helps reduce the risk of unauthorised content, such as USB sideloading.

The project also supports the airport’s ESG goals; LG UH series screens carry Carbon Trust footprint-reduction certification, LG offers a free e-waste program, and power consumption can be monitored and optimised from LG SuperSign CMS.

“At an airport, a screen is only as useful as the information on it, and how quickly someone knows when it stops working. Brisbane Airport shows what happens when displays and management software are planned together as operational infrastructure, with a local integrator who knows the site. We’re grateful to Brisbane Airport and Programmed for the partnership, and we look forward to supporting the airport as it grows,” says Chris Wilson, Sales General Manager – Information Display at LG Electronics Australia.

Looking ahead

BAC sees LG as a long-term partner as it progresses its $5 billion Future BNE transformation, paving the way for the expansion of Terminal 3 and more LED and messaging capabilities ahead of the 2032 games. By transitioning from a fragmented legacy setup, BAC has unlocked a foundation built for long-term operational efficiency.

“For me, managing an ageing infrastructure before we moved to the new LG digital displays was costing us quite a lot from a maintenance and an ongoing perspective,” says Tully-Smith, “The move to the new LG SuperSign, but also the new LG screens, has driven down my operational cost significantly across the airport.”

This newfound efficiency has helped BAC focus on what’s most critical – passenger experience.

“It’s important for us to have a partner like LG. The innovation and the fresh thought that team brings has really helped me accelerate the digital experience across all of our terminals,” says Tully-Smith.

Read the full case study: LG Displays and SuperSign CMS power Brisbane Airport’s digital transformation

LG SuperSign CMS is purchased separately.

About LG Electronics
LG Electronics is focused on developing new innovations across information displays. We are committed to providing commercial electronic products that help businesses perform better. We offer a wide range of products, including information displays, digital signage for advertising, commercial system air conditioners, VRF systems and tailored solutions for different vertical markets.

About Brisbane Airport Corporation
Brisbane Airport Corporation (BAC), the operator of Brisbane Airport (BNE), is a private, unlisted Queensland company that proudly takes on the challenge of connecting Australia to the world. BAC’s passion and perseverance have cemented BNE as Queensland’s most important gateway, a leading hub for Australia, and an award-winning source of pride for its communities.

About Programmed
Programmed is a leading provider of Facility Management, Maintenance, and Staffing solutions across Australia and New Zealand. Programmed employs over 32,000 people every year across a broad range of industries and partners with more than 10,000 customers, small and large.

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Advantech Powers High-Density Edge Infrastructure with the Intel Atom P6900 Processor-Based SOM-5994 Module

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TAIPEI, Nov. 10, 2026 /PRNewswire/ — Advantech, a global leader in embedded computing and edge AI solutions, has announced the launch of the SOM-5994, a COM Express Basic Type 7 module powered by Intel Atom P6900 processors. Designed for compute-intensive edge networking, 5G infrastructure, and next-generation telecommunication applications, the SOM-5994 delivers high-core-density processing, advanced networking connectivity, and flexible expansion capabilities in a standardized COM Express form factor. The module supports up to 24 server class efficient- cores, PCIe Gen4 expansion, DDR5 SODIMM memory, and integrated Intel Ethernet technology supporting 10GBASE-KR connectivity. An extended operating temperature range of -40°C to 85°C is available as an option for industrial deployments. Combined with Advantech’s Computer On Module (COM) Design-In Services—which include carrier board design support, BIOS customization, thermal design guidance, system validation, and lifecycle management—the SOM-5994 enables OEMs and system integrators to accelerate product development, reduce engineering complexity, and shorten time-to-market. Optimized for packet-processing and data-intensive networking workloads, it provides a scalable foundation for next-generation network edge appliances.

Optimized for High-Performance Networking Workloads

Powered by Intel Atom P6900 processors specifically designed for networking and telecommunications applications, the SOM-5994 combines high core density, advanced I/O connectivity, and flexible scalability within a compact COM Express Basic Type 7 module.

When compared to the Intel Xeon D-1700 processor family, the SOM-5994 with Intel Atom P6900 processors delivers higher overall performance. Offerings range from efficient 8-core to 24-core SoCs with thermal design power (TDP) spanning 50W to 86W, enabling system designers to balance compute density, power consumption, and thermal budgets to meet specific application requirements.

