Technology

3D Artificial Cornea from Stem Cells: Chula Researchers Advance Canine Corneal Wound Treatment

Published

2 years ago

July 10, 2024

BANGKOK, July 10, 2024 /PRNewswire/ — Chulalongkorn University’s Faculty of Veterinary Science and the Faculty of Engineering have worked together to research and develop a three-dimensional artificial cornea from stem cells that offers a way to treat deep corneal wounds in dogs. The innovation helps to solve the problem of treatment methods that rely on tissue replacement which is hard to find and very expensive. It makes it possible for dogs to be able to see clearly and comfortably once again.

Does your dog have any of these symptoms? The inability to fully open its eyes, squinting or blinking frequently, shedding lots of tears, sometimes the tears are thick, and the mucus appears greenish. The sclera is unusually red and not clear like before. The cornea becomes cloudy and there are blood vessels in it.

If your answer is “yes” then your pet might be suffering from a corneal ulcer which, if left untreated could eventually cause blindness.

Nowadays, the number of dogs receiving treatment for corneal ulcers has increased tremendously. The small animal hospital at the Faculty of Veterinary Medicine, Chulalongkorn University alone is already treating dogs with corneal ulcers daily.

“We find quite a number of lesions like this in dogs. Corneal ulcers occur as a result of many reasons, such as dogs scratching their own eyes because they have allergies causing itching around the eyes followed by scratching until the lesions form. Fights with other dogs, being scratched by a cat, or accidentally bumps into objects” Veterinarian Dr. Chutirat Torssahakul of the Department of Internal Medicine, Faculty of Veterinary Medicine, Chulalongkorn University addressed the problems that became the starting point for the research and innovation development. “Three-dimensional artificial cornea from stem cells” enables your beloved pet to have perfect vision once again. “The current treatment being used is to have grafts made from replacement tissue derived from porcine bladder or canine placentas which are rare and relatively expensive. There is also the possibility of causing post-surgery reaction and inflammation. Therefore, we thought that if we could produce our own innovative artificial cornea using natural materials that are easily found and reduce the chance of causing inflammation this might be a better option.” Dr. Chutirat explained.

Three-dimensional artificial cornea from stem cells – a brighter alternative

As a result of the effort and intention to solve eye problems for dogs, the Faculty of Veterinary Science’s research team through the Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC) has therefore embarked on additional studies on stem cells and is working with the Biomedical Engineering Research Center of the Faculty of Engineering, Chulalongkorn University recognizing its expertise in tissue engineering to help make adhesive materials for growing stem cells.

According to Veterinary Professor Dr. Chutirat “Artificial corneal tissue is obtained by cultivating real dog corneal stem cells on a natural material structure made from silk fibroin mixed with gelatin. The material can be cheaply and easily found in Thailand. It is strong and durable, clear and transparent, and adheres well to cells making them three-dimensional which is comparable to real corneal tissue.”

This innovation can be used to treat corneal perforations in dogs as well as large corneal wounds where the tissue cannot be stitched or even deep wounds in which a large amount of corneal tissue has been lost. In cases of dogs with mild or moderate levels of corneal ulcer problems, currently, 2 methods for treatment are still in use.

Treatment with topical eye drops is usually used in cases that are not too severe, such as a superficial wound or a bit deeper layer. Treatment with eye drops can help prevent complications due to secondary infections. The drops do not help, however, with healing wounds since that depends on the dog’s own body mechanisms. If the body is strong and there is normal cell growth, then most cases will recover on their own.

Treatment with surgery is used in cases of very deep wounds, complicated wounds, reaching the last layer of the cornea, or penetrating wounds where it is still possible to stitch the corneas together normally.

“But in cases where the wound in the cornea is so large that tissue must be used to replace the missing part, we usually use a graft which could be the dog’s own conjunctiva. The other option is to use replacement tissue such as tissues derived from human or canine placentas. These are costly and difficult to find so we have invented a new way to treat them and that is the three-dimensional artificial cornea made from stem cells.”

