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3D Artificial Cornea from Stem Cells: Chula Researchers Advance Canine Corneal Wound Treatment

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BANGKOK, July 10, 2024 /PRNewswire/ — Chulalongkorn University’s Faculty of Veterinary Science and the Faculty of Engineering have worked together to research and develop a three-dimensional artificial cornea from stem cells that offers a way to treat deep corneal wounds in dogs. The innovation helps to solve the problem of treatment methods that rely on tissue replacement which is hard to find and very expensive.  It makes it possible for dogs to be able to see clearly and comfortably once again.  

Does your dog have any of these symptoms? The inability to fully open its eyes, squinting or blinking frequently, shedding lots of tears, sometimes the tears are thick, and the mucus appears greenish.  The sclera is unusually red and not clear like before.  The cornea becomes cloudy and there are blood vessels in it.   

If your answer is “yes” then your pet might be suffering from a corneal ulcer which, if left untreated could eventually cause blindness.   

Nowadays, the number of dogs receiving treatment for corneal ulcers has increased tremendously.  The small animal hospital at the Faculty of Veterinary Medicine, Chulalongkorn University alone is already treating dogs with corneal ulcers daily.   

“We find quite a number of lesions like this in dogs.  Corneal ulcers occur as a result of many reasons, such as dogs scratching their own eyes because they have allergies causing itching around the eyes followed by scratching until the lesions form.  Fights with other dogs, being scratched by a cat, or accidentally bumps into objects” Veterinarian Dr. Chutirat Torssahakul of the Department of Internal Medicine, Faculty of Veterinary Medicine, Chulalongkorn University addressed the problems that became the starting point for the research and innovation development.  “Three-dimensional artificial cornea from stem cells” enables your beloved pet to have perfect vision once again.  “The current treatment being used is to have grafts made from replacement tissue derived from porcine bladder or canine placentas which are rare and relatively expensive.  There is also the possibility of causing post-surgery reaction and inflammation.  Therefore, we thought that if we could produce our own innovative artificial cornea using natural materials that are easily found and reduce the chance of causing inflammation this might be a better option.”  Dr. Chutirat explained.    

Three-dimensional artificial cornea from stem cells – a brighter alternative 

As a result of the effort and intention to solve eye problems for dogs, the Faculty of Veterinary Science’s research team through the Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC) has therefore embarked on additional studies on stem cells and is working with the Biomedical Engineering Research Center of the Faculty of Engineering, Chulalongkorn University recognizing its expertise in tissue engineering to help make adhesive materials for growing stem cells. 

According to Veterinary Professor Dr. Chutirat “Artificial corneal tissue is obtained by cultivating real dog corneal stem cells on a natural material structure made from silk fibroin mixed with gelatin.  The material can be cheaply and easily found in Thailand.  It is strong and durable, clear and transparent, and adheres well to cells making them three-dimensional which is comparable to real corneal tissue.” 

This innovation can be used to treat corneal perforations in dogs as well as large corneal wounds where the tissue cannot be stitched or even deep wounds in which a large amount of corneal tissue has been lost.  In cases of dogs with mild or moderate levels of corneal ulcer problems, currently, 2 methods for treatment are still in use.   

Treatment with topical eye drops is usually used in cases that are not too severe, such as a superficial wound or a bit deeper layer. Treatment with eye drops can help prevent complications due to secondary infections.  The drops do not help, however, with healing wounds since that depends on the dog’s own body mechanisms. If the body is strong and there is normal cell growth, then most cases will recover on their own.  

Treatment with surgery is used in cases of very deep wounds, complicated wounds, reaching the last layer of the cornea, or penetrating wounds where it is still possible to stitch the corneas together normally. 

“But in cases where the wound in the cornea is so large that tissue must be used to replace the missing part, we usually use a graft which could be the dog’s own conjunctiva.  The other option is to use replacement tissue such as tissues derived from human or canine placentas.  These are costly and difficult to find so we have invented a new way to treat them and that is the three-dimensional artificial cornea made from stem cells.” 