The module supports up to 128GB of DDR5-5600 memory and provides up to 16 PCIe Gen4 lanes and 16 PCIe Gen3/Gen2 lanes, delivering the bandwidth required for virtualization, packet inspection, software-defined networking (SDN), network security, and other data-intensive networking workloads. For networking connectivity, the SOM-5994 integrates four 10GBASE-KR Ethernet interfaces for backplane applications alongside an integrated Ethernet controller supporting up to 2.5GbE, enabling flexible deployment across a wide range of networking architectures.

Comprehensive Software and Design-In Support

Beyond hardware performance, the SOM-5994 is backed by Advantech’s comprehensive Embedded Solutions and Design-In Services, helping customers accelerate product development and reduce engineering risks. These services include carrier board design support, BIOS customization, thermal solution consultation, Linux development resources, system validation, and long-term lifecycle management. Together, they enable OEMs to streamline development while ensuring platform reliability across the entire operating lifespan.

The module also supports Advantech SUSI APIs, Yocto project integration, and customizable BIOS features, providing developers with a flexible software framework for hardware monitoring, system management, and Linux deployment. Furthermore, when paired with the optional SOM-RM10 BMC carrier card, the platform enables robust out-of-band (OOB) management—delivering secure real-time monitoring, remote debugging, and automated system recovery.

Accelerating Next-Generation Edge Networking Deployment

As edge computing, AI services, and industrial networking demand higher throughput, lower latency, and greater power efficiency, OEMs face mounting pressure to innovate under tight schedules and budgets. Powered by Intel Atom P6900 Series processors, the SOM-5994 COM Express Basic Type 7 module offers a modular, ready-to-integrate solution. By leveraging existing carrier board designs across multiple product generations, customers can drastically cut NRE costs, streamline validation, and lower design risks. Supported by Advantech’s global ecosystem and design-in services, the SOM-5994 delivers a scalable foundation that empowers OEMs to bring robust networking and edge infrastructure solutions to market faster.

Key Features

Intel Atom P6900 ProcessorsCOM Express R3.1 Basic Module Type 7 pinout8~24 Efficient-cores, with Max. TDP 86WDual-Channel DDR5-5600MT/s up to 128GB SODIMMHigh speed Intel Ethernet (4 x 10GBASE-KR interfaces, one 2.5GbE)Multiple Expansions (16x PCIe Gen4, 16x PCIe Gen3/2, 4x USB3.0, SATA3)Supports Yocto, Embedded BIOS, SUSI API and DeviceOn

The Advantech SOM-5994 will be available in Q2, 2027. For more information regarding SOM-5994 or other Advantech products and services, please contact Advantech’s sales support team or visit our website at https://www2.advantech.com/embedded-boards-design-in-services/com/

About Embedded Solutions & Design-in Service

Advantech Embedded Solutions & Design-in Service offers a one-stop service model for the integration of embedded boards, systems, software, displays, and peripherals. This model uses customer-centric design-in services to accelerate AI and IoT deployment. Solution providers expect to reduce the time and resources required for system integration by collaborating with reliable professional embedded partners. We offer the latest embedded technology and value-added software that customers can leverage to integrate their end application software. Our comprehensive range of peripherals free customers from worrying about compatibility and longevity issues. Advantech Embedded Design-in Services provide a value-added service that eliminates complex integration difficulties.
https://www.advantech.com/en-us/solutions/embedded-modules-and-design-in-services 

About Advantech

Advantech’s corporate vision is to enable an intelligent planet. The company is a global leader in the fields of IoT intelligent systems and embedded platforms. To embrace the trends of IoT, big data, and artificial intelligence, Advantech promotes IoT hardware and software solutions with the Edge Intelligence WISE-PaaS core to assist business partners and clients in connecting their industrial chains. Advantech is also working with business partners to co-create business ecosystems that accelerate the goal of industrial intelligence. (www.advantech.com)

©Intel, the Intel logo and other Intel marks are trademarks of Intel Corporation or its subsidiaries. 

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