4 outstanding features of the 3D artificial cornea innovation

It appears very similar to the real corneal surface – Research shows that stem cells grown in the lab can create tissue cells. The extracellular matrix is interconnected and the outline is similar to the real corneal surface. In particular, the arrangement of stem cells in the cornea is remarkable in that it is more orderly than other positions. This will help maintain the clarity of the cornea compared to other alternative materials currently in use that are somewhat opaque. It derives entirely from all-natural substances- The stem cells used are those that have been harvested from the cornea of the dog being treated or collected from recently deceased corpses so there is little chance of post-transplantation inflammation or irritation. The structure for cells to adhere to is made from silk fibroin mixed with gelatin. As time passes, stem cells create their own network of cells that form three-dimensional pieces even though the structural materials are naturally degraded by enzymes. They can be trimmed during the transplantation process – since the parts are three-dimensional sheets they can be trimmed to fit the wound where the cornea is missing. Wounds heal faster – stem cells are living cells and have properties that help in network formation causing cell adhesion. They also help with strengthening and building collagen so that wound healing can occur. This is different from using graft sheets that do not contain living cells.

At present, the “3D artificial cornea from stem cells” innovation is still in the laboratory testing stage to study whether the 3D artificial cornea can actually be used as a cornea replacement, and to determine how it interacts with the animal’s body. According to Veterinary Professor Dr. Chutirat in many countries research on such innovations is also currently underway at the laboratory level.

“The research we have done has produced satisfactory results. It is expected that this innovation will be applied to dogs in the next few years. Moreover, we have plans to apply this knowledge to cats as well from cell collection, locating cells, separating cells, and arranging cells” Dr. Chutirat concluded.

Those who are interested can further read the research paper on the subject at https://pubmed.ncbi.nlm.nih.gov/35120168/

For the full release and more images, please visit: https://www.chula.ac.th/en/highlight/170754/

About Chulalongkorn University

Chulalongkorn University has made the world’s top 50 university list for employment outcomes, which reflects both the high employment rate and workability of Chula graduates. The university is also listed as the best in Thailand for the 15th Consecutive Year (since 2009), according to the newly released QS World University Rankings 2024, putting Chula at 211th in the world, up from 244th last year.

Social Media:
Facebook: https://www.facebook.com/ChulalongkornUniversity
Youtube: https://www.youtube.com/chulauniversity
Linkedin: https://www.linkedin.com/school/15101896/

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/3d-artificial-cornea-from-stem-cells-chula-researchers-advance-canine-corneal-wound-treatment-302191982.html

SOURCE Chulalongkorn University

Technology

Meridian Singapore Immigration Launches New Website to Simplify the PR Application Journey for Foreigners in Singapore

Published

3 hours ago

April 30, 2026

New online platform provides clear, structured guidance for Employment Pass and S Pass holders navigating Singapore’s residency and Permanent Residency pathways

SINGAPORE, April 30, 2026 /PRNewswire/ — Meridian Singapore Immigration Pte. Ltd. has officially launched its new website at meridianimmigration.sg, a resource built specifically for foreigners living and working in Singapore who are exploring Permanent Residency or long-term residency options.

The platform arrives at a time when Singapore’s expatriate and foreign professional community is growing rapidly, yet many EP and S Pass holders report struggling to find clear, reliable information on the PR application process. Singapore’s immigration framework is among the most structured in Southeast Asia, with eligibility criteria, documentation requirements, and submission windows that change frequently. For individuals navigating this process without professional guidance, the stakes are high and the margin for error is narrow.

Meridian’s website was built to address that gap directly. The platform offers detailed explanations of available immigration pathways, structured consultation options, and educational resources developed by the firm’s team of immigration specialists. Rather than presenting a services catalogue, the site walks users through the considerations relevant to their specific situation, whether they hold an Employment Pass, S Pass, or are planning for their family’s long-term residency in Singapore.

“We built this platform because we saw how overwhelming and confusing the immigration process can be for people who genuinely want to build their lives here,” said a spokesperson for Meridian Singapore Immigration. “Our goal is to be the trusted partner that walks them through every step with clarity and integrity.”

Singapore’s continued attractiveness as a regional hub for multinational corporations, financial institutions, and technology firms means the pipeline of foreigners seeking long-term residency options remains substantial. At the same time, the ICA’s PR application framework has grown more nuanced, with factors such as economic contributions, family ties, and community integration weighed during assessment. Applicants who proceed without a clear understanding of these criteria often submit applications that are either premature or structurally incomplete.