4 outstanding features of the 3D artificial cornea innovation  

It appears very similar to the real corneal surface – Research shows that stem cells grown in the lab can create tissue cells.  The extracellular matrix is interconnected and the outline is similar to the real corneal surface.  In particular, the arrangement of stem cells in the cornea is remarkable in that it is more orderly than other positions.  This will help maintain the clarity of the cornea compared to other alternative materials currently in use that are somewhat opaque.  It derives entirely from all-natural substances- The stem cells used are those that have been harvested from the cornea of the dog being treated or collected from recently deceased corpses so there is little chance of post-transplantation inflammation or irritation.  The structure for cells to adhere to is made from silk fibroin mixed with gelatin.   As time passes, stem cells create their own network of cells that form three-dimensional pieces even though the structural materials are naturally degraded by enzymes. They can be trimmed during the transplantation process – since the parts are three-dimensional sheets they can be trimmed to fit the wound where the cornea is missing.    Wounds heal faster – stem cells are living cells and have properties that help in network formation causing cell adhesion.  They also help with strengthening and building collagen so that wound healing can occur.  This is different from using graft sheets that do not contain living cells.    

At present, the “3D artificial cornea from stem cells” innovation is still in the laboratory testing stage to study whether the 3D artificial cornea can actually be used as a cornea replacement, and to determine how it interacts with the animal’s body.  According to Veterinary Professor Dr. Chutirat in many countries research on such innovations is also currently underway at the laboratory level. 

“The research we have done has produced satisfactory results.  It is expected that this innovation will be applied to dogs in the next few years.  Moreover, we have plans to apply this knowledge to cats as well from cell collection, locating cells, separating cells, and arranging cells” Dr. Chutirat concluded.   

Those who are interested can further read the research paper on the subject at https://pubmed.ncbi.nlm.nih.gov/35120168/ 

For the full release and more images, please visit: https://www.chula.ac.th/en/highlight/170754/

About Chulalongkorn University

Chulalongkorn University has made the world’s top 50 university list for employment outcomes, which reflects both the high employment rate and workability of Chula graduates. The university is also listed as the best in Thailand for the 15th Consecutive Year (since 2009), according to the newly released QS World University Rankings 2024, putting Chula at 211th in the world, up from 244th last year.

Social Media:
Facebook: https://www.facebook.com/ChulalongkornUniversity
Youtube: https://www.youtube.com/chulauniversity
Linkedin: https://www.linkedin.com/school/15101896/

 

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SOURCE Chulalongkorn University

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Siemon Appoints Trey Somers as Vice President of Product Management

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The Siemon Company, a global leader in network infrastructure solutions, announces the appointment of Trey Somers as Vice President of Product Management, effective Monday, July 15th, 2024.

WATERTOWN, Conn., July 20, 2024 /PRNewswire-PRWeb/ — The Siemon Company, a global leader in network infrastructure solutions, announces the appointment of Trey Somers as Vice President of Product Management, effective Monday, July 15th, 2024. In this role, Somers will lead Siemon’s global product management team and drive the development of innovative solutions that meet the evolving needs of the market. With a distinguished career spanning over two decades in the industry, Somers brings a wealth of experience in enterprise product management, OEM product management, and consulting services. Most recently, he served as Managing Director at Align Communications where he successfully led a team delivering smart building solutions to major financial institutions across the globe. “We are thrilled to welcome Trey to the Siemon team,” said Henry Siemon, President and CEO. “His deep industry knowledge and proven track record in product management make him an invaluable asset to our organization. We are confident that under Trey’s leadership, Siemon will continue to deliver cutting-edge solutions that drive customer success.” In his new role, Somers will oversee both the OEM and Enterprise Product Management teams, combining them into a unified global product management organization. He will also collaborate closely with the marketing team to align product development with current market needs and developing industry trends. “I am excited to join the Siemon team and contribute to the company’s continued growth and success,” said Trey Somers, Vice President of Product Management. “Siemon has CONNECTING THE WORLD TO A HIGHER STANDARD www.siemon.com a strong reputation for innovation and customer focus. I look forward to working with the team to develop groundbreaking solutions that address the challenges and opportunities of today’s dynamic market.” Learn more about Siemon at www.siemon.com.