Meridian’s approach centres on preparation and transparency, helping applicants understand where they stand before they apply and what supporting documentation strengthens their case.

Meridian Singapore Immigration Pte. Ltd. is a professional immigration consultancy dedicated to guiding individuals and families through Singapore’s immigration process. Specialising in Permanent Residency (PR) applications, residency pathways, and compliance support, Meridian offers clear, structured solutions tailored to each client’s unique circumstances. Founded on the values of Guidance, Integrity, and Success, Meridian is committed to making immigration simple, transparent, and accessible for everyone. For more information, visit meridianimmigration.sg or contact info@meridianimmigration.sg / +65 8873 1113.

View original content:https://www.prnewswire.com/apac/news-releases/meridian-singapore-immigration-launches-new-website-to-simplify-the-pr-application-journey-for-foreigners-in-singapore-302757392.html

SOURCE Meridian Singapore Immigration Pte. Ltd.

Technology

Socomec, Daitron team up to meet Japan’s growing power demands

Published

3 hours ago

April 30, 2026

TOKYO, April 30, 2026 /PRNewswire/ — Socomec, a century-old electrical group specialising in mission-critical energy, and Japan’s Daitron, an electronics components distributor, have signed a partnership to deliver power conversion solutions and service backup power and electrical-switching systems across Japan.

The deal combines Socomec’s equipment with Daitron’s on-the-ground engineering team, which has more than 74 years of experience in the Japanese market. The two companies will handle everything from project delivery to ongoing maintenance and spare parts.

The partnership covers three product areas: uninterruptible power supplies (UPS), which keep facilities running during outages; power conversion systems, which ensure the availability and continuity of high-quality energy; and static transfer switches, which automatically reroute power loads between sources without interruption.

Beyond equipment sales, the agreement includes training, spare parts, long-term service contracts and a full range of expert services covering prevention, measurement and analysis, consultancy, deployment and optimisation. Socomec will provide product and technical training to Daitron’s team, while Daitron handles installation, servicing and day-to-day client support in Japan.

The target market spans data centres, semiconductor plants, industrial facilities, hospitals and green buildings, all areas where even brief power interruptions can prove costly. Data center demand in particular is surging, driven by the rapid expansion of artificial intelligence infrastructure, with colocation and enterprise facilities among the primary targets.

“Daitron knows the Japanese market inside and out. They have the people, the relationships, and the hands-on experience, and we bring the technology to match,” said Socomec Asia-Pacific CEO O’Niel Dissanayake. “It’s a natural fit, and together we can offer something neither company could deliver alone.”

“Japan’s data centres, chip factories and industrial plants all require power systems they can count on,” said Masaharu Kato, corporate officer of Daitron. “Socomec’s technology is exactly what these customers need, and our job is to make sure it’s installed, maintained and supported properly. That’s what we do best.”

The partnership comes as Japan faces a step change in power demand. Electricity consumption is expected to grow 5.3% over the next decade, driven by data centres and semiconductor factories, according to the country’s grid operator. Industrial energy demand alone is forecast to rise 18.3% over the same period.

That growth is creating strong demand for reliable power infrastructure. Data centres, for example, run around the clock and cannot afford downtime, making backup power and efficient energy management essential. Socomec’s systems are designed to reduce power consumption without sacrificing reliability, a balance that is becoming increasingly important as operators look to manage both costs and environmental commitments.

Both companies say project planning and bids are already underway, with a long-term goal of expanding the partnership’s reach across Japan as demand grows.

About Daitron

Daitron Co., Ltd. is a Japanese engineering and trading company founded in 1952 and headquartered in Osaka. Listed on the Tokyo Stock Exchange (TYO: 7609), Daitron sells and manufactures electronic components, semiconductor processing equipment and power supply systems. The company has more than seven decades of experience serving Japan’s electronics and manufacturing industries.

SOCOMEC: When energy matters

Founded in 1922, SOCOMEC is an independent industrial group of more than 4,800 experts spread across the world in 30 subsidiaries. Our vocation: design, manufacture and sale of electrical equipment, with a strong expertize in critical power applications. In 2025, SOCOMEC achieved a turnover of 997 million euros (not yet audited).