“We are thrilled to welcome Trey to the Siemon team,” said Henry Siemon, President and CEO. “His deep industry knowledge and proven track record in product management make him an invaluable asset to our organization.”

About Siemon – Established in 1903, Siemon is an industry leader specializing in the design and manufacture of high-quality, high-performance IT infrastructure solutions and services for Data Centers, LANs, and Intelligent Buildings. Headquartered in Connecticut, USA, with global sales, technical, and logistics expertise spanning 150 countries, Siemon offers the most comprehensive suites of copper and optical fiber cabling systems, racks, cable management, and Intelligent Infrastructure Management solutions. With more than 400 patents specific to structured cabling, Siemon Labs invests heavily in R&D and the development of Industry Standards, underlining the company’s long-standing commitment to its customers and the industry. Through an ongoing commitment to waste and energy reduction, Siemon’s environmental sustainability benchmarks are unparalleled in the industry.

Contact Information: Brian Baum, brian_baum@siemon.com

Media Contact

Brian Baum, Siemon, 1 860 945-4213, brian_baum@siemon.com

View original content:https://www.prweb.com/releases/siemon-appoints-trey-somers-as-vice-president-of-product-management-302201236.html

SOURCE Siemon

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Online Generator Seller Announces Cummins 7-Day Inflation Fighter Discount For Homeowners

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Cordova, Tennessee based Buckeye Power Systems, LLC announced its partnership with Cummins Power Generation and a 7-day inflation fighting 5% discount on the popular Cummins 20kW RS20A air-cooled home standby generator. The discount applies for purchases between July 25th and August 1st, 2024.

CORDOVA, Tenn., July 20, 2024 /PRNewswire-PRWeb/ — Cordova, Tennessee based Buckeye Power Systems, LLC announced its participation with Cummins Power Generation and its 7-day 5% discount for homeowners on the popular RS20A 20kW HSB air-cooled home standby generator. The discount also applies to the RS20AC kit which includes a 200-Amp Automatic Transfer Switch. The discount applies for purchases between July 25th and August 1st, 2024.

“The 7-day special discount applies to Cummins 20kW air-cooled home standby generator which is also its most popular model.”

David Richey, president of Buckeye Power Systems, said today, “The 7-day special discount applies to Cummins 20kW air-cooled home standby generator which is also its most popular model. The 20kW generator provides whole house coverage for homes up to 2000 square feet. The same generator also provides managed whole house coverage for homes up to 3000 square feet.”

Richey said the Cummins 20kW includes a built-in load management feature which manages the operation of high-power consumers like air conditioners, kitchen ovens, and clothes dryers. “The load management feature prevents certain loads from operating when the generator is already operating at or near peak performance,” Richey continued. “So, the RS20A offers managed whole house coverage for homes up to 3000 square feet.”

When fueled by natural gas, homeowners enjoy an unlimited supply of fuel from their utility supplier, thus eliminating the need for fuel storage. The same generator can also be fueled by liquid-propane (LP). A 5-year manufacturer’s warranty is standard and extended warranty coverage up to 10 years is available as an option.

In the current inflationary economic environment, the price rollback should be warmly welcomed among homeowners looking for special deals on standby power. The Buckeye Power Systems website currently offers the Cummins RS20A for $5,069 with no sales tax in most states, less the $253.45 discount. The Cummins RS20AC kit includes a 200-Amp Automatic Transfer Switch and is offered for $5995 less a $299.75 discount during the 7-day special promotion.

Buckeye Power Systems is also offering a $500 VISA Gift Card for purchase of the two other Cummins air-cooled home standby generators including the 13kW Cummins RS13A and the 17kW Cummins RS17A.