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/socomec-daitron-team-up-to-meet-japans-growing-power-demands-302755570.html

SOURCE Socomec

Technology

Multi-Destination Travel Surges Across Asia-Pacific This Labour Day, Trip.com Group Data Shows

Published

3 hours ago

April 30, 2026

Multi-city travel across Asia-Pacific grew 35% year-on-yearMulti-city travel outpaces single-destination growth by more than 2xSoutheast Asia sees strong double-digit growth, with Thailand up to 52% YoY

SINGAPORE, April 29, 2026 /CNW/ — Multi-city travel across Asia-Pacific grew 35% year-on-year this Labour Day period, according to data from Trip.com Group. Several Asia-Pacific markets including Japan, South Korea, parts of Southeast Asia and Mainland China celebrate Labour Day, driving strong cross-border and domestic travel flows across the region.

Over 30% of international trips now span multiple destinations, highlighting a continued shift towards more complex, itinerary-led travel. This shift reflects a growing preference to maximise time and value with multiple destinations within a single trip rather than a single location.

Multi-destination trips become a defining travel pattern

While single-destination travel continues to account for most bookings, growth is increasingly driven by more complex itineraries. Multi-destination bookings are growing at more than twice the pace of single-destination travel, reflecting stronger demand for flexibility and deeper exploration.

Travellers are increasingly structuring trips across multiple cities to maximise both time and value, with popular combinations including:

Tokyo – Osaka – Kyoto (Japan)Seoul – Busan (South Korea)Bangkok – Phuket (Thailand)

These itineraries reflect a growing preference for multi-stop journeys that blend urban experiences with leisure destinations.

Southeast Asia sees fast growth in multi-destination travel

Across Southeast Asia, demand for multi-destination travel is rising steadily, with strong growth across key markets of Thailand: 52%, Malaysia: 40%, and Singapore: 17%, according to Trip.com Group data.

Top outbound destinations across Southeast Asian markets include Japan (Tokyo, Osaka), South Korea (Seoul), China (Shanghai, Beijing), Thailand (Bangkok), Indonesia (Bali).

In other parts of Asia such as Hong Kong SAR, multi-destination travel also grew by over 50% year-on-year, highlighting growing preference for more complex itineraries over traditional single-destination trips, particularly in well-connected urban markets.

In Mainland China, domestic travel remains a strong base, while overseas journeys are increasingly shaped by multi-destination itineraries, with over 40% of outbound trips spanning multiple destinations and continuing to grow.

This suggests that travellers in this region are increasingly combining multiple cities within a single trip, supported by strong regional connectivity.

Japan’s domestic travel momentum on the rise

Japan is also seeing shifts in domestic travel behaviour, even as outbound demand continues to grow.

In Japan, domestic travel is growing rapidly, indicating rising interest in travelling within the country, accounting for one-quarter of all flight bookings, and to cities such as Tokyo, Sapporo and Okinawa.

Intra-Asia travel dominates Labour Day demand

The Labour Day holiday period continues to be driven by regional travel within Asia-Pacific, with travellers favouring destinations that offer ease of access, diverse experiences, and flexible itineraries.

The Group’s data highlights the continued strength of short-haul travel, supported by strong connectivity and shorter flight durations.

More broadly, the way people travel across Asia-Pacific is evolving. Travellers taking a more deliberate approach to how they plan their trips. While cross-border journeys are increasingly shaped by multi-city itineraries, domestic travel remains a strong and steady part of the landscape. Together, these patterns point to a more flexible and value-conscious mindset, as travellers look to make the most of both time and budget.

About Trip.com Group

Trip.com Group is a leading global travel service provider comprising of Trip.com, Ctrip, Skyscanner, and Qunar. Across its platforms, Trip.com Group helps travellers around the world make informed and cost-effective bookings for travel products and services and enables partners to connect their offerings with users through the aggregation of comprehensive travel-related content and resources, and an advanced transaction platform consisting of apps, websites and 24/7 customer service centres. Founded in 1999 and listed on NASDAQ in 2003 and HKEX in 2021, Trip.com Group has become one of the best-known travel groups in the world, with the mission “to pursue the perfect trip for a better world”. Find out more about Trip.com Group here: group.trip.com.