Media Contact

Steve Baker, Buckeye Power Systems, LLC, 1 19013798097, steve@benchmarkelectric.us, https://buckeyepowersystems.com

David Richey, Buckeye Power Systems, LLC, 1 9013798097, david@buckeyepowersystems.com, https://buckeyepowersystems.com

View original content to download multimedia:https://www.prweb.com/releases/online-generator-seller-announces-cummins-7-day-inflation-fighter-discount-for-homeowners-302201860.html

SOURCE Buckeye Power Systems, LLC

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UBX Cloud Creates A Rapid Solution To The Crowdstrike Outage Affecting Millions Worldwide.

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Download the newest version of the “CrowdFix” update on UBX Cloud’s website.

DETROIT, July 20, 2024 /PRNewswire-PRWeb/ — UBX Cloud, a dedicated cloud hosting provider with experience in IT solutions on a global scale, has developed a safe automated repair for the CrowdStrike outage that has affected millions worldwide. The new update has been named “CrowdFix” by UBX Engineers. The solution has been tested on thousands of servers that UBX Engineers manage internally with results that work highly efficiently.

“Our engineers have developed a countermeasure within 2.5 hours after the first reported incident. I appreciate the team working to create a solution that makes it simple, effective, and secure.” – Steven Panovski, President and Founder of UBX Cloud.

“Our engineers have developed a countermeasure within 2.5 hours after the first reported incident. I appreciate the team working to create a solution that makes it simple, effective, and secure,” stated Steven Panovski, President and Founder of UBX Cloud.

CrowdFix Solution Developed by UBX Cloud

To implement the CrowdFix solution, Engineers can simply boot the CrowdFix ISO on the impacted system and it’ll automatically detect all attached disks on the system, while deleting the CrowdStrike related files that are preventing impacted Windows systems. Administrative access or restoration from the backups isn’t required.

For step-by-step instructions on implementing the CrowdFix, please view the documentation in or video to implement. Complete Disclaimer will be listed on our company blog.

Instructions are to boot the ISO file and run the batch file.
Primary LINK 1: http://ubx.link/csfix
Alternate LINK: TBA

Filename: WinPE_UBXCloud_CSFix103.iso
MD5 Hashes: 623c3e11895dda4015bd02f0f8b49313e1fdf2806c961f71d41fbdc96cdc03b5
Size: 380 MB

UBX Cloud Inc.

UBX Cloud is a global IT and Engineering company founded in Michigan in 2008. After steady growth, they opened a new satellite office in India. The company has a team of Engineers working to develop and manage cloud solutions for businesses around the world. This ensures business continuity and secure cloud solutions that give customers peace of mind. To learn more about partnering with UBX Cloud on secure cloud solutions and managed services, please visit the website and contact the team.

With the growing dependence on technology and software solutions, it’s even more important for cloud service providers to develop solutions that support the overall architecture and framework of interconnectivity.

“We’re happy to develop a solution that supports business continuity and operations worldwide. Our team is dedicated to helping customers and the industry at large with cybersecurity and IT solutions that bring value. I especially want to thank our Engineer Mohammed Ali, for developing the solution rapidly,” Steven Panovski said passionately.

In addition to the CrowdFix solution, UBX Cloud previously supported other large enterprises with cybersecurity and cloud solutions. They’re quickly becoming a resource for Engineers across the globe that collaborate on developing technology solutions.

For more information, please visit UBX Cloud’s website at https://www.ubxcloud.com.

UBX Cloud LinkedIn

Media Contact

Carrie Stapleford, UBX Cloud, 1 (586) 808-5000, oop@ubxcloud.com, https://www.ubxcloud.com/

View original content to download multimedia:https://www.prweb.com/releases/ubx-cloud-creates-a-rapid-solution-to-the-crowdstrike-outage-affecting-millions-worldwide-302201954.html

SOURCE UBX Cloud